Respiratory system disorder

This trial is testing an experimental therapy called IOV-5001, which uses a patient's own immune cells (tumor-infiltrating lymphocytes) to attack cancer. The study involves adults with advanced solid tumors, including non-small cell lung cancer, triple-negative breast cancer, col…

This phase 2 trial tests whether three cycles of the immunotherapy drug cemiplimab can cure patients with stage I non-small cell lung cancer who cannot undergo surgery or radiation. Researchers will select patients likely to respond to immunotherapy and treat them with cemiplimab…

This phase II trial tests whether giving a combination of firmonertinib, anlotinib, and chemotherapy before surgery can shrink or eliminate tumors in people with resectable EGFR-mutant non-small cell lung cancer. The study enrolls adults with stage IIA-IIIB disease who have speci…

This trial is testing a surgical technique called septum-guided segmentectomy for people with early-stage (2-3 cm) non-small cell lung cancer. The surgery aims to remove only the diseased part of the lung, guided by natural anatomical landmarks, while preserving healthy tissue. T…

This Phase 1 trial tests experimental mRNA vaccines designed to protect against many types of influenza A by targeting a stable part of the virus. Healthy adults aged 18 to 59 receive one or two doses of the vaccine candidates, alone or in combination. The study checks for side e…

Researchers are testing an RSV vaccine in healthy adults aged 60 and older to see how safe it is and how well it triggers an immune response. The trial enrolls about 600 people in China and the United States. In China, participants receive either the vaccine or a placebo; in the …

Researchers are testing an experimental vaccine against respiratory syncytial virus (RSV) in adults aged 18 and older. The trial aims to see if the vaccine is safe and whether it triggers an immune response. Participants receive one of several vaccine formulations or a placebo, a…

This Phase 3 trial tests updated versions of the BNT162b2 COVID-19 vaccine in adults and children aged 5 and older. Participants include those aged 5 to 64 with medical conditions that raise their risk of severe COVID-19, as well as everyone aged 65 and older. The study compares …

This study tests a new vaccine called TdaP2gen in 320 pregnant women in Thailand to see if it safely protects their babies from tetanus, diphtheria, and whooping cough. The vaccine is given during pregnancy, and researchers measure antibody levels in mothers and infants up to 18 …

Researchers are testing whether combining BL-B01D1, an experimental antibody-drug conjugate, with glecirasib, a targeted KRAS G12C inhibitor, can shrink tumors in adults with locally advanced or metastatic non-small cell lung cancer that carries a KRAS G12C mutation. The phase 2 …

Researchers test whether rituximab helps maintain lung function in adults with systemic sclerosis and interstitial lung disease whose disease has stabilized after initial rituximab treatment. Participants receive rituximab or placebo infusions at months 0, 6, and 12. The main mea…

Researchers are studying depemokimab, an injected biologic drug, in adults aged 18 to 75 who have allergic bronchopulmonary aspergillosis (ABPA) along with severe eosinophilic asthma. The study tracks how many asthma attacks need systemic steroids and whether participants' qualit…

This phase II trial tests whether combining bevacizumab, a drug that limits blood vessel growth, with PRGN-2012, a vaccine-based therapy, can help adults with recurrent respiratory papillomatosis (RRP) avoid needing more surgeries. RRP causes wart-like growths in the airway that …

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

Researchers are testing whether a shared checklist used during lung cancer surgery helps surgeons achieve cleaner, more complete tumor removal. The trial enrolls adults with early-stage non-small cell lung cancer who are scheduled for surgery. Half the participating hospitals use…

Researchers are testing REGEND001, a therapy made from a patient's own airway basal stem cells, to see if it can improve lung function in people with chronic obstructive pulmonary disease (COPD) and emphysema. The trial enrolls adults aged 40 to 75 with moderate to severe COPD. P…

This early-phase trial tests a new therapy for people with advanced small cell lung cancer or similar neuroendocrine cancers that have not responded to prior treatment. The approach involves collecting a patient's own immune cells, modifying them in a lab to recognize a protein c…

Researchers are comparing an experimental oral drug called VT3989 with standard chemotherapy drugs gemcitabine or vinorelbine in adults with advanced epithelioid pleural mesothelioma. All participants have already received platinum-based chemotherapy and immunotherapy, and their …

Researchers are testing whether adding CT-guided thermal ablation of liver or lung metastases to standard systemic therapy improves tumor response in people with nasopharyngeal carcinoma. The trial enrolls 138 adults whose primary tumor was cured but who later developed up to fiv…

This study tests whether the drug telaglenastat, taken twice daily for 12 weeks, can safely lower blood pressure in the lungs and improve heart and lung function in adults with pulmonary hypertension. About 28 participants will receive the drug on top of their usual care. The mai…

This study tests an experimental drug called centhaquine in 80 adults with moderate to severe ARDS, a life-threatening lung condition. The drug is added to standard care to see if it improves oxygen levels and reduces deaths. Participants must be in the ICU and start treatment wi…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

Researchers compare two oral antifungal medicines, itraconazole and posaconazole, in people with chronic pulmonary aspergillosis, a fungal infection that damages the lungs over time. The trial enrolls 220 adults who have not yet received antifungal treatment and assigns them to o…

Researchers are testing whether adding the immunotherapy adebrelimab to HS-20093 (risvutatug rezetecan) works better than HS-20093 alone in adults with advanced or metastatic non-squamous non-small cell lung cancer that has already been treated and has no actionable gene changes.…

This phase II trial tests whether the experimental drug BL-B01D1, given with or without a PD-1 antibody, can improve tumor shrinkage in people with high-risk locally advanced nasopharyngeal carcinoma, a type of throat cancer. Participants also receive standard chemotherapy drugs …

Researchers are testing whether adding the experimental oral drug HS-10370 to platinum-based chemotherapy, with or without the immunotherapy adebrelimab, works better than tislelizumab plus chemotherapy. The trial enrolls about 448 adults with previously untreated, locally advanc…

This trial tests whether a single 10-minute lesson from an artificially intelligent robot can improve inhaler technique and asthma control in children ages 4 to 11. Researchers will compare standard asthma education with the robot-led session, measuring inhaler skills, medication…

Researchers are testing whether adding focused radiation to the few remaining cancer spots helps people with advanced EGFR-mutant non-small cell lung cancer live longer without their disease getting worse. Participants first receive a third-generation EGFR-targeted drug plus plat…

Researchers are testing an experimental drug called RO7830698 to see if it is safe and well tolerated. The trial includes healthy volunteers and people with chronic obstructive pulmonary disease (COPD). Participants receive either RO7830698 or a placebo, and researchers track sid…

Researchers are testing whether an experimental drug called telisotuzumab adizutecan works better than standard chemotherapy for people with non-squamous non-small cell lung cancer that has grown after earlier treatment. The trial enrolls about 660 participants whose tumors are E…

This study tests whether a pharmacist-led electronic consultation can improve lung health for people with HIV who smoke or use certain medications that raise pneumonia risk. Pharmacists will review records and suggest changes like smoking cessation aids, vaccines, or stopping unn…

This trial tests an experimental drug called TUB-040 in adults with advanced non-small cell lung cancer that cannot be removed with surgery or has spread. TUB-040 is designed to attach to a protein on cancer cells and deliver a toxic payload directly to the tumor, potentially kil…

Researchers at a Malaysian hospital reviewed ten years of records for 160 adults who received intrapleural fibrinolytic therapy, a mix of alteplase and DNase delivered through a chest tube, for complicated pleural infection. The study compares how well the treatment cleared fluid…

Researchers are studying the safety of selpercatinib, an oral drug, in people in India with advanced cancers that have changes in the RET gene. The trial includes adults with RET fusion-positive non-small cell lung cancer and adults and children aged 12 and older with RET-mutant …

Researchers are testing a combination of paclitaxel polymeric micelles and ivonescimab in adults with small cell lung cancer that has returned or stopped responding after platinum-based chemotherapy and anti-PD-1/PD-L1 therapy. The phase 2 trial aims to see how many participants'…

This phase III trial is testing whether adding an experimental drug called BL-B01D1 to standard maintenance therapy with a PD-1 antibody can help people with recurrent or metastatic nasopharyngeal carcinoma live longer without their cancer progressing. Participants first receive …

Researchers are testing whether giving toripalimab plus sacituzumab tirumotecan before surgery helps people with resectable non-small cell lung cancer. The trial enrolls about 30 adults with stage II to IIIB disease that has not been treated and lacks certain driver mutations. Pa…

Researchers are comparing an experimental oral drug called JYP0322 with crizotinib in adults who have not yet received treatment for ROS1-positive locally advanced or metastatic non-small cell lung cancer. The phase III trial aims to see which drug keeps cancer from worsening lon…

Researchers are testing an experimental drug called BL-M08D1 in adults with nasopharyngeal carcinoma that has come back or spread, as well as other solid tumors. Participants receive the drug by intravenous infusion every three weeks. The trial aims to find a safe dose for furthe…

Researchers are testing whether adding stereotactic radiation to two drugs, envafolimab and endostar, helps people with stage IV non-small cell lung cancer. Participants have tumors without common EGFR, ALK, or ROS1 mutations and have not received prior systemic treatment. Everyo…

This study will follow 600 adults in Korea who have been prescribed Breztri for COPD, a long-term lung disease. Researchers want to see how safe the drug is in everyday use and whether it works as expected. Participants will take Breztri as their doctor prescribes, and the study …

Researchers at Buraidah Central Hospital in Saudi Arabia are testing whether a pharmacist-led educational program helps COPD patients take their medications as prescribed, enjoy a better quality of life, and lower their direct healthcare costs. The program uses the Health Belief …

This study tests whether giving high-precision radiation (SBRT) to the main tumor and nearby lymph nodes, along with standard chemotherapy, can better control stage III non-small cell lung cancer. The trial will enroll 20 adults whose tumors are less than 6 cm and who have not sp…

This early-phase study tests a new cancer vaccine (EVM14) combined with an immunotherapy drug (ivonescimab) in 13 people with advanced squamous non-small cell lung cancer that has not been treated before. The main goals are to check safety and find the right dose, while also look…

Researchers are studying whether a structured care plan called the Indian Asthma Care Bundle (I-ACB) helps adults and children in India manage asthma after a severe attack. The study follows patients discharged from the hospital and compares those who receive the bundle with thos…

Researchers are testing whether a tablet form of the experimental cystic fibrosis drug VX-581 gets into the bloodstream as well as the liquid form. Sixteen healthy adults will take both forms in a randomized order, and researchers will measure drug levels in their blood over time…

This study tests whether a blood test that detects HPV DNA can help doctors choose the right treatment for people with HPV-positive oropharyngeal cancer. About 116 participants with stage I to III cancer will receive either the immunotherapy drug pembrolizumab (Keytruda) or stand…

This trial tests a device that uses pulsed electric fields to destroy lung tumors. It is for people with early-stage non-small cell lung cancer or lung metastases that cannot be removed with surgery or treated with radiotherapy. Participants receive the ablation under general ane…

