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Breathing treatment showdown: no clear winner in lung opening study

NCT ID NCT04664322

Knowledge-focused Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at two breathing treatments—high-flow oxygen and non-invasive ventilation—in 16 adults with sudden breathing failure from pneumonia. The goal was to see which one better opens up the lungs. The results showed no major difference in lung opening, though non-invasive ventilation improved oxygen levels more. This helps doctors understand the pros and cons of each treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

16 people

The number who actually took part.

Started

Feb 2016

Finished

Feb 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults referred in ICU

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients referred in ICU * with hypoxemic acute respiratory failure due to a community acquired pneumonia confirmed by chest X ray, * with PaO2 \< 60mmHg in ambient air, without hypercapnia (PaCO2 \< 45 mmHg), * requiring more than 6L/min of O2 on admission with high concentration FM, and justifying HFNC or NIV for the attending ICU physician Exclusion Criteria: * cardiogenic pulmonary oedema, * moderate to severe underlying respiratory disease including COPD (chronic obstructive pulmonary disease) * contraindication to or failure of previous NIV or HFNC with the need for immediate invasive ventilation * pregnant or breast-feeding women * carrier of an implantable defibrillator or pacemaker * body mass index (BMI)\>50 kg/m2 * with cutaneous lesion next to the positioning zone of the Pulmovista® (Dräger, Lübeck, Germany) belt

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Conditions

The condition(s) this trial relates to.

acute respiratory failure respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory failure with hypoxia

Contacts and locations

Locations

  • CHU de ROUEN

    Rouen, 76031, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.