Spinal cord injury

This trial tests whether a spinal cord stimulator, implanted surgically, combined with intensive motor rehabilitation can help people with spinal cord injury regain the ability to stand and step. Ten adults with complete or incomplete spinal cord injury who cannot currently stand…

This study tests whether a two-step drug treatment can improve bone density in people with long-term spinal cord injury who have bone loss. Participants receive either romosozumab (a bone-building drug) or a placebo for 12 months, followed by denosumab (a bone-strengthening drug)…

This trial tests whether regular walking with a robotic exoskeleton can improve bone health and quality of life in people with spinal cord injury. Participants will train three times a week for 26 weeks, aiming for an hour of continuous walking each session. Researchers will meas…

This trial tests whether a 5-week ketogenic diet—high in fat and low in carbohydrates—can improve motor and sensory recovery in people with acute spinal cord injury. Participants receive either the ketogenic diet or a standard diet starting within 72 hours of injury. Researchers …

This trial is testing an implantable wireless brain-computer interface (BCI) called NEO in people with tetraplegia caused by cervical spinal cord injury. The device is designed to let participants control external equipment using their brain signals, potentially improving their a…

This study tests whether a non-invasive nerve stimulation on the leg, called transcutaneous tibial nerve stimulation (TTNS), can help maintain bladder function in people with recent spinal cord injury. Researchers will enroll 120 adults with spinal injuries at level T9 or above, …

This study tests whether adding Hunova® robotic rehabilitation to standard therapy improves trunk control in people with spinal cord injuries. 78 participants will receive either standard rehab alone or standard rehab plus Hunova® sessions. The goal is to see if the robotic devic…

This trial tests whether long-term electrical stimulation of the genital nerves can reduce bladder spasms and improve continence in people with neurogenic bladder dysfunction due to spinal cord injury, stroke, or multiple sclerosis. Participants will use a home-based stimulation …

This study tests whether applying noninvasive electrical stimulation to the spinal cord before robotic gait training can improve walking recovery in people with motor-incomplete spinal cord injury. Participants receive 40 sessions of either standing or lying stimulation followed …

This early study tests an implanted device called the Intelligent Spine Interface (ISI-C) in people with spinal cord injuries. The device is designed to bridge the gap in the spinal cord, picking up signals from above the injury and sending them to nerves below. The goal is to un…

This trial tests whether a spinal implant that delivers electrical stimulation, combined with robot-assisted rehabilitation, can improve walking ability in people with chronic spinal cord injury. Participants will have a device implanted and then undergo months of training. The g…

This study tests an implanted device that sends electrical pulses to the spinal cord to help people with spinal cord injury regain walking ability and reduce pain. Twelve adults with chronic spinal cord injury will receive the implant and then undergo physical therapy. The goal i…

This study tests whether epidural electrical stimulation, combined with a structured rehabilitation program, can improve functional independence in people with spinal cord injury affecting the conus region. Participants receive an implanted stimulator and undergo task-oriented ex…

This pilot study tests whether electrical stimulation of the spinal cord can improve motor function and reduce spasticity in people with spinal cord injury. Participants receive epidural and dorsal root stimulation during 10 rehabilitation sessions. The study measures changes in …

This study tests whether watching a video of someone walking, projected below a mirror, can help people with incomplete spinal cord injury improve their walking, strength, and sensation. The idea is that mirror neurons in the brain may be activated by seeing the movement, promoti…

This early-phase study tests whether a combination of two medications (neostigmine and glycopyrrolate) can be delivered through the skin using a mild electric current to help people with spinal cord injury have a bowel movement. Participants first receive the medication intraveno…

This trial investigates whether nerve transfer surgery can restore hand function in people with cervical spinal cord injury. Participants undergo a personalized nerve transfer procedure to reconnect nerves and improve arm and hand strength. Researchers track changes in motor stre…

This study tested an experimental drug called NVG-291 in people with spinal cord injuries to see if it could help improve movement and strength. The trial was stopped early and included 24 adults with cervical spinal cord injuries. Participants received either the drug or a place…

This study tested whether a smartphone app could help people with incomplete spinal cord injury manage bladder issues. 88 adults were split into two groups: one received standard nursing, the other used a special app for 4 weeks that provided health education, bladder tracking, a…

This completed early-phase trial tested whether the drug 4-AP (dalfampridine), combined with special nerve stimulation and leg exercises, could improve muscle strength and control in people with spinal cord injury. 26 adults with injuries at or above the lower back took part. The…

This pilot study tested a sleeve worn on the forearm that uses muscle signals to stimulate hand muscles, helping people with tetraplegia from spinal cord injury grasp and manipulate objects. Twelve adults with chronic cervical SCI completed a 12-week training program using the de…