Researchers are testing whether adding rimegepant to standard chemoimmunotherapy before surgery helps shrink oral or oropharyngeal squamous cell carcinoma more effectively. The trial enrolls adults with primary or recurrent disease who are scheduled for surgery. Participants rece…

Researchers are testing a new drug called TS-104 in adults with advanced solid tumors, including lung, head and neck, ovarian, endometrial, esophageal, and gastric cancers. TS-104 is a peptide drug conjugate: it uses a targeting peptide to carry the chemotherapy drug MMAE directl…

People newly diagnosed with breast, colorectal, lung, or prostate cancer often also manage other long-term conditions and take multiple medications. This pilot study tests whether a pharmacist-led medication review plus the Medisafe mobile app helps them stick to those regimens. …

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

Researchers are testing an investigational oral drug called catequentinib hydrochloride (AL3818) in adults with advanced or metastatic endometrial cancer, low grade serous ovarian cancer, soft tissue sarcoma, or glioblastoma. The trial has two parts: a phase 1b part to find safe …

This early-phase study is testing a combination of two experimental drugs, Ris-Rez and ivonescimab, in about 184 adults with advanced solid tumors that have spread. The main goals are to find a safe dose, understand side effects, and see if the combo can shrink tumors. It's a fir…

Some newborns with HIE, a brain injury from lack of oxygen at birth, also develop heart problems. This pilot trial tests whether starting a heart medication called dobutamine early, before heart failure signs appear, is feasible and safe. Forty babies receiving cooling therapy wi…

This study tests whether a very thin freezing needle can safely biopsy and destroy suspicious lung nodules in one procedure. About 30 adults with small lung nodules who are not candidates for or decline surgery will undergo the combined approach under CT guidance. Researchers wil…

This phase 2 trial tests an inhaled drug called YKYY018 in adults with respiratory syncytial virus (RSV) infection. The goal is to see if the drug can shorten the time until lower respiratory symptoms, like cough and wheezing, improve. Participants receive either YKYY018 or a pla…

This early-phase trial tests an oral drug called R01 in people with advanced squamous cell lung cancer, gastric cancer, or esophageal cancer that has progressed after standard treatment. The study aims to find the safest dose and check whether R01 can shrink tumors. Participants …

This study tests whether metformin, a standard diabetes medicine, can slow the worsening of idiopathic pulmonary fibrosis (IPF), a serious lung disease. About 400 high-risk patients will receive either metformin or a placebo. The goal is to see if metformin can delay death, hospi…

This phase 3 trial tests whether UBT251, an investigational drug given as a weekly injection, can reduce breathing pauses during sleep in adults with moderate-to-severe obstructive sleep apnea who also have obesity. Participants continue their usual positive airway pressure (PAP)…

This trial tests a device called C-Lift, a neck brace with sensors that detect breathing pauses and low oxygen during sleep. When a problem is sensed, the brace inflates or deflates to open the airway. Researchers will enroll 10 adults with moderate to severe obstructive sleep ap…

This early-stage trial tests an experimental drug called STRO-006 in adults with advanced solid tumors, including head and neck, lung, esophageal, gastric, colorectal, endometrial, bladder, and breast cancers that have not responded to standard treatments. The study has three par…

This early-stage trial tests an investigational drug called ABBV-253 in adults with advanced solid tumors, including lung, colorectal, and pancreatic cancers. The study aims to find safe doses and see whether the drug can shrink tumors. Participants receive the drug by infusion, …

This trial tests whether inhaling bacteriophages, which are viruses that specifically kill Pseudomonas aeruginosa bacteria, can help clear a serious lung infection in patients on breathing machines. The study includes adults with ventilator-associated pneumonia caused by this bac…

This Phase 3 extension study evaluates the long-term safety and efficacy of lunsekimig, an injectable drug, in adults with COPD who completed earlier lunsekimig trials. Participants receive lunsekimig for up to 96 weeks, and a sub-study tests whether they can safely withdraw from…

This Phase 2 trial tests whether adding lurbinectedin to paclitaxel works better than paclitaxel alone for people with advanced small cell lung cancer that has returned after first treatment. About 69 adults will be randomly assigned to one of two groups. The study measures how m…

This phase 3 trial tests an inhaled drug called treprostinil palmitil in adults with progressive pulmonary fibrosis, a condition where lung scarring worsens over time despite standard care. Participants inhale the drug or a placebo once daily for 52 weeks. Researchers measure whe…

This Phase 1 trial tests a personalized approach to treating acute viral respiratory infections using a platform called Dynamic Pathology-Based Therapy (DPBT). Researchers use a predefined algorithm to match each adult participant's specific inflammatory state with a botanical fo…

This trial studies people with pulmonary arterial hypertension (PAH) who live permanently above 2600 meters. Researchers want to see if spending one week at sea level and then returning to high altitude changes pressure in the lung's blood vessels. They will measure heart and lun…

This phase 2 trial tests whether zipalertinib, an oral drug that targets cancer cells with atypical EGFR mutations, can eliminate remaining cancer cells in people with early-stage non-small cell lung cancer. Participants who have completed standard treatment and show signs of min…

This pilot study tests a digital spacer device called aflo™ in children aged 6 to 18 with uncontrolled asthma. The device attaches to a standard inhaler and gives real-time feedback on technique, reminders, and tracks symptoms through a mobile app. Researchers want to see if usin…

This study tests a drug called nerandomilast in 466 adults with fibrosing interstitial lung disease (ILD) who are at risk of worsening. Participants take either the drug or a placebo for at least 52 weeks. Doctors measure lung function and use CT scans to see if the drug slows di…

This trial tests whether a coordinated care pathway, involving oncologists, geriatricians, pharmacists, and pharmacologists, can reduce severe side effects in adults over 70 with certain cancers who are starting oral therapy. Participants receive extra monitoring, including blood…

This phase III trial compares an experimental combination of two drugs, QLC5508 and QL2107, against the current standard treatment (tislelizumab plus chemotherapy) as a first-line therapy for people with extensive-stage small cell lung cancer. The study enrolls adults who have no…

This 52-week study will compare three drugs—tocilizumab, telitacicept, and methotrexate—in 204 people with rheumatoid arthritis who also have interstitial lung disease. The main goal is to see which drug best improves lung function. Participants will continue their usual arthriti…

This phase 2 trial tests whether combining an experimental drug called SHR-7787 with the immunotherapy adebrelimab can help people with limited-stage small cell lung cancer. The study enrolls adults aged 18 to 75 whose cancer has not progressed after standard chemotherapy and rad…

This study tests whether using the Provox ActiValve voice prosthesis as a first choice can reduce the number of times the device needs to be replaced each year in people who have had their voice box removed (laryngectomy) and have a tracheoesophageal puncture (TEP). The trial wil…

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This trial tests whether a wireless wearable monitor (chest patch or wristband) plus a smartphone-based rehab program can help people recover lung function after surgery for non-small cell lung cancer. Participants who have had curative-intent surgery will either receive standard…

This phase 1 trial tests whether combining an experimental oral drug, JIN-A02, with an existing intravenous drug, amivantamab, is safe and can shrink tumors in people with advanced EGFR-mutant non-small cell lung cancer that has progressed after treatment with a third-generation …

This study tests a combination of two experimental drugs, obrixtamig and ZL-1310, designed to help the immune system fight cancer. It is for adults with advanced small cell lung cancer or other neuroendocrine cancers. The trial has two parts: the first finds a safe dose of the tw…

This trial tests whether adding a nasal spray made from pistacia lentiscus oil can help people with chronic rhinosinusitis control their symptoms while using a lower dose of a standard corticosteroid spray. Adults with the condition will be randomly assigned to either the oil spr…

This trial tests whether a newer ventilation method, called flow-controlled ventilation, keeps the lungs and diaphragm in better shape than the standard pressure-controlled method during elective heart bypass surgery. About 154 adults scheduled for on-pump coronary artery bypass …

This trial compares two models of doula support for pregnant people on Medicaid in North Central Florida. One group receives enhanced support that starts earlier in pregnancy, happens more often, and continues through the first year after birth. The other group receives standard …

This trial tests a cell therapy called DC-CTL, made from a patient's own immune cells, combined with standard anti-tumor treatment. The goal is to see if this approach is safe and may help control solid tumors such as colorectal, esophageal, lung, liver, and breast cancer. About …

This study tests whether adding a cancer vaccine (CIMAVAX-EGF) to standard targeted drugs (sotorasib or adagrasib) can help control advanced lung cancer with a KRAS G12C mutation. About 29 adults with stage III or IV non-small cell lung cancer will receive the combination. The go…

This trial tests whether four weeks of supervised aerobic exercise can improve sleep and nervous system function in adults with mild to moderate obstructive sleep apnea. Researchers will compare an exercise group with a sleep-education-only group, measuring changes in sleep apnea…

This trial tests whether a digital rehabilitation program, combined with wireless wearable monitors, can help people recover faster between two planned lung cancer surgeries. Participants with multiple primary non-small cell lung cancer will be randomly assigned to either standar…

This trial tests a type of radiation called brain-avoidant proton craniospinal irradiation (BRAVO-pCSI) in people with leptomeningeal metastases, a condition where cancer spreads to the fluid and lining around the brain and spinal cord. The study includes adults with breast cance…

This trial tests whether prescribing exercise based on a person's individual metabolic threshold, measured during a cardiopulmonary exercise test, improves outcomes more than the standard six-minute walk test approach. Researchers will compare exercise capacity, adherence, muscle…

This trial tests how different levels of spontaneous breathing during a ventilation mode called APRV affect lung function in adults with moderate-to-severe acute respiratory distress syndrome (ARDS). Each participant receives three breathing conditions in random order: low, high,…

Researchers are testing an experimental oral drug called SYH2085 in adults with uncomplicated influenza. The study compares SYH2085 against a placebo to see if it can shorten the time to resolution of flu symptoms like fever, cough, and body aches. Participants must have tested p…

This trial tests a new monitoring device, the Linshom CPRM, which fits into an oxygen mask or nasal cannula and alerts nurses when a patient's breathing starts to fail. Researchers will compare standard monitoring plus the Linshom alarm against standard monitoring alone in about …

This early-phase trial tests whether a special MRI scan using hyperpolarized xenon gas can help doctors plan radiation treatment for non-small cell lung cancer. The goal is to deliver enough radiation to the tumor while avoiding healthy lung tissue, which could reduce side effect…

This trial studies people with pulmonary arterial hypertension, a condition where high blood pressure strains the lungs, who live permanently above 2600 meters. Researchers test whether spending one week at sea level and then returning to altitude changes how far participants can…

This early-stage trial tests an experimental medicine called BI 3822971 in adults with advanced or metastatic solid cancers, such as lung, head and neck, breast, esophageal, bladder, vulvar, or cervical cancer, who have no standard treatment options left. The goal is to find out …

This pilot trial tests a ventilator strategy that targets a specific measure of lung stress, called mechanical power, in adults with severe ARDS who are on VV ECMO. The goal is to see if this approach is feasible and safe compared to standard ultra-low tidal volume ventilation. R…

