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Bedside ultrasound may reveal hidden diaphragm weakness in older patients struggling to breathe

NCT ID NCT04520815

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de la Réunion Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 11, 2026

Summary

Researchers at a French hospital are studying people over 75 who arrive in the emergency department with acute respiratory distress. They use a non-invasive ultrasound probe at the bedside to measure how far the diaphragm moves during breathing. The study aims to find out how common diaphragm weakness is in this group and how it changes over time. A secondary goal is to see whether these measurements can predict who will need a ventilator.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the ultrasound measurements prove reliable, doctors could one day use a quick bedside scan to spot diaphragm weakness and predict which older patients will need breathing support.
What could go wrong
This is a small observational study of 85 people at a single hospital, so the results may not apply to other settings. Ultrasound readings can vary between operators, and the study cannot prove that diaphragm weakness causes worse outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

85 people

The number who actually took part.

Started

Jun 2020

Finished

Dec 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Recruitment of all patients over the age of 75, presenting to adult emergency departments and in spontaneous ventilation and having at least one criterion of acute respiratory distress.

Ages

75 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient in spontaneous ventilation at the admission on emergency room * Presence of acute respiratory distress defined by at least 1 of the following criteria: * Respiratory rate \> 25/min and/or clinical signs of acute respiratory distress, * Hypoxia defined by Sp02 \< 90 %, * Hypercapnia defined by PaC02 \> 45 mmHg with respiratory acidosis defined by a pH value \<7.35. * Absence of opposition of the patient to his participation in the study and the use of his data or the trusted person if the state of the patient does not allow it. Exclusion Criteria: * Presence of a preexisting diaphragmatic dysfunction appearing in the history or the medical file of the patient and explored on the electro-physiological level, * Patient with acute respiratory distress on arrival at the SAU with clinical criteria justifying immediate use of invasive mechanical ventilation and not allowing ultrasound measurements to be carried out or patient admitted to the SAU with mechanical ventilatory support from the outset, * Poor command of the French language or state incompatible with the patient's understanding and / or informed adherence to the study protocol, * History of surgery involving the integrity of the diaphragmatic muscle (diaphragm plication or diaphragmatic lumpectomy or placement of diaphragmatic pacemaker), * Criteria for shock or severe hemodynamic instability, * Intra-cranial hypertension.

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Conditions

The condition(s) this trial relates to.

adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Respiratory distress syndrome, adult

Contacts and locations

Locations

  • Centre Hospitalier Universitaire de la Réunion

    Saint-Denis, 97400, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.