This small pilot study tested two ways to stimulate the spinal cord—one with a surgically implanted device and one with surface electrodes—combined with a robotic exoskeleton to help people with spinal cord injury walk. Four men with complete paralysis below the chest took part. …

This study tested a device called ExaStim that uses mild electrical stimulation on the skin over the spinal cord to help people with chronic cervical spinal cord injury improve arm and hand function. Thirty-three participants used the device at home for 4 weeks after a training p…

This study tested a special balance training program for people with incomplete spinal cord injury who are at high risk of falling. The training involved unexpected pushes or pulls to trigger a stepping response, with some participants also receiving electrical stimulation to hel…

This pilot study tested whether adding a special type of electrical stimulation to standard wound care helps heal chronic pressure injuries (bedsores) in people with spinal cord or brain injuries. Twenty adults with stage II-IV pressure sores that hadn't healed after four weeks o…

This study tested a new rehabilitation approach for people with spinal cord injury. Ten participants received a spinal cord stimulation implant and used a robotic exoskeleton to help them walk. The goal was to improve leg muscle strength and overall quality of life. The combinati…

This study tested a new therapy that combines two types of electrical stimulation with balance training (like video games) to help people with incomplete spinal cord injury improve their standing balance. Seventeen participants completed 12 sessions over 4 weeks. The goal was to …

People with spinal cord injury (SCI) face higher risks of heart disease and diabetes, partly due to chronic inflammation and poor blood vessel function. Exercise helps but is often not possible. This small study tested whether repeated passive heating (using a water-perfused suit…

This study tested whether a person with chronic paralysis from a spinal cord injury could control hand movements using only their thoughts. The participant, who already had a brain implant from the BrainGate study, used a computer to decode their intended grasp patterns. Those si…

This study tested whether combining a mild brain stimulation technique (tDCS) with a new mental and physical rehab method (NEUROM) can help people with chronic spinal cord injury regain leg movement and feeling. Fifty-six participants with paralysis below the lower back were rand…

This study tested an experimental drug called elezanumab in people with a recent cervical spinal cord injury. The goal was to see if the drug could improve arm and hand movement and was safe. About 60 adults aged 18-75 with severe neck-level injuries received either the drug or a…

This pilot study tested whether combining neuromuscular electrical stimulation with daily vitamin D could improve bone health in veterans with chronic spinal cord injury. Six participants underwent 9 months of treatment, with bone changes measured by MRI and DXA scans. The goal w…

This study tested whether a home exercise program using electrical stimulation to move the legs, combined with a personalized diet, could improve body composition and metabolism in adults with spinal cord injury. Twenty-six participants were assigned to either exercise plus diet …

This study tested a drug called MT-3921 (Unasnemab) in 72 people with recent severe neck spinal cord injuries. The goal was to see if it could improve arm and hand function better than a placebo. Participants received the drug or placebo by IV over 6 months, and their motor score…

This study tested whether adding functional electrical stimulation (FES) bicycle ergometry to robotic rehabilitation helps people with chronic incomplete spinal cord injury walk better. 38 participants completed 20 sessions over 4 weeks. The goal was to see if the combination imp…

This study tested whether a bone-building drug (teriparatide) and a vibrating platform, alone or together, could improve bone density in 60 adults with chronic spinal cord injury who had low bone mass. Participants received daily injections of teriparatide, used a vibration devic…

This early-stage trial tested a single dose of an experimental drug called ALMB-0166 in 24 people with acute spinal cord injury. The main goal was to check safety and how the drug moves through the body. Participants had moderate to severe injuries and were scheduled for surgery …

This small pilot study tested whether pairing vagus nerve stimulation with rehabilitation is safe and feasible for people with cervical spinal cord injury. Six participants received an implanted nerve stimulator and underwent rehab sessions. The study focused on safety and whethe…

This study tests whether a 12-week adaptive exercise program can reduce chronic inflammation in people with spinal cord injury (SCI). Chronic inflammation is linked to heart and lung disease, the top causes of death in SCI. Twenty-four adults with SCI will be randomly assigned to…

This study tested three different weight loss strategies in 110 adults with chronic spinal cord injury who were overweight. The strategies included portion-controlled meals, enhanced self-monitoring with technology, and a tailored lifestyle program called GLB-SCI. The goal was to…

This phase 2 trial tested whether combining testosterone therapy with a special type of electrical stimulation (long pulse width) could rebuild leg muscle in 12 people with spinal cord injury whose muscles no longer respond to standard electrical stimulation. Participants receive…

This pilot study tested whether a year of monthly romosozumab injections, followed by a year of weekly alendronate pills, can improve bone health in women with chronic spinal cord injury and osteoporosis. Twelve non-ambulatory women participated. The goal was to see if this two-s…

