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Buspirone tested to boost breathing in spinal cord injury patients

NCT ID NCT05041322

Symptom relief Sponsor: Spaulding Rehabilitation Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial tested whether buspirone, a drug usually used for anxiety, can improve breathing capacity in people with chronic high-level spinal cord injuries. Thirteen participants took either buspirone or a placebo for 14 days. Researchers measured lung function, breathing drive, sleep quality, and exercise capacity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
buspirone (BuSpar)
What this could lead to
If it works, this could point toward a medication that helps people with spinal cord injuries breathe more easily.
What could go wrong
This is a very small, early-phase trial with only 13 participants. The results may not apply to everyone, and the drug may not improve breathing enough to be noticeable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

13 people

The number who actually took part.

Started

Nov 2020

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Chronic high-level SCI (at least 24-months post injury) * Age 18 to 50 years. * Medically stable * Spinal Cord Injury ≥T3 * American Spinal Injury Association grade A or B or C. * Able to perform arm crank exercise. Exclusion Criteria: * Cardiomyopathy * High blood pressure( \>140/90 mmHg or you are taking high blood pressure medication) * Significant irregular heartbeat * Heart disease * Chronic lung disease (COPD, bronchitis) * Current use of cardioactive or antidepressant drugs * Family history of significant irregular heart beat or sudden cardiac death * Orthostatic hypotension (symptomatic fall in blood pressure \>30 mmHg when upright) * Current grade 2 or greater pressure ulcers at relevant contact site * Neurological disease (stroke, peripheral neuropathy, myopathy) * Arm or shoulder conditions that limit ability to perform arm crank exercise * History of bleeding disorder, diabetes, kidney disease, cancer, other neurological disease * Recent weigh change (greater than 10 pounds) * Regular use of tobacco * Intrathecal baclofen pump, * Current use of cardioactive, antidepressant, other sedating agents * Suicidal ideation * Pregnant and/or breastfeeding women. In addition, subjects must have no known hypersensitivity to Buspar and must not be taking a monoamine oxidase inhibitor.

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spinal cord injuries

Contacts and locations

Locations

  • Spaulding Hospital Cambridge

    Cambridge, Massachusetts, 02138, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.