Respiratory system disorder

Researchers in India are studying whether a 4-month daily regimen that includes moxifloxacin can cure newly diagnosed, microbiologically confirmed pulmonary tuberculosis as effectively as the standard 6-month treatment. The study enrolls 550 adults aged 18 to 65 who have not yet …

This trial tests whether a combination of the immunotherapy drug pembrolizumab, chemotherapy, and radiation can control advanced larynx cancer while preserving the voice box. Adults with stage III or IV larynx cancer who are candidates for organ preservation receive three cycles …

This large Phase 3 trial tested an experimental mRNA-based flu vaccine (mRNA-1010) against standard flu shots in over 40,000 adults aged 50 and older. The goal was to see if the new vaccine is safer and better at preventing flu-like illness caused by influenza A or B. Researchers…

This early-stage trial tested a new self-amplifying mRNA vaccine (ARCT-2304) designed to protect against pandemic influenza. 212 healthy adults aged 18-80 received either two doses of the experimental vaccine or one dose of a licensed flu vaccine plus placebo. Researchers monitor…

Researchers are testing a new vaccine called LBVD that combines protection against diphtheria, tetanus, whooping cough, hepatitis B, polio, and Hib into a single injection. The study will enroll healthy infants aged 6 to 8 weeks, who will receive three doses at 6, 10, and 14 week…

This phase 2 trial tests whether a vaccine made from immune cell-derived exosomes can slow cancer growth in people with advanced non-small cell lung cancer who have responded to initial chemotherapy. Participants receive low-dose cyclophosphamide followed by weekly injections of …

This early-stage trial tests an experimental nasal spray vaccine called BW-1014, designed to protect against pandemic flu. Healthy adults aged 18 to 45 receive two doses of the spray, with or without a nanoemulsion adjuvant, followed by a standard flu shot six months later. Resea…

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participa…

Researchers are testing whether a breath test called FeNO, which measures inflammation in the airways, can help primary care doctors better adjust asthma treatment for adults. The study assigns entire clinics to either use FeNO measurements alongside usual care or continue with u…

This study tests a vaccine designed to help the immune system fight HPV-positive throat cancer. It is for patients who have completed surgery or chemoradiation and show no signs of cancer remaining. The trial will enroll 24 adults to find the safest and most effective dose by mea…

Researchers are testing an experimental antibody drug called verekitug in adults with chronic rhinosinusitis with nasal polyps, a condition where inflamed tissue grows inside the nasal passages and causes congestion. Participants receive either verekitug or a placebo injection wh…

This study tests a nasal spray called OPN-375 in about 72 teenagers (ages 12-17) who have nasal polyps—growths inside the nose that cause stuffiness and breathing trouble. The spray is given twice a day for 16 weeks, and some participants receive a placebo (inactive spray) for co…

This completed Phase 4 trial tested two different doses of chemotherapy (standard and low-dose) combined with the immunotherapy drug Sintilimab in 20 people with advanced squamous non-small cell lung cancer. The goal was to see if the lower-dose combination could shrink tumors an…

This Phase 3 study tests whether adding tiragolumab (an experimental immunotherapy) to the standard combination of atezolizumab plus chemotherapy can help people with untreated, widespread small cell lung cancer live longer without their disease worsening. About 123 participants …

This study tests a new drug combination for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The two drugs, LY3295668 and osimertinib, work by blocking enzymes that help cancer cells grow. The goal is to find the safest dose and see if…

This study looks at the long-term safety of a drug called itepekimab for people with chronic obstructive pulmonary disease (COPD). About 700 adults who already completed earlier itepekimab studies will receive the drug every 2 or 4 weeks for up to 52 weeks, plus a 20-week follow-…

Researchers are testing whether a higher dose of dexamethasone works better than a lower dose for adults on ventilators with acute hypoxemic respiratory failure caused by infections, including COVID-19. The trial enrolls 980 patients in Spanish intensive care units and randomly a…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study tests whether special breathing techniques called neurophysiological facilitation of respiration can improve oxygen levels and shorten hospital stays in children aged 6 months to 2 years with pneumonia. The techniques involve gentle stretches and co-contraction of the …

Researchers are testing whether adding vitamin B12 to standard chemotherapy helps people with pleural mesothelioma that cannot be removed by surgery. The trial gives participants pemetrexed and cisplatin, two chemotherapy drugs that block tumor cell growth in different ways, alon…

Researchers are testing an experimental immunotherapy called GNR-051 in adults with advanced lung cancer, kidney cancer, or melanoma that has returned or not responded to other treatments. The Phase 1 trial aims to find the highest dose people can tolerate and to track side effec…

This early-phase trial tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to turn back on genes that may slow tumor growth. The main goal was to find a safe dose and check for side effect…

This Phase 2 trial tests whether rademikibart, an injected drug, can help adults with COPD who are having a sudden flare-up and have a specific type of inflammation (type 2). The study will compare the drug to a placebo in 160 participants, looking at whether it reduces treatment…

This trial compares two common steroid treatments for chronic cough that occurs with nose or sinus symptoms, known as upper airway cough syndrome. Adults with chronic cough and signs of rhinitis or sinusitis are randomly assigned to either an inhaled steroid (budesonide) or a ste…

This Phase 2 trial tests whether adding rademikibart (a shot) to standard care can help adults and teens with asthma and type 2 inflammation avoid hospital visits or needing more steroids during an attack. About 160 participants will receive either the drug or a placebo. The main…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This early-phase study tested the safety of rituximab, a drug that targets faulty white blood cells, in 7 adults with rare immune diseases like pulmonary alveolar proteinosis and severe candidiasis. Participants received several doses over 6 months and were monitored for 18 month…

This study tested a two-week course of antibiotics (TMP/SMX or minocycline) given twice to people with cystic fibrosis who had early MRSA lung infections. The goal was to see if this approach could clear the bacteria better than standard care. The trial included 37 participants a…

Birth asphyxia, when a baby does not get enough oxygen around birth, can lead to brain injury and long-term disability. This Phase 1 trial in Uganda tests sildenafil, a drug that widens blood vessels, in 18 newborns with birth asphyxia. Researchers want to find the highest dose t…

Researchers compare two approaches to managing antibiotics in adults hospitalized with community-acquired pneumonia. One approach uses doctors' clinical reassessment to decide whether to continue, stop, or change antibiotics. The other uses blood levels of a marker called procalc…

This phase 3 trial tests whether a once-daily pill called orforglipron can improve sleep apnea in 600 adults with moderate-to-severe sleep apnea who are also obese or overweight. Participants are split into two groups: those who cannot or will not use a CPAP machine, and those wh…

Researchers are testing whether adding brain radiotherapy to PD-1/PD-L1 inhibitors and chemotherapy helps people with untreated stage IV non-small cell lung cancer that has spread to the brain. The trial enrolls about 40 adults whose tumors lack common driver mutations and whose …

This early-phase trial tests a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe…

This study tests a new drug, Tuvusertib, combined with an immunotherapy called Cemiplimab in people with a specific type of advanced lung cancer (non-squamous non-small cell) that has worsened after prior treatments. The trial aims to see if the combination can shrink tumors and …

This study tests a new fixed-dose combination of two drugs (ensifentrine and glycopyrrolate) given via nebulizer twice daily for 28 days in 480 adults with COPD. The goal is to see if the combination improves lung function more than either drug alone or placebo. The trial is curr…

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

Researchers are comparing two doses of chest radiation therapy, 45 Gy and 70 Gy, in people with limited-stage small cell lung cancer. All participants also receive chemotherapy with cisplatin or carboplatin plus etoposide. The trial measures overall survival to see whether the hi…

This study tested a new, environmentally friendly propellant (HFA-152a) in a common asthma inhaler (CHF5993) to see if it is as safe as the current propellant. Over 800 adults with moderate to severe asthma used the inhaler twice daily for 12 weeks. The main goal was to check for…

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This study tests whether adding a new drug called SION-719 to the standard CF medication Trikafta is safe and helps people with cystic fibrosis who have two copies of the F508del mutation. Sixteen participants will receive either SION-719 or a placebo alongside their usual Trikaf…

This pilot study tested a new, non-invasive way to locate multiple small lung nodules (under 20 mm) before surgery, comparing it to the standard CT-guided needle method. Forty people with early-stage lung cancer took part. The goal was to see if the new method could help surgeons…

Researchers are testing an experimental oral drug called sabizabulin (VERU-111) in hospitalized adults with confirmed SARS-CoV-2 infection who are at high risk for acute respiratory distress syndrome (ARDS). Participants receive either sabizabulin plus standard care or a placebo …

Researchers are testing lebrikizumab, an antibody given by injection every four weeks, in adults with chronic obstructive pulmonary disease (COPD) who have had recent flare-ups. The trial compares lebrikizumab with a placebo in people already using standard inhaled steroids and b…

Cerebral aspergillosis is a rare and serious brain infection caused by a mold. Doctors often use voriconazole as the first treatment, but a newer drug called isavuconazole may work as well with fewer side effects. This study looks back at the medical records of 41 children and ad…

This early-stage trial tests the safety of three experimental drugs (SION-451, SION-2222, and SION-109) given together to healthy adults aged 18–55. The study aims to see if the combinations are safe and how the body processes them. It is a first step toward possibly developing a…

This study looked at 620 adults with asthma that was not well controlled on their current treatment. They were given a combination inhaler (beclometasone/formoterol) to use daily. After 6 months, researchers measured how many patients improved their asthma control using a standar…

This study tests a single booster dose of a combined vaccine against diphtheria, tetanus, and whooping cough (dTpa) in 85 healthy Japanese adolescents aged 11 to 13. Researchers will check if the shot triggers a strong immune response and monitor for side effects one month after …

Researchers are testing an experimental drug called MRG003 in adults with EGFR-positive advanced non-small cell lung cancer that has worsened after at least two standard treatments. The trial enrolls about 87 participants across multiple sites and gives MRG003 intravenously as a …

Researchers are testing whether an automated oxygen delivery system called O2matic keeps blood oxygen levels in a safe range better than manual adjustment for patients hospitalized with a COPD flare-up. The device continuously measures oxygen saturation and uses an algorithm to c…

This phase 2 trial is testing a drug called ado-trastuzumab emtansine (Kadcyla) in 131 adults with advanced solid tumors that have a specific HER2 gene change. The drug combines an antibody that targets HER2 with a chemotherapy agent, aiming to deliver treatment directly to cance…

This trial tests whether removing lung nodules with non-intubated video-assisted thoracic surgery, which avoids a breathing tube and ventilator, helps patients recover faster and feel better than traditional intubated surgery. Researchers will compare symptom burden, quality of l…