This study follows over 2,000 elderly patients hospitalized with community-acquired pneumonia to see whether adding traditional Chinese medicine (TCM) to standard care improves recovery. Researchers will compare patients who receive TCM with those who do not, tracking hospital st…

This trial tests whether an automated oxygen titration system, called FreeO2, can improve oxygen weaning in patients recovering from acute hypoxemic respiratory failure. The device continuously adjusts oxygen flow based on oxygen saturation levels, potentially reducing episodes o…

This trial tests whether a single inhaled dose of peramivir can help adults with uncomplicated influenza feel better faster. About 600 adults aged 18 to 64 with lab-confirmed flu and symptoms starting within 48 hours will receive either the drug or a placebo. Researchers will mea…

This study tests an investigational drug called XTMAB-16 in people with pulmonary sarcoidosis, a condition that causes inflammation and scarring in the lungs. The trial aims to see if the drug can improve lung function (measured by forced vital capacity) and quality of life. Part…

This trial tests whether a high-dose continuous infusion of magnesium sulfate can improve outcomes for adults with severe asthma attacks in the emergency department. Participants are randomly assigned to receive either the high-dose infusion or the standard dose. Researchers meas…

This trial tests whether two existing drugs, simvastatin and baricitinib, can help people with acute respiratory distress syndrome (ARDS), a severe lung condition that causes breathing failure. Participants are grouped by biological markers into subtypes, then randomly assigned t…

This phase II trial tests a new treatment approach for people with locally advanced nasopharyngeal carcinoma, a type of head and neck cancer. The regimen avoids platinum-based chemotherapy, using a combination of gemcitabine, camrelizumab, endostar, and low-dose radiotherapy befo…

This phase 3 trial tests whether the experimental drug ZL-1310, when combined with an immunotherapy drug, can help people with extensive-stage small cell lung cancer live longer than those receiving standard chemotherapy plus immunotherapy. The study enrolls about 530 adults who …

This trial tests two oral drugs, roflumilast and azithromycin, as add-on treatments for people with severe COPD and a chronic bronchitis pattern. About 70 adults will take one of the drugs daily for six months while continuing their usual inhaled therapy. The goal is to see which…

This trial is testing an experimental drug called JNJ-95597528 in adults with moderate to severe asthma that is not well controlled by current treatments. The goal is to see if the drug can reduce the number of asthma attacks over 48 weeks compared to a placebo. Participants will…

This trial tests whether a four-step ladder made with goat milk formula helps children aged 1 to 5 with cow's milk allergy build tolerance to milk better than the standard cow's milk ladder. Both ladders start with baked goods and progress to plain milk over 12 weeks, with each s…

This trial is testing whether CRB-701, a targeted chemotherapy that delivers a potent drug directly to cancer cells, can shrink tumors and extend life in people with recurrent or metastatic oropharyngeal (throat or tonsil) cancer. Participants will have already tried platinum-bas…

This trial tests whether an investigational drug called HDM1005, given as a weekly injection, can help people with obstructive sleep apnea and obesity. Participants will receive either HDM1005 or a placebo for 52 weeks, alongside lifestyle counseling on diet and physical activity…

This phase III trial asks whether giving dexamethasone early to adults with severe influenza pneumonia and low blood oxygen can improve outcomes. Participants in intensive or intermediate care receive either the steroid or a placebo for up to 10 days, alongside standard flu treat…

This trial tests whether using electrical impedance tomography (EIT) to guide ventilator pressure settings improves lung function in patients with moderate-to-severe acute respiratory distress syndrome (ARDS) who are placed face down (prone positioning). Researchers will compare …

This phase 2 trial tests whether daily ginger extract capsules can improve airway responsiveness and reduce inflammation in adults with asthma. Participants with mild to severe persistent asthma, despite using inhaled corticosteroids, will receive either ginger extract or a place…

This trial tests whether a ventilator method called variable ventilation, which changes the size of each breath slightly, is safe and feasible for adults with acute respiratory distress syndrome (ARDS) who need breathing support. Participants receive 24 hours of variable ventilat…

This trial tests a new approach to pulmonary rehabilitation, a standard programme of exercise and education for people with chronic lung disease. The twist is that informal carers, often family members, join the education and support sessions. The goal is to see if this carer-inc…

This trial tests whether a long-range drone can carry donor lungs from one city to another for people with end-stage lung disease awaiting a transplant. Researchers will measure the total door-to-door transport time and compare it with ground transport estimates. They will also t…

This early-stage trial is testing whether combining two chemotherapy drugs—liposomal irinotecan and cisplatin—can safely shrink or control advanced solid tumors that have not responded to standard treatments. The study will enroll about 44 adults aged 20 to 85 with various types …

This trial tests whether a structured exercise program can strengthen the immune system's attack on non-small cell lung cancer. Patients receiving chemo-immunotherapy before surgery will either follow an exercise plan with a stationary bike or receive standard recommendations. Th…

This phase 3 trial compares two surgical approaches for early-stage non-small cell lung cancer with small (≤2 cm), solid-dominant tumors located deep within the lung. One group receives segmentectomy, which removes only the affected segment of the lung, while the other receives l…

This phase 3 trial is testing whether an investigational drug called UBT251 can reduce the severity of obstructive sleep apnea in people who are obese and do not use positive airway pressure (PAP) therapy. Participants will receive weekly injections of UBT251 or a placebo for 52 …

This trial is testing an investigational drug called brenipatide in adults with moderate-to-severe COPD. Participants will receive either brenipatide or a placebo for about a year, alongside standard care. The goal is to see if brenipatide improves lung function and reduces the n…

This phase 3 trial tests whether the experimental drug felcorekibart, added to standard care, can reduce nasal polyps and improve symptoms like nasal blockage and loss of smell in adults with chronic rhinosinusitis with nasal polyps. Participants receive either felcorekibart or a…

This phase 3 trial tests whether an experimental drug called felcorekibart can reduce nasal polyps and improve symptoms like nasal blockage and loss of smell in adults with chronic rhinosinusitis with nasal polyps. Participants receive either felcorekibart or a placebo on top of …

This trial tests whether tirzepatide, a medication used for weight management, can reduce the rapid weight gain and metabolic changes caused by lorlatinib, a targeted therapy for ALK-positive non-small cell lung cancer. Adults already taking lorlatinib will receive weekly tirzepa…

This phase II trial is testing whether giving the chemotherapy drug thiotepa directly into the spinal fluid—via a small device called an Ommaya reservoir—can help control cancer that has spread to the lining of the brain and spinal cord (leptomeningeal metastases) in people with …

This trial tests whether a digital rehabilitation programme called I-IMPACT can be a practical alternative to traditional centre-based pulmonary rehabilitation for adults with interstitial lung disease (ILD). The study will compare the two approaches, focusing on feasibility—such…

This phase 2 trial is testing whether new combinations of anti-tuberculosis drugs, including the experimental drug TBAJ-587, can effectively treat newly diagnosed, drug-sensitive pulmonary tuberculosis. The study involves 135 adults and compares several experimental regimens agai…

This phase 2 trial is testing whether combining the immunotherapy drug pembrolizumab with a short course of high-dose radiation, with or without additional radiation to nearby lymph nodes, can shrink or eliminate head and neck tumors before surgery. Adults with resectable squamou…

This trial tests whether epidural spinal cord stimulation can help people with severe brain injury breathe without a ventilator. Ten patients with stroke or traumatic brain injury who need mechanical ventilation will receive a surgically implanted electrode that delivers electric…

This trial is testing whether a blood test that detects cancer DNA can guide the use of durvalumab, an immunotherapy, after standard chemoradiotherapy in patients with stage III lung cancer that cannot be removed by surgery. The goal is to see if giving durvalumab only to patient…

This study looks at whether a newer opioid painkiller, oliceridine, is less likely than the standard sufentanil to cause breathing problems after surgery in people at high risk of obstructive sleep apnea. About 851 adults with known or suspected sleep apnea will receive one of th…

This trial tests whether using a colorimetric carbon dioxide (CO₂) detector to guide non-invasive breathing support (ventilation) improves care for premature infants born before 32 weeks. The detector changes color to show how well the baby is exhaling CO₂, which may help doctors…

This trial is testing whether a special type of radiation called radscopal radiotherapy—which combines low-dose radiation to the main tumor and precise high-dose radiation to distant metastases—can enhance the effects of two immunotherapy drugs (sintilimab and ipilimumab) in peop…

This study tests whether mepolizumab, an injectable medication, can improve lung ventilation and reduce mucus plugs in adults with COPD who have elevated eosinophils. Participants receive mepolizumab every 4 weeks for 48 weeks and undergo MRI and CT scans along with breathing tes…

This pilot trial tests whether tirzepatide, a once-weekly injection used for diabetes and weight loss, can improve lung function and muscle health in overweight adults with COPD. About 30 participants will receive either tirzepatide or standard care for 12 months, with tests meas…

This trial investigates whether a sensitive blood test (Signatera) can detect when it is safe to pause immunotherapy in people with advanced solid tumors like lung cancer, melanoma, and colorectal cancer. Participants are randomly assigned to either continuous standard immunother…

This study looks at people with COMISA, a condition where obstructive sleep apnea and insomnia occur together. Many people with this combination struggle to use CPAP, a standard treatment for sleep apnea, consistently. The study will compare those who take daridorexant, a sleep a…

This trial is testing whether giving radiotherapy to the main lung tumour, in addition to standard chemotherapy or immunotherapy, can reduce cancer spread and help people with metastatic non-small-cell lung cancer live longer. Around 420 adults with newly diagnosed stage IV lung …

This trial tests whether MRI-guided stereotactic body radiotherapy (SBRT) can safely treat ultra-central lung tumors—growths located near the windpipe and major airways. Using an MR-LINAC machine, doctors can adjust the radiation beam in real time as the patient breathes, potenti…

This trial tests whether common antibiotics—amoxicillin or amoxicillin-clavulanate—actually reduce symptoms in children aged 2 to 12 with acute sinusitis. About 1,100 children are randomly assigned to one of the two antibiotics or a placebo, and parents track daily symptoms. The …

Many people who recover from tuberculosis are left with long-term lung damage, known as post-tuberculosis lung disease (PTLD), which can cause breathing problems and reduce quality of life. This study follows 760 participants—including people with active TB, those with establishe…

This study follows over 500 hospitalized adults with drug-resistant bacterial pneumonia to see whether those who receive systemic traditional Chinese medicine (such as herbal decoctions or injections) have fewer lower respiratory tract infections in the six months after leaving t…

This phase 2 trial tests whether an experimental drug called HSK50042 can improve lung function in adults with idiopathic pulmonary fibrosis (IPF), a chronic condition that causes lung scarring and breathing difficulties. Participants take HSK50042 or a placebo once daily for 26 …

