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Exercise may fight hidden inflammation in spinal cord injury

NCT ID NCT05376449

Disease control Sponsor: HealthPartners Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a 12-week adaptive exercise program can reduce chronic inflammation in people with spinal cord injury (SCI). Chronic inflammation is linked to heart and lung disease, the top causes of death in SCI. Twenty-four adults with SCI will be randomly assigned to start exercise right away or after a 12-week delay, and researchers will measure changes in inflammatory markers like C-reactive protein.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Adaptive exercise program (HealthPartners NeuroWell Exercise Program)
What this could lead to
If it works, this could point toward a simple, non-drug way to reduce inflammation and improve long-term health for people with spinal cord injury.
What could go wrong
This is a small, early study with only 24 participants, so results may not apply to everyone. Exercise may not reduce inflammation enough to make a real difference in disease risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Started

May 2022

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ability to provide and provision of signed and dated informed consent form * Age 18-70 * Diagnosis of SCI and post injury ≥ 6 months * Able to achieve adequate active range of motion at the elbow and wrist (flexion/extension) and able to achieve at least 90° active shoulder flexion, in order to complete study activities Exclusion Criteria: * Non-English speaking * Exercise program participation ≤1 month from study enrollment or any other exercise participation during the duration of the study * Patients with significant cognitive impairment of any etiology that prevents them from being able to participate * Patients that were given sternal or spinal precautions that would prevent excessive twisting, bending, overhead reaching and lifting over 10 pounds * Patients with a history heart failure, chronic lung disease, angina or any other condition that causes unreasonable shortness of breath on exertion * Has been diagnosed with autonomic dysreflexia that is severe, unstable, and uncontrolled * Requires ventilator support * Spasms that limit the ability of the subjects to participate in the study training as determined by the Investigator * Pregnant, planning to become pregnant * Any other medical conditions that could affect their ability to participate in the exercise program (as determined by study investigators) * Active participation or past participation ≤3 months in any other interventional study. * Unwilling to participate in all study related activities

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spinal cord injuries

Contacts and locations

Locations

  • HealthPartners Neuroscience Center

    Saint Paul, Minnesota, 55130, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.