This phase 2 trial tests whether adding an experimental drug called pixatimod to the immunotherapy nivolumab can shrink tumors in people with advanced melanoma, non-small cell lung cancer, or colorectal cancer that has stopped responding to prior treatment. One group with colorec…

This phase 2 trial tests whether adding inhaled corticosteroids to standard COPD treatment improves blood vessel function in the lungs. Thirty adults with COPD, aged 40-80, will take either Bevespi or Bretzri for four weeks. Researchers will measure how well lung blood vessels wi…

This study tested two new treatments for people with small cell lung cancer that came back after initial chemotherapy. The experimental drugs, lurbinectedin alone or with irinotecan, were compared to standard treatments (topotecan or irinotecan). The goal was to see if the new op…

This study tests whether a new propellant (HFO) for the budesonide/albuterol inhaler works as well as the current one (HFA) in adults with asthma. Over 400 participants will use three different inhalers over 12 weeks to compare lung function. The goal is to see if the new propell…

This study follows adults with asthma whose doctors have prescribed a single-inhaler triple therapy combining an anti-inflammatory steroid, a long-acting bronchodilator, and an anticholinergic. Researchers will collect data from routine care visits to see how well the treatment c…

This phase 3 trial tested whether a combination of sitravatinib (a targeted drug) and nivolumab (an immunotherapy) works better than docetaxel (standard chemo) for people with advanced non-squamous non-small cell lung cancer that got worse after platinum chemo and checkpoint inhi…

This trial tests whether CP006, an investigational inhaler combining three medications (budesonide, formoterol, and umeclidinium), improves lung function in adults with asthma better than a standard two-drug inhaler. Participants take either a high or low dose of CP006 or the com…

This trial studies people with advanced non-small cell lung cancer who have already tried platinum-based chemotherapy. Researchers compare those who receive immunotherapy with those who receive standard chemotherapy as a second-line treatment. The goal is to see which approach he…

This study asks whether critically ill adults on ventilators do better if doctors reduce breathing support early, within a day after a 48-hour stability checkpoint, or if they keep support at the same level for longer. Researchers will compare two strategies: early de-escalation,…

This trial tests a system that evaluates donor lungs outside the body to see if they are suitable for transplant. The goal is to increase the number of lungs available for people with severe, life-limiting lung disease who are waiting for a transplant. Participants are adults alr…

This trial tests two mechanical ventilation strategies in adults with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition that makes breathing difficult. Half the participants receive airway pressure release ventilation (APRV), while the other …

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This trial tests an experimental drug called FLX475, given alone or with the immunotherapy pembrolizumab, in people with advanced cancers that have not responded to standard treatments. The study aims to find the safest dose and to see whether the combination can shrink tumors. P…

This pilot study tests whether injecting a corticosteroid called dexamethasone directly into the salivary glands can prevent dry mouth in people receiving radiation therapy for head and neck cancer. Researchers will enroll 10 adults with certain types of throat cancer who are sch…

This study tests whether a fine-mist inhaler can deliver salbutamol deeper into the lungs than standard inhalers. People with COPD, asthma, and healthy volunteers inhale salbutamol in different particle sizes, some tagged with a radioactive tracer to track where the drug lands. R…

This study tested a special nursing strategy to prevent pressure sores in patients with severe lung problems who need to lie face down (prone position). The trial included 160 adults in intensive care who were on breathing machines. The strategy involved protecting the eyes, tilt…

Researchers are testing whether slow release DHEA, a hormone supplement, is safe and well tolerated in adults with asthma. The trial gives two dose levels, 50 mg and 100 mg, and measures how the hormone builds up in the blood and clears from the body. Participants are adults aged…

This trial tests whether ECMO, a machine that temporarily takes over heart and lung function, can safely help adults with respiratory failure who are not improving with standard care. Researchers will enroll 30 patients with high carbon dioxide levels and low blood pH, including …

Researchers are testing whether Lactobacillus GG, a probiotic, can help children with cow's milk allergy develop tolerance to milk. The study involves 20 children aged 4 months to 4 years. The goal is to see if the probiotic changes how genes related to the immune system are turn…

This trial tests an experimental drug called SNS-101, which targets a protein called VISTA that may help tumors evade the immune system. Researchers give SNS-101 alone or with another immunotherapy, cemiplimab, to adults with advanced solid tumors that have not responded to stand…

This trial tests whether combining the immunotherapy drug atezolizumab with precise, high-dose radiation (SABR) can better control metastatic cancers, including colorectal, lung, kidney, and sarcoma. The idea is that radiation may make tumors more visible to the immune system, wh…

This trial tests three steroid drugs, methylprednisolone, dexamethasone, and hydrocortisone, in people with acute respiratory distress syndrome (ARDS), a severe lung condition that often requires a ventilator. The goal is to see if one steroid works better than the others at redu…

This phase 1 trial tests an experimental drug called MRG003 in people with advanced solid tumors, including colorectal cancer, head and neck squamous cell carcinoma, and nasopharyngeal carcinoma. The study aims to find a safe dose and to see whether the drug can shrink tumors. Pa…

This trial tests an experimental antibiotic called BTZ-043 in adults with newly diagnosed, drug-sensitive pulmonary tuberculosis. Participants take the drug by mouth once daily for 14 days, and researchers compare it to a standard combination treatment. The main goal is to check …

This trial tests whether high-flow nasal oxygenation (HFNO) keeps breathing and oxygen levels steadier than standard low-flow nasal oxygenation (LFNO) in patients undergoing sedated vitrectomy, a type of eye surgery. Participants are normal-weight adults with different anesthesia…

This phase 3 trial tests whether a new drug combination (MK-7684A) plus chemoradiotherapy helps people with stage III non-small cell lung cancer live longer than the current standard treatment. About 611 participants will receive either the new combo or durvalumab. The study is a…

This Phase 3 trial tests whether a new budesonide/formoterol dry powder inhaler works as well as the established Symbicort Turbuhaler in adults with asthma. About 338 participants will take either the test inhaler or Symbicort twice daily for six weeks. Researchers will measure c…

This study looks at whether dupilumab, an injectable medication, can improve lung function and reduce symptoms in adults with COPD who have a specific type of inflammation. The researchers are reviewing medical records from patients who received dupilumab as part of routine care,…

This trial tests whether ashwagandha (Withania somnifera) root powder, taken as a daily supplement for 10 weeks, can offer extra benefits for adults with moderate-to-severe asthma who are already on standard inhaler therapy. Researchers will measure changes in lung function, asth…

This trial investigates whether combining two targeted drugs—erlotinib and bevacizumab—can help people with advanced non-small cell lung cancer that has specific EGFR mutations. The goal is to see if the combination extends the time before the cancer grows or spreads. Participant…

This phase 2 trial investigates whether afatinib, an oral targeted therapy, can control advanced non-small cell lung cancer (NSCLC) that carries a specific HER2 exon 20 mutation. Participants have already received prior chemotherapy and have stage IIIB or IV disease. The study me…

This trial is testing whether a blood test called VeriStrat can help choose between two drugs for people with advanced squamous non-small cell lung cancer that has progressed after initial chemotherapy. Participants are grouped by their VeriStrat result (good or poor) and then ra…

This trial is investigating whether adding the immunotherapy drug nivolumab to the usual chemotherapy and radiation can improve outcomes for people with stage III non-small cell lung cancer. The study will measure how well the combination works and how tolerable the side effects …

This trial is investigating whether adding two immunotherapy drugs, nivolumab and ipilimumab, after standard chemotherapy and radiation can help people with limited-stage small cell lung cancer. Even though initial treatment often works well, the cancer frequently returns within …

This trial compares two treatments for people with advanced malignant pleural mesothelioma, a cancer of the lining of the lungs, that has progressed after initial chemotherapy. Half of the participants receive pembrolizumab, an immunotherapy that helps the immune system fight can…

This trial tests whether mepolizumab, an injectable biologic, can reduce the number of moderate or severe flare-ups in people with chronic obstructive pulmonary disease (COPD) who have high levels of eosinophils (a type of white blood cell linked to inflammation). Participants re…

This trial tests whether a home breathing support program, guided by respiratory therapists, is practical and helpful for people with severe COPD who do not have high carbon dioxide levels. Participants use a bilevel positive airway pressure device at home for at least 6 hours a …

This trial tests an experimental antiviral pill, EDP-938, in adults with a confirmed RSV infection who are at high risk for complications—such as those over 65 or with asthma, COPD, or heart failure. Participants take the drug or a placebo once daily for five days. The goal is to…

This trial is testing whether giving the immunotherapy drug atezolizumab before surgery can help people with early-stage non-small cell lung cancer. The study includes adults with stage IB to IIIA (non-N2) disease who are eligible for surgery. Participants receive one dose of ate…

This study follows over 14,000 adults with sleep apnea who are prescribed positive airway pressure (PAP) therapy. It investigates whether using telemonitoring—where the device sends usage data to their doctor remotely—helps people use the therapy more consistently and effectively…

This study looks at whether using a breathing machine (non-invasive ventilation) at home, with remote monitoring, can help people with advanced COPD avoid hospital visits. It tracks how often patients need unplanned hospital care and whether the monitoring data can predict proble…

This trial tests whether using a blood test that measures procalcitonin—a marker of bacterial infection—can safely guide decisions about antibiotics in people hospitalized for a COPD flare-up. Participants are randomly assigned to either usual care or procalcitonin-guided treatme…

This study tests whether wet cupping therapy, an ancient practice of drawing blood through small skin incisions, can help adults with asthma. Researchers will compare lung function, asthma control, fatigue, and quality of life between a group receiving two cupping sessions and a …

This phase 2 trial is testing whether two investigational drugs, AD109 and AD504, taken as a pill at bedtime, can reduce the number of breathing pauses in people with obstructive sleep apnea. The study compares these drugs against atomoxetine (an existing medication) and a placeb…

This study compares two different mandibular advancement devices—oral appliances that hold the jaw forward during sleep—to see which works better for people with mild-to-moderate obstructive sleep apnea. Participants will wear each device for three months, with a two-week break i…

This trial tests whether an automated oxygen delivery system, called FreeO2, can help patients with pneumonia recover faster and leave the hospital sooner. The device automatically adjusts oxygen flow based on continuous monitoring of blood oxygen levels, aiming to keep patients …

This trial tests whether continuous pulse oximetry with wireless alerts to clinicians can reduce serious breathing complications (respiratory depression) after surgery. Patients on two surgical wards will be monitored continuously instead of every four hours. The goal is to see i…

This trial compares two widely used combination inhalers—Foster (beclomethasone plus formoterol) and Seretide (fluticasone plus salmeterol)—in people with chronic obstructive pulmonary disease (COPD). The goal is to see if Foster works better at improving lung function right afte…

