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Breathing low oxygen boosts hand strength in spinal cord injury patients?

NCT ID NCT03643770

Symptom relief Sponsor: Shirley Ryan AbilityLab Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tested whether short bursts of low-oxygen breathing (acute intermittent hypoxia) combined with high-intensity arm training could improve hand and arm function in 58 people with chronic spinal cord injury. Participants had injuries between neck levels C1 and T1 and were at least 6 months post-injury. The goal was to see if this safe, non-invasive approach could boost nerve signals and help with daily tasks like grasping and coordination.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

58 people

The number who actually took part.

Started

Nov 2018

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * History of a non-progressive spinal cord injury, inclusive of levels of C1-T1. * Etiology of spinal cord injury is non-progressive in nature * Be able to demonstrate some hand muscle activation, or use of a tenodesis grasp (wrist extension) * At least 6 months post injury * Participants do NOT have to stop taking antispasticity medications to participate in the study. * Must be tested for anemia with a value of at least 10g/dl (for both men and women). * Patients will be recommended to their primary care physician to correct anemia if low levels are detected * Blood pressure must fall within this range- high: 160/110mmHg low: 85/55 mmHg * Must be asymptomatic (no dizziness, lightheadedness, etc) Exclusion Criteria: * Medical conditions, including: congestive heart failure, cardiac arrhythmias, uncontrolled hypertension, uncontrolled diabetes mellitus, chronic obstructive pulmonary disease, emphysema, severe asthma, previous myocardial infraction, or known carotid/intracerebral artery stenosis. * Women who are currently pregnant or planning on becoming pregnant * Current tracheostomy placement * Utilization of mechanical ventilator for breathing * Current diagnosis of obstructive sleep apnea * Orthopedic injuries or surgeries that would limit participation * Concurrent participation in another research study or therapy services * Comorbid traumatic brain injury or other neurologic injuries that would impact cognition

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Conditions

The condition(s) this trial relates to.

Hypoxia spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spinal cord injuries

Contacts and locations

Locations

  • Shirley Ryan AbilityLab

    Chicago, Illinois, 60611, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.