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Spinal injury study maps brain pathways to restore hand movement

NCT ID NCT02451683

Knowledge-focused Sponsor: Shirley Ryan AbilityLab Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at how the brain controls muscles after a spinal cord injury. Researchers tested 120 people with chronic neck-level injuries to measure nerve signals and motor function. The goal was to better understand how to improve hand and arm movement for daily tasks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could point toward new rehabilitation strategies to improve hand and arm function after spinal cord injury.
What could go wrong
This is an observational and early-stage study, not a treatment trial. Results may not directly lead to a therapy or benefit all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

120 people

The number who actually took part.

Started

Oct 2020

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Inclusion criteria for individuals with SCI: 1. Male and females between 18-85 years, 2. Chronic SCI (≥ 6 months post injury), 3. Cervical injury at C8 or above, 4. Intact or impaired but not absent innervations in dermatomes C6, C7, and C8 using the American Spinal Injury Association sensory scores, and 5. Ability to reach and grasp a small object located at least 8 cm forward, above, and laterally without leaning forward with the trunk Inclusion criteria for healthy controls: 1. Male and females between 18-85 years, 2. Right handed, 3. Ability to reach and grasp a small object located at least 8 cm forward, above, and laterally without leaning forward with the trunk Exclusion Criteria: * Exclusion criteria for individuals with SCI and Healthy Controls: 1. Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease 2. Any debilitating disease prior to the SCI that caused exercise intolerance 3. Premorbid, ongoing major depression or psychosis, altered cognitive status 4. History of head injury or stroke 5. Pacemaker 6. Metal plate in skull 7. History of seizures 8. Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants 9. Pregnant females 10. Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida or herniated cervical disk. 11. History of brain tumor and or brain infection

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spinal cord injury

Contacts and locations

Locations

  • Shirley Ryan AbilityLab

    Chicago, Illinois, 60611, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.