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Can switching ventilator mode early save lives? new trial aims to find out

NCT ID NCT07519512

Disease control Sponsor: Southeast University, China Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether changing the ventilator settings early—from full control to a mode where the patient does some of the work—helps critically ill adults get off the machine faster. About 1,600 patients across 10 ICUs will be randomly assigned to either early switching or usual care. The main goal is to see if more patients are successfully breathing without a ventilator by day 28.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
early transition to assisted ventilation (behavioral intervention)
What this could lead to
If it works, this could lead to shorter time on ventilators and better outcomes for critically ill patients.
What could go wrong
This is an early-stage trial with no phase, so results are uncertain. The open-label design may introduce bias, and findings may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,600 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years. * Expected ICU stay and mechanical ventilation (MV) ≥ 48 hours. * Currently receiving controlled ventilation mode * No neuromuscular blocking agents in use, and sedation level RASS ≥ -3. * P/F ≥ 150 mmHg. Exclusion Criteria: * Severe end-stage irreversible respiratory, cardiac, or neurologic disease that may lead to long-term/chronic ventilator dependence or inability to wean from MV (e.g., interstitial lung disease/pulmonary fibrosis, cardiomyopathy, valvular disease, severe traumatic brain injury, Guillain-Barré syndrome, amyotrophic lateral sclerosis, multiple sclerosis, high cervical spinal cord injury, or other restrictive diseases). * Expected death or transfer out of the ICU within 48 hours. * Hemodynamic instability judged by the treating clinician. * Pregnancy. * Currently participating in other clinical studies related to mechanical ventilation. * Any other condition considered unsuitable for participation by the investigator. Written informed consent not obtained.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilator care

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Zhongda Hospital, School of Medicine, Southeast University

    RECRUITING

    Nanjing, Jiangsu, 210009, China

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