Southeast University, China

This study tests whether the steroid dexamethasone, when added to standard care, can lower the chance of death within 90 days for people with a serious lung condition called ARDS caused by sepsis. About 1,474 adults on breathing machines will take part. The goal is to see if this…

This trial studies adults with moderate-to-severe acute respiratory distress syndrome (ARDS) who need ECMO life support. Researchers aim to classify patients into immune-based subtypes, understand why complications like kidney injury and bleeding occur, and develop a personalized…

This study investigates whether a standardized, full-course management pathway for ECMO can improve outcomes for adults with moderate-to-severe acute respiratory distress syndrome (ARDS). The pathway covers everything from deciding when to start ECMO through weaning and follow-up…

This study tests whether using a lung imaging tool called EIT to set ventilator pressure (PEEP) can improve survival in patients with moderate-to-severe ARDS. The trial will enroll 2400 adults and compare EIT-guided PEEP to the standard method. The main goal is to see if this app…

This study tests whether remimazolam, a newer sedative, can improve outcomes for ICU patients who need a breathing tube and sedation. Researchers will compare remimazolam to standard sedatives in 80 adults. The main goal is to see if patients spend more days free from the ventila…

This study looks at whether changing the ventilator settings early—from full control to a mode where the patient does some of the work—helps critically ill adults get off the machine faster. About 1,600 patients across 10 ICUs will be randomly assigned to either early switching o…

This study looks at 40 adults with severe lung injury (ARDS) who need to lie on their stomachs while on a breathing machine. Researchers want to see if feeding through a tube into the stomach or deeper into the small intestine helps patients get better nutrition and recover faste…

This trial tests whether inhaling the antibiotic colistin can prevent ventilator-associated pneumonia in people with acute brain injury who need a breathing machine. Ventilator-associated pneumonia is a common and dangerous infection in the ICU, often caused by drug-resistant bac…

This study looks at 500 adults with a severe lung condition called ARDS to see if they fall into two different inflammatory groups. By identifying these groups, doctors hope to choose the right treatments—like fluids, breathing support, or steroids—for each patient. The goal is t…

This study is observing how prone positioning (lying face down) affects patients with moderate-to-severe ARDS, a serious lung condition. Researchers will track 1000 adults in intensive care to see if factors like lung shape or brain injury influence outcomes. The goal is to learn…

This study looks at how changing the way a ventilator lets patients breathe out (called RCexp) affects air and blood flow in the lungs of people with ARDS. Researchers will use a special imaging technique (EIT) to measure these changes in 60 adults on ventilators. The goal is to …