How strong should you be? new study aims to find out
NCT ID NCT07628530
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will measure leg and handgrip strength in about 2,800 healthy adults and people with chronic lung diseases across Spain, Portugal, and Italy. Researchers want to create normal muscle strength values for these populations and see if the same standards can apply to people with respiratory conditions. Participants attend one visit for strength tests, mobility tasks, and questionnaires.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 2,815 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Community-dwelling healthy adults and adults with chronic respiratory diseases recruited from participating centres in Spain, Portugal and Italy. Healthy participants will be recruited from the general population to develop reference equations and normative values for isometric quadriceps and handgrip strength. Participants with chronic respiratory diseases will be recruited from clinical settings to externally validate the developed reference equations and assess their clinical applicability.
- Ages
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18 to 89 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Healthy adults cohort Inclusion Criteria: * Age between 18-89 years. * Spanish, Portuguese or Italian, or permanently resident in one of those countries for at least five years. * Be community-dwelling (i.e., not hospitalised or institutionalised). * Be functionally independent and capable of performing study assessments without assistance or limiting pain. * Be able to follow verbal instructions in the local language (Spanish, Portuguese or Italian, as appropriate). * Provide written informed consent. Exclusion Criteria: * Acute or chronic musculoskeletal conditions affecting strength: recent fractures, severe osteoarthrosis, ligament injury, acute tendinitis in hands/knee areas, among others. * Recent surgery (e.g., within the past six months) in upper or lower limbs. * Neuromuscular disorders: Parkinson, multiple sclerosis, stroke, peripheral neuropathies, among others. * Non-communicable diseases affecting strength or functional status: active cancer, any unstable heart diseases; any CRD; active rheumatological diseases, obesity (BMI≥30kg/m2), uncontrolled metabolic diseases, among others (not included: controlled dyslipidaemia or arterial hypertension). * Cognitive impairments (e.g., dementia) or psychiatric disorders impairing following instructions. * Aid devices for walking or compromised functional mobility. * Moderate-to-severe pain during the assessment (VAS ≥4). * Systemic corticosteroids use for over one week in the previous six months (i.e., risk of muscle atrophy in type II fibres; or steroid myopathy). * Muscle relaxants use during the previous week (i.e., risk of not full muscle activation). * Pregnancy and postpartum (i.e., potential physiological changes which may alter muscle strength). * Current smoking. Chronic respiratory disease cohort Inclusion criteria: * Aged 18-89 years. * Clinical diagnosis of a chronic respiratory disease (e.g., COPD, interstitial lung disease, asthma, bronchiectasis, cystic fibrosis), confirmed by spirometry or clinical records. * Clinically stable (no exacerbation within the past four weeks). * Capacity to provide informed consent and complete study procedures. Exclusion criteria: * Coexisting conditions which meet the exclusion criteria defined for healthy participants, apart from chronic respiratory diseases. * Current requirement for hospitalisation or acute medical management. * Severe functional limitation preventing completion of assessments.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Alcalá
Alcalá de Henares, Madrid, 28805, Spain
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