This early-phase trial tested a device called SC0806, which is surgically implanted into the spine. It releases a growth factor to encourage nerve repair in people with complete spinal cord injury. Ten participants were randomly assigned to receive either the device plus rehabili…

This early study tested a wireless patch that uses a tiny electric current to push two drugs (neostigmine and glycopyrrolate) through the skin and into the blood. The goal is to help people with spinal cord injury have predictable bowel movements without needles. Only 2 healthy v…

This study tested whether a brain-computer interface (BCI) training program could improve hand and arm function in people with recent spinal cord injuries. Thirty participants used a system that reads brain signals during hand motor imagery exercises. The goal was to see if this …

This trial tests whether contrast-enhanced ultrasound can detect spinal cord injury during decompression surgery for chronic spinal cord compression. Researchers inject an ultrasound contrast agent before, during, and after the procedure to visualize blood flow changes in the spi…

This study tested a simple, portable virtual reality balance test (called VETS) to see if it could help diagnose and track cervical spondylotic myelopathy (CSM), a spinal cord condition common in veterans. Eight participants with CSM and a control group performed balance tasks un…

This study tests whether a personalized nutrition plan can help people with a recent spinal cord injury avoid gaining unhealthy body fat and becoming obese. About 56 participants will receive tailored dietary advice for one year. The goal is to improve long-term health and preven…

This study tested whether a single dose of zoledronic acid, a drug already used for osteoporosis, can prevent the rapid bone loss that often follows a spinal cord injury. Researchers enrolled 60 adults who had recently lost the ability to walk due to injury. They measured changes…

Researchers are testing a home-based program called action observation and motor imagery (AOMI) training for adults with spinal cord injury. Participants watch exercise videos and imagine themselves doing the movements without actually moving. The trial aims to see if this traini…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

Researchers are testing whether short, repeated sessions of mild low oxygen (mild intermittent hypoxia) can strengthen upper airway muscles and improve sleep apnea treatment. Adults with newly diagnosed obstructive sleep apnea and prehypertension or stage 1 hypertension, includin…

Children with spinal cord injury often struggle to sit upright because their trunk muscles are paralyzed. Researchers are testing a device that sends electrical pulses through the skin to the spinal cord, called transcutaneous spinal stimulation, to see if it can improve sitting …

Researchers at the University of Louisville are testing whether combining activity-based locomotor training with non-invasive spinal stimulation can improve sitting posture and trunk control in children with chronic spinal cord injuries. The trial enrolls 14 children, ages 3 to 1…

This study tested two types of magnetic brain stimulation (iTBS and rTMS) combined with robotic walking therapy in 30 people with chronic spinal cord injury. The goal was to see if these treatments could improve leg strength, walking ability, and daily independence. All participa…

Researchers want to know if a wireless peripheral nerve stimulator, already implanted in some patients for chronic arm pain, can also make paralyzed muscles contract. The trial enrolls adults with stroke or spinal cord injury who have the device on nerves in the arm. Participants…

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study tests a special fabric shoulder brace designed to mimic muscle support for people with neuromuscular disorders like muscular dystrophy, SMA, and ALS. About 30 participants will wear the brace and perform arm tasks to see if it improves movement, strength, and daily fun…

This study tests whether an 8-week group exercise class done over video can improve psychological and social well-being in people with spinal cord injury. The class is tailored for wheelchair users and co-led by someone with lived experience. Researchers will measure changes in m…

This small early-phase trial tests whether a single oral dose of a hemp-derived CBD/CBD-A extract can reduce neuropathic pain and change brain activity in people with spinal cord injury. Six participants with moderate to severe nerve pain for at least three months will receive ei…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This pilot study tests whether a technique called conditioning with open-label placebo (COLP) can help patients with spinal cord injuries, polytrauma, or burns reduce their opioid painkiller doses without losing pain relief. Participants receive a sugar pill and an essential oil …

This study tests a new way to use deep brain stimulation for people with severe, treatment-resistant chronic pain from stroke, spinal cord injury, or phantom limb pain. Instead of constant stimulation, the device delivers electrical pulses only when the brain senses high pain sig…

This early study tests a simple idea: temporarily numbing non-paralyzed arm muscles with an over-the-counter lidocaine cream while exercising paralyzed muscles. Researchers hope this will improve strength, function, and sensation in people with spinal cord injury. About 30 adults…

This trial investigates whether acupuncture can reduce pain and improve function in people with spinal cord injury. Participants receive either acupuncture with electrical stimulation plus ear acupuncture, or standard care alone, for eight weeks. The study measures pain levels, q…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tested a special exercise called blood flow-restricted resistance exercise (BFRE) in 10 people with incomplete spinal cord injury. Participants did arm exercises with a cuff that limits blood flow, plus electrical stimulation if needed, twice a week. The goal was to se…