This trial is testing a combination of three drugs—benmelstobart, anlotinib, and etoposide—as a first treatment for elderly patients (65 and older) or those too frail for standard intensive chemotherapy. The goal is to see if this platinum-free regimen can control the cancer and …

This trial compares custom-made, 3D-printed airway stents to standard ones in people with non-cancerous narrowing of the windpipe or main airways. The goal is to see if a personalized fit reduces serious complications like stent movement or tissue irritation. About 96 adults who …

This trial investigates whether continuous positive airway pressure (CPAP) can help adults with sickle cell disease recover faster from acute chest syndrome, a serious lung complication. Participants who need extra oxygen are randomly assigned to receive either standard oxygen al…

This trial tests whether a structured care pathway — based on standard asthma guidelines — can improve disease management for adults with uncontrolled asthma who already use high-dose inhalers. Doctors and nurses at some clinics will receive extra training and tools to follow the…

This trial tests a cryotherapy procedure that freezes and destroys excess fat in the upper airway to reduce airway collapse during sleep. It enrolls adults with moderate-to-severe obstructive sleep apnea who cannot use standard treatments like CPAP. The study measures whether the…

This phase 3 trial investigates whether adding platinum-based chemotherapy to the immunotherapy drug tislelizumab helps people with a specific type of advanced lung cancer live longer without the disease worsening. Participants have non-small cell lung cancer that has spread, sho…

This study compares two breathing exercises—box breathing and rhythmic breathing—to see which better reduces breathlessness, improves lung function, and enhances sleep quality in adults with mild to moderate asthma. Participants are randomly assigned to one of the two techniques …

This trial compares two oxygen methods for tracheostomized patients who are being weaned off a mechanical ventilator. Half receive high-flow oxygen directly into the tracheostomy tube, while the other half receive conventional oxygen. The goal is to see if high-flow oxygen helps …

This trial investigates a personalized approach for people with advanced EGFR-mutant non-small cell lung cancer who have not had prior treatment. Participants first take the targeted pill befotertinib for three weeks, then a blood test checks for minimal residual disease (MRD). T…

This trial investigates whether a 7-day course of antibiotics works as well as the standard 14-day course for adults hospitalized with a sudden worsening of COPD. The study involves over 500 participants and measures clinical success at 30 days, including symptom improvement and …

This study tests whether a modified version of the Crohn's Disease Exclusion Diet (CDED) can ease symptoms of non-constipation irritable bowel syndrome (IBS) better than the standard low FODMAP diet. About 150 adults with moderate-to-severe IBS will follow one of the two diets fo…

This study tests a program called Snacktivity, which involves doing very short bursts of moderate exercise—like brisk walking for 2 to 5 minutes, several times a day—to see if it can improve thinking skills and the ability to manage daily health in people aged 60 and older with C…

This study tests whether taking chromium picolinate daily for 12 weeks improves asthma control in obese adults. Researchers believe that chromium may help by addressing metabolic issues like insulin resistance that can worsen asthma. Sixty participants will receive either the sup…

This trial tests whether a telemonitoring device called HCAlert can reduce hospitalizations and emergency visits for people with chronic obstructive pulmonary disease (COPD). Participants use the device at home to regularly measure their health, allowing doctors to spot worsening…

This phase 2 trial is testing whether giving platinum-based chemotherapy (carboplatin and etoposide) together with the immunotherapy tarlatamab can help patients with advanced small-cell lung cancer whose disease has worsened while on tarlatamab alone. The study enrolls about 54 …

This trial investigates whether children and teens with cystic fibrosis who are already taking highly effective modulator therapy can safely use inhaled airway clearance treatments only when they have a respiratory illness, instead of every day. Participants stop their usual dail…

This study looks at whether the RSV vaccine given in late pregnancy can help protect babies born to mothers with HIV. RSV is a leading cause of infant hospitalization, and babies exposed to HIV are at higher risk. Researchers will measure antibody levels in mothers and infants to…

This trial tests a combination of two drugs—tislelizumab and SYS6010—in people with advanced non-small cell lung cancer (NSCLC) whose cancer has progressed after immunotherapy. Tislelizumab is an approved immunotherapy, and SYS6010 is an experimental drug that targets EGFR on can…

This trial investigates whether lemborexant, a sleep medication, can reduce the number of breathing pauses in adults with moderate obstructive sleep apnea who have a low arousal threshold (wake up easily). Participants take either lemborexant or a placebo daily for 30 days in thr…

This trial tests whether a less intensive antiplatelet therapy is safer and as effective as standard dual therapy for people with spontaneous coronary artery dissection (SCAD), a rare cause of heart attack in women aged 30–55. Unlike typical heart attacks, SCAD involves a tear in…

This trial investigates a surgical procedure to divide the fissure between lung lobes in people with COPD and emphysema who did not improve after endobronchial valve treatment. The goal is to see if the surgery is safe and feasible, potentially leading to better lung collapse and…

This study tests a new way of using a breathing machine (ventilator) called time-controlled adaptive ventilation (TCAV) in people with severe lung injury from pneumonia. The goal is to see if TCAV reduces fluid buildup in the lungs compared to standard ventilation. The trial invo…

This study looks at whether adding a home telemonitoring system to standard nighttime breathing support (non-invasive ventilation) can help people with severe COPD and high carbon dioxide levels. About 92 participants will be split into two groups: one using standard home ventila…

This pilot study tests whether an inhaled drug called cromolyn sodium, already used for asthma, is safe and feasible for people with locally advanced lung cancer. The drug works by calming mast cells, which may play a role in tumor growth and treatment resistance. About 5 to 10 p…

This study tests whether adding a Chinese herbal formula (Xuanyin Ning) to a standard cancer drug (bevacizumab) can better control malignant pleural effusion—fluid buildup in the chest caused by advanced lung cancer. About 308 participants will receive either the herbal formula o…

This Phase II trial tests whether a combination of therapeutic plasma exchange (filtering the blood), rituximab (a drug that targets certain immune cells), and intravenous immunoglobulin (IVIg) can slow lung decline in people with progressive idiopathic pulmonary fibrosis (IPF). …

This study tests whether a dedicated clinic for COPD flare-ups can reduce the number of future attacks and improve quality of life. About 240 people who recently had a severe COPD attack will be split into two groups: one gets follow-up at the special clinic, the other gets stand…

This study looks at whether shorter, rifapentine-based treatments for tuberculosis and latent TB are safe and effective in real-world settings in Kazakhstan. It will follow 350 adults, including those with HIV, comparing a 4-month regimen to the standard 6-month one for active TB…

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This study tests whether a 5-day course of inhaled amikacin can prevent ventilator-associated pneumonia in critically ill patients who already have a milder airway infection called tracheobronchitis. 250 adults on breathing machines will receive either the drug or a placebo. The …

This study tests whether a structured remote clinic using video calls can reduce the number of severe asthma attacks in adults who have just been discharged from the hospital after an asthma flare-up. 220 participants will be randomly assigned to either two remote pulmonology vis…

This early-phase study tests an inhaled mRNA immunotherapy for adults with advanced lung cancer or solid tumors that have spread to the lungs. The treatment is given as a dry powder through an inhaler. The main goal is to check safety and find the best dose, with 60 participants …

This study tests whether frequent sauna baths can reduce or eliminate bacteria that cause stubborn lung infections in people with conditions like COPD, asthma, or bronchiectasis. Researchers will track how long participants go without needing antibiotics and whether the bacteria …

This study tests a specially designed suction tube that cleans deep throat secretions under direct laryngoscope guidance. The goal is to see if it reduces pneumonia within 28 days in stroke patients who have trouble swallowing or coughing. Participants are adults with acute ische…

This early-phase study tests an oral drug called SNH-118110 in 240 adults with advanced solid tumors that have a specific genetic change (RET). The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. Participants must have tried other treatm…

This study tests whether a 3-day course of amoxicillin works as well as a 5-day course for children aged 3 months to 5 years with uncomplicated pneumonia. The goal is to see if shorter treatment can reduce side effects, lower costs, and fight antibiotic resistance. About 250 chil…

This study aims to improve treatment for severe high altitude pulmonary edema (fluid in the lungs) and cerebral edema (brain swelling). Researchers will test breathing support devices and inhaled nitric oxide gas in over 3,000 patients in Tibet. The goal is to speed up recovery, …

This study tests whether using cord blood, rich in fetal hemoglobin, for transfusions in preterm infants can reduce serious complications like blindness, lung disease, and gut problems. Researchers will compare outcomes in 200 very low birth weight babies who receive either cord …

This early-stage trial tests R-3750, a live biotherapeutic product, in 20 adults with late-stage acute respiratory distress syndrome (ARDS). The main goal is to see if it is safe and tolerable, while also checking for signs of improved lung function and less need for a ventilator…

This phase 2 trial tests whether combining two drugs, lomustine and anlotinib, can shrink tumors or slow disease in people with extensive-stage small cell lung cancer that has not responded to at least two prior treatments. About 46 participants will receive the drug combination …

This pilot study tests whether an inhaled drug called AER101 can reduce glycolysis—the process cancer cells use to break down sugar for energy—in early-stage non-small cell lung cancer. Participants inhale the drug three times daily for two weeks before their scheduled surgery. T…

This study tests a new nasal spray for adults with chronic sinusitis. The spray turns into a gel inside the nose and releases three active ingredients: stem cell exosomes to help repair the nasal lining, an antihistamine to reduce inflammation, and an antiviral agent. The goal is…

This study tests whether adding tarlatamab to durvalumab after standard chemotherapy and radiation can delay cancer return and extend life in people with limited-stage small cell lung cancer. Tarlatamab works by helping immune cells recognize and attack cancer cells. About 430 pa…

This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucu…

This study tests whether an Ayurvedic treatment that targets digestion and gut health can reduce allergy symptoms and immune markers in people with allergic rhinitis (hay fever). 104 adults aged 18-40 with confirmed allergies will receive either the Ayurvedic treatment plus stand…

This study tests a new combination of two drugs (becotatug vedotin and pucotenlimab), with or without radiation, as a first treatment for people with advanced non-small cell lung cancer that has a specific protein (EGFR) on its surface. About 39 participants will receive the drug…

This study tests whether giving a combination of anlotinib (a targeted therapy) and epirubicin (chemotherapy) before surgery can improve outcomes for people with advanced sinonasal adenoid cystic carcinoma, a rare and aggressive cancer of the nasal cavity and sinuses. About 76 pa…

This study tests a new method for setting ventilators during abdominal surgery to prevent postoperative respiratory failure. The approach adjusts settings based on 'mechanical power,' a measure that combines several ventilator parameters. The trial will enroll 490 adults having a…

This study tests whether taking a low dose of the antibiotic azithromycin every day for a year can reduce the number of serious lung infection flare-ups in adults with non-CF bronchiectasis. About 500 participants will receive either azithromycin or a placebo pill, added to their…

Researchers are testing a new PET/CT imaging tracer called [68Ga]-LY4257529 that targets a protein called GRPR, which some cancers make in large amounts. The study includes up to 60 adults with breast cancer or other tumors known or suspected to express GRPR, such as prostate, ov…

