Can a simple ventilator setting during surgery prevent breathing problems?
NCT ID NCT07613177
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will test whether using higher or standard pressure on a ventilator during surgery helps patients breathe better after waking up. About 360 adults having planned non-chest, non-heart surgery will be randomly assigned to one of two pressure levels. The main goal is to see how well their lungs oxygenate the blood once they are fully awake, using a simple oxygen measurement.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Positive end-expiratory pressure (PEEP) during mechanical ventilation
- What this could lead to
- If successful, this could help doctors choose the best ventilator settings during surgery to reduce breathing problems after surgery.
- What could go wrong
- This is an early-stage study that hasn't started recruiting yet. It focuses on a short-term oxygen measurement, not long-term outcomes, so the real-world benefit is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 360 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age greater than or equal to 18 years. * Planned elective non-cardiac and non-thoracic surgical intervention requiring general anesthesia with mechanical ventilation. * Airway protection utilizing an endotracheal tube. * Assignment to one of the four specific surgical strata: non-abdominal, major open abdominal, major laparoscopic abdominal, or low-trauma laparoscopic surgery. * Baseline lung ultrasound showing no pathological findings, corresponding to a total preoperative LUS score of 0. * Technical feasibility of performing a postoperative lung ultrasound within the first 2 hours after the completion of surgery. * Signed written informed consent to participate in the clinical trial. Exclusion Criteria: * Planned cardiac or thoracic surgery (e.g., coronary artery bypass grafting, valve replacement, heart transplantation, lung resection, esophageal surgery). * Pneumothorax diagnosed before or during the surgical procedure. * Inability to adequately visualize the target dorsal-basal lung zones by ultrasound due to physical limitations (e.g., morbid obesity, massive surgical dressings, anatomical anomalies, or dermatological lesions in the scanning area). * Presence of hydrothorax detected on the baseline preoperative ultrasound. * Confirmed perioperative aspiration of gastric contents or other foreign material. * Any pathological changes identified during the baseline ultrasound of the dorsal-basal lung regions (a total preoperative LUS score greater than 0). * Requirement for massive blood transfusion during the surgery, defined according to local institutional criteria. * Surgical interventions directly involving or violating the diaphragm. * Expected inability to conduct reliable postoperative clinical and ultrasound assessments (e.g., need for deep sedation preventing wakefulness and contact, or planned transfer to another facility).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Moscow Multi-disciplinary Clinical Center "Kommunarka"
Moscow, Moscow, 108814, Russia
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