This study tested a smart faucet that uses voice, motion, and remote controls to help people with spinal cord injury (SCI) get water for drinking, grooming, and washing without needing help. 40 participants with SCI and control subjects used the faucet in clinics and at home. The…

This completed study tested three different rehabilitation approaches—robotic rehabilitation, functional electrical stimulation (FES), and occupational therapy—to see which works best for improving hand and arm function in people with tetraplegia (paralysis of all four limbs) due…

This study tested whether adding core stability training to standard physical therapy improves trunk control and sitting balance in people with incomplete spinal cord injury. 46 participants aged 25-35 with injuries between T6 and T12 took part. The core training focused on exerc…

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This study tested a smart faucet that can be controlled by voice, eye gaze, or hand motion to help people with cervical spinal cord injury drink water and groom themselves. Twenty-eight participants tried the faucet to see if they could complete tasks like drinking, rinsing, and …

This small study tested whether a device that gently stimulates a nerve in the ear (called auricular vagus nerve stimulation) is safe for people with chronic spinal cord injuries. Sixteen participants received the stimulation over two visits. The main goal was to check for side e…

This completed Phase 2 trial tested a smart, hands-free faucet called Access-H2O for people with spinal cord injury. The faucet uses voice, motion, and remote controls to let users get water for drinking, grooming, and washing without help. Twenty-three participants with spinal c…

This study tested whether brief periods of breathing low-oxygen air (acute intermittent hypoxia) can improve arm, leg, and walking function in people with incomplete spinal cord injury. Sixty-eight participants received either the low-oxygen treatment or a sham (normal air) over …

This study tested a 'Digital Strolling' program where people with severe mobility impairment use a virtual reality headset to walk in a digital world. 24 participants either used the VR walking or watched walking videos for 10 days. The goal was to see if this approach could impr…

This small study tested whether training with a robotic exoskeleton (a wearable robot suit) can help improve bowel function in people with spinal cord injury. Ten adults with long-term spinal cord injury used the exoskeleton in a supervised program. Researchers measured changes i…

This study tested whether adding a special nerve stimulation treatment to standard exercise could improve neck disability in people with whiplash from a car accident. 44 adults with recent whiplash were split into two groups: one did only exercises, the other did exercises plus t…

This study tested a home-based program for people with spinal cord injury that combines leg cycling with electrical stimulation, arm exercise, and a hormone treatment. The goal was to see if this combination improves aerobic fitness, daily function, and overall health better than…

This study tested a low-cost elastic band device designed to help therapists assist people with spinal cord injury while walking on a treadmill. The device uses rubber bands to help move the legs forward during walking. Nineteen participants with spinal cord injury tried the devi…

This completed study tested a 7-week, peer-led program for adults with spinal cord injury and chronic pain. The program combined education about pain neuroscience with body-based tools like red light therapy, massage, and guided movement. Twelve participants attended group sessio…

This study tested whether people with spinal cord injuries can reach a high-intensity heart rate while walking in a robotic exoskeleton. Eleven participants completed five training sessions using the Ekso device. Researchers measured heart rate, walking speed, and endurance befor…

This study tested whether a mild electrical stimulation (40 kHz) applied through the skin can safely reduce nerve pain in people with spinal cord injury. Thirty adults with paraplegia and chronic nerve pain received either real or placebo stimulation alongside their usual treatme…

This study tested a special wheelchair that lets people with spinal cord injuries stand up and move around at the same time. The goal was to see if using this chair at home and in the community helps them stand more often and feel more satisfied with their daily activities. Twent…

This study tested two types of magnetic brain stimulation (TMS) to see if they can reduce nerve pain in people with spinal cord injury. 26 adults with long-term nerve pain that didn't respond to medication took part. The goal was to measure changes in pain severity, daily functio…

This pilot study tested whether a non-invasive treatment called extracorporeal shockwave therapy (ESWT) can safely reduce spasticity—muscle stiffness and spasms—in people with chronic spinal cord injury. Five participants received ESWT or a sham treatment, and researchers measure…

This completed Phase 3 trial tested whether brivaracetam, a drug used for seizures, can reduce chronic nerve pain in people with spinal cord injury. 44 adults with persistent pain took part. The study compared brivaracetam to a placebo and measured changes in pain intensity and d…

This study tested a device that combines mild electrical muscle stimulation with a balance-board video game to help people with spinal cord injury or stroke improve their balance and reduce fall risk. 18 adults who were at least one year past their injury took part. The goal was …

This study tested two 8-week home exercise programs for 96 adults with spinal cord injury. One program used movement to music, the other standard exercises. Researchers measured physical activity levels and pain to see which approach worked better.