This trial tests whether a breath-activated dry powder inhaler (NEXThaler) delivers the same asthma control as a traditional pressurized inhaler (pMDI), both containing the same combination of medications (beclometasone and formoterol). Adults with well-controlled asthma will use…

This pilot study investigates whether an 8-week ketogenic diet—high in fat and very low in carbs—can improve lung function, reduce inflammation, and boost exercise capacity in men aged 40–75 with mild-to-moderate COPD. Participants are randomly assigned to either the ketogenic di…

This trial tests whether performing stepwise, oxygenation-guided lung recruitment maneuvers at regular intervals during high-frequency oscillatory ventilation (HFOV) can improve oxygen levels in extremely preterm infants born before 28 weeks of gestation. The study compares this …

This trial tests whether a standardized respiratory physiotherapy program, delivered in primary care over six months, can improve quality of life and key health measures in adults aged 40 to 74 with mild COPD. Participants are randomly assigned to either the physiotherapy program…

This trial tests whether stroke patients with bulbar palsy—a condition that makes swallowing difficult—are less likely to develop pneumonia if they receive nutrition through a nasogastric tube or through an IV (total parenteral nutrition). The study will compare the incidence of …

This trial tests whether a program using a consumer wearable device—which tracks oxygen levels during sleep—along with personalized weekly reports can help adults with obstructive sleep apnea use their positive airway pressure (PAP) therapy more consistently. Participants who are…

This early-stage trial is testing an experimental stem cell therapy called VUM02 in people with idiopathic pulmonary fibrosis (IPF), a condition that causes progressive lung scarring and breathing difficulty. The study aims to see if the treatment is safe and tolerable, and wheth…

This trial tests whether dupilumab, an injectable drug that blocks certain inflammatory signals, can reduce sinus swelling and improve symptoms like loss of smell and runny nose in adults with chronic sinusitis who do not have nasal polyps. Participants receive either dupilumab o…

This trial tests whether a two-day course of intravenous dexamethasone works as well as a standard five-day course of methylprednisolone for children having a severe asthma attack. Children aged 2 to 18 with a severe exacerbation are randomly assigned to one of the two treatments…

This phase 3 trial tests whether Jinhua Qinggan Granules, a traditional Chinese herbal medicine, can eliminate symptoms of acute upper respiratory infections (like fever, sore throat, and congestion) within three days. About 273 adults with early-stage cold or flu will receive ei…

This trial tests whether a drug called IHL-42X can reduce breathing pauses during sleep in people with obstructive sleep apnea who cannot tolerate or do not use a CPAP machine. The study has two parts: first, a short dose-finding phase to pick the best dose, then a longer phase c…

This trial tests whether a pharmacist, at the time of hospital admission, can review a patient's prescribed inhaler for insurance coverage and clinical appropriateness. The goal is to see if this simple check helps patients get the most cost-effective inhaler and reduces the chan…

This trial investigates whether custom-made stents, designed using 3D computer modeling and printing, can safely treat complex airway narrowing that standard stents cannot fit. Ten adults with symptomatic, anatomically complex airway stenosis will receive a personalized stent and…

This phase 3 trial tests whether mepolizumab, an injectable drug, can reduce nasal polyp size and improve symptoms like nasal blockage in adults with chronic rhinosinusitis and nasal polyps. Participants receive either mepolizumab or a placebo every four weeks for a year. The stu…

This phase II trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation can help people with stage III non-small cell lung cancer that cannot be surgically removed. About 50 participants will receive the combination treatment, and …

This study looks back at health records from over 46,000 people in Denmark and Sweden with allergic rhinitis (hay fever), some of whom also have asthma. It compares those who used SQ sublingual immunotherapy (SLIT) tablets — a daily tablet placed under the tongue containing grass…

This trial investigates whether combining stereotactic body radiotherapy (SBRT), a precise form of radiation, with the immunotherapy drug nivolumab is safe and tolerable for people with early-stage non-small cell lung cancer. Participants receive SBRT followed by nivolumab infusi…

This trial tests a device called the aura6000 that stimulates a nerve in the neck to keep the airway open during sleep. It is for adults with moderate to severe obstructive sleep apnea who cannot or will not use a CPAP machine. Participants are randomly assigned to have the devic…

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This trial tests whether using a lower oxygen saturation threshold (88%) versus the standard (92%) to decide when to give supplemental oxygen helps children aged 6 weeks to 12 years recover faster from respiratory distress. Participants are randomly assigned to one of two groups,…

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This phase 3 trial tests whether tezepelumab, an injectable drug, can reverse airway wall thickening (remodeling) in adults with asthma. Participants, aged 18 to 85 with moderate-to-severe asthma, will receive either tezepelumab or a placebo for about a year. Researchers will use…

This trial investigates whether adding the immunotherapy drug atezolizumab (Tecentriq) to standard chemotherapy (carboplatin and etoposide) helps people with a rare and aggressive lung cancer called large cell neuroendocrine carcinoma (LCNEC). The study enrolls adults with advanc…

This phase II trial tests whether adding canakinumab, an anti-inflammatory drug, to standard chemoradiation and immunotherapy (durvalumab) helps control locally advanced non-small cell lung cancer. About 41 participants will receive the combination to see if it improves progressi…

This trial investigates whether exposing preterm infants to their mother's natural body odor can reduce apnea episodes (pauses in breathing) and improve heart rate, oxygen levels, and weight gain. Sixty preterm babies in the NICU are randomly assigned to either receive a cloth ca…

This study tests whether virtual or in-person care transition programs are better at helping people with COPD avoid emergency room visits and hospital readmissions within 30 days of discharge. The trial enrolls hospital sites across the U.S., not individual patients, and compares…

This study tests whether a high dose of montelukast (Singulair), given by mouth, can help children aged 4 to 12 who are in the hospital with a moderate or severe asthma attack. The goal is to find the best dose for a future larger study. Children receive either the high-dose mont…

This study tests whether combining two targeted drugs, avutometinib and adagrasib, can shrink tumors in people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. Participants must have already tried a KRAS G12C inhibitor and seen their c…

This study investigates whether following the DASH diet—a heart-healthy eating plan—can improve quality of life for adults whose asthma is not well controlled by medication. Participants are randomly assigned to either a DASH-focused behavioral coaching program or standard asthma…

This study tests whether a three-in-one inhaler (budesonide, glycopyrronium, and formoterol) works better than two-drug inhalers for people aged 12 to 80 with asthma that is not well controlled by their current treatment. Participants receive either the triple inhaler, a two-drug…

This trial tests whether a gentler suction level (-2 cmH2O) on chest tubes after keyhole lung cancer surgery works as well as the standard stronger suction (-10 cmH2O). The goal is to see which setting allows tubes to be removed sooner and causes fewer complications. About 230 ad…

This study tests whether using continuous positive airway pressure (CPAP) or positive end-expiratory pressure (PEEP) during resuscitation helps extremely low birth weight infants (born before 28 weeks) breathe better and avoid lung damage. Half of the babies receive standard care…

This study tests whether a nasal spray containing adelmidrol can reduce inflammation and shrink nasal polyps in people with chronic sinusitis. Participants are adults aged 18 to 70 who are scheduled for sinus surgery. Half receive standard care plus the adelmidrol spray, while th…

This study tests whether washing the infected chest cavity with povidone-iodine (an antiseptic) helps adults with pleural empyema recover faster than using normal saline alone. Participants receive chest tube drainage plus daily irrigation with either povidone-iodine or saline. T…

This phase II trial tests whether a low-dose, frequent schedule of the chemotherapy drug vinorelbine, taken orally, can boost the effects of the immunotherapy atezolizumab in people with stage IV non-small cell lung cancer. The study enrolls adults whose cancer has progressed aft…

This study tests whether a three-in-one inhaler (budesonide, glycopyrronium, and formoterol) works better than two standard two-drug inhalers for people with asthma that is not well controlled. Adults and adolescents aged 12 to 80 with moderate-to-severe asthma will use the tripl…

This study tested a new inhaler that combines three medicines (beclometasone, formoterol, and glycopyrronium) against a standard two-medicine inhaler in over 1,100 adults with asthma that was not well controlled. The goal was to see if the triple combination improves lung functio…

This trial tests a 12-week virtual program called Conmigo, designed to help Latina girls aged 8-11 and their mothers become more physically active together. The program includes weekly 1.5-hour sessions with teaching, skill-building, and at least 30 minutes of exercise. Researche…

This phase 2 study tested three different drug combinations in 151 people with advanced non-small cell lung cancer that had not been treated before. The drugs help the immune system attack cancer cells. Researchers measured how many patients' tumors shrank or stopped growing, and…

This study tested whether a smartphone chatbot called Vik-Asthme can teach adults with asthma how to manage their condition as well as the usual in-person training. 73 adults with asthma were split into two groups: one received standard education, the other used the chatbot. Rese…

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This study tested giving immunotherapy drugs (nivolumab alone or with relatlimab) for four weeks before surgery in 90 people with early-stage non-small cell lung cancer. The goal was to see if this approach is feasible and helps shrink tumors before removal. Results help determin…

This study looked at whether giving a sedative called propofol to very premature babies (under 32 weeks) before a less invasive breathing treatment (LISA) is safe and reduces the need for a breathing machine. The trial involved 233 infants with breathing problems. Researchers com…

This study investigates whether adding a contract-relax physical therapy technique to standard respiratory care can improve diaphragm function in patients who develop diaphragmatic paresis after cardiac surgery. The trial enrolls adults who have undergone heart surgery with a hea…

This study tested whether taking high-dose fish oil (n-3 PUFA) for 6 months can improve asthma control in adults with a specific type of asthma called N-ERD, which is triggered by aspirin or NSAIDs. The 18 participants had poorly controlled asthma despite standard treatment. The …

This study followed 105 teenagers with severe uncontrolled asthma who were starting treatment with dupilumab (Dupixent). Researchers tracked their asthma control, flare-ups, and safety over one year. The goal was to see if this medication helps teens manage their condition better…

This study tested an oral drug called PLB1001 in 145 people with advanced non-small cell lung cancer whose tumors have a specific genetic change (c-Met dysregulation). The main goal was to see how many patients' tumors shrank or disappeared. The drug is taken twice daily and aims…

This study looked at whether giving immunochemotherapy in the morning or afternoon affects how long people with advanced non-small cell lung cancer live without their disease getting worse. 210 patients were randomly assigned to receive treatment before or after 3 PM. The goal is…

This pilot study tested a procedure called FETO, where a tiny balloon is placed in the windpipe of an unborn baby with severe congenital diaphragmatic hernia (CDH). The goal was to see if the balloon could be safely placed and removed to help the lungs grow. Four pregnant women p…

