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Can lung imaging guide ventilator settings to save lives in ARDS?

NCT ID NCT06990477

Disease control Sponsor: Southeast University, China Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tests whether using a lung imaging tool called EIT to set ventilator pressure (PEEP) can improve survival in patients with moderate-to-severe ARDS. The trial will enroll 2400 adults and compare EIT-guided PEEP to the standard method. The main goal is to see if this approach reduces deaths within 28 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
EIT-guided PEEP (a device-based method to set ventilator pressure using electrical impedance tomography)
What this could lead to
If successful, this could become a standard way to set ventilator pressure for ARDS patients, potentially reducing deaths.
What could go wrong
This is a large trial, but the approach is still experimental. It may not improve survival compared to current methods, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 2,400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Feb 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age≥18 years 2. Moderate-to-severe ARDS, defined by the ARDS Definition Task Force in the Berlin definition (partial pressure of arterial oxygen \[PaO2\]:FiO2 ratio ≤200 mmHg with a PEEP ≥5 cmH2O) 3. Diagnosis of ARDS less than 72 hours Exclusion Criteria: 1. Expected to be mechanically ventilated for less than 48 hours 2. Severe chronic respiratory diseases requiring long-term home oxygen therapy or noninvasive MV 3. Undrained pneumothorax or subcutaneous emphysema 4. Contraindication to the use of EIT (pacemaker, automatic implantable cardioverter defibrillator, and implantable pumps) 5. Severe neuromuscular disease 6. Hemodynamic instability 7. Contraindications to hypercapnia, such as intracranial hypertension or acute coronary syndrome 8. Severe other organs dysfunction with a low expected survival (7 days) or palliative care 9. Severe liver disease (Child-Pugh Score ≥10) 10. Pregnancy 11. Refusal to sign the informed consent

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Conditions

The condition(s) this trial relates to.

acute lung injury acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARDS (acute respiratory distress syndrome)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    17 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Affiliated Beijing Chaoyang Hospital of Capital Medical University

    NOT_YET_RECRUITING

    Beijing, China

  • Asan Medical Center

    NOT_YET_RECRUITING

    Seoul, South Korea

  • Department of Critical Care Medicine, Renji Hospital

    NOT_YET_RECRUITING

    Shanghai, China Mainland, 20000, China

  • Department of Critical Care Medicine, Zhongshan Hospital of