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Breathing trick and back zap boost walking after spinal injury

NCT ID NCT03922802

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new approach to help people with spinal cord injury walk better. Participants received brief sessions of mild low-oxygen air (acute intermittent hypoxia) combined with gentle electrical stimulation on the back, plus walking practice. The goal was to see if this combination improves walking distance and speed more than walking practice alone. The study included 14 adults with spinal cord injury and compared the new method to a sham treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

14 people

The number who actually took part.

Started

Dec 2020

Finished

Jan 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants have been diagnosed with a spinal cord injury below level C2 * ASIA Impairment Scale Grade A-D * Participants are 18 years of age or older * Participants are at least 6 months post spinal cord injury * Participants with paraplegia or tetraplegia secondary to a single spinal cord injury * Participants are able to provide informed consent * Participants are not currently receiving regular physical therapy services Exclusion Criteria: * Individuals less than 18 years of age * Individuals less than 6 months post spinal cord injury * Individuals with ataxia * Individuals with multiple spinal cord injury history * Pregnancy or nursing * Pacemaker or anti-spasticity implantable pumps * Active pressure sores * Unhealed bone fractures * Peripheral neuropathies * Painful musculoskeletal dysfunction due to active injuries or infections * Severe contractures in the lower extremities * Active urinary tract infection * Clinically significant depression, psychiatric disorders, or ongoing drug abuse * Diagnosed with any of the following medical conditions: congestive heart failure, cardiac arrhythmias, uncontrolled hypertension, uncontrolled diabetes mellitus, chronic obstructive pulmonary disease, emphysema, severe asthma, previous myocardial infraction, or known carotid/intracerebral artery stenosis * Individuals with a tracheostomy or who utilize mechanical ventilation. * Individuals who are currently enrolled in another interventional research study or in therapy related to upper extremity function. * Participants will be excluded if they have had a botulinum toxin injection to lower extremity musculature within the last 3 months. Participants will need to refrain from lower extremity botulinum toxin injections for the duration of the study. If participants wean off antispasticity medications to successfully complete the responsiveness to AIH screening session, they will need to refrain from the medications for the duration of the study. * Documented sleep apnea. * Orthopedic injuries or surgeries that would impact an individual's ability to use the lower extremity. * Traumatic brain injury or other neurological conditions that would impact the study. * Blood hemoglobin levels less than 10g/dL. We will not include the following populations: * Adults unable to consent, unless accompanied by a legally authorized representative. * Individuals who are not yet adults (infants, children, teenagers) * Pregnant women * Prisoners

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Shirley Ryan AbilityLab

    Chicago, Illinois, 60611, United States

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