Researchers are testing a new face mask, the Smart Mask V1 System, that uses built-in light sensors to measure blood oxygen (SpO2) and pulse rate. The study enrolls healthy adults aged 18 to 65 who wear the mask while breathing air with gradually lower oxygen levels in a special …

People with cystic fibrosis often develop prediabetes and then diabetes, but doctors lack a good way to predict who will progress. This pilot study at Indiana University tests whether a continuous glucose monitor worn for up to 10 days, combined with a mathematical model called t…

Researchers in Senegal are testing a new way to care for children under 15 who come to primary health clinics with fever or diarrhea. The strategy combines rapid tests for malaria, dengue, and strep A with a digital tool that suggests treatment based on symptoms and test results.…

This study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researc…

This study tests a smart mask that uses AI to detect sleep stages and breathing-related arousals in adults with sleep apnea. About 150 participants will wear the mask during an overnight sleep study, and its results will be compared to standard lab tests. If accurate, the mask co…

Researchers are studying whether lung ultrasound can reliably show the patterns of COVID-19 pneumonia in hospitalized patients. The trial enrolls adults admitted with confirmed COVID-19 and respiratory symptoms who need a chest CT scan. By comparing ultrasound images with CT scan…

Researchers are studying whether a specialized lung MRI scan can detect changes in lung blood flow in children with cystic fibrosis before and after they start Trikafta, an FDA-approved treatment. The study enrolls 48 children aged 6 to 11 who have cystic fibrosis and at least on…

This pilot study explores whether three different home sleep apnea testing devices—NightOwl, SleepImage, and Nox T3—are practical and user-friendly for adults with type 2 diabetes. Participants will wear each device at home for three nights and answer questionnaires about their e…

Researchers test whether adding ketamine to propofol improves sedation for drug-induced sleep endoscopy in adults with obstructive sleep apnea. The procedure lets doctors see where the airway collapses during sleep. Thirty adults receive either propofol alone or propofol plus ket…

Researchers are testing whether a quick lung ultrasound and a blood test for the protein ANGPTL4 can predict which late preterm and full-term newborns with breathing trouble will need NICU admission. The study includes 80 newborns born at 34 weeks or later who show signs of respi…

Researchers are studying whether volumetric high-resolution CT scans can give a detailed picture of lung damage in people with stable chronic obstructive pulmonary disease (COPD). The study enrolls 75 patients with COPD confirmed by breathing tests. Participants receive both a sp…

This trial tests whether using a laser-based imaging tool called confocal laser endomicroscopy (pCLE) to guide lung biopsies improves diagnosis in people with suspected interstitial lung disease. Researchers will compare this approach with the standard method, which uses X-ray gu…

Researchers are testing a portable device called Truenat MTB Plus/COVID-19 to see if it can accurately detect both tuberculosis and COVID-19 from the same sample. The study will enroll about 2,000 adults who have symptoms like a long-lasting cough, fever, or weight loss, which co…

This trial tests a blood-based test designed to detect multiple cancers early in people aged 40 to 74 who have no cancer symptoms. The study will enroll about 2,500 participants and will check how well the test identifies lung, colorectal, liver, gastric, and esophageal cancers. …

This study looked at whether a special PET scan (18FDG dual-point) can tell the difference between real tumor growth and harmless inflammation caused by immunotherapy. Researchers studied 100 people with advanced lung cancer or melanoma who were being treated with drugs like nivo…

This study evaluates whether two newer line probe assays, the YD REBA MTB-MDR and Hain Genotype MTBDRplus V2, perform as well as the older Hain Genotype MTBDRplus V1 in detecting drug-resistant tuberculosis. Researchers will test stored, de-identified samples from adults with sym…

This study looks at whether a bedside ultrasound (POCUS) can help doctors quickly diagnose acute chest syndrome in children and young adults with sickle cell disease. Researchers will enroll 30 hospitalized patients aged 0-25 to see if the ultrasound is practical and reliable com…

This study is testing new rapid tests (lateral flow and microfluidic devices) to detect respiratory infections in children and adults in Uganda, Ethiopia, and Senegal. Researchers want to see if these tests are accurate and easy to use in low-resource clinics. Participants with r…

This study tests whether an enhanced diagnostic workup can identify lung diseases other than tuberculosis in patients who are about to start TB treatment based on clinical signs but have negative sputum tests. Participants will undergo a thorough review and possibly additional te…

This trial tests whether a new imaging tracer, gallium-68-deferoxamine, can make Aspergillus fungus infections in the lungs visible on a PET/CT scan. The study involves 10 adults with suspected chronic pulmonary aspergillosis or allergic bronchopulmonary aspergillosis. The goal i…

This study looks at children aged 5 to 18 who had an exercise challenge test to see if certain symptoms, like wheezing or coughing during exercise, can predict a positive result. The goal is to find simpler ways to diagnose exercise-induced bronchoconstriction, a condition where …

This trial tests whether an ultra-low-dose CT scan, using a new image reconstruction algorithm, can produce images good enough for diagnosing lung, abdominal-pelvic, and bone lesions, compared to a standard-dose CT scan. About 116 adults will receive both scans as part of their u…

This study investigates whether a liquid biopsy taken from the airways during a bronchoscopy can help diagnose lung cancer and identify genetic mutations. The approach aims to be less invasive and faster than traditional tissue biopsies. Researchers will compare the accuracy of t…

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This study tests whether a wearable home sleep apnea device called WatchPAT200 can accurately detect central sleep apnea in people who take narcotic medications. Participants wear the device during an overnight lab sleep study, and results are compared to the standard in-lab test…

This study investigates whether patterns in speech and breathing can indicate the presence of obstructive respiratory diseases like COPD. Researchers will collect short voice recordings from patients with and without lung disease and compare them to standard lung function tests. …

This study evaluates a rapid viability test for tuberculosis bacteria in sputum samples. The goal is to see if this test can accurately tell whether a patient is still contagious, compared to the standard culture method that takes weeks. If the test works, it could help doctors d…

This study explores whether ultrafast ultrasound can accurately assess diaphragm function in adults with known or suspected diaphragm dysfunction. Researchers will compare ultrasound measurements with standard tests like pressure measurements and electrical signals from the diaph…

This study tested a new way to diagnose cystic fibrosis in unborn babies using a simple blood sample from the mother. Instead of using a needle to take fluid from around the baby, researchers used advanced DNA sequencing to read the baby's genes from tiny bits of fetal DNA floati…

This study explores whether ultrasound can identify the reasons some patients fail to come off a mechanical ventilator. Researchers will scan the heart, lungs, and diaphragm of adults who have been on a ventilator for at least 24 hours and have not passed a spontaneous breathing …

This study tested two new rapid tests that use a single nose swab to detect COVID-19, influenza A/B, and RSV. Researchers checked how accurate the tests are compared to standard lab methods and whether healthcare workers find them easy to use. The study involved 589 people with s…

This study collected nasal swabs, throat swabs, and saliva samples from 79 people with symptoms of flu, RSV, or COVID-19. The samples were used to help evaluate a point-of-care device called LumiraDx, which aims to quickly and accurately detect these viruses. The study focused on…

This study tested whether a simple mouth rinse could help diagnose Pneumocystis pneumonia, a serious lung infection in people with weakened immune systems. Researchers used a PCR test on the rinse sample to look for the fungus, aiming to find a threshold that indicates active inf…

This study checked how well a new rapid test (LumiraDx) detects COVID-19 and flu A/B from a simple nose swab. Over 1,000 people with symptoms took part at clinics. The test aims to give fast results at the point of care, helping doctors tell these illnesses apart quickly.

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study tested whether a thermal camera could detect intestinal inflammation in 43 children with Crohn disease. The camera measures heat patterns on the belly, which may reflect underlying inflammation. Researchers compared these readings to standard stool tests and symptom sc…

This study checked how accurate two rapid tests (LumiraDx SARS-CoV-2 Ag Ultra and LumiraDx SARS-CoV-2 & Flu A/B) are at detecting COVID-19 and flu in people with symptoms. 716 participants provided nasal swabs at clinics. The results were compared to standard lab tests to measure…

This study tested a new rapid test (LumiraDx Influenza A/B + RSV Test) that uses a nasal swab to quickly detect flu A, flu B, and RSV. Over 500 people with cold or flu-like symptoms took part. The test was performed by healthcare workers at point-of-care sites and compared to sta…

This study tested whether an ultra-low dose CT scan, combined with a deep-learning AI reconstruction, can detect lung nodules as accurately as the standard low-dose CT. 70 adults having a chest CT for nodule check-up or follow-up received an extra ultra-low dose scan. The goal wa…

This study tested whether giving general practitioners a rapid C-reactive protein (CRP) test helps them decide when antibiotics are truly needed for patients with respiratory infections. 140 patients with symptoms like cough, fever, or sore throat took part. Doctors in the test g…

This study tested whether a special MRI technique can measure airway thickness in asthma patients as well as CT scans do, but without radiation. Thirty adults with asthma underwent both scans. The goal is to find a safer way to monitor airway changes over time.

This study looked at whether monitoring oxygen levels at home for 14 nights gives a more accurate diagnosis of obstructive sleep apnea than the standard single-night test in a hospital. Researchers enrolled 130 adults with suspected sleep apnea. They compared results from home mo…

Researchers are testing whether pirfenidone, a drug that reduces inflammation and scarring, can prevent radiation pneumonitis in people with advanced lung cancer. Participants have already received immune checkpoint inhibitors and need chest radiation. The trial gives pirfenidone…

This study tests several new mRNA-based flu vaccines in about 971 healthy adults aged 18 and older. The goal is to see how well they trigger an immune response and how safe they are compared to standard flu shots. Participants receive one dose of an experimental vaccine or a comp…

Researchers test whether short messages sent through a mobile wellness app can increase flu vaccination rates among insured adults. The messages, delivered as push notifications and in-app posts, either highlight incentives or use generic wording. The study compares vaccination r…

This phase III trial tests whether the immunotherapy drug durvalumab (MEDI4736) can prevent non-small cell lung cancer from returning after patients have surgery and possibly chemotherapy. Participants have completely resected stage IB, II, or IIIA lung cancer and are randomly as…

This study tests whether a community-based communication program can increase flu vaccination rates among people over 65 in Can Tho City, Vietnam. The program includes direct counseling, weekly health tips via the Zalo app, and printed leaflets. Researchers will compare vaccinati…

This trial tests three flu vaccines in adults aged 65 and older: a standard dose, one with an adjuvant to boost response, and a high-dose version. Researchers measure antibody levels and immune cell activity to see which vaccine triggers the strongest protection. They also examin…