Researchers at Mayo Clinic are testing an investigational radioactive tracer called 68Ga-FAPI-46 to see how it distributes in the lungs of people with interstitial lung disease. About 10 participants with a clinical diagnosis of ILD and lung abnormalities on a recent CT scan rece…

Radiation pneumonitis is a lung inflammation that can appear weeks after radiotherapy for lung cancer, and patients may not link their symptoms to the earlier treatment. Researchers developed a smartphone app called PneumoCheck for patients to use at home, hoping it helps detect …

Researchers compare automated software with manual scoring by expert sleep specialists for sleep study records from adults with obstructive sleep apnea. The study measures how closely the two methods agree on the apnea-hypopnea index, a key measure of breathing pauses during slee…

Researchers at Penn State University are testing three software innovations designed to improve bronchoscopy guidance during lung cancer evaluations. The study enrolls a small number of adults who are already scheduled for a clinical bronchoscopy to examine abnormal lung tissue o…

Researchers are testing a noninvasive MRI technique that uses inhaled hyperpolarized xenon gas to measure lung function in adults with interstitial lung disease, pulmonary hypertension, and systemic sclerosis. The study includes about 51 participants, including healthy volunteers…

Researchers swab the noses of children scheduled for elective surgery under general anesthesia to check for respiratory viruses. They want to learn how many children carry viruses without showing symptoms and whether those children have more breathing problems during or after sur…

Researchers are testing a new imaging agent called 111In-TJD-31 that targets placental alkaline phosphatase (ALPP), a protein found on many solid tumor cells but rarely in healthy adult tissue. The study enrolls 8 participants: 2 healthy volunteers who give blood samples and 6 pa…

Many cancer trials require patients to have specific molecular markers, so researchers test large numbers of people to find the few who qualify. This study evaluates FATHOM, an AI system that reads clinical trial records and routine tumor slides to predict which patients carry th…

Researchers are testing artificial intelligence models that analyze CT scans to find lung nodules and estimate whether they are benign or malignant. The study enrolls adults who have at least one non-calcified lung nodule measuring 3 to 30 mm. Participants receive no drugs or pro…

This trial tests whether an artificial intelligence model can assess the severity of obstructive sleep apnea in children using noninvasive sensors instead of a standard sleep study. Researchers will compare signals from a fingertip pulse oximeter, pressure-sensing mattresses, and…

Obstructive sleep apnea is common but often undiagnosed, and standard sleep tests can be slow to access. Researchers are studying Apneal Dx, a CE-marked smartphone app that uses the phone's sensors worn on the chest to record breathing during sleep. The study follows adults in fi…

Blunt chest trauma can lead to serious breathing problems, but current imaging tools have limits. This study tests whether adding a diaphragm ultrasound to the standard lung ultrasound helps doctors predict which patients will develop hypoxemic respiratory failure. Adults with is…

Researchers at Assiut University are testing whether lung ultrasound can diagnose pneumonia in newborns as reliably as the standard chest X-ray. The study will enroll 100 infants in the neonatal intensive care unit who have a clinical diagnosis of pneumonia within their first 28 …

Researchers are testing whether an electronic nose that analyzes exhaled breath can serve as a noninvasive prescreening tool for several diseases at once. The study plans to enroll up to 20,000 adults and will first standardize the breath-sampling procedure, then evaluate how wel…

This study tests whether newer breathing technologies, such as capnography and oscillometry, can diagnose COPD as accurately as the standard spirometry test. Spirometry requires forceful blowing, which can be uncomfortable. Researchers will compare these tests in 300 adults with …

This trial tests whether a new imaging method, using femtosecond laser light and artificial intelligence, can accurately predict high-risk features in lung cancer, such as spread to lymph nodes. Researchers will compare the AI's predictions with actual pathology results from surg…

This study tests whether special MRI scans can predict how well HPV-positive throat cancer responds to standard chemotherapy and radiation. Researchers will scan 30 adults before treatment and track their outcomes. The goal is to see if MRI patterns can identify low-risk patients…

This trial tests whether adding a small probe called the Iriscope to standard bronchoscopy improves the diagnosis of lung nodules. Doctors usually guide the biopsy with real-time X-rays, but sometimes they cannot see the nodule directly. The Iriscope slides into the bronchoscope …

This trial tests whether a femtosecond laser imaging technique, combined with artificial intelligence, can accurately distinguish benign from malignant lung tissue in surgical specimens. Researchers will compare the AI-assisted diagnosis against standard pathology results. The st…

This study tests whether a machine-learning model can automatically detect pauses in breathing, called apnoea, in preterm infants born before 32 weeks of gestation. The model uses signals from the diaphragm muscle, along with airway pressure and oxygen levels, recorded over eight…

This study tests whether a bedside lung ultrasound, done within six hours of arriving at the emergency department, can help diagnose acute chest syndrome in adults with sickle cell disease experiencing a vaso-occlusive crisis. Acute chest syndrome is a serious lung complication t…

This study tests whether a quick, bedside ultrasound of the internal jugular vein in the neck can help tell how severe bronchiolitis is in infants aged 1 to 23 months. Researchers will measure how much the vein's diameter changes with breathing and compare that to standard clinic…

This study tests whether a small device called Mitra can collect a tiny drop of blood from premature babies to measure caffeine levels. Caffeine is commonly given to preterm infants to prevent apnea, but finding the right dose is tricky—too little may cause breathing pauses, and …

This study tests whether a new breathing measurement, called respiratory admittance, can better identify children who have asthma triggered by exercise. Children aged 5 to 16 who are already scheduled for an exercise challenge test will have their breathing measured using this ne…

This pilot study will offer low-dose CT scans to about 500 high-risk smokers aged 50-80 in Kuwait to see if this screening approach is practical and acceptable. The goal is to measure how many people agree to screening, identify barriers, and evaluate the use of AI to help read t…

This study looks at whether two simple calculations, called Cancer Ratio and Cancer Ratio Plus, can help doctors tell the difference between fluid around the lungs caused by cancer and fluid caused by tuberculosis. These calculations use results from routine blood and fluid tests…

This study tests whether a computer algorithm can analyze standard EEG recordings from full-term newborns who experienced oxygen deprivation at birth to tell apart mild brain injury from moderate or severe forms. The algorithm's readings are compared against expert review of the …

This trial tests whether performing a sleep study at home through primary care is more cost-effective than the standard hospital-based approach for diagnosing obstructive sleep apnea. Adults with suspected apnea will be randomly assigned to either home testing via their local hea…

This study tests a new imaging tracer called [18F]FAPI-74, which attaches to a protein found on cells in tumors and scarred or inflamed tissue. Researchers want to see if it can show these areas more clearly than current scans. About 770 adults with various cancers or non-cancer …

This pilot study explores whether a breath sample collected with the VosCryo device can provide enough cellular material to help diagnose advanced lung cancer. Researchers will compare breath samples from 12 people with late-stage lung cancer and 12 healthy relatives to see if th…

This study tests whether an AI-powered digital stethoscope can help health workers more accurately diagnose pneumonia in children aged 2 months to 5 years. 350 children with cough or breathing difficulty will be randomly assigned to standard care or care plus the AI stethoscope. …

This study explores whether analyzing tumor DNA in cerebrospinal fluid can help doctors make better treatment decisions for people with malignant brain tumors or brain metastases from lung or breast cancer. Participants undergo a standard spinal tap or fluid collection, and the f…

This study investigates whether a real-time breath analysis device can quickly and non-invasively diagnose lower respiratory tract infections. Researchers will collect breath samples from 450 patients with suspected infections or chronic airway colonization and analyze volatile o…

This study tests an artificial intelligence (AI) prototype designed to quickly evaluate tissue samples taken during a bronchoscopy, a procedure used to diagnose lung cancer. The AI analyzes microscope images of the samples to determine if they are adequate for diagnosis and wheth…

This early-phase trial will test a new radioactive tracer called [68Ga]Ga-PentixaFor in 15 people with metastatic small cell lung cancer. The goal is to see if this PET-CT scan can find tumors as well as the standard FDG PET-CT scan, both at diagnosis and when the disease gets wo…

This study looks at whether certain blood inflammation markers can help doctors tell the difference between harmless, precancerous, and cancerous vocal cord growths. Researchers will check medical records of 250 adults who have been diagnosed with a vocal cord lesion. The goal is…

This study will test a new type of PET/CT scanner, called Long-Axial Field-of-View (LAFOV), to see if it can provide clearer images of blood vessel inflammation in people with large vessel vasculitis (LVV). The scanner is more sensitive and can image the whole body faster, potent…

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study will test artificial intelligence algorithms that analyze video from routine endoscopies of the head and neck. The AI will try to detect, classify (benign vs. malignant), and outline lesions, comparing its performance to doctors and lab results. About 283 adults with s…

Trastuzumab deruxtecan (T-DXd) treats metastatic breast cancer but can cause interstitial lung disease (ILD), a form of lung inflammation that sometimes forces patients to stop treatment. Researchers are testing whether giving dexamethasone before each T-DXd infusion lowers the c…

Researchers are testing whether a single dose of the antiviral drug baloxavir marboxil can stop influenza from spreading among people who live with someone who has the flu. The trial enrolls households in China where one person has confirmed influenza and up to five other members…

Clesrovimab is an FDA-approved antibody shot for infants under 8 months entering their first RSV season when their mothers did not get an RSV vaccine in pregnancy. Researchers at Emory University are measuring antibody levels in the blood and noses of 24 healthy infants who recei…

This study tests whether a program led by community health workers can improve lung health for 800 people in Bhaktapur, Nepal, who are at risk for chronic respiratory diseases. The program includes tobacco cessation counseling, mask use during high pollution, handwashing, and flu…

Researchers at Johns Hopkins University are testing whether a short animated video and brochure, sometimes followed by a phone call, can help people at higher risk of lung cancer get low-dose CT screening. The trial enrolls adults aged 50 to 80 with a significant smoking history …

This trial tests whether training nursing home staff to provide better oral hygiene can reduce pneumonia in residents aged 60 and older. Participants will use special toothpastes and mouthwashes, including stannous fluoride and chlorhexidine options. The study measures how many r…

This trial tests whether mailed letters, patient portal messages, or texts can encourage flu vaccination among adults with multiple risk factors for severe influenza. Researchers will identify high-risk patients using a simple rule-based scoring system, then send reminders and tr…

This trial tests whether a single combined mRNA vaccine, mCombriax (mRNA-1083), can protect adults aged 65 and older against both influenza and COVID-19 as effectively as getting two separate shots on the same day. Researchers will compare how many participants in each group deve…

This trial tests whether a daily supplement called Immune X can help prevent common colds in healthy adults who often get upper respiratory infections. Over 16 weeks during winter, participants take either Immune X or a placebo and track any cold symptoms. The study compares how …

This trial tests whether offering a needle-free flu vaccine (FLUMIST) for self-administration at home, picked up from a pharmacy, increases flu vaccination rates compared to usual care. Households with children aged 2 to 17 in Burlington, Ontario, are randomly assigned to either …