This study tested a lightweight robotic suit called the Myosuit in 34 people with incomplete spinal cord injury. Participants used the suit during walking exercises and then took it home for six weeks to see if it improved their daily walking. The goal was to measure changes in w…

This small study tested whether functional electrical stimulation (FES) arm cycling could improve arm strength and function in people with recent spinal cord injury. Six participants with cervical-level injuries cycled with electrical stimulation 3 times a week for 6 weeks. The s…

This study looked at whether a type of talk therapy called prolonged exposure therapy can help reduce PTSD symptoms in people with spinal cord injuries. Thirty adults with both conditions were randomly assigned to receive the therapy or continue their usual care. The main goal wa…

This study tested a new online program to help people with spinal cord injury cope better and improve their mental health. Twelve adults with spinal cord injury and mild anxiety or depression took part in eight weekly online group sessions led by a nurse. The main goal was to see…

This study looked at whether high-intensity walking training is better than lower-intensity walking exercise for people with chronic, motor incomplete spinal cord injury. Researchers measured walking speed and distance in 53 participants. The goal was to find a more effective way…

This study tested a new approach to help people with spinal cord injury walk better. Participants received brief sessions of mild low-oxygen air (acute intermittent hypoxia) combined with gentle electrical stimulation on the back, plus walking practice. The goal was to see if thi…

This study tested an intensive motor rehabilitation program that uses advanced technology to help adults with chronic stroke or spinal cord injury improve their daily functioning. 102 participants were randomly assigned to either the tech-enhanced rehab or a control group. The go…

This study tested a computer game-based exercise program to help people with stroke or spinal cord injury improve hand and arm function. Thirty-five adults who were at least six months post-injury used a special mouse-like device to play games designed to practice hand movements.…

This study tested a new approach to help people with cervical spinal cord injury improve arm and hand function. Participants received non-invasive brain stimulation combined with upper limb training over several weeks. The goal was to see if this combination could strengthen musc…

This study tested whether combining two drugs—dextromethorphan (taken by mouth) and lidocaine (given through a vein)—can reduce central neuropathic pain in people with spinal cord injury. 26 adults with moderate or worse pain for at least 3 months took part. Each person received …

This study tested three doses of dextromethorphan (a common cough medicine) against a placebo to see if it could reduce nerve pain in people with spinal cord injuries. 26 adults with chronic central neuropathic pain took part. The goal was to measure pain relief and satisfaction …

This completed Phase 1 trial tested whether three FDA-approved drugs (cyproheptadine, carbidopa-levodopa, and atomoxetine) could improve hand function when combined with hand training exercises in 25 people with chronic spinal cord injury. Participants took a single dose of one d…

This study tested a special talking therapy (values-based cognitive behavioral therapy) for 6 adults with spinal cord injury from road accidents. The goal was to see if it helps reduce daily pain and improve living according to personal values. Participants attended 10 therapy se…

This early-phase study tested whether short bursts of low-oxygen breathing (acute intermittent hypoxia) combined with high-intensity arm training could improve hand and arm function in 58 people with chronic spinal cord injury. Participants had injuries between neck levels C1 and…

This study tested whether starting gentle leg cycling in bed within 48 hours after spinal surgery is safe and doable for people with severe spinal cord injuries. Forty-five adults took part, cycling for 30 minutes daily for two weeks. Researchers checked for safety, how many sess…

This study tested whether daily electrical stimulation of the buttock muscles can help people with chronic spinal cord injury. Thirty participants used a device for 35 minutes each day over six months. Researchers measured muscle volume and sitting pressure to see if the stimulat…

This study tested whether therapy sessions delivered via iPad FaceTime could help people with spinal cord injury who feel depressed. 75 adults with recent spinal cord injury and mild to moderate depression received cognitive behavior therapy from a psychologist. The goal was to r…

This study tested whether using a device that electrically stimulates the abdominal muscles can help people with spinal cord injury manage their bowel movements more quickly and comfortably. 36 adults with injuries at or above T12 were randomly assigned to receive real or low-dos…

This small study tested whether combining virtual walking (watching a first-person walk video) with mild brain stimulation (tDCS) could help ease chronic nerve pain in people with spinal cord injury. Four participants tried the 2-week program, keeping pain diaries and reporting h…

This study tested a new, non-invasive treatment for people with cervical spinal cord injury who have difficulty using their hands and arms. Fifteen participants received either electrical stimulation of the spinal cord combined with physical therapy, or physical therapy alone. Th…

This study tested whether a high-intensity exercise program, run by physical therapy students, can help people with neurologic disabilities move better in everyday life. Fifteen participants with conditions like cerebral palsy, stroke, or spinal cord injury completed the program.…

This pilot study tested whether brivaracetam, a drug used for seizures, can reduce severe nerve pain in people with chronic spinal cord injury. 24 participants received either brivaracetam or a placebo for 3 months. The study aimed to see if a larger trial is possible and measure…