This large study tested whether an enhanced flu vaccine (Fluad) works better than standard flu shots in adults aged 65 and older. Over 38,000 participants received either Fluad or a regular vaccine. The goal was to see if Fluad prevents confirmed flu cases more effectively. Resul…

This pilot study tests a peer-led program designed to help Black Veterans at high risk for lung cancer get screened. Veterans who have not yet had lung cancer screening will receive group orientations and one-on-one support from a peer to navigate the process. The study aims to s…

This study tests a program called FLARE that teaches families how to protect children from the sun. It includes children ages 8 to 17 who have a parent who survived melanoma and who have had at least one sunburn in the past year. Families are randomly assigned to either the FLARE…

This trial investigates whether a low-level diode laser can prevent or reduce severe mouth sores (mucositis) caused by radiation and chemotherapy in people with advanced head and neck cancer. Participants receive either real laser therapy or a non-functional placebo laser during …

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

Researchers compare two chest drain sizes, 20-Fr and 24-Fr, in people having part of a lung removed for early-stage lung cancer. After surgery, each participant receives one of the two drains to clear fluid and air from the chest. The trial tracks complications such as collapsed …

Researchers at the University of Washington are testing whether combining non-invasive spinal stimulation with an ankle exoskeleton can improve walking in people with neurologic conditions such as cerebral palsy, stroke, and premature birth. The study includes up to 10 participan…

Researchers are testing whether adding neuromuscular electrical stimulation (NMES) to chest physiotherapy helps older adults with severe COPD walk farther and gain muscle strength. Sixty participants receive either chest physiotherapy alone or chest physiotherapy plus NMES applie…

Researchers at Pamukkale University are testing whether adding virtual reality cycling to standard pulmonary rehabilitation helps people hospitalized for a COPD flare. Fifty participants with moderate COPD receive either the virtual reality add-on or standard rehab alone. The tri…

This trial tests whether immersive virtual reality or relaxing nature videos can reduce symptom severity, distress, and improve quality of life in people with lung cancer who are starting chemotherapy. Participants will be randomly assigned to one of three groups: virtual reality…

Researchers test a guided exercise program for people aged 60 and older recovering from lung cancer surgery. The program combines breathing exercises, shoulder training, and strength work, taught through videos and a manual. The trial measures how far participants can walk in six…

This study tests whether a program combining resistance training and a Mediterranean diet is practical and helpful for people with head and neck cancer undergoing radiation. Forty participants will receive supervised exercise sessions and pre-made meals, plus dietary coaching. Th…

Researchers are testing whether AI-generated videos shown through a virtual reality headset can reduce fear and pain for boys aged 4 to 12 during circumcision. The trial assigns 80 children to either the VR distraction or routine care. Children, parents, and nurses rate pain and …

Researchers compare two ultrasound-guided nerve blocks to see which one better controls pain after video-assisted thoracoscopic surgery (VATS), a minimally invasive lung operation. The trial enrolls 46 adults scheduled for VATS. Participants receive either a serratus posterior su…

Researchers are testing a biodegradable nasal dressing called OCEAN that releases the steroid mometasone furoate. The dressing is placed in the nose after endoscopic sinus surgery in adults with chronic rhinosinusitis, with or without nasal polyps. The trial checks safety by coun…

Researchers are testing whether injecting dexamethasone, a steroid, into the soft palate during tonsillectomy reduces uvula swelling and improves recovery. The study includes 74 adults aged 18 to 44 having tonsillectomy for recurrent tonsillitis. Half receive the steroid injectio…

Researchers are testing whether adjusting a patient's body position based on where the lung infection sits, combined with mechanical vibration on the chest, helps clear infected mucus better than routine position changes. The trial enrolls 384 adults in intensive care who need a …

Researchers compare two ways of giving nasal breathing support to preterm infants born before 32 weeks of pregnancy. One method delivers puffs of air on a fixed rhythm, while the other syncs each puff to the baby's own breathing using a flow sensor. The trial tracks how often bab…

This study tests the MedCline Sleep System, a device placed on the bed to keep people sleeping on their side. It aims to reduce breathing pauses and snoring in adults with mild obstructive sleep apnea. Researchers will measure changes in apnea and oxygen levels during sleep. The …

When a baby is deprived of oxygen around birth, doctors cool the body to limit brain damage, but some infants still suffer lasting injury. This early-stage trial tests whether adding oral sildenafil, a drug that widens blood vessels, can further protect or repair the brain. Resea…

After heart surgery, part of a lung can collapse, a common problem called atelectasis. Researchers are testing whether adding a breathing device called EzPAP, which provides positive pressure on exhale, to standard manual chest physiotherapy helps clear this collapse better than …

Researchers are testing whether short, repeated sessions of mild low oxygen (mild intermittent hypoxia) can strengthen upper airway muscles and improve sleep apnea treatment. Adults with newly diagnosed obstructive sleep apnea and prehypertension or stage 1 hypertension, includin…

This study looked at whether an 8-week Pilates exercise program could improve breathing in overweight and obese women. 54 women were split into an exercise group and a control group. The exercises focused on core strength and abdominal endurance. Researchers measured lung functio…

Shots and blood draws cause pain and anxiety in children, and numbing creams take time to work. Researchers are testing a device that uses cold, vibration, and distraction to block needle pain. The trial compares this device with standard numbing cream in children aged 4 to 15 at…

Researchers are studying how a three-week inpatient pulmonary rehabilitation program affects breathing in people with COPD whose blood oxygen drops during exercise. Participants train while breathing normal air, air that mimics moderate altitude, or extra oxygen. A wearable senso…

Researchers are studying whether a pulmonary rehabilitation program at moderate altitude changes airway resistance in adults with COPD. Participants complete an endurance training cycle, with some sessions using extra oxygen through a nasal tube and others breathing regular room …

This study tested a new combination pill called AD109 for obstructive sleep apnea (OSA) in 646 adults who could not tolerate CPAP machines. The pill aims to reduce breathing pauses during sleep by targeting brain chemicals. Results will show if it improves the apnea-hypopnea inde…

This study tested a new care plan that gets people eating and moving sooner after lung surgery. 232 adults took part. The goal was to see if this approach, based on the ERAS protocol, improves recovery quality, reduces complications, and shortens hospital stays compared to standa…

Researchers are testing whether breathing extra oxygen during exercise training helps people with COPD who have normal oxygen levels at rest but drop low during activity. The trial enrolls 54 adults in a three-week inpatient rehab program. Participants cycle and walk while breath…

Many people with obstructive sleep apnea struggle to use their CPAP machine every night. This trial compares three ways to support them: weekly phone calls from the sleep center, a printed list of frequently asked questions, or the usual care from equipment renters and sleep spec…

This early-stage study tests a new inhaled drug called HRS-9821 in 160 people. First, healthy volunteers get a single dose to check safety. Then, people with COPD receive multiple doses. The main goal is to see what side effects occur and how the drug moves through the body. This…

This study tests whether a daily probiotic blend can improve quality of life for adults with persistent allergies to dust mites, cats, or dogs. For 12 weeks, 98 participants will take either the probiotic or a placebo and track their symptoms and antihistamine use. The goal is to…

Researchers are testing a nasal spray called PG-011 in adults with moderate to severe seasonal allergic rhinitis. The trial compares two strengths and dosing schedules of the spray against a placebo to see which might best reduce nasal symptoms like runny nose, sneezing, congesti…

Researchers are studying whether they can safely perform talc pleurodesis on both lungs at the same time in people with malignant pleural effusions, which is fluid that builds up around the lungs because of cancer. The procedure uses medical-grade talc to seal the space around th…

This trial tests whether adding mini-doses of dexmedetomidine and esketamine to standard pain relief can improve sleep quality after surgery in people at high risk of obstructive sleep apnea. Participants receive either the drug combo or a placebo through a patient-controlled pai…

This trial tests whether a spray made from lavender and ginger oils can ease sore throat, thirst, and nausea after kidney stone surgery. About 110 adults who have the surgery under general anesthesia will receive the aromatic spray, a placebo, or standard care. Researchers will m…

This study tested a device called NEUROMARK that uses radiofrequency energy to disrupt nerves in the nose. It included 36 adults with moderate to severe chronic rhinitis. The goal was to see if the procedure safely reduces symptoms like runny nose and congestion over 3 months.

This study tested a new drug called BLU-808 in 21 adults with ragweed allergies. The goal was to see if it is safe and helps reduce sneezing, runny nose, and itchy eyes caused by ragweed pollen. Participants were exposed to ragweed in a special chamber to measure the drug's effec…

This study tests whether a web-based training program helps people with COPD who use a noninvasive ventilator (NIV) at home stick to their therapy and sleep better. Participants receive online lessons on using the device, and researchers measure their compliance and insomnia seve…

This pilot study tests whether four sessions of cognitive-behavioral therapy (CBT) can help teenagers with vocal cord dysfunction. The therapy teaches teens to identify triggers, self-monitor symptoms, and use breathing and relaxation techniques to reduce symptom reactivity. Rese…

This Phase 2 trial tests whether an injection called DM-101PX can reduce nasal symptoms caused by birch pollen allergy. About 100 adults with birch pollen allergic rhinitis or rhinoconjunctivitis will receive either the drug or a placebo. The main goal is to see if the treatment …

This trial tests whether a structured patient education program can lower the risk of severe immune-related side effects in people receiving immunotherapy for certain cancers, including melanoma, lung, kidney, and head and neck cancers. Participants either attend five educational…

This pilot study is testing whether a device called a 'scare ventilator' can help preterm babies breathe more regularly and sleep better. Ten healthy preterm babies will be observed for two hours without the device, then for two hours with the device set at 20 air puffs per minut…

Pulmonary fibrosis is a chronic lung condition that causes breathlessness and often brings anxiety and depression, yet few psychological supports exist. This trial tests a 4-week online mindfulness program, called Compassionate Mindful Resilience, designed to improve emotional we…

This trial explores whether an internet-based cognitive behavioral therapy (CBT) program, combined with COPD education, can improve mental health, disease knowledge, and quality of life in adults with chronic obstructive pulmonary disease (COPD). Participants complete the 8-10 we…

This pilot study explores whether cancer patients are willing to complete a quick self-screening for insomnia during clinic visits, and whether a video-based cognitive behavioral therapy (CBT-I) could help them sleep better. The study involves adults with breast, colorectal, lung…

This trial investigates whether Su Jok therapy, a complementary technique that stimulates specific points on the hands, can reduce dyspnea (breathlessness) and fatigue in people with chronic obstructive pulmonary disease (COPD). The study will include 30 hospitalized adults with …

This study tests whether teaching family caregivers about lung cancer care—through a handbook and personalized guidance—can reduce stress and improve quality of life for patients undergoing lung cancer surgery. The trial involves 160 patients and their caregivers, with some recei…

