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Could a Heart-Healthy diet tame uncontrolled asthma?

NCT ID NCT05251402

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study investigates whether following the DASH diet—a heart-healthy eating plan—can improve quality of life for adults whose asthma is not well controlled by medication. Participants are randomly assigned to either a DASH-focused behavioral coaching program or standard asthma education. Researchers will track asthma symptoms, daily activities, and emotional well-being over 12 months to see if the diet makes a meaningful difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
DASH dietary pattern (behavioral intervention)
What this could lead to
If it works, this could provide a practical, safe dietary approach to help adults with uncontrolled asthma feel better and have fewer symptoms.
What could go wrong
This is a mid-stage trial, so results are not yet proven. The diet may not improve asthma control for everyone, and sticking to the program can be challenging.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

323 people

The number who actually took part.

Started

Mar 2022

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older at study enrollment * Diagnosis of asthma with currently prescribed controller therapy (i.e., Step 2 or above) according to the 2020 asthma guideline update (EPR4) * Uncontrolled asthma on study screening based on Asthma Control Test (ACT) scores \<20 * Being able and willing to provide written informed consent and HIPAA authorization Exclusion Criteria: * Inability to speak, read or understand English sufficiently to provide valid informed consent * Primary diagnosis of COPD (emphysema or chronic bronchitis) * Previous cardiovascular disease: coronary heart disease (myocardial infarction, angina pectoris, percutaneous coronary intervention, coronary artery bypass graft surgery), cerebrovascular disease (stroke, transient ischemic attack), peripheral vascular disease, heart failure, or aortic aneurysm * Diabetes (other than during pregnancy) * Diagnosis of cancer (other than non-melanoma skin cancer) within the past year and/or actively receiving cancer treatment * Inflammatory bowel disease, colostomy, malabsorption, or major gastrointestinal resection * Diagnosis of bipolar or psychotic disorder * Hospitalization for psychological or emotional problems within the last 2 years * Cognitive impairment based on the Callahan 6-item screener67 * Terminal illness or in hospice or long-term care * Current diet of good quality (DASH concordance index ≥6 out of 9 total) * Current/planned participation in another structured program that overtly focuses on diet and nutrition * On special diet that precludes changes adherent to the DASH dietary pattern or otherwise unwillingness to modify current diet * Current use of prescription or non-prescription weight-loss products and unwillingness to stop taking them for the duration of the study * Underweight per body mass index (BMI) below 18.5 kg/m2 based on measured height and weight at study enrollment * Actively attempting to lose weight or weight change \>15 lbs during prior 3 months * Active alcohol or substance use disorder (including prescription drugs) based on the CAGE Questionnaire Adapted to Include Drugs (CAGE-AID)68 * Current within the past 6-months or former smoker (more than 20-packs of cigarettes in the lifetime, or current smoker) * Current or planned pregnancy or currently lactating * Planning to move out of the area during the study period * Participation in another clinical trial or investigational treatment study * Family/household member of an already enrolled participant or of a study team member * Investigator discretion for clinical safety or protocol adherence reasons

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Department of Medicine

    Chicago, Illinois, 60608, United States

  • UIC CCTS Clinical Research Center

    Chicago, Illinois, 60608, United States

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