This study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…

This study tested prefabricated carbon fiber ankle-foot orthoses (AFOs) in 65 children and teenagers with conditions like cerebral palsy, spina bifida, or spinal cord injuries that affect walking. Researchers measured stride length, walking speed, and user satisfaction by compari…

This study tested whether virtual reality (VR) games could help people with tetraplegia (paralysis of all four limbs) improve arm and hand function during hospital rehabilitation. Twelve participants either received standard therapy or added VR games to their routine for 12 weeks…

This study tested whether applying mild electrical stimulation to the skin over the spinal cord could help regulate blood pressure in veterans with spinal cord injury who have chronically low blood pressure. Ten participants with injuries at or above T6 received stimulation at di…

This completed study tested whether a new type of electrical stimulation, called spatially distributed sequential stimulation, works better than standard stimulation for people with upper motor neuron disease. Ten adults with stable symptoms used both methods while cycling. Resea…

This phase 2 trial tested whether buspirone, a drug usually used for anxiety, can improve breathing capacity in people with chronic high-level spinal cord injuries. Thirteen participants took either buspirone or a placebo for 14 days. Researchers measured lung function, breathing…

This Phase 2 trial tested whether KAI-1678, given as a single injection under the skin, can reduce pain in people with spinal cord injury. Only 5 adults with long-term spinal cord injury and chronic pain took part. The study compared KAI-1678 to a placebo to see if it improved pa…

This study tested whether walking training overground with body weight support helps people with chronic spinal cord injury walk better. Fourteen participants were randomly assigned to either overground or treadmill training for four weeks. The goal was to see if the overground a…

This Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …

Researchers are testing whether a type of non-invasive brain stimulation, called intermittent theta burst stimulation, can change how the brain controls hand muscles. The study includes adults with and without spinal cord injuries to compare brain-muscle connections. By measuring…

This study looked at two community-based wellness programs for adults with disabilities like spina bifida, cerebral palsy, spinal cord injury, and traumatic brain injury. Researchers measured changes in health, mood, quality of life, and healthcare costs over up to 24 months. The…

Researchers are studying whether a muscle-released hormone called irisin is linked to bone strength in people with spinal cord injury. They will compare irisin levels and bone density between individuals with spinal cord injury and healthy controls. Participants will also do one …

This study follows 100 people with brain or spinal cord injuries to see how their ability to judge their own memory (metacognition) changes over time. Researchers want to know if better self-awareness helps people stick with rehabilitation. Participants complete computer memory t…

This study aims to create a smartphone system that sends personalized pain management tips to adults with multiple sclerosis or spinal cord injury who have chronic pain. Researchers will interview participants to understand their preferences for the content and timing of these no…

This study looks at how lung function, respiratory muscle strength, balance, and quality of life relate in Paralympic athletes. Researchers will measure breathing capacity, muscle strength, and balance in 24 athletes from sports like athletics, swimming, archery, and wheelchair b…

This observational study looks at how people with spinal cord injuries maintain balance while performing a stationary wheelchair wheelie. Participants will be asked to hold a wheelie for at least 20 seconds while sensors track their body movements and balance. The goal is to unde…

This study uses ultrasound to measure the thickness of ankle cartilage in people with spinal cord injuries and compares it to healthy individuals. The goal is to see if cartilage damage starts early, which could help prevent osteoarthritis. Researchers will also assess participan…

Osteoporosis is a common complication after spinal cord injury, raising the risk of broken bones. This study surveys 94 adults with chronic traumatic spinal cord injury to measure their awareness of osteoporosis and identify factors — such as education level or healthcare visits …

This study is translating and testing a short questionnaire called the Neurogenic Bladder Symptom Score Short Form (NBSS-SF) into Turkish. It will involve 120 adults with spinal cord injury or multiple sclerosis who have bladder problems. The goal is to make sure the Turkish vers…

This study looks at how young people with conditions like cerebral palsy, spina bifida, and spinal cord injury move from pediatric to adult medical care. Researchers will review medical records from the past 10 years and interview patients who have already made the switch. The go…

This study explores whether electrically stimulating the leg muscles of people with spinal cord injury can improve cognitive function. Participants will receive 12 weeks of neuromuscular electrical stimulation (NMES) to their quadriceps, three times a week. Researchers will measu…

This study tested whether a special ultrasound with a contrast agent (DEFINITY®) can measure blood flow in the spinal cord during surgery for acute spinal cord injury. 27 patients received the contrast agent while surgeons performed routine decompression. The goal was to see if t…

This study follows 113 people who recently had a spinal cord injury to understand how feelings of injustice (like blaming others or feeling cheated) change over time and affect their mental health, pain, and quality of life. Researchers will interview some participants and use su…

This study asks 30 adults with spinal cord injury about their exercise habits and what they would want in a physical activity program. Researchers will use surveys and interviews to learn what helps people start and keep exercising. The goal is to design better exercise programs …

This study will video-record occupational therapy sessions for adults recovering from stroke or spinal cord injury. Researchers want to understand exactly what therapists do to help patients improve arm and hand movement. The goal is to create a toolkit that makes rehabilitation …

This study tested two different robotic exoskeletons—one that balances itself and one that requires the user to balance—in 6 people with spinal cord injury. Researchers measured how fast and far participants could walk with each device, along with muscle activity and user feedbac…

This completed study from France reviewed the long-term results of a surgery called continent cutaneous urinary diversion in 70 spinal cord injury patients. The surgery creates a new way to drain urine through the belly when patients cannot use a catheter normally. Researchers co…

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This completed trial tested how quickly paramedics can stabilize a patient's spine using a scoop stretcher versus a vacuum mattress. Fifteen emergency medical workers participated in a simulated emergency. The goal was to see which device is faster and whether the quality of stab…

This study looked at how the interaction between a physical therapist and a patient affects recovery during robot-assisted walking training for people with spinal cord injury. 55 participants were split into two groups: one with high therapist interaction and one with minimal int…

This study looked at whether slow, yogic-style breathing can affect heart rate and blood pressure in people with spinal cord injuries. Seventeen wheelchair users completed breathing exercises while their heart and blood pressure were measured. The goal was to learn more about how…

This study checks whether a simple six-minute pegboard and ring test is a valid and reliable way to measure upper body exercise capacity in people with spinal cord injury. Researchers will compare the pegboard results with standard strength and function tests in 34 adults who use…

This study tested a new robotic device called REACTION that combines an exoskeleton and a gait trainer to help people with stroke or spinal cord injury improve walking and balance. Seven participants completed two sessions of walking and balance tasks, followed by an interview. T…

This study looked at whether robotic gait training helps people with spinal cord injury walk better compared to standard walking therapy. 115 patients in inpatient rehab took part. The goal was to measure improvements in walking ability and speed.

This study looked at how spinal cord epidural stimulation affects bladder, bowel, and blood pressure control in 61 adults with spinal cord injury. Researchers monitored participants in a lab and at home to understand autonomic dysreflexia and test stimulation as a therapy. The go…

This study looked at 22 adults with spinal cord injury to understand whether anxiety or physical discomfort causes changes in heart rate and blood pressure during bladder catheterization. Participants either did the procedure themselves or had a nurse do it, with some not knowing…

This study looked back at 170 adults with chronic neck pain from whiplash injuries to compare two treatments: radiofrequency (a nerve-blocking procedure) and neck fusion surgery. Researchers reviewed medical records from a 20-year period to see which treatment provided better pai…

This study tested whether a gentle electrical stimulation on the ear (taVNS) can improve how the heart and nervous system respond during exercise in people with chronic spinal cord injury. 35 adults completed two exercise sessions—one with real stimulation and one with a sham (fa…

This completed study surveyed 70 women with spinal cord injury to learn about their experiences with fertility, contraception, and pregnancy. Researchers asked closed- and open-ended questions to understand how the injury affects decisions about having children and choosing birth…

This study looked at what resilience means for people living with a spinal cord injury. Researchers interviewed 28 adults who had their injury at least one year ago, asking about their experiences and having them fill out surveys. The goal was to find common themes among people a…

This study tested whether a special type of MRI (called DBSI) can predict how well people recover after surgery for a compressed spinal cord. 71 patients with cervical spondylotic myelopathy had this MRI before surgery and again 2 years later. Researchers looked for imaging marke…

This study tested a new training device called an eccentric arm-crank in 12 athletes with spinal cord injury. Over 20 training sessions, participants used the device to build upper body strength and endurance. The goal was to see if the device is practical and effective for impro…

This small study tested whether it is safe and practical to use two devices together in people with recent spinal cord injury. Eight participants received both a mild electrical stimulator placed on the back and leg, and a low-level laser. The main goal was to see if the equipmen…

This study looked at how the calf muscle and Achilles tendon work together during walking in people who have had a stroke or spinal cord injury, compared to healthy individuals. Researchers used ultrasound and motion analysis to measure muscle and tendon lengths in 64 adults. The…

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and their mood to understand why weight gain happens. The goal is to use this information to design better programs that help people wi…

This completed study looked at how the brain controls muscles after a spinal cord injury. Researchers tested 120 people with chronic neck-level injuries to measure nerve signals and motor function. The goal was to better understand how to improve hand and arm movement for daily t…

This study looked at how walking with a robot (Lokomat) helps people with spinal cord injuries recover movement. Ten patients were assessed before, during, and after training, plus one month later. The goal was to understand how gait improves over time, not to test a new drug or …

This study tested a new way to control a robotic arm mounted on a power wheelchair. The arm uses a camera to help guide movements, making tasks like grabbing a drink easier. 21 adults who use power wheelchairs and have trouble with everyday tasks took part. They compared the new …

This study looked at whether ultrasound can measure bladder wall thickness in people with spinal cord injury and how it relates to standard bladder function tests. Researchers studied 116 adults to see if this non-invasive method could help assess bladder health. The goal is to f…

This completed study surveyed 56 adults with spinal cord injury in Türkiye to find out which everyday activities—like eating, bathing, or using a wheelchair—they value most and how independent they hope to become. Participants rated each activity on a 0–10 scale and stated their …

This study analyzed blood and other samples from 106 adults with recent spinal cord injuries to find molecules linked to better recovery. Researchers measured changes in these molecules before and after rehabilitation and one year after injury. The goal is to identify biological …

This pilot study tested a wearable robotic exoskeleton called EksoNR in 5 people with stroke, spinal cord injury, cerebellar ataxia, or spastic paraplegia. The goal was to see if using the device for gait training in an outpatient setting is safe, tolerable, and feasible. Researc…

This study looked at 94 adults with a recent spinal cord injury to see if keeping their blood pressure at a higher or lower target helped them heal better. Participants were split into two groups: one with a standard blood pressure goal and one with a higher goal, maintained for …

This study tested whether a brain-spinal cord-muscle training program can strengthen connections that control movement in people with spinal cord injury. Twenty-one participants completed four months of training using brain stimulation and muscle monitoring. The goal was to see i…

This completed study looked at 80 people with spinal cord injuries to understand how arm, shoulder, and wrist problems relate to their daily lives. Researchers used ultrasound to examine these areas and compared the findings with pain levels and physical exams. The goal was to id…

This study tested whether personalized walking training based on detailed 3D movement analysis works better than standard walking therapy. 63 people with spinal cord damage from injury or multiple sclerosis took part. The goal was to see if customizing exercises to each person's …

This study involved 32 adults with arm weakness from stroke, multiple sclerosis, or spinal cord injury. Researchers measured how much force patients could voluntarily produce in their arms and used that data to build mathematical models. The goal is to use these models to improve…

This completed study used MRI scans to see how thinking difficulties appear in the brains of people with spinal cord injury. Fifty-four participants completed cognitive tasks while their brain activity was measured. The goal was to better understand non-motor challenges that ofte…

This small study tested whether mild nerve stimulation could increase vaginal blood flow in women with sexual problems, spinal cord injury, or no issues at all. Nine women had a small sensor placed in the vagina to measure blood flow changes during stimulation. The goal was to un…

This study tested a mobile app called SCI-Lynx designed to help people with spinal cord injury connect with others who have similar exercise goals. Over one month, 33 participants used the app to find exercise buddies, set goals, and track progress. The goal was to see if the app…

This small study tested whether briefly restricting blood flow to one arm (called remote ischemic conditioning, or RIC) could improve hand function in people with spinal cord injury or ALS. Participants did hand exercises while receiving either active RIC or a sham version. The g…

This study looked at 43 adults with incomplete spinal cord injury to see how their own views on safe walking matched their therapists' views and actual walking ability. Researchers measured walking independence, leg strength, balance, and fall risk. The goal is to improve dischar…

This study from the University of Zurich looked at how people with different neurological conditions walk. Researchers measured walking patterns in 208 adults, including those with stroke, Parkinson's, multiple sclerosis, and spinal cord injury, as well as healthy volunteers. The…

This early-phase trial in 13 healthy volunteers measures how two drugs, neostigmine and glycopyrrolate, enter the bloodstream when given through a skin patch using a mild electric current (iontophoresis) compared to an IV. The goal is to see if this needle-free method could one d…

This study followed 35 men with spinal cord injuries over 18 months to see how their sperm quality changes and what factors might cause problems. Researchers measured sperm health, inflammation, and infections from ejaculates collected every 6 months. The goal is to find ways to …

This study looked at how sleep apnea and low oxygen levels affect muscle strength and breathing in people with chronic spinal cord injury. Thirty adults with neck-level spinal cord injuries were tested using hand grip strength and muscle activity measurements. The goal was to und…

This study tested whether robotic training that adjusts errors based on each person's abilities can improve motor learning in healthy adults and people with neurological conditions like stroke. Over 250 participants performed arm tasks with robotic devices while researchers measu…

This study looks at how a robotic body-weight support system called FLOAT affects the way people with incomplete spinal cord injury perform everyday tasks like walking, standing up, and climbing stairs. Researchers measure movement and muscle activity with and without the robot's…

This study tested whether a single session of high-intensity interval training (three 20-second all-out efforts on an arm bike) could improve heart and brain function in 30 people with spinal cord injury compared to uninjured controls. The goal was to see if this type of exercise…