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Immune clues may unlock better ECMO care for lung failure patients

NCT ID NCT07726940

Disease control Sponsor: Southeast University, China Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial studies adults with moderate-to-severe acute respiratory distress syndrome (ARDS) who need ECMO life support. Researchers aim to classify patients into immune-based subtypes, understand why complications like kidney injury and bleeding occur, and develop a personalized, full-cycle ECMO management plan. The goal is to improve survival and recovery by tailoring ventilation and ECMO strategies to each patient's immune profile.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
extracorporeal membrane oxygenation (ECMO) support
What this could lead to
If successful, this could lead to a precision, full-cycle ECMO management pathway that reduces complications and improves survival in severe ARDS.
What could go wrong
This is a large mechanistic study, not a simple drug trial. The complexity of immune phenotyping and ECMO management means results may take years to translate into bedside practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,776 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Feb 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients diagnosed with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS) who are admitted to the Intensive Care Units (ICUs) of participating tertiary hospitals. This cohort includes patients requiring advanced respiratory support, specifically focusing on those managed with or without Extracorporeal Membrane Oxygenation (ECMO) based on clinical indications.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1.Age ≥ 18 years 2.Meet the global new definition of moderate-to-severe Acute Respiratory Distress Syndrome (ARDS). Exclusion Criteria: \- 1.Patients with a prior tracheostomy. 2.Patients who have received a lung transplant or initiated VV-ECMO support as a bridge to lung transplantation. 3.Patients with comorbid cardiogenic shock requiring VA-ECMO or VAV-ECMO support.

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome (ARDS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    39 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Affiliated Hospital of Nantong University

    NOT_YET_RECRUITING

    Nantong, China

  • Affiliated Hospital of Qinghai University

    NOT_YET_RECRUITING

    Xining, China

  • Affiliated Hospital of Xuzhou Medical University

    NOT_YET_RECRUITING

    Xuzhou, China

  • Beijing Anzhen Hospital, Capital Medical University

    RECRUITING

    Beijing, Beijing Municipality, China

  • Fujian Provincial Hospital

    RECRUITING

    Fuzhou, Fujian, China

  • General Hospital of Ningxia Medical University

    NOT_YET_RECRUITING

    Ningxiang, China

  • Hangzhou First People's Hospital, Westlake University School of Medicine

    NOT_YET_RECRUITING

    Hangzhou, China

  • Henan Provincial People's Hospital

    RECRUITING

    Zhengzhou, China

  • Huai'an First People's Hospital

    NOT_YET_RECRUITING

    Huai'an, China

  • Jiangsu Province Hospital

    NOT_YET_RECRUITING

    Nanjing, China

  • Kunshan First People's Hospital

    NOT_YET_RECRUITING

    Kunshan, China

  • Liuzhou People's Hospital

    RECRUITING

    Liuzhou, China

  • Nanjing Drum Tower Hospital

    RECRUITING

    Nanjing, China

  • People's Hospital of Guangxi Zhuang Autonomous Region

    NOT_YET_RECRUITING

    Naning, China

  • Qilu Hospital of Shandong University

    RECRUITING

    Jinan, Shandong, China

  • Quzhou People's Hospital

    RECRUITING

    Quzhou, China

  • Sichuan Provincial People's Hospital

    RECRUITING

    Chengdu, Sichuan, China

  • Subei People's Hospital

    NOT_YET_RECRUITING

    Yangzhou, China

  • Suining Central Hospital

    NOT_YET_RECRUITING

    Suining, China

  • The First Affiliated Hospital of Guangxi Medical University

    NOT_YET_RECRUITING

    Nanning, China

  • The First Affiliated Hospital of Guangzhou Medical University

    RECRUITING

    Guangzhou, China

  • The First Affiliated Hospital of Harbin Medical University

    NOT_YET_RECRUITING

    Ha’erbin, China

  • The First Affiliated Hospital of Soochow University

    NOT_YET_RECRUITING

    Suzhou, China

  • The First Affiliated Hospital of Xiamen University

    NOT_YET_RECRUITING

    Xiamen, China

  • The First Affiliated Hospital of Zhengzhou University

    NOT_YET_RECRUITING

    Zhengzhou, China

  • The First Hospital of Lanzhou University

    NOT_YET_RECRUITING

    Lanzhou, China

  • The First People's Hospital of Chenzhou

    RECRUITING

    Chenzhou, China

  • The First People's Hospital of Lianyungang

    NOT_YET_RECRUITING

    Lianyungang, China

  • The Second Affiliated Hospital of Dalian Medical University

    NOT_YET_RECRUITING

    Dalian, China

  • The Second Affiliated Hospital of Guangxi Medical University

    NOT_YET_RECRUITING

    Nanning, China

  • The Second Affiliated Hospital of Harbin Medical University

    RECRUITING

    Ha’erbin, China

  • The Second Affiliated Hospital of Xi'an Jiaotong University

    RECRUITING

    Xi'an, China

  • The Second Affiliated Hospital, Zhejiang University School of Medicine

    RECRUITING

    Hangzhou, Zhejiang, China

  • The Second Hospital of Jilin University

    NOT_YET_RECRUITING

    Changchun, China

  • West China Tianfu Hospital, Sichuan University

    NOT_YET_RECRUITING

    Sichuan, China

  • Wuxi People's Hospital

    RECRUITING

    Wuxi, China

  • Xinyang Central Hospital

    NOT_YET_RECRUITING

    Xinyang, China

  • Zhongda Hospital, Southeast University

    RECRUITING

    Nanjing, Jiangsu, 210009, China

  • Zhongshan Hospital of Traditional Chinese Medicine

    RECRUITING

    Zhongshan, China

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