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Smart ventilator settings may cut Post-Surgery lung failure

NCT ID NCT07620132

Disease control Sponsor: University Hospital, Montpellier Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new method for setting ventilators during abdominal surgery to prevent postoperative respiratory failure. The approach adjusts settings based on 'mechanical power,' a measure that combines several ventilator parameters. The trial will enroll 490 adults having abdominal surgery lasting at least 2 hours and compare this individualized strategy to standard care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Mechanical power-guided ventilatory strategy
What this could lead to
If it works, this could lead to a standard way to set ventilators during surgery that reduces lung injury and prevents respiratory failure.
What could go wrong
This is a new approach not yet tested in a large trial, so it may not prove better than current methods. The ventilator adjustments also carry risks like drops in blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 490 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult (≥ 18 years) * Laparoscopic or non-laparoscopic abdominal surgery * With an expected duration of at least 2 hours Exclusion Criteria: * Patients already receiving mechanical ventilation \> 12 hours before surgery; * Chronic respiratory disease requiring oxygen therapy or mechanical ventilation at home; * Undrained pneumothorax or subcutaneous emphysema; * Intracranial hypertension; * Patients for which death is deemed imminent and inevitable or patients with an underlying disease process with a life expectancy of less than 3 months; * Patients already enrolled in the IMPROVE III trial; * Pregnancy in progress or planned during the study period or breastfeeding women (Art. L1121-5 of the French Public Health Code); * Patients protected by law (Art. L1121-6 to L1121-8 of the French Public Health Code): Individuals deprived of their liberty by judicial or administrative decision, vulnerable persons, minors, adults under guardianship or curatorship; * Patients not covered by a French social security scheme and not benefiting from such a scheme; * Absence of free and informed oral consent from the patient before inclusion (except in emergency situation where the patient is unable to provide consent), or absence of written informed consent from his/her proxy if present in an emergency situation (except in life-threatening emergency, where inclusion without consent from the patient or his/her proxy is permitted), in which case consent will be obtained as soon as possible after inclusion.

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Conditions

The condition(s) this trial relates to.

respiratory failure prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abdominal surgery Morality Postoperative pulmonary complications Postoperative respiratory failure

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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Other studies related to the condition(s) this trial covers.