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This study tests a program called Empower LCS/Call+ to help adults who are at high risk for lung cancer complete their recommended screening. The program includes educational materials, reminders for patients and doctors, and support with financial or community resources. Some pa…

This study tests whether a special combination of supplements (sodium nucleinate, magnesium, vitamin B6, and high-dose vitamin D) can prevent respiratory infections like colds and flu better than standard multivitamins. Two hundred healthy male military recruits in Kazakhstan wil…

This study tests whether a special pacifier, called CURAPROX, can reduce the severity of obstructive sleep apnea (OSA) in infants with Down syndrome. Fifty infants will be enrolled at one month old, with half using the pacifier and half not. At six months, sleep tests will measur…

This pilot study tests two light therapy devices—one placed inside the mouth and one outside—to prevent and treat painful mouth sores caused by radiation therapy. Sixty adults with oral cavity or oropharynx cancer will receive light sessions twice a week for prevention, then thre…

This study tests whether a lower dose of the antibiotic TMP-SMX works as well as the standard dose to prevent a serious lung infection called PJP in people who have just had a kidney transplant. About 1,084 adult first-time kidney transplant recipients will take either a low or s…

This study aims to find the best ways to increase lung cancer screening among current and former smokers aged 50-80 in community health centers. About 19,000 participants will receive text messages and clinic support to complete eligibility checks and low-dose CT scans. The goal …

This pilot study tests a 12-month structured nursing program called RESPiraIA-Asma for adults with poorly controlled, non-severe asthma. The program combines education, inhaler training, home peak-flow monitoring, and personalized care plans, offered in-person, digitally, or mixe…

This study tests whether taking dronabinol (a cannabis-derived medication) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. Th…

Researchers are testing the F&P Licorice mask, a device used with PAP or NIV breathing machines, in people who have obstructive sleep apnea or other chronic respiratory conditions. The study follows about 45 adults who already use this type of therapy at home. Over roughly two we…

This study compares two ways to give steroid medicine to people with chronic sinusitis who have lost their sense of smell due to blocked nasal passages. One group will get standard steroid spray, while the other gets steroid drops placed directly where smell happens. The goal is …

Researchers are testing whether a monthly injection of berobenatide can reduce the severity of obstructive sleep apnea and lower body weight in adults who have overweight or obesity and use a PAP breathing machine. The trial enrolls about 258 adults with moderate to severe sleep …

Researchers are testing whether pranayama breathing exercises, done to the sound of rain, can ease breathlessness and improve confidence in daily activities for people with COPD. The trial enrolls 114 adults with mild to moderate COPD and assigns them to one of three groups: pran…

RESP-FIT tests whether a home-based breathing muscle training program, paired with a mobile app for symptom tracking and activity monitoring, can improve breathlessness, breathing strength, and physical activity in adults with COPD. Researchers are enrolling 288 adults aged 40 an…

Researchers want to see whether facial photographs can show how well a fluticasone propionate nasal spray eases facial allergy symptoms. The study enrolls 16 adults with moderate to severe seasonal allergic rhinitis. Participants use the nasal spray and have their faces photograp…

Researchers are testing whether a structured breathing program called Active Cycle of Breathing Techniques, combined with a handheld positive expiratory pressure device, can improve breathing, sleep, and mood in people with COPD. The trial enrolls 60 adults aged 40 to 90 with dia…

This study compares two doses of the antibiotic ceftriaxone for adults hospitalized with pneumonia (but not in the ICU). The goal is to see if a 1-gram daily dose works just as well as a 2-gram daily dose while causing fewer side effects. About 430 participants will be followed t…

Researchers compare two breathing techniques added to standard medical care for people with stable pulmonary fibrosis. Forty adults with mild to moderate lung restriction join the study. One group receives a manual diaphragmatic release technique, where a therapist applies gentle…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This trial tests whether a midwife-led cognitive behavioral intervention can reduce depression, boost social support, and lower stress in pregnant women in Ethiopia. Pregnant women in their third trimester who screen positive for depression will receive either the seven-session g…

This early-stage trial tests whether the drug ponsegromab can help adults with advanced non-small cell lung cancer who are losing muscle mass (cachexia). About 80 participants will receive either ponsegromab or a placebo. The study measures changes in muscle size and physical fun…

This trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve sleep quality in adults undergoing surgery for lung cancer. Participants with poor sleep before surgery will receive either active rTMS or a sham (inactive) treatment over five …

This trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve sleep quality in adults with advanced non-small cell lung cancer who have trouble sleeping during hospital stays. Researchers will randomly assign 160 participants to receive ei…

This study tests whether an extra virgin olive oil and water mouthwash can remove more leftover asthma medication from the mouth than plain water. The medication residue can cause problems like thrush or sleep apnea. Twenty healthy adults and adults with asthma will rinse with di…

This trial tests whether wearing a virtual reality headset during pulmonary rehabilitation can reduce shortness of breath and improve exercise tolerance in people with chronic respiratory disease like COPD. Participants will do a cycling exercise test twice, once with VR and once…

This trial tests whether Sleep Island, a WeChat mini-program for parents, can help preschool children sleep longer. Researchers will randomly assign 122 families to either use the app for 4 weeks or receive standard sleep education. The app tracks the child's sleep, gives persona…

This study tests a program called ICU-SUCCEED, designed to help survivors of acute respiratory failure and their family caregivers cope and manage recovery together. The program includes one in-person session and four follow-up sessions by phone or video, focusing on communicatio…

This trial tests whether Yanlishuang buccal dropping pills, a traditional Miao medicine, can relieve the sore throat and pain of acute pharyngitis. About 400 adults with a sore throat that started within the last 48 hours will be randomly assigned to take either the herbal drops …

This randomized trial tests whether immersive virtual reality (VR) can reduce anxiety in people with lung cancer during immunotherapy or chemo-immunotherapy infusions. Half of the 60 participants will use a VR headset showing calming nature scenes during four infusion visits, whi…

This trial tests whether a 12-week virtual breathing training program can improve quality of life in adults with asthma that is not fully controlled by medication. Participants are randomly assigned to either the online breathing program or usual care. The program includes weekly…

Shortness of breath, or dyspnea, affects most lung cancer patients and often persists despite standard treatments. This pilot study tests a stepped-care behavioral intervention called INSPIRE, which starts with brief coping skills and adds more intensive psychological support onl…

This study looks at whether adding a continuous saltwater mist to warm, humidified air can make thick lung mucus easier to clear. 35 adults hospitalized with lung conditions like COPD or cystic fibrosis will receive both treatments on separate days. Researchers will measure mucus…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study tests whether adding a muscle relaxant (rocuronium) to standard painkiller (fentanyl) helps doctors place breathing tubes in newborns on the first try, without causing dangerous drops in oxygen or heart rate. About 102 premature or sick babies in a Brazilian NICU will …

This trial compares standard radiation therapy with a new method that specifically avoids damaging small airways in the lungs. The goal is to see if this airway-sparing approach helps patients with stage III non-small cell lung cancer retain better breathing function after treatm…

This pilot study tests whether using bright light therapy for an hour each morning, delivered through an iPad app, is tolerable for people with advanced melanoma or non-small cell lung cancer who are about to start immunotherapy. The idea is that synchronizing the body's internal…

This study tests whether a 12-week remote group rehabilitation program, done via video calls and a smartphone app, can help COPD patients living in remote areas start and stick with rehab. It compares this approach to standard in-person rehab. The goal is to see if the remote opt…

This study tests a new herbal blend designed to shorten the duration and reduce the severity of common cold symptoms. Researchers will enroll 300 healthy adults in Australia who get frequent colds. Participants will take the herbal product or a placebo whenever they feel a cold c…

This study tests whether several sessions of medical hypnosis can improve quality of life for people with COPD who still have severe shortness of breath despite standard treatment. About 154 adults with advanced COPD will be randomly assigned to either five hypnosis sessions or f…

This study tests whether a smartphone reminder app can help lung cancer patients stay physically active during radiation therapy. About 32 adults with lung cancer will use the app or standard care, and their daily step counts will be compared. The goal is to see if simple digital…

This study looks at how well and how safely SIROPSEDAL syrup works for acute cough caused by colds or upper respiratory infections. About 124 children and adults will take the syrup as prescribed by their doctor and report their cough severity over one week. The main goal is to s…

This study tests whether wearing a special LED vest for 20 minutes twice a week can improve lung function and exercise ability in children aged 6 to 17 with mild to moderate asthma. The vest uses light to reduce inflammation without heat. Half the children will get the active ves…

This study tests whether a 12-week exercise program, delivered via Zoom, is practical and helpful for older adults (65+) with cancer who live in rural areas. Participants will do two supervised exercise sessions per week. The goal is to see if the program improves quality of life…

This study looks at how well RHINOSEDAL works for people aged 8 and older with a stuffy nose caused by colds, allergies, or sinus issues. About 126 participants will use the treatment as prescribed and report their symptoms over 6 days. The goal is to see if it provides meaningfu…

This study looks at whether changing body position and doing special breathing exercises can help prevent lung issues like pneumonia after heart surgery. About 124 adults having planned heart surgery will be split into four groups: one getting usual care, one doing only breathing…

Researchers at the University of California, San Francisco are studying how well a calibrated touch device measures sensation in the larynx and throat. The study includes adults with larynx or throat disorders, including those whose condition followed radiation or other cancer tr…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study tests whether a new questionnaire called PLATO can help dentists track how well oral appliance therapy works for people with obstructive sleep apnea. The questionnaire, developed by the American Academy of Sleep Medicine, measures patient-reported outcomes. Researchers…

Researchers at Assiut University Children Hospital are tracking 100 preterm infants who need invasive mechanical ventilation in the neonatal intensive care unit. The study aims to identify which early factors predict prolonged ventilation, defined as more than 7 days or frequent …

Researchers are testing whether people with non-small cell lung cancer can collect their own small blood samples at home using a finger-prick kit. Participants receive standard treatment with docetaxel, paclitaxel, alectinib, or lorlatinib, and the samples measure how much cancer…

ARDS is a severe lung condition that damages the tiny air sacs and blood vessels in the lungs, leading to low oxygen and unstable circulation. Researchers at Hospices Civils de Lyon are measuring blood viscosity, or how thick and resistant to flow the blood is, in ICU patients wi…

This study explores whether artificial intelligence can help perform high-field whole-body MRI scans faster while keeping image quality high. Researchers will compare standard MRI sequences with AI-accelerated versions in 600 adults undergoing screening for prostate, lung, or vas…

Researchers at Radboud University Medical Center are studying whether the diaphragm, the main breathing muscle, enters a hibernation-like state in ICU patients who need a breathing machine. The study follows 112 adults on invasive mechanical ventilation for at least three days. S…

Researchers are studying whether repeated bedside ultrasound scans of the diaphragm can predict breathing failure in adults with septic shock. The study follows 120 patients in intensive care for up to 72 hours, measuring how far the diaphragm moves and how thick it is. The team …

