Low Oxygen's hidden impact on spinal cord injury recovery
NCT ID NCT04017767
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at how sleep apnea and low oxygen levels affect muscle strength and breathing in people with chronic spinal cord injury. Thirty adults with neck-level spinal cord injuries were tested using hand grip strength and muscle activity measurements. The goal was to understand if sleep apnea makes muscle weakness worse, which could guide future treatments.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Jul 2021
- Finished
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Jul 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 18 or older, 2. Chronic (≥ 1-year post-injury), non-progressive SCI, 3. Asia Impairment Scale (AIS) C or D, 4. Resting Saturated oxygen (SaO2) ≥ 95%, 5. Cervical injury (C5-C8) Exclusion Criteria: 1. Currently hospitalized, 2. Resting heart rate ≥120 Beats per minute (BPM), 3. Resting systolic blood pressure \>180 mmHg, 4. Resting diastolic Blood Pressure \>100 mmHg, 5. Self-reported history of unstable angina or myocardial infarction within the previous month, 6. OSA that is being treated with positive airway pressure therapy, 7. Women who know or suspect they may be pregnant or who may become pregnant, 8. Known underlying lung disease, 9. Pregnant Women, 10. Prisoners, 11. Unable to consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Miami
Miami, Florida, 33136, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could a simple mouthpiece silence snoring?
- Serotonin precursor probed for spinal cord injury effects
- Breathing brief Low-Oxygen bursts may boost sleep apnea treatment
- Pure oxygen tested as a switch for dormant nerves after spinal cord injury
- Spinal stimulation tested to help kids with spinal cord injuries sit taller