This trial tests whether a continuous infusion of the local anesthetic ropivacaine, delivered through small catheters placed near the breastbone, can improve recovery after cardiac surgery. The study focuses on patients at higher risk of respiratory complications, such as older a…

This study asks whether Su Jok therapy, a complementary technique that gently stimulates specific points on the hands, can reduce shortness of breath and improve sleep in adults with asthma. Participants will be randomly assigned to receive either Su Jok therapy alongside their u…

This study looks at two ways of delivering palliative care—specialized support to ease symptoms and stress—for people recently diagnosed with advanced lung cancer. One approach starts with basic palliative care and adds more if needed, while the other provides full palliative car…

This trial tests whether low-intensity body weight exercises combined with blood flow restriction (BFR) are safe and acceptable for people with COPD. Participants perform simple moves like sit-to-stand and knee raises at home, wearing inflatable cuffs on their thighs. The study f…

This phase 3 trial tests whether a once-daily pill combining desloratadine (an antihistamine) and betamethasone (a corticosteroid) relieves nasal allergy symptoms better than desloratadine alone. About 70 adults with moderate-to-severe allergic rhinitis will take either the combo…

This study tests an experimental drug called BLU-5937 (camlipixant) in adults with refractory chronic cough, including unexplained chronic cough, that has lasted at least a year. Participants take the drug or a placebo daily for 52 weeks to see if it reduces coughing frequency an…

This study tests whether osteopathic manipulation—a hands-on therapy—can reduce chronic chest, neck, or back pain in adults with cystic fibrosis. Participants are randomly assigned to receive real osteopathic treatment, a sham version, or standard pain care. The goal is to see if…

This study investigates whether a 12-week program of tai chi and qigong (called Body Mind Training) can reduce fatigue in male cancer survivors aged 55 and older. Participants are randomly assigned to the mind-body training, a light exercise-only group, or a usual-care group. Res…

This trial tests whether daily bright light therapy can improve sleep and reduce biological aging in people with lung cancer. Participants wear a light visor for 4 weeks and track sleep, fatigue, and stress. The study compares bright light to usual light exposure to see if it hel…

This trial investigates whether adding high-flow nasal oxygen during exercise training can improve endurance and quality of life for people with chronic fibrotic interstitial lung disease (ILD). Participants undergo a 4-week pulmonary rehabilitation program, receiving either high…

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This study tested whether an extended-release form of nalbuphine, a pain medication, can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF). 165 participants received either different doses of the drug or a placebo for 6 weeks. The main goal was to see if …

This study tested a special lollipop containing the painkiller diclofenac to help children aged 4 to 12 manage pain after having their tonsils removed. Fifty children received a weight-adjusted dose every 8 hours for the first day after surgery. The goal was to see if the lollipo…

This study looked at 300 infants under 6 months old with severe bronchiolitis in the pediatric ICU. Researchers compared two flow rates of high-flow nasal cannula (2 vs 3 liters per minute per kilogram) to see which one reduced breathing failure within 24 hours. The goal is to fi…

This study looked at whether a specific breathing exercise (forced expiration while lying on the side of the surgery) can shorten the time children need a chest tube after lung surgery. The tube drains fluid that builds up after the operation. The study involved 140 children aged…

This study tested two ways of positioning patients with severe lung injury (ARDS) who are on ventilators and placed face-down (prone) to help breathing. The goal was to see if a 'swimmer' position—where the head is turned and one arm is bent—causes fewer severe pressure sores tha…

This study tested whether giving extra oxygen through a small tube in the nose during breathing tube placement can prevent dangerous drops in oxygen levels in newborns. About 110 infants in the NICU took part. The approach is simple and could make a common emergency procedure saf…

After surgery, painkillers can slow breathing. This study tested a device that uses a mild electrical pulse on the skin to wake patients when their breathing stops for 10 seconds. Researchers enrolled 60 adults recovering from surgery to see if the system is practical and accepta…

This study tested whether a numbing injection behind the nose (sphenopalatine ganglion block) could reduce confusion and agitation after sinus surgery. 100 adults received either the nerve block or a placebo. The goal was to see if the block helped patients wake up more calmly an…

This study tested whether using a smaller amount of a weaker numbing medicine (ropivacaine) during a shoulder nerve block could reduce the risk of temporary diaphragm paralysis. 60 adults having shoulder surgery took part. The goal was to see if the low-dose approach could still …

This study tested whether a personalized exercise program helps people with early-stage lung cancer or cancer that spread to the lungs recover better after surgery. 182 participants were randomly assigned to either the exercise program or usual care. The main goal was to see if t…

This study looked at whether breathing exercises can improve quality of life for adults with asthma who also have dysfunctional breathing (a pattern of breathing that causes shortness of breath). About 190 adults with poorly controlled asthma took part. Half received usual care, …

This study looked at 100 adults with COPD who needed a breathing tube and a ventilator. It compared two approaches: giving sedation with daily breaks versus giving no sedation at all. The goal was to see which method leads to more days off the ventilator and fewer complications i…

This study tested an investigational drug called ponsegromab in 187 adults with lung, pancreatic, or colorectal cancer who also had cachexia—a condition causing severe weight loss, loss of appetite, and fatigue. The goal was to see if ponsegromab could help patients gain weight a…

Bronchoscopy lets doctors look inside the airways to diagnose and treat lung diseases, and deep sedation can make the procedure more comfortable and efficient. Deep sedation also carries risks, including low oxygen levels and airway blockage. This study observes whether giving a …

This study tested a new MRI technique using inhaled hyperpolarized xenon gas to detect early signs of bronchiolitis obliterans syndrome (BOS), a common form of chronic rejection after lung transplant. Only 3 participants were involved, and the goal was to see if the imaging could…

This study compares two oral formulations of pranlukast, a drug used for asthma and allergic rhinitis, to see if they are equivalent. Sixty healthy adults will receive a single dose of each version in random order under fasting conditions. The main goal is to measure drug levels …

Researchers are looking at whether the FIB-4 index, a blood-based score that estimates liver fibrosis risk, tracks with the severity of obstructive sleep apnea (OSA) and low oxygen levels during sleep. They will review records from 373 adults who had full-night sleep studies, gro…

This study looks at how common sleep breathing problems are in children with cerebral palsy across the UK, and how often they use breathing support like CPAP machines. Researchers will track new cases over a year and explore what helps or hinders access to care. The goal is to im…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

Researchers are studying how chronic obstructive pulmonary disease (COPD) relates to sensorimotor function, thinking skills, pain sensitivity, and muscle quality. The study compares adults aged 40 to 65 with COPD at different disease stages against healthy adults of the same age.…

Metered-dose inhalers release propellant gases that add to the NHS carbon footprint, while dry powder inhalers do not. Researchers want to know whether giving NHS clinicians the carbon footprint of each inhaler changes which device they prefer for asthma patients. The trial asks …

Researchers are studying blood and tumor tissue from people with squamous cell cancer of the larynx, pharynx, or oral cavity who have no history of smoking, heavy drinking, or workplace exposure to substances like asbestos or wood dust. The goal is to learn how DNA changes and bi…

This completed study looked at levels of a specific antibody (IgG4) to cow's milk and egg in 135 children, both with and without allergies. Researchers wanted to see if these levels could help tell which children have outgrown their allergy. The study involved a single blood draw…

This early-stage study tests a new drug called ENA-001 in 36 healthy adults to see if it is safe and how the body processes it. Participants receive a single dose either through a vein or as a shot. The goal is to gather safety information before testing it in patients with respi…

This completed study looked at how genetic differences might change the way immune cells in the lungs respond to environmental triggers like dust and germs. Researchers collected blood and lung samples from 20 healthy adults to compare cell function between people with different …

Researchers are testing two ways to train VA primary care clinicians to hold goals of care conversations with veterans who have serious illnesses such as cancer, heart failure, or dementia. One approach gives clinicians written materials and online training. The other adds team f…

Researchers at Erasmus Medical Center are studying whether switching patients with acute hypoxemic respiratory failure from controlled to assisted mechanical ventilation earlier than usual changes the stress on different parts of the lungs. The study enrolls 20 adults on a breath…

This study looks at whether closely following a standard enhanced recovery after surgery (ERAS) protocol affects nutritional status in 120 adults undergoing lung cancer surgery. Researchers will measure nutritional risk and a nutritional index before surgery and two days after, a…

This study collected and stored biological samples from nearly 10,000 tin miners in China who are at high risk for lung cancer due to workplace exposures. The goal is to use these samples to discover early markers of the disease, which could lead to better screening and preventio…

This study follows 157 adults with pulmonary fibrosis who are taking nintedanib and enrolled in a patient support program in Spain. Researchers will measure how satisfied patients are with the program, their quality of life, and any depression symptoms over 12 months. The goal is…

This study looks at two ways to manage pain in children having the Nuss procedure for pectus excavatum (a sunken chest). One group received standard nerve freezing (cryoanalgesia) alone, while the other also had a nerve block near the diaphragm. Researchers will compare pain scor…

Researchers want to learn which molecules on cancer cells the immune system attacks when checkpoint inhibitor drugs work well. They collect tumor and blood samples from adults with solid tumors who respond to these drugs, either during treatment or after surgery. The team then se…

This study looked at whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery helps preserve diaphragm movement and reduce lung problems after surgery. Sixty adults having elective coronary artery bypass surgery were randomly assigned to receive either…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

This study observes how doctors decide when to remove breathing tubes (extubation) in extremely preterm infants born before 28 weeks. Researchers will track 100 babies in the NICU, asking doctors daily why they choose to extubate or not. The goal is to understand current practice…

This study looks at how different types of tuberculosis affect lung function and physical capacity in teenagers who have recovered from the disease. Researchers will measure lung function with a breathing test and walking ability with a 6-minute walk test in 20 adolescents aged 1…

This study reviews medical records of 350 adults who had surgery for esophageal cancer in France between 2017 and 2024. Researchers want to understand how often infections happen after surgery, what causes them, and how they affect recovery. The goal is to find ways to prevent th…

This study looked at whether new computer methods can create higher-resolution images from a standard CT scan. Researchers compared the quality of regular CT images with enhanced versions from the same scan. 148 adults scheduled for a CT scan participated. The goal was to see if …

Researchers at a French hospital are studying people over 75 who arrive in the emergency department with acute respiratory distress. They use a non-invasive ultrasound probe at the bedside to measure how far the diaphragm moves during breathing. The study aims to find out how com…

Researchers want to know whether problems in the smallest airways of the lungs explain why some people with asthma have worse symptoms. The study enrolls 872 adults aged 18 to 65 with a confirmed asthma diagnosis. Participants complete breathing tests and other assessments, and r…