This study looks at how much pembrolizumab (an immunotherapy drug) remains in the blood after treatment ends and whether that affects how well chemotherapy works later. Researchers will follow 110 people with non-small cell lung cancer or head and neck cancer who have stopped pem…

This study is testing a program called Mothers and Babies for Down Syndrome (MBDS) to help prevent depression in new and expectant parents of infants with Down syndrome. About 72 parents will take part in a small pilot study to see if the program helps with feelings of grief and …

Researchers are testing whether specialized tests of airway inflammation and lung abnormalities can predict asthma remission and relapse better than standard clinical assessments. The trial enrolls adults with severe asthma who are starting biologic therapy. Participants are rand…

Researchers are studying how the cystic fibrosis drugs elexacaftor, tezacaftor and ivacaftor move through the body. The trial enrolls people aged 6 and older with cystic fibrosis who carry at least one F508del mutation and already take this drug combination. Participants keep the…

Researchers are studying whether the mix of bacteria in a person's gut can predict how well they respond to immunotherapy drugs called immune checkpoint inhibitors. The trial enrolls about 360 adults with advanced non-small cell lung cancer, melanoma, endometrial cancer, or cervi…

Researchers are following about 1,200 children in Zhejiang Province, China, from birth through age 7 to understand how the immune system develops and why some children get more respiratory infections or asthma. The study includes healthy children, children with a history of serio…

Researchers at Assiut University are studying whether long-standing untreated enlarged adenoids are linked to nasal septum deviation in adolescents aged 10 to 18. The adenoids are immune tissues at the back of the nose that can stay enlarged and block airflow. The study will comp…

Researchers at Emory University are running a study to see whether influenza A or B spreads from adults who caught the flu in the community to healthy adults under controlled hospital conditions. Instead of using a lab-made flu strain, the study uses naturally infected donors as …

This study will screen 477 current or former smokers in Brazil for lung cancer using CT scans. It aims to see how often the scans give false alarms (false positives) in a region where lung infections are common. The goal is to improve screening accuracy and reduce unnecessary fol…

This study aims to develop a new pain assessment scale, called EDEX, specifically for extremely premature infants born before 27 weeks. Current scales may not work well for these fragile babies, who show pain in subtle ways. Researchers will create the scale and then test it agai…

Researchers are testing an experimental cryoablation catheter that freezes lung tissue, using donated human lungs kept alive outside the body. The goal is to see whether the device can reach and cool tumors through the airways, which could offer a less invasive option than surger…

Some people who have keyhole lung cancer surgery develop lasting breathlessness and struggle with gentle exercise, even if their breathing was fine before. Researchers suspect the right side of the heart, which pumps blood to the lungs, may be weakened by the extra pressure it fa…

Researchers are tracking 1,000 hospitalized patients aged 65 and older who test positive for a respiratory virus, including human metapneumovirus (hMPV), influenza, RSV, and others. The study compares how each virus relates to death, organ complications, loss of independence, and…

Researchers at a French sleep center are studying adults with obesity who are referred for a sleep study because of suspected obstructive sleep apnea. The team measures how much carbon dioxide builds up in the blood overnight using a skin sensor, then compares that cumulative exp…

Researchers at Vanderbilt University Medical Center want to understand how immune cells use glucose, the body's main sugar, during critical illness. They give 25 adult ICU patients an intravenous infusion of a non-radioactive carbon-13 glucose tracer over a few hours. Then they c…

This study looks for early signs of brain injury in newborns who experienced oxygen deprivation at birth (perinatal asphyxia). Researchers will use EEG brain wave monitoring and eye-tracking tests, along with blood markers, to see if they can detect damage sooner than current met…

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This study follows adults hospitalized with a lower respiratory tract infection, such as pneumonia or bronchitis, to measure how their quality of life changes over one year. Researchers use a standard questionnaire to track physical, mental, and social well-being at several point…

This study looks at whether a one-week stay at sea level helps people with pulmonary arterial hypertension (PAH) who live permanently above 2600 meters. Researchers will measure lung function, blood oxygen, and sleep quality before, during, and after the descent and re-ascent. Th…

Researchers are testing whether a one-week stay at sea level improves walking ability and blood oxygen in people with pulmonary arterial hypertension who live permanently above 2600 meters. The study compares these patients with healthy controls from the same altitude, measuring …

This study will enroll 1,500 current or former smokers aged 50-80 to see if an artificial intelligence (AI) model can help doctors better detect lung nodules and predict cancer spread. Participants will undergo CT scans, and the AI's results will be compared to standard radiologi…

Researchers are studying healthy adults who live above 2600 meters to see how their lungs respond when they descend to sea level for a week and then return to their usual altitude. The trial measures pulmonary resistance, which is how hard the heart must work to pump blood throug…

Researchers are studying what happens when people who live permanently above 2600 meters, such as in Quito, Ecuador, spend a week at sea level. They will measure lung blood pressure and other heart and lung functions in healthy adults and in patients with pulmonary arterial hyper…

This study follows healthy adults who live above 2600 meters as they descend to sea level for one week and then return to their usual altitude. Researchers measure lung function, blood oxygen, and sleep before, during, and after the trip. The goal is to see how the lungs respond …

This trial asks whether a one-week stay at sea level can lower blood pressure in the lungs of people with pulmonary arterial hypertension who live permanently above 2600 meters. Researchers will compare heart and lung measurements taken at high altitude with those taken after sev…

This international study follows about 565 patients who need advanced breathing support, such as high-flow oxygen or a ventilator, while being transported within or between hospitals. Researchers will track what happens during these trips, including any equipment problems or inte…

This study looks at what happens when people with pulmonary arterial hypertension, a condition that raises pressure in the lung's blood vessels, travel from their homes above 2600 meters down to sea level for a week, and then return. Researchers will measure heart rate variabilit…

This study looks at what happens when people who live above 2600 meters, in places like Quito, spend a week at sea level and then return to altitude. Researchers will measure sleep quality, oxygen levels during the night, and breathing patterns in healthy adults and in people wit…

Researchers are studying healthy adults who live permanently above 2600 meters, like in Quito, Ecuador. They will travel by bus to sea level for one week, then return to high altitude. The study measures heart rate variability, blood oxygen levels, and sleep patterns during the d…

This study will give the nasal flu vaccine to 25 people who are already scheduled to have their tonsils or adenoids removed for sleep apnea. Researchers will then study the removed tissue to see how the vaccine affects immune cells near the nose. The goal is to better understand …

Researchers at Queen's University are testing a method to safely trigger eye allergies in a research setting. They will apply timothy grass extract to the eyes of allergic and non-allergic volunteers, then measure symptoms and collect tear and nasal fluid samples. The goal is to …

Researchers are studying what happens when people with pulmonary arterial hypertension who live above 2600 meters spend a week at sea level. The trial compares their sleep, blood oxygen, and breathing during sleep at altitude and after seven days at sea level. It includes both pa…

Researchers are testing whether a new inhaled version of glycopyrrolate, called AERO-002, delivers the drug to the lungs with less of it entering the bloodstream compared to a standard inhaled glycopyrrolate product. The study enrolls healthy adults aged 18 to 55 who will receive…

This study looks at what happens when healthy people who live above 2600 meters, such as in Quito, Ecuador, spend a week at sea level. Researchers will measure walking distance, oxygen levels, and other health markers before and after the descent. The goal is to understand how th…

Researchers at Hacettepe University are comparing muscle oxygen levels in people hospitalized with a COPD flare-up versus those with stable COPD. They use a light-based sensor to measure oxygen in breathing and limb muscles during simple tasks like standing up and walking. The go…

This study looks at whether a new method of interpreting fetal heart rate recordings (cardiotocography) can better identify when a baby is not getting enough oxygen during labor. Researchers will review data from 1,000 full-term pregnancies, combining past records and new enrollm…

This pilot study follows 15 adults with COPD who recently left the hospital after a flare-up. Researchers place sensors in their homes to measure air quality, light, noise, and temperature, while participants wear a smartwatch that tracks health data. For one month, participants …

This study looks at what happens when healthy people who live above 2600 meters spend a week at sea level and then return to their high-altitude home. Researchers measure walking distance, oxygen levels, and heart rate before and after the re-ascent. The goal is to understand how…

Researchers are collecting blood and tumor tissue samples from 30 adults with relapsed small-cell lung cancer who are receiving a standard DLL3 T cell engager therapy. The goal is to track changes in tumor markers over time and see if those changes relate to how well the treatmen…

This study follows about 1,000 adolescents and adults in China with severe chronic rhinosinusitis with nasal polyps, a condition causing nasal blockage, loss of smell, and poor quality of life. Over 36 months, researchers will track the treatments patients actually receive, such …

This observational study explores whether a specialized MRI technique using inhaled hyperpolarized xenon gas can detect how approved antifibrotic therapies affect the lungs of adults with fibrotic interstitial lung disease. Researchers will compare imaging changes with standard t…

This study reviews medical records of 250 people with advanced or metastatic non-small cell lung cancer that has a specific change in the EGFR gene. Researchers want to learn about patients' backgrounds, the treatments they receive, and how well those treatments work. The goal is…

This study explores whether wearable devices like the Oura Ring and EmbracePlus watch can help track mood changes during pregnancy and after birth. Ten pregnant individuals with a history of major depressive disorder will wear a device daily from the third trimester to three mont…

This study aims to create a large collection of lung and airway tissue samples from people with COPD, asthma, and healthy volunteers. Researchers will gather samples through bronchoscopy, sputum, nasal brushing, and blood draws during routine procedures or surgeries. The goal is …

This study tests whether MRI scans can reliably measure fluid movement in the gut of adults with cystic fibrosis, and whether the drug linaclotide changes those measurements. Linaclotide, already used for constipation, works by drawing fluid into the gut to help things move along…

This study looks at whether new, non-invasive tests can predict bronchopulmonary dysplasia (BPD), a common lung complication in extremely preterm infants. Researchers will monitor 140 babies born before 26 weeks of gestation using lung and diaphragm ultrasounds, respiratory funct…

This study looks at whether people with cystic fibrosis (CF) who take newer modulator drugs are developing heart disease. Researchers will use ultrasound to measure blood vessel and heart health, then repeat the tests a year later to see how things change. They will also check if…

This study evaluates whether several sleepiness questionnaires are reliable for children and adolescents aged 6 to 17. It includes three groups: children from the general population, those with sleep disorders or conditions like narcolepsy or ADHD, and healthy volunteers. The goa…

This pilot study is testing whether a wireless adhesive thermometer can safely and accurately monitor body temperature in newborns undergoing therapeutic hypothermia, a cooling treatment for brain injury. Currently, temperature is tracked with an invasive rectal probe, which carr…

This study looks at why some adults with chronic obstructive pulmonary disease (COPD) accept or decline a home-based pulmonary telerehabilitation program. By comparing the characteristics of those who agreed to participate with those who did not, researchers hope to identify barr…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks at how nasal high-flow therapy—a device that delivers warm, moist air through small nasal tubes—affects the airways of people with severe chronic obstructive pulmonary disease (COPD). Researchers will measure airway resistance and other lung mechanics using a non…

