ENDOMETRIAL CANCER

This study tests a drug called retifanlimab, given alone or with other treatments, for people with advanced or metastatic endometrial cancer that got worse after platinum chemotherapy. About 206 participants will receive the drug(s) to see if tumors shrink or stop growing. The go…

This early-stage study tests adding an immunotherapy drug (TSR-042) to standard radiation for people with endometrial cancer that cannot be removed by surgery. The goal is to see if the combination is safe and can help the immune system fight the cancer more effectively. About 10…

This study looks at whether giving chemotherapy after surgery can help people with early-stage (stage 1 or 2) endometrial cancer who have a higher chance of the cancer coming back. About 244 patients who had their cancer removed and no cancer in their lymph nodes will either rece…

This early-stage study tests an experimental pill, ATV-1601, in people with advanced solid tumors (including certain breast, ovarian, and prostate cancers) that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the …

This study tested whether a combination of two drugs, letrozole and everolimus, can help control advanced or recurrent endometrial cancer. The trial enrolled 42 participants whose cancer had returned or progressed. Researchers measured how many patients had their tumors shrink or…

This early-phase study tests a new drug called AI-061, which combines two immunotherapy agents (anti-PD-1 and anti-CTLA-4) into one treatment. The goal is to find the safest dose and see if it can shrink tumors in people with advanced cancers like melanoma, lung, and ovarian canc…

This study tests an experimental pill (GSK4418959) in adults with advanced solid tumors that have specific genetic changes (dMMR or MSI-H). The drug targets a DNA repair protein to try to shrink tumors. The trial will check safety, side effects, and how well the drug works alone …

This early-phase trial tests a new drug called IMGN151 in adults with certain gynaecological cancers that have come back. The study aims to find a safe dose and check for side effects. About 256 participants with recurrent endometrial, ovarian, fallopian tube, primary peritoneal,…

This study tests the drug pembrolizumab in about 1,600 people with advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can shrink tumors and to identify biomarkers that predict response. Participants receive pembrolizumab and are m…

This study tested whether a combination of three drugs—everolimus, letrozole, and metformin—can help control advanced or recurrent endometrial cancer. The 62 participants had cancer that came back or spread and had limited prior treatments. The goal was to see how many patients h…

This study tests a combination of two drugs, cadonilimab and lenvatinib, in 32 people with advanced endometrial cancer that has spread or returned and is no longer responding to standard chemotherapy. The goal is to see if this treatment shrinks tumors and how safe it is. Partici…

This study tests whether the drug sacituzumab govitecan can help people with endometrial cancer that has come back after chemotherapy and immunotherapy. About 640 participants will receive either the study drug or a standard treatment chosen by their doctor. The goal is to see if…

This early-stage study tests two experimental drugs (botensilimab and balstilimab) that help the immune system fight cancer. It includes about 500 adults with advanced solid tumors like lung, ovarian, or colorectal cancer that haven't responded to standard treatments. The main go…

This early-stage trial tests a combination of two drugs, naptumomab estafenatox and durvalumab, in 120 adults with advanced or metastatic solid tumors that have not responded to standard treatments. The main goal is to find safe doses and check for side effects, while also measur…

This study compares a new drug, MK-2870, to standard chemotherapy for people with endometrial cancer that has already been treated with platinum chemo and immunotherapy. About 710 participants will receive either MK-2870 alone or a doctor-chosen chemo. The goal is to see if MK-28…

This study tests two drugs, abemaciclib and letrozole, in 53 people with advanced or returning endometrioid endometrial cancer that cannot be cured by surgery or radiation. The goal is to see if the combination can stop the cancer from growing for at least 6 months. Treatment con…

This study tests whether the immunotherapy drug dostarlimab works better than standard chemotherapy for people with advanced or recurrent endometrial cancer that has a specific genetic feature (MMR deficient). About 260 participants will be randomly assigned to receive either dos…

This study is testing an experimental drug called AZD5305, a PARP inhibitor, in people with advanced solid tumors like ovarian, breast, pancreatic, and prostate cancer. The goal is to see if the drug is safe and tolerable when given alone or with other cancer treatments. About 70…

This study tests a combination of two drugs, atezolizumab and bevacizumab, in 110 women with advanced, recurrent, or persistent endometrial cancer that has not responded to standard treatments. The goal is to see if this drug pair can shrink tumors or slow cancer growth. Particip…

