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Could a Two-Day steroid course replace five days for severe asthma in kids?

NCT ID NCT07731217

Disease control Sponsor: Istanbul Medeniyet University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial tests whether a two-day course of intravenous dexamethasone works as well as a standard five-day course of methylprednisolone for children having a severe asthma attack. Children aged 2 to 18 with a severe exacerbation are randomly assigned to one of the two treatments. Researchers measure breathing improvement using a standard asthma severity score at the 4-hour mark and two days after discharge.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intravenous dexamethasone compared with intravenous methylprednisolone
What this could lead to
If dexamethasone works as well as the standard longer treatment, children with severe asthma attacks could receive a shorter, simpler steroid course.
What could go wrong
This is a single-center trial with 129 children, so results may not apply to all patients. Dexamethasone might prove less effective or have different side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

129 people

The number who actually took part.

Started

Sep 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:Aged between 2 and 18 years. History of receiving salbutamol ± steroid treatment for two or more previous wheezing attacks, OR physician-diagnosed asthma. Patients admitted to the Pediatric Emergency Department due to severe asthma exacerbation (Pediatric Respiratory Assessment Measure \[PRAM\] score ≥8). \- Exclusion Criteria: Patients with suspected or confirmed foreign body aspiration. Patients with concurrent croup. Presence of comorbidities (cardiovascular, neurological, malignancy, chronic kidney or lung disease). Patients with pneumonia. Patients with air leaks (pneumothorax, pneumomediastinum). Patients requiring immediate Intensive Care Unit (ICU) admission. Systemic steroid use within the last 8 weeks. Failure to obtain informed consent. \-

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Conditions

The condition(s) this trial relates to.

asthma disease status asthmaticus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma (diagnosis) Asthma exacerbations Status asthmaticus

Contacts and locations

Locations

  • Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital

    Istanbul, Turkey (Türkiye)

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