Could a spirometer test guide breathing support in respiratory failure?
NCT ID NCT07750717
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This study looks at whether the amount of air a person breathes in on their own matches the amount they breathe when using a non-invasive ventilation (NIV) mask. It involves 30 adults with acute respiratory failure who are in intensive care. Researchers will measure tidal volume (breath size) during spontaneous breathing with a handheld spirometer and then during NIV with optimized settings. The goal is to see if a simple test can help predict how patients will respond to NIV, potentially aiding in personalized treatment decisions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Hand-held spirometer and non-invasive ventilation (NIV)
- What this could lead to
- If a link is found, doctors might use simple breathing tests to predict which patients will benefit from non-invasive ventilation, potentially improving care for acute respiratory failure.
- What could go wrong
- This is a small pilot study, so results may not apply broadly. The measurements might not correlate as expected, and the study does not test a treatment's effectiveness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Sep 2026
An estimate. Start dates often move.
- Expected to finish
-
Jan 2029
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient over 18 years of age; * Patient hospitalized in intensive care for less than 24 hours; * Patient with severe hypoxemic acute respiratory failure characterized by a PaO2/FiO2 ratio \< 300 mmHg and \> 150 mmHg under high-flow oxygen therapy at 60 L/min; * Patient able to cooperate with the spirometry test; * Patient able to follow the protocol and having given their informed written consent to participate in the study; * Patient affiliated with the social security system or entitled to benefits; Exclusion Criteria: * Patients with an indication for intubation; * Patients with a contraindication for or who refuse NIV; * Patients with hemodynamic instability requiring vasopressor support greater than 0.25 μg/kg/min of norepinephrine; * Patients with a Glasgow score \< 15; * Patients with hypercapnia (PaCO2 \> 45 mmHg); * Patients with a PaO2/FiO2 ratio \< 150 mmHg; * Patients with cardiogenic pulmonary edema; * Patients who have already undergone a session of NIV in intensive care during this stay; * Patients with chronic respiratory failure (home oxygen therapy or home non-invasive ventilation (excluding indications solely for sleep apnea syndrome)); * Patients who have recently had a pneumothorax; * Patients who have recently undergone eye surgery (e.g., cataract surgery) or throat surgery; * Patients with significant arterial disease: recent heart attack, pulmonary embolism, poorly controlled hypertension despite treatment, etc. * Patients already included in the study; * Pregnant women, women in labor, or women who are breastfeeding; * Patients under guardianship, conservatorship, or deprived of their liberty; * Patients under an activated future protection mandate; * Patients under family authorization; * Patients under judicial protection;
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Acute respiratory distress syndrome are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Centre Hospitalier Universitaire de Nantes - Hôpital Hôtel Dieu
Nantes, 44093, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can donated immune cells calm the cytokine storm?
- Steroid dose showdown: can more dexamethasone save lives in respiratory failure?
- Breathing machine settings put to the test in severe lung injury
- The hidden breath: how a mismatch between patient and machine may shape ARDS recovery
- Scientists hunt for hidden subgroups in sudden respiratory failure
- AI plus ultrasound could catch heart and lung decline before it turns critical