ENDOMETRIAL CANCER

This early-phase study tested a new drug called TPST-1495, alone or with another drug (pembrolizumab), in 89 people with advanced solid tumors (like colorectal, lung, or head and neck cancer) that had stopped responding to standard treatments. The main goal was to find the safest…

This study tested a combination of three drugs (afuresertib, sintilimab, and chemotherapy) in 22 adults with solid tumors like lung, cervical, or stomach cancer that had stopped responding to prior immunotherapy. The goal was to find the safest dose and see if the combo could shr…

This study tested a drug called selinexor as a maintenance treatment for people with advanced or recurrent endometrial cancer who had already responded to chemotherapy. The goal was to see if taking selinexor could delay the cancer from growing back. The study involved 263 partic…

This study tested a combination of three drugs (bevacizumab, atezolizumab, and rucaparib) in 30 people with recurrent or progressive endometrial cancer that had not responded to prior treatments. The goal was to see if the combination could shrink tumors or slow cancer growth. Pa…

This study tested a shorter course of pelvic radiation given after hysterectomy for endometrial cancer. The goal was to see if a shorter treatment (instead of the usual 5-6 weeks) could cause fewer side effects while still controlling the cancer. 25 patients with stage III-IVA or…

This study tested a type of internal radiation called high-dose brachytherapy in 43 people with cervical, endometrial, esophageal, prostate, or biliary cancer. The goal was to see if the radiation implants could be placed accurately to deliver a high dose directly to the tumor. P…

This study tested whether high-intensity interval training (HIIT) before surgery could slow endometrial cancer growth. Thirty women with early-stage endometrial cancer did supervised HIIT sessions before their planned hysterectomy. Researchers measured changes in a cancer growth …

This study looked at whether a 12-week program of aerobic and strength exercises could improve heart health in women who had finished treatment for endometrial cancer. Thirty-three women in remission took part. They received exercise equipment and a Fitbit, and had their blood ve…

This study tested a new drug combination (MK-4280A) in people with certain skin cancers (cutaneous squamous cell carcinoma) or endometrial cancer. The goal was to see if the treatment could shrink or eliminate tumors. 163 participants received either the combination or a standard…

This early-stage study tested a new drug called RP903 in 69 people with advanced solid tumors (like ovarian, breast, or cervical cancer) who had no other treatment options. The main goal was to check the drug's safety and find the right dose, not to cure the cancer. While some pa…

This early-phase study tested a shorter, more intense radiation schedule (hypofractionated whole pelvis radiation) in 8 women with endometrial cancer who needed pelvic radiation after surgery. The main goal was to check safety and side effects, especially on the bladder and bowel…

This study tested whether adding the drug aprepitant to standard anti-nausea medicines could better prevent nausea and vomiting caused by chemotherapy in 143 women with gynecologic cancers like ovarian or cervical cancer. Participants received either the three-drug combo or a pla…

This study tested a home-based brain training program for 60 women who had finished chemotherapy for gynecologic cancers (like ovarian or uterine cancer) and were experiencing memory or thinking problems. Participants used a computer program called BrainHQ for 10 weeks. The goal …

This study measured 14 different trace elements (like iron, selenium, and lead) in the blood of 40 women — some with endometriosis, some with ovarian or endometrial cancer, and some healthy. Researchers wanted to see if certain element levels are higher or lower in these conditio…

This study looked at 66 women having a hysterectomy (removal of the uterus) to compare two surgical methods: standard laparoscopic surgery and a newer technique called vNOTES (done through the vagina). The goal was to see if vNOTES causes less pressure on the brain during the ope…

This study looked at 150 women with intermediate- or high-risk endometrial cancer to compare two ways of removing lymph nodes near the aorta (para-aortic area). One method removes nodes above a certain artery (high-level), the other below (low-level). The goal was to see which ap…

This study looked at whether a special website or two phone calls with a health coach could encourage more people with a personal or family history of certain cancers to get genetic testing. Over 800 adults who already completed a family health survey were randomly assigned to on…

This study tested a new method for injecting a green dye to help surgeons find the first lymph nodes that cancer might spread to in early-stage endometrial cancer. 80 women took part, and the new method aimed to show the dye moving in real time. The goal was to see if this approa…

This study tested whether a special clinic for women who finished treatment for early-stage breast or gynecologic cancer is practical. About 200 women used an app to report their symptoms, which triggered check-ins from nurses or dietitians when needed. The goal was to see if thi…

This study looked at medical records from 509 adults in Taiwan to find out how often a protein called HER2 IHC 3+ appears in advanced endometrial, ovarian, and cervical cancers. The goal was to better understand these cancers and help guide future treatment options. No new treatm…

This study looks at how well the drug T-DXd works compared to usual treatments for people with advanced HER2-positive solid tumors (like lung, colon, and ovarian cancers). Researchers will use data from past clinical trials and real-world patient records to compare survival rates…

This study followed 102 women with ovarian, fallopian tube, or endometrial cancer to see how standard chemotherapy (carboplatin and paclitaxel) affects their sense of taste, muscle mass, and nutrition. Researchers measured these changes before, during, and after six cycles of tre…

This study tested a new follow-up approach for people treated for gynecologic cancers like ovarian, endometrial, cervical, or vulvar cancer. Instead of seeing a doctor every time, patients met with a nurse at every other visit and used a smartphone app to learn self-management sk…

This study tested a digital tool (a chatbot) to help cancer survivors learn about genetic testing for hereditary cancer risk. 50 adults who had certain cancers (like breast, ovarian, or prostate) took part. The goal was to see if the chatbot was easy to use and if it helped more …

This study looked at how chemotherapy affects the overall quality of life in women treated for stage II or III endometrial cancer. Researchers surveyed 51 women at least two years after their treatment ended, using standard questionnaires to measure physical, emotional, and socia…