ARDS ventilator tool faces reliability test

NCT ID NCT07666503

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether the recruitment-to-inflation ratio (R/I ratio), a measurement used to guide ventilator settings in patients with acute respiratory distress syndrome (ARDS), gives the same result when repeated in the same patient. Researchers will measure it twice in 80 ICU patients under stable conditions. No new treatments are being tested; the goal is to see if this tool is reproducible enough to trust in routine care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If the R/I ratio is reproducible, it could become a trusted tool to help doctors set ventilators more precisely for ARDS patients.
What could go wrong: This is a small, early-stage observational study with only 80 patients. It does not test any treatment, so even if successful, it won't directly improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients admitted to intensive care units in participating centers for acute respiratory distress syndrome and requiring invasive mechanical ventilation will be screened for inclusion. The study population will be drawn from routine clinical practice in four French academic intensive care units where airway opening pressure and recruitment-to-inflation ratio measurements are performed as part of standard care in selected patients with moderate to severe disease.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patient (age ≥ 18 years) * Patient hospitalized in the Intensive Care Unit (ICU) for acute respiratory distress syndrome (according to the Berlin definition), requiring invasive mechanical ventilation with deep sedation and controlled mechanical ventilation mode * Patient or next of kin informed about the study and not objecting to participation Exclusion Criteria: * Undrained pneumothorax or any contraindication to a transient increase in airway pressure * Known or suspected intracranial hypertension * Patient under legal protection (e.g., guardianship) * Not affiliated with a social security system * Presence of spontaneous respiratory effort * Presence of a leak in the ventilatory circuit * Hemodynamic instability (e.g., uncontrolled shock, increasing vasopressor requirement) * Uncontrolled severe hypoxemia * Undrained pneumothorax or any contraindication to a transient increase in airway pressure * Known or suspected intracranial hypertension

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome (ARDS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

4 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

ARDS ventilator tool faces reliability test

What the study statuses mean