CT scan could predict asthma drug success, saving months of trial and error

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Understanding and acceptance of the protocol * The patient has given his/her informed consent and signed the consent form * Affiliation with or beneficiary of the French national health insurance system * Female and male patients aged 18 to 75 years (inclusively) with a history of physician-diagnosed severe asthma (according to GINA criteria) requiring treatment with high-dose inhaled corticosteroid (ICS) plus long-acting beta-agonists for at least 12 months prior to inclusion * Documented current treatment with high daily doses of ICS (\>1000 µg equivalent beclomethasone) plus at least one other asthma controller for at least 6 months prior to inclusion * History of at least 2 asthma exacerbations while on ICS plus another asthma controller that required treatment with systemic corticosteroids (any administration route) in the 12 months prior to inclusion. For patients receiving corticosteroids as a maintenance therapy, the corticosteroid treatment for the exacerbation is defined as a temporary increase in their maintenance dose. * Uncontrolled disease (Asthma Control Questionnaire \>1.5) * Pre bronchodilator forced expiratory volume at 1 second (% predicted) between 40% and 85%, established according to the NHANESIII criteria * Blood eosinophilia ≥ 300 cells / µl at least once during the previous 12 months -OR- blood eosinophilia ≥ 300 cells / µl upon inclusion * Women of childbearing potential must use at least one acceptable and effective form of birth control * Weight ≥ 40 kg Exclusion Criteria: * Other respiratory diseases or associated lung infections * Patient treated with a monoclonal antibody in the 5 months preceding inclusion * Patient who participated in a therapeutic study in the month prior to inclusion * Patient deprived of liberty by judicial or administrative decision * Major (adult) protected by the law (under any kind of guardianship) * Patient in an exclusion period determined by another protocol * Patient who participated in another research protocol with X-ray exposure in the past 12 months * Patient who has already participated in the present protocol * Hypersensitivity to benralizumab or to any of the excipients: histidine, histidine hydrochloride monohydrate, trehalose dehydrate, polysorbate 20 and water for injections * Exacerbation, antibiotics, or non-maintenance systemic steroids during the 6 weeks prior to inclusion * Subjects with untreated helminthic parasitic infection * Lactating or pregnant\* females or females who intend to become pregnant * Subjects with a history of anaphylaxis to any biologic therapy * Subjects taking immunosuppressive medications (except oral prednisone and inhaled and topical corticosteroids) * Subjects with intercurrent illnesses (eg, viral illnesses) that may compromise the safety of the subject * Subjects who are febrile (≥ 38°C) * Currently smoking or smoking history ≥ 20 pack years * Subjects who have had basal cell carcinoma, localized squamous cell carcinoma of the skin, or in situ carcinoma of the cervix are eligible provided that the subject is in remission and curative therapy was completed at least 12 months prior to the date of informed consent, and assent when applicable was obtained * Subjects who have had other malignancies are eligible provided that the subject is in remission and curative therapy was completed at least 5 years prior to the date of informed consent, and assent when applicable, was obtained