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Brain zaps + arm training: new hope for spinal injury patients?

NCT ID NCT03892746

Symptom relief Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new approach to help people with cervical spinal cord injury improve arm and hand function. Participants received non-invasive brain stimulation combined with upper limb training over several weeks. The goal was to see if this combination could strengthen muscles and improve daily living skills. The study involved 47 adults with incomplete spinal cord injury at least one year after injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

47 people

The number who actually took part.

Started

Jul 2019

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with incomplete (having sparing to muscles in the upper extremities below the level of injury) C1-C8 SCI * at least 1 year post injury * weakness of the triceps or biceps muscle in the weaker upper limb, defined as a clinically detectable difference in power compared to the power of the spared antagonist(biceps and triceps respectively) muscle, i.e., at least one muscle grade lower on the MRC scale. Exclusion Criteria: * contraindications to tDCS and TMS including: pacemaker, metal in the skull, seizure history, pregnancy. * pressure ulcers * traumatic brain injury (TBI), diagnosed based upon acute injury Rancho scale \<5 or positive MRI/CT findings at the time of injury will also be excluded to prevent confounding of TMS metrics. * excessive tone/spasticity and severe contractures or soft tissue shortening at the elbow/wrist * participating in ongoing upper-limb therapies

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical spinal cord injruy

Contacts and locations

Locations

  • Kessler Foundation

    West Orange, New Jersey, 07052, United States

  • Lerner Research Institute; Cleveland Clinid Foundation

    Cleveland, Ohio, 44195, United States

  • Louis B. Stokes Cleveland VA Medical Center

    Cleveland, Ohio, 44106, United States

  • The MetroHealth System

    Cleveland, Ohio, 44109, United States