This study asks whether a portable external power supply can keep respiratory support equipment running without interruption during ambulance transport. Researchers survey healthcare workers worldwide about current transport practices and then test the power device during 25 ambu…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looked at whether teaching children (ages 2-15) with bronchospasm and their families how to properly use inhaler chambers can cut down on repeat emergency room visits. Half of the 121 participants received special education on inhaler use, while the other half got stan…

This study collected fluid and cells from the lungs of 574 people with asthma and healthy volunteers using a thin tube called a bronchoscope. The goal was to learn more about airway inflammation and what causes it. The findings may help identify new targets for future asthma trea…

This study follows 500 people in China with moderate-to-severe asthma to see how doctors adjust their treatments over 24 weeks. Researchers focus on patients whose symptoms remain uncontrolled despite using standard inhaler therapy, and they track whether these patients are moved…

This study looks at how changing sleep time affects the immune system and breathing in urban children with asthma. Researchers will ask some children to go to bed 90 minutes later for a week, while others keep their usual bedtime. They aim to understand if short sleep worsens ast…

This study follows 236 smokers or ex-smokers who have respiratory symptoms but normal spirometry, a standard test for COPD. Researchers measure a different lung function called DLCO, which checks how well oxygen moves from the lungs into the blood. Participants are split into two…

This study looked at whether giving nutrition through a tube into the stomach (enteral) or through a vein (parenteral) early on affects survival in very sick patients who need a breathing machine and heart-support medications. Over 2,400 adults in intensive care units were random…

This trial tests whether a new formulation of budesonide and formoterol inhalation powder delivers the same amount of medication into the body as the approved Symbicort Turbuhaler. Healthy adults aged 18 to 45 will receive a single dose of each inhaler in random order, with a 4-d…

This study looks at how doctors currently diagnose lung and breast cancer using tissue samples. It will also test whether artificial intelligence (AI) can help analyze these samples faster and more accurately. Researchers will review records from 600 patients to measure diagnosis…

This study tests whether a software tool called Synapse Medicine can help hospital pharmacists who work with medical teams make better and faster medication recommendations. The tool analyzes each patient's health information to flag potential drug-related risks, such as harmful …

This study follows a large group of COPD patients over many years, using routine clinic visits and standard tests. Researchers aim to describe how the disease changes over time, identify different patterns of progression, and see how various treatments affect those patterns. The …

This completed phase 1 study tested whether giving healthy adults a controlled dose of whooping cough bacteria via nasal spray can safely cause mild infection. The goal was to establish a human infection model for future vaccine and treatment research. 79 participants aged 18-40 …

This pilot study from the University of Aberdeen is looking at how dietary protein (from plants and animals) relates to sarcopenic obesity—a condition where muscle loss and obesity happen together—in 30 women aged 55+ with COPD. Researchers will also check lung function and infla…

Researchers are studying the gut bacteria of infants with cow milk allergy compared to healthy infants. They aim to see if differences in the types and functions of gut microbes are linked to food allergy. The study includes 600 children aged 6 to 12 months and also compares chil…

This study follows 450 patients who recently had cardiac surgery to see how often sleep disordered breathing occurs and whether it changes over time. Researchers screen participants with the ApnoeLink Air device at the start of cardiac rehabilitation, again after 3 weeks, and at …

This study looks at 20 patients who have both high pressure in their belly (intra-abdominal hypertension) and severe lung injury (ARDS). Researchers will compare two methods for setting the ventilator's positive end-expiratory pressure (PEEP): one based on lung pressure measureme…

This early-stage trial tests two experimental drugs, AG2203L and AG2203E, in healthy adults to see if they are safe when taken together and whether they affect each other. Participants receive each drug alone and then both together in a random order. The goal is to measure how th…

This study looked at how small differences in the COX-2 gene affect the balance of immune cells that play a role in allergies and asthma. Researchers analyzed blood and urine samples from 117 adults who were part of a larger genetic registry. No treatments were given; the goal wa…

This completed study looked at 83 adults of African, African American, or African Caribbean descent to find genetic and environmental factors linked to asthma. Participants provided blood, skin, and breathing test data. The goal was to build a resource for future research, not to…

This study reviews the medical records of about 284 adults who developed chronic lung allograft dysfunction with bronchiolitis obliterans syndrome (CLAD-BOS) after a lung transplant. Researchers will track how lung function, measured by FEV1, changes each year after diagnosis. Th…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study looked at how itepekimab, an experimental drug, affects airway inflammation in 49 adults aged 40-70 with COPD who smoke or used to smoke. Participants stayed on their usual COPD medications while receiving itepekimab for 12 weeks. The goal was to understand the drug's …

This study looked at different ways to collect sputum (phlegm) from people with a lung infection called nontuberculous mycobacterial (NTM) infection. The goal was to see which method gives the best samples for diagnosing and understanding the infection. Participants provided thro…

This trial tests a new monitoring device, the Linshorn CPRM, which fits into an oxygen mask and tracks breathing and oxygen levels every second. Researchers will compare its predictions with standard monitoring in 320 adults recovering from non-cardiac surgery in the post-anesthe…

This study examined whether a chemical called TGF-Beta, which is more common in the lungs of people with asthma, makes them more vulnerable to respiratory syncytial virus (RSV). Researchers collected lung cells from 113 healthy adults and mild asthmatics using a bronchoscopy. The…

Researchers at Hacettepe University are using video conferencing to compare physical activity, exercise capacity, quality of life, cognitive function, and COVID-19 phobia in adults with cystic fibrosis against healthy individuals. Participants complete simple remote tests like a …

This study investigates whether electrical impedance tomography (EIT) — a non-invasive imaging technique — can help doctors choose the best ventilator settings for each patient with acute respiratory distress syndrome (ARDS). Researchers will compare different methods of setting …

This study evaluates the 6-minute stepper test as a way to measure exercise capacity in people with COPD or interstitial lung disease. Participants will perform the stepper test, a standard walk test, and a cycling test to see if the results match. The study also checks whether t…

This trial tests whether a 15-minute educational video and a list of suggested questions can improve understanding of immunotherapy among patients with advanced cancer and their caregivers. Participants are randomly assigned to receive the educational materials or usual care, and…

This study investigates whether different types of sleep apnea—a condition where breathing repeatedly stops during sleep—are linked to future heart problems or death in people who have recently had a heart attack. Researchers will use a home sleep test called polygraphy to measur…

This study follows children and adults with severe asthma over three years to see how their airways change and how lung function declines. Using advanced imaging and breathing tests, researchers aim to understand the process of airway remodeling and what makes some patients worse…

This study looks at whether adults with acute respiratory failure who need non-invasive ventilation (a breathing mask) are getting enough calories and protein. Researchers will track what each patient eats for five days after starting ventilation and compare it to recommended tar…

This trial is testing whether using whole-body PET/CT scans and liquid biopsies (blood tests that detect cancer DNA) can improve the follow-up care of people who have completed treatment for early-stage non-small cell lung cancer. The goal is to see if these advanced tools can fi…

This international survey asks practicing physicians how they diagnose and treat acute asthma exacerbations—sudden worsening of asthma symptoms. It aims to uncover variations in clinical practice, including medication choices and use of breathing support. The findings could revea…

This research program aims to deepen understanding of severe asthma by closely studying its clinical and biological features over time. Researchers will follow more than a thousand people with asthma, aged 6 and older, measuring lung function and tracking how often severe asthma …

This study evaluates whether prismaLINE PAP devices accurately count breathing events (apneas and hypopneas) compared to the gold-standard polysomnography (PSG) in people with sleep apnea. Participants will use a full face mask during a titration night, where the device briefly l…

This study investigates the link between the physical structure of the upper airway and its tendency to collapse during sleep, which is a key factor in obstructive sleep apnea. Researchers will measure airway collapsibility using a special pressure device, and assess anatomy via …

This trial investigates whether a recruitment maneuver—a brief procedure to open collapsed lung areas—affects blood levels of sRAGE, a marker of lung cell injury, in patients with diffuse acute respiratory distress syndrome (ARDS). The study involves 24 mechanically ventilated IC…

This study looks at whether certain proteins linked to the RAGE receptor—found in lung fluid and blood—are elevated in ICU patients with acute lung injury or ARDS. Researchers will measure these proteins in 60 mechanically ventilated patients within the first day of injury and tr…

This study tests whether gradually tilting patients with acute respiratory distress syndrome (ARDS) upright—from lying flat to a 90° seated position—improves how their lungs handle mechanical ventilation. Researchers will measure lung pressure, aeration, and oxygen levels at each…

This study surveys senior managers at companies in Zambia with silica dust exposure to assess their knowledge, attitudes, and practices regarding tuberculosis. Since these leaders shape workplace policies, their understanding is key to protecting workers. The findings could highl…

This study looks at whether anxiety about climate change is linked to worse sinusitis symptoms and lower quality of life in adults with chronic rhinosinusitis. Researchers will ask about 134 adults to complete questionnaires measuring sinus symptoms, quality of life, and climate …

This study observes people in Belgium with non-invasive pneumococcal infections like pneumonia, ear infections, and sinusitis. Researchers will collect bacterial samples to see which strains are circulating and how they compare to invasive infections. The goal is to understand ho…

This study investigates whether individual physiological traits that cause obstructive sleep apnea (OSA) can predict how well CPAP therapy works. Researchers will follow adults newly diagnosed with OSA who are starting CPAP, measuring factors like arousal threshold and breathing …

This study aims to adapt and validate a French version of the PAPA questionnaire, a tool designed to screen for psychological distress in fathers during the perinatal period. Researchers will test the questionnaire with 343 couples to see if it accurately captures symptoms like a…

This study aims to find the lowest concentrations of ragweed and birch pollen that cause allergy symptoms in people with seasonal allergic rhinitis. Participants sit in a special chamber where pollen levels are carefully controlled, and their nasal symptoms are measured. The goal…

This study looks at how anti-tumor T-cell responses change in people with lung or head-and-neck cancer who are receiving radiochemotherapy. Researchers will collect blood and tumor samples to track immune markers. The goal is to understand whether this standard treatment can boos…

This trial investigates whether a short stay at high altitude (up to 3,545 meters) is safe for people with asymptomatic moderate or severe aortic stenosis. Participants will undergo heart tests—including ECG, echocardiography, and exercise stress tests—both at low altitude and af…

This study tests whether a very short sleep survey, called the Sleep Vital Sign, can help primary care doctors recognize sleep disorders like sleep apnea, insomnia, and restless leg syndrome. About 1,260 adults visiting their Kaiser Permanente doctor will fill out the survey, whi…