This study looks at whether the amount of air a person breathes in on their own matches the amount they breathe when using a non-invasive ventilation (NIV) mask. It involves 30 adults with acute respiratory failure who are in intensive care. Researchers will measure tidal volume …

This study looks at whether diaphragm ultrasound gives consistent results when performed by different anesthesiologists. Two doctors will each scan the diaphragm using three different methods, and their measurements will be compared to see which method is most reliable. The goal …

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…

This study compares different bedside methods for choosing the optimal ventilator pressure (PEEP) in patients with moderate-to-severe acute respiratory distress syndrome (ARDS). The goal is to see if these methods give similar results and which one best balances keeping lungs ope…

This study investigates how common malnutrition and sarcopenia (muscle loss) are in children and adolescents with primary ciliary dyskinesia (PCD), a rare genetic condition affecting the lungs. Researchers will measure grip strength, body composition, and nutritional risk in 15 p…

This study aims to better understand tuberculosis (TB) across its entire spectrum—from early, symptom-free infection to active disease and after treatment. Researchers will recruit TB patients and their close contacts to analyze immune responses and identify biomarkers that could…

This study examines whether vitamin D levels are linked to asthma control, lung function, and oxidative stress in Egyptian adults with bronchial asthma. Researchers will measure vitamin D in the blood, assess asthma symptoms with a standard test, and check lung function and marke…

This study looks at whether the force of mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) can damage the brain. Researchers will measure a protein called S100B in the blood, which is a sign of brain injury, and track thinking and memory problems …

This study investigates how the immune system inside the nose responds to the FluMist nasal flu vaccine in healthy adults aged 18 to 65. Participants receive a single dose of the vaccine, and researchers collect nasal swabs and gentle saline washes before vaccination and again tw…

This study uses web-based interviews to explore how adults in Japan with pulmonary fibrosis decide whether to continue or stop antifibrotic therapy after experiencing side effects. Researchers aim to understand the personal and psychological factors behind these decisions. The fi…

This study is testing whether an integrated precision medicine platform can improve how doctors diagnose and manage chronic inflammatory lung diseases like COPD and idiopathic pulmonary fibrosis. Researchers will collect blood and saliva samples for biomarker analysis, monitor in…

This study investigates whether obstructive sleep apnea is linked to metabolic associated fatty liver disease (MAFLD) in adults. Researchers will measure sleep apnea severity using overnight sleep tests and liver fat using a special ultrasound-like scan. The goal is to see if wor…

This phase 1 trial tests whether an inhaled experimental drug called ICF004 is safe and how the body processes it. Healthy Chinese adults aged 18 to 50 will breathe in either a single or multiple doses of ICF004 or a placebo via a dry powder inhaler. The study aims to identify an…

This study explores the personal stories of people diagnosed with cancer of unknown primary (CUP) and their carers. Through interviews and focus groups, researchers aim to understand the emotional and practical challenges of living with this uncertain diagnosis. The findings will…

This study looks at two bedside methods to measure how much of the lung can be reopened in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. It also compares four different ways to set the ventilator's positive end-expiratory pressure (PEEP). The g…

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study tests a new way to see where an immunotherapy drug goes in the lungs of people with stage III lung cancer. Twenty participants will receive a small dose of a fluorescent version of the drug durvalumab, then have a special camera bronchoscopy to spot the drug in tumors …

This study follows 250 adults with severe COPD who use a breathing machine at home. Researchers collect data from sensors and regular check-ups to build a model that can warn of an upcoming flare-up. The goal is to catch problems early and reduce hospital visits.

This study looks at whether the standard dose of the antibiotic ceftazidime-avibactam reaches high enough levels in the blood of people with blood cancers or those who have had a stem cell transplant. These patients are at high risk for severe infections from drug-resistant bacte…

This pilot study tests whether using pleuropulmonary ultrasound in the emergency department can help doctors prescribe antibiotics sooner for suspected pneumonia. Fifteen adults with respiratory symptoms will receive an ultrasound in addition to standard care. The main goal is to…

This study looks at how exercise and a saltwater mist (hypertonic saline) affect mucus clearance in people with primary ciliary dyskinesia (PCD), a rare lung condition where tiny hairs in the airways don't work properly. Researchers will measure how fast the lungs clear inhaled p…

This study takes leftover tumor samples from people with EGFR-mutant non-small cell lung cancer and grows them in the lab as cell cultures and organoids. Researchers will test different anti-EGFR drugs on these models to see which ones work best for each type of mutation and expl…

This study investigates whether a particularly dangerous strain of Klebsiella pneumoniae bacteria (hvKP) raises the risk of lung injury in adults with sepsis, compared to a more common strain. Researchers will analyze blood samples for tiny bacterial particles and markers of a sp…

This study is testing whether a blood test can locate where colorectal cancer has returned or spread after surgery. Researchers are analyzing genetic markers in the blood to build a model that predicts whether a recurrence is local or distant. The goal is to improve early detecti…

This study looks at 200 people with pneumonia to find out how many actually have an infection caused by Chlamydia pneumoniae, a type of bacteria. Researchers will use PCR tests to check for the germ and compare results with standard care. The goal is to see if this infection is o…

This study compares two ways to rebuild the nose after partial or total loss: surgery using skin flaps, or a custom-made prosthetic nose (epithesis). Researchers will ask people who had either treatment at least one year ago to fill out a questionnaire about how their nose looks …

This study looks at how two sedative drugs, dexmedetomidine and remifentanil, affect breathing effort in patients with acute hypoxemic respiratory failure who are receiving high-flow nasal oxygen. Researchers will measure changes in inspiratory effort and symptoms like shortness …

This study measures how children ages 7 to 15 with normal hearing understand speech in realistic noisy environments, like a school cafeteria or playground. Using a 360-degree sound system, researchers play sentences in different background noises to see how well kids repeat them.…

This study uses a quick, non-invasive breath test (FeNO) to measure airway inflammation in adults with asthma who are treated in primary care or community specialty clinics. The goal is to see how many patients have type 2 inflammation, which often goes undetected. Researchers ho…

This study collects blood samples and health data from 1,200 adults with ARDS in intensive care. Researchers aim to identify biological markers that can group patients into subtypes and predict how they will respond to different treatments. The goal is to improve care for this li…

This study tests whether using a blood flow restriction (BFR) device during exercise can increase muscle fatigue in people with COPD, potentially making rehab more effective. Forty participants will do one session of resistance or cycling exercise with and without BFR. The goal i…

This study tests whether people with fibrotic interstitial lung disease can use home monitoring devices—like a spirometer, pulse oximeter, and scale—to help detect serious lung events such as flare-ups or hospitalizations. About 200 participants will use these devices connected t…

This study tests whether adding special air quality sensors and software to hospital ventilation systems can lower the number of respiratory infections among healthcare workers. About 850 Mayo Clinic staff will report symptoms and provide self-swabs when sick. The goal is to see …

This study uses blood tests (liquid biopsies) to track how small cell lung cancer changes during chemotherapy and immunotherapy. Researchers will analyze DNA from blood samples taken before, during, and after treatment in 50 patients. The goal is to understand why some cancers be…

This study looks at whether the recruitment-to-inflation ratio (R/I ratio), a measurement used to guide ventilator settings in patients with acute respiratory distress syndrome (ARDS), gives the same result when repeated in the same patient. Researchers will measure it twice in 8…

This study looks at 88 ICU patients who are ready to try breathing on their own after being on a ventilator. Some patients will be taken off the ventilator completely (T-piece test), while others will breathe with a little machine help (PS-ZEEP test). The goal is to see which tes…

This study will enroll 200 children with cystic fibrosis (100 Hispanic, 100 non-Hispanic white) to measure indoor and outdoor air pollution and see how it relates to lung function, inflammation, and airway bacteria. Researchers hope to understand why Hispanic children often have …

This study explores whether a hair follicle or cheek swab can accurately measure a person's internal body clock (circadian rhythm) in patients with advanced lung cancer receiving immunotherapy. Researchers will use a new tool called TimeTeller to analyze gene activity from these …

This study follows people with chronic lung diseases like bronchiectasis, cystic fibrosis, and COPD to understand how bacteria become resistant to antibiotics. Researchers will collect samples and health data over time to map resistance patterns and genetic causes. The goal is to…

This study will collect data from 624 patients in respiratory intermediate care units (RICUs) across Catalonia to build a model that predicts 30-day survival. Researchers will also test an artificial intelligence approach and create a quick app for doctors. The goal is to better …

This study will develop an artificial intelligence model that uses a patient's series of CT scans over time to predict whether a lung nodule will grow or become cancerous. Researchers will analyze scans from nearly 5,000 people to train the AI to recognize different growth patter…

This observational study looks at adults with non-small cell lung cancer that has spread to the brain. Researchers want to see if getting radiation and immunotherapy 30 days apart or closer together changes how long the brain tumors stay stable and how long patients live. Partici…

This study follows 150 adults aged 60 and older who have a respiratory infection (flu, RSV, or COVID-19) or who test negative. Researchers will measure specific immune markers in the blood over 60 days to see how they change from early infection to recovery. The goal is to better…

This study looks at how often ICU patients silently inhale food or liquid into their lungs after a breathing tube is removed, without showing obvious signs like coughing. Researchers will compare a routine bedside swallowing test with a more detailed camera test to see if the bed…

This study will measure leg and handgrip strength in about 2,800 healthy adults and people with chronic lung diseases across Spain, Portugal, and Italy. Researchers want to create normal muscle strength values for these populations and see if the same standards can apply to peopl…

This study looks at whether placing patients face-down (prone) soon after heart surgery can improve how well the right side of the heart works. The idea is that this position helps open up collapsed parts of the lungs, making it easier for the heart to pump blood. About 80 adults…

This study will track 427 adults with interstitial lung disease (ILD) who need a bronchoscopy as part of their care. Researchers want to see how often complications happen within 30 days after the procedure. The goal is to better understand the risks so doctors can make safer cho…

This study looks at a specific type of lung cancer called lung adenocarcinoma and how it can spread through tiny air spaces in the lungs. Researchers will collect tumor and healthy tissue samples from 140 patients to find genetic markers that might predict this spread. The goal i…

This study looks at medical records of 3,000 adults with lung cancer to see if the stage at diagnosis is shifting to earlier, more curable stages. Researchers will track how often cancer is found through screening programs, chest X-rays, or heart scans. No new treatments or tests…

This study will test whether using higher or standard pressure on a ventilator during surgery helps patients breathe better after waking up. About 360 adults having planned non-chest, non-heart surgery will be randomly assigned to one of two pressure levels. The main goal is to s…

This study will use artificial intelligence to analyze data from over 31,000 tuberculosis patients. The goal is to create a system that helps doctors decide which patients can be cured with a short treatment course and which need longer therapy. The AI will be tested to see if it…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…