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Spinal zaps + robotic steps: a new hope for walking after injury?

NCT ID NCT04807764

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This study tests whether applying noninvasive electrical stimulation to the spinal cord before robotic gait training can improve walking recovery in people with motor-incomplete spinal cord injury. Participants receive 40 sessions of either standing or lying stimulation followed by assisted stepping, with brain and spinal cord function measured before and after. The goal is to see if this priming approach enhances the benefits of locomotor training.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Noninvasive high-frequency transcutaneous spinal stimulation (transspinal stimulation) followed by robotic gait training
What this could lead to
If effective, this approach could enhance walking recovery and improve quality of life for people with spinal cord injury.
What could go wrong
The trial is small (14 participants) and early-stage, so results may not apply broadly. Stimulation may not produce meaningful gains, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

14 people

The number who actually took part.

Started

Aug 2021

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Willingness to comply with all study procedures and availability for the duration of the study. * Ability to understand the consent form, and sign the consent form. * Male or female, age 18-70 years old. * In good general health as evidenced by medical history. * Diagnosed with motor incomplete SCI (AIS C-D). * Bone mineral density of the hip (proximal femur) T-score \<3.5 SD from age- and gender-matched normative data. * Lesion above thoracic (T) 10 to ensure absent lower motoneuron lesion. * Presence of tendon reflexes to be able to elicit the soleus H-reflex. * Absent permanent ankle joint contractures that prevent passive or active ankle movement because corticospinal and spinal excitability is based on the ankle angle. The ankle straps of the Lokomat require also flexible ankle joints. * A diagnosis of first time SCI due to trauma, vascular, or orthopedic pathology. * Time after SCI of more than 6 months. * Stable medical condition without cardiopulmonary disease or cognitive impairment. Exclusion Criteria: * Supraspinal lesions. * Significant neuropathies of the peripheral nervous system. * Significant degenerative neurological disorders of the spine or spinal cord. * AIS A or B. * Presence of pressure sores. * Advanced urinary tract infection. * Neoplastic or vascular disorders of the spine or spinal cord. * Participation in an ongoing research study or new rehabilitation program. * Pregnant women or women who suspect they may be, or may become pregnant will be excluded from participation because the risks of thoracolumbar stimulation to the fetus are unknown. * People with cochlear implants, pacemaker, implanted infusion device, and/or implanted stimulators of any type and purpose will be excluded to avoid their malfunction due to stimulation. * People with history of seizures. * Medical conditions that increase the possibility of seizures. * Medications that may change the seizure threshold.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Department of Physical Therapy, Motor Control and NeuroRecovery Laboratory

    Staten Island, New York, 10314, United States

  • Veterans Affairs Medical Center

    The Bronx, New York, 10468, United States

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