This study looks at whether placing patients face-down (prone) to help them breathe can damage nerves in the shoulder area. Researchers will use electrical tests to check for nerve injury in adults with severe lung failure who are sedated and on a ventilator. The goal is to find …

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study tests whether machine learning can predict death in the intensive care unit for patients with acute hypoxemic respiratory failure (AHRF), a common cause of ICU admission. Researchers will analyze data from over 1,200 patients, using several machine learning algorithms …

This study investigates why COVID-19 causes severe lung injury (ARDS) by looking at tiny blood vessels in the lungs. Researchers will compare 39 patients with COVID-19 ARDS to those with ARDS from other causes. They measure 'alveolar dead space' — lung areas that get air but not …

This study tests whether machine learning can predict if a patient with acute hypoxemic respiratory failure will need a breathing machine for a week or longer. Researchers analyzed data from over 1,200 ICU patients in Spain, using information from the first 48 hours to build a pr…

This study uses French national health data to compare the risk of major heart problems—like heart attack, stroke, and death—in people with Takayasu arteritis versus similar people without the disease. It also looks at how steroid use may affect these risks. The goal is to better…

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study explores whether analyzing the chemicals in exhaled breath can detect early changes in children with cystic fibrosis who start taking a medication called Kaftrio. Researchers will collect breath samples from 50 children under 12 before and after they begin treatment, l…

This study develops and tests a tool designed to help lung cancer nurses talk to patients about clinical trials. The tool provides information on available trials, communication tips, and practical guidance. Researchers will test it in four UK hospitals to see if it improves nurs…

This study aims to develop and test a tool that helps lung cancer nurses talk to patients about clinical trials. Only about 8% of lung cancer patients in the UK join trials, and nurses often lack the time or confidence to discuss them. The tool will be tested in four UK hospitals…

This pilot study tracks changes in a specific inflammatory marker (IL-1β) in the nasal passages of adolescents during an asthma attack. Researchers collect nasal fluid samples daily for five days during an attack and compare them to baseline samples taken when the participant is …

This study investigates how a specific strain of pneumococcus bacteria (serotype 3) colonizes the nose of healthy adults. Researchers will give volunteers nose drops containing the bacteria to see what dose leads to colonization and how long the bacteria stay before the immune sy…

This study looks at whether chronic lung inflammation from bronchiectasis raises the risk of heart disease and accelerates aging. Researchers will measure heart function, artery stiffness, bone density, muscle mass, and blood markers in 110 adults aged 40 to 80 with confirmed bro…

This observational study looks at why some people with severe asthma continue to have flare-ups even while taking tezepelumab, an approved treatment. Researchers will track 150 patients over a year, measuring changes in inflammatory cells and markers in blood and airways during a…

This study looked at 30 people with early-stage non-small cell lung cancer who had surgery. Researchers collected blood from a vein near the tumor and from a regular arm vein to study tiny particles called exosomes. The goal was to see if these particles could help predict whethe…

This completed study looked at 40,000 people with metastatic cancer who received the drug nivolumab. Researchers compared the old way of dosing (based on body weight) with a newer, simpler fixed dose. They used national health data to see if the fixed dose was just as good and mo…

This study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to unders…

This study tested a non-invasive imaging method called electrical impedance tomography (EIT) to measure airway opening pressure in 6 adults with acute lung injury or ARDS. The goal was to see if EIT could detect where and when small airways open during a slow breath, which might …

This study measured levels of mannose-binding lectin (MBL), a protein involved in immune response, in 97 ICU patients with severe H1N1-related acute respiratory distress syndrome (ARDS). Researchers wanted to see if higher or lower MBL levels were linked to a higher risk of death…

This study used ultrasound to measure how much the diaphragm thickens during a sniff in 60 healthy adults. The goal was to define a normal range for this measurement, which could help doctors spot diaphragm problems in the future. Participants were grouped by age and gender to se…

This completed study in Greece enrolled 200 people with stage 4 non-small cell lung cancer. Researchers used genetic testing to map each tumor's unique features and gave half the patients access to a digital platform to report side effects. The goal was to see if combining person…

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This study looks at how the community of bacteria, fungi, and viruses in the lungs changes when a person with COPD has a severe flare-up that requires intensive care. Researchers collect sputum samples from patients to analyze the genetic material of these microbes. The goal is t…

This study followed 39 lung cancer patients who received radiation therapy to see how it affected their breathing. Researchers measured lung volume and gas exchange capacity before and after treatment, looking for a 20% or greater drop in diffusion capacity at 3 months. The goal …

This completed study looked at 44 patients who had lung cancer surgery to understand how the arteries in the lungs can vary from person to person. Using CT scans and 3D models, researchers mapped these variations to help surgeons avoid complications during lobectomy. The goal was…

This study tracks how many infants in Germany receive nirsevimab, a long-acting antibody that helps protect against severe RSV disease. Researchers will survey parents of babies born during three RSV seasons (2024–2027) to measure immunization rates. The goal is to see how well t…

This study looked at immune cells called alveolar macrophages in the lungs of 18 people with non-infectious lung diseases. Researchers used a technique called flow cytometry to study the surface proteins on these cells. The goal was to better understand the role of these cells in…

This study uses lung ultrasound to measure how the lungs change after surgery to remove part of a lung due to cancer. Researchers will check lung aeration before surgery, right after, and 24 hours later in about 32 adults. They aim to see if ultrasound findings relate to oxygen l…

This completed study enrolled 336 people with non-small cell lung cancer to collect detailed family cancer histories using a questionnaire. Researchers want to see if certain patterns of cancer in relatives, along with smoking and other risk factors, can help identify patients wh…

This study investigates why people develop obstructive sleep apnea (OSA) and whether the underlying cause affects how they respond to different treatments. Researchers will test three approaches—CPAP, a sleep medication (eszopiclone), and supplemental oxygen—in adults with OSA. T…

This study tested whether a protein called GLUT1 could help doctors better classify lung neuroendocrine tumors. Researchers analyzed tumor samples from 36 patients to see if GLUT1 staining patterns matched tumor type. The goal was to find a more reliable diagnostic tool than curr…

This study investigates whether spores from birch rust fungi trigger seasonal allergies in autumn. Researchers will compare 30 people with suspected birch rust allergy to 15 non-allergic controls, tracking symptoms and spore levels. The goal is to understand a possible cause of a…

This study tested whether a CT scan of the lungs could predict which patients with severe eosinophilic asthma would respond well to the drug benralizumab. 59 adults received benralizumab for 48 weeks and had CT scans at the start, middle, and end of treatment. The goal was to see…

This study examined whether a marker of cellular aging called p16Ink4a is linked to bronchopulmonary dysplasia (BPD), a serious lung disease in premature babies. Researchers measured p16 levels in blood from 80 newborns and children, comparing those with and without BPD. The goal…

This study looked at whether a narrower oxygen saturation target range helps an automated oxygen control system work better for very low birth weight infants on breathing support. Eleven babies were randomly assigned to either a 3% or a shifted 3% target range. The goal was to se…

This study looks at why some people develop pneumonia after accidentally inhaling food, drink, or stomach contents. Researchers will track patients in intensive care and general medicine who have had a known or suspected inhalation event. The goal is to identify risk factors and …

This study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…

This study observed 61 adults having shoulder surgery to see how a specific combination of nerve blocks affects the diaphragm, the main muscle for breathing. Researchers used ultrasound to measure diaphragm movement before and after the block. The goal was to find out if this tec…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study looked at whether measuring procalcitonin (PCT) levels in the blood could help detect infections earlier in people with stage IV non-small cell lung cancer starting chemotherapy. Researchers enrolled 45 patients and took a PCT blood sample before their first chemo sess…

This study tested a new sensor placed inside the nose to measure carbon dioxide levels in 21 people with breathing conditions like COPD or obesity-related breathing problems. The goal was to see if the sensor is safe, easy to use, and gives accurate readings compared to standard …

This study looked at whether using a bedside ultrasound device to measure blood clotting can reduce the amount of blood products given during double-lung transplantation. The trial involved 128 adult patients. The goal was to see if this quick test helps doctors make better decis…

This study examined 41 patients treated for non-tuberculous mycobacteria (NTM) infections, comparing those with and without cancer. The goal was to count side effects from NTM treatment in each group to understand why cancer patients often stop therapy. Researchers hope this will…

This study explored sleep disorders in 37 adults with non-small cell lung cancer. Participants filled out questionnaires about their sleep, symptoms, mood, and quality of life. The goal was to create a guide to help doctors diagnose and treat sleep issues in this group, ultimatel…

This study looks at how exercise training affects the growth and maturation of tiny blood vessels in the leg muscles of people with COPD. Researchers will compare healthy volunteers and COPD patients doing different exercise intensities for 5 to 10 weeks. The goal is to understan…

This study investigates whether tiny molecules in the blood, called miRNAs, can act as markers of lung disease in people with cystic fibrosis. Researchers will compare miRNA patterns between cystic fibrosis patients and healthy volunteers, and also between patients with mild vers…

This study enrolled 200 adults with lung adenocarcinoma that has spread to the bones. Researchers took bone biopsies, scans, and blood tests to measure bone and metabolic markers. The goal is to see if these markers are linked to how long patients live. This is an observational s…

This study explores whether certain blood cells called fibrocytes play a role in the airway remodeling seen in chronic obstructive pulmonary disease (COPD). Researchers will compare blood samples and lung function between people with COPD and healthy volunteers, including smokers…

This study tested whether a defined mixture of live gut bacteria from a healthy donor (MET-4) is safe and can be detected in patients with advanced oropharyngeal cancer receiving standard chemoradiation. Thirty participants took the bacteria by mouth daily for up to four weeks. T…

This study looks at fibrocytes—cells involved in scarring—in the lungs and blood of 50 people with COPD compared to healthy controls. Researchers want to understand how these cells contribute to airway remodelling, the abnormal tissue repair that makes COPD worse. The goal is to …

This study looked at how repeatable and reproducible ADC maps are for measuring head and neck cancer in 58 adults. Participants had MRI scans using a standard method to see if results were consistent across different machines and sessions. The goal was to improve the reliability …

This study looked at 103 adults with narcolepsy or obstructive sleep apnea to see if anxiety, social, or work factors affect their ability to stay awake during a standard test. Participants filled out an anxiety questionnaire before the test. The goal is to better understand why …

This study looked at two breathing treatments—high-flow oxygen and non-invasive ventilation—in 16 adults with sudden breathing failure from pneumonia. The goal was to see which one better opens up the lungs. The results showed no major difference in lung opening, though non-invas…

This completed study followed 5 people with cystic fibrosis over two years to track COVID-19 antibodies from infection or vaccination. Researchers collected blood samples every six months to see how antibodies develop and last. The goal was to understand if people with CF have di…