This study tests a drug called ceralasertib, either alone or combined with olaparib or durvalumab, in people with advanced solid tumors like kidney, bladder, pancreatic, endometrial, and prostate cancers. The goal is to see if these combinations can shrink tumors or slow their gr…

This study tests whether adding the immunotherapy drug pembrolizumab to standard radiation and chemotherapy can help control high-risk endometrial cancer after surgery. About 45 participants who have had a hysterectomy will receive radiation to the vagina, followed by three cycle…

This early-phase study tests whether combining two drugs, DKN-01 and pembrolizumab, can help control advanced or recurrent endometrial cancer that cannot be cured with surgery or radiation. Eight adult women with this type of cancer are taking part. The main goal is to check safe…

This study tests a daily pill called giredestrant in 30 people with Grade 1 endometrial cancer (a low-grade uterine cancer). The goal is to see if the drug can shrink or stop the cancer from growing over 6 months, possibly avoiding or delaying surgery. Participants take the drug …

This early-phase study tests a personalized cell therapy (ADP-A2M4CD8) for people with advanced cancers like lung, ovarian, or melanoma that have a specific marker called MAGE-A4. The treatment uses the patient's own immune cells, modified to better attack the cancer, and is give…

This early-phase study tests whether injecting a radioactive sugar (18F-FDG) into the cervix before a PET/CT scan can more clearly show which pelvic lymph nodes contain cancer in women with stage IB1 cervical cancer or high-grade endometrial cancer. About 42 women scheduled for s…

This study looks at whether group support or one-on-one peer support helps Black patients with endometrial cancer complete their treatment and feel less alone. About 252 participants will be randomly assigned to one of three groups: group support, peer support, or enhanced usual …

This study looks at whether a ketogenic diet—a very low-carbohydrate diet that forces the body to burn fat for energy—is safe and tolerable for overweight or obese patients with newly diagnosed endometrial cancer. Nineteen participants followed the diet before surgery to see if i…

This early study looks at whether a 10-week exercise program done at home can improve physical fitness in women who have finished treatment for endometrial cancer. Ten participants will do exercises like chair stands and arm curls, guided by remote coaching. The goal is to see if…

This study tests a program called Journey Ahead that helps women with gynecologic cancers (like ovarian, endometrial, or cervical cancer) improve their coping and communication skills. About 30 women who have been diagnosed or had a recurrence in the past 5 years will take part. …

This study collects fresh tumor samples from 416 adults with various cancers (bladder, kidney, colorectal, head and neck, liver, lung, skin, endometrial) to develop and train a live tumor diagnostic platform. The goal is to see how accurately the platform can predict whether a pa…

This study looks at ways to help people who have inherited gene changes that raise cancer risk. The goal is to see if certain tools can help them follow recommended cancer screening and prevention steps, and also share their genetic test results with family members. About 720 adu…

This study tests a program called IGNITE-TX that uses a website and a genetic family navigator to help relatives of people with hereditary cancer get free genetic counseling and testing. It involves 205 adults who have a known cancer gene mutation and their at-risk family members…

This study follows 100 women with breast or gynecological cancer to see if what they eat in the month before starting chemotherapy is linked to levels of a protein called hepcidin. Researchers will also check if hepcidin levels relate to how much of the planned chemo dose patient…

This study tests whether using a real-time tissue analysis during surgery can help doctors decide which lymph nodes to remove in women with endometrial cancer. The goal is to avoid unnecessary removal of lymph nodes, which can cause side effects, while still effectively treating …

This study collects data from 300 Asian patients with endometrial cancer to see how doctors use tumor features (like cell type and genetic markers) to choose treatments. The goal is to learn which patients need more or less aggressive therapy, reducing side effects while improvin…

This study aimed to see if a special PET/MRI scan could predict which women with early endometrial cancer or a precancerous condition would respond to hormone therapy. It planned to enroll 8 women who would get one scan and be followed for 6 months. However, the study was withdra…

This study was designed to test a mobile health app that helps patients with recurrent head and neck or gynecologic cancers track their symptoms, treatment side effects, and quality of life. The goal was to see if patients find the app easy to use and helpful. However, the study …

This study looks at how diet, lifestyle, and genetics influence the risk of getting endometrial cancer. Researchers will compare women who have or had the cancer with those who do not. The goal is to identify factors that may lead to the disease. About 1,315 women from New Jersey…