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Short, intense workout may boost heart and brain in spinal cord injury

NCT ID NCT06274658

Knowledge-focused Sponsor: State University of New York at Buffalo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a single session of high-intensity interval training (three 20-second all-out efforts on an arm bike) could improve heart and brain function in 30 people with spinal cord injury compared to uninjured controls. The goal was to see if this type of exercise helps regulate blood pressure and sharpen thinking. Results are not yet available.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-intensity interval exercise
What this could lead to
If successful, this could point toward exercise-based strategies to improve heart and brain health in people with spinal cord injury.
What could go wrong
This is a small, early-stage study with only 30 participants, looking at immediate effects of a single exercise session. Results may not apply to long-term training or to all types of spinal cord injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

30 people

The number who actually took part.

Started

Feb 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will include people with SCI with level of injury T6 or above and age- and sex-matched non-injured controls.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosed with a traumatic or non-traumatic spinal cord injury and have ≥4/5 strength in at least one cervical 5 myotome (elbow flexors), allowing to utilize the arm ergometer and level of injury at or above the 6th thoracic vertebra 2. Classified as A, B, C, D (motor and sensory complete or incomplete) on the American Spinal Injury Association (ASIA) Impairment Scale (AIS) 3. Longer than 6 months post the onset of injury and have been discharged to the community from inpatient rehabilitation prior to enrollment 4. English is the first language 5. At least one of the cerebral arteries (i.e., middle cerebral artery and/or posterior cerebral artery) can be found via transcranial Doppler Exclusion Criteria: 1. Medical conditions that preclude exercise, such as unstable angina, uncontrolled arrhythmias, a recent history of congestive heart failure that has not been evaluated and effectively treated, severe valvular disease, uncontrolled hypertension (i.e., resting systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 105 mmHg) 2. Moderate-severe traumatic brain injury 3. Diabetes 4. Color blindness 5. Pre-existing shoulder injuries 6. Pregnancy

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Conditions

The condition(s) this trial relates to.

autonomic nervous system disorder cognitive disorder spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Autonomic nervous system disease Cognition Spinal cord injuries

Contacts and locations

Locations

  • University at Buffalo, South Campus

    Buffalo, New York, 14214, United States

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