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Could short bursts of low oxygen help spinal cord injury patients move better?

NCT ID NCT05491837

Symptom relief Sponsor: Riphah International University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether brief periods of breathing low-oxygen air (acute intermittent hypoxia) can improve arm, leg, and walking function in people with incomplete spinal cord injury. Sixty-eight participants received either the low-oxygen treatment or a sham (normal air) over multiple sessions. The goal was to see if this simple, non-drug approach could boost neuroplasticity and enhance daily activities.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
acute intermittent hypoxia (brief low-oxygen air)
What this could lead to
If it works, this could offer a simple, drug-free way to boost movement and walking ability after spinal cord injury.
What could go wrong
This is a small, completed trial with no phase designation, so results are preliminary. The effect may be modest or not last long, and the treatment involves brief low-oxygen exposure, which may not be safe for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

68 people

The number who actually took part.

Started

Mar 2023

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Incomplete SCI≥ 3 months(21); 2. Traumatic and non-traumatic, non-progressive lesions, Aged ≥ 18 years ; 3. LesionC4 and below as classified ASIA category C and D; 4. Both gender 5. Ability to ambulate with or without assistive devices; and 6. Ability to follow verbal and visual command. Exclusion Criteria: 1. Participants with complete spinal cord injury; 2. Unstable orthopedic injuries and joint contractures 3. Osteoporosis with high risk of fracture; 4. Pressure ulcers and cutaneous lesion(4) 5. Cognitive impairment, severe cardiopulmonary complication such as severe breathing disorder

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Incomplete spinal cord injury

Contacts and locations

Locations

  • Riphah International University Islamabad

    Islamabad, 44000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.