Scientists to peek inside tonsils after nasal flu vaccine
NCT ID NCT07093281
First seen Jun 24, 2026 · Last updated Sep 04, 2026 · Updated 3 times
Summary
This study will give the nasal flu vaccine to 25 people who are already scheduled to have their tonsils or adenoids removed for sleep apnea. Researchers will then study the removed tissue to see how the vaccine affects immune cells near the nose. The goal is to better understand how nasal vaccines work, since they don't cause the same blood changes as shots.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Live attenuated influenza vaccine (nasal spray)
- What this could lead to
- If successful, this could help design better nasal vaccines that boost immunity right where the flu enters the body.
- What could go wrong
- This is a very small, early-stage study (25 people) focused on understanding immune responses, not on treating or preventing disease. Results may not apply to the general population.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 25 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2027
An estimate. Start dates often move.
- Expected to finish
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Jul 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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2 to 89 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient undergoing tonsillectomy and adenoidectomy as part of the standard of care for sleep apnea Exclusion Criteria: * Chronic Tonsillitis * Immune Deficiency * Already received this year's flu vaccine
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Get notified about this study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Maryland Medical Center
Baltimore, Maryland, 21231, United States
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Other studies related to the condition(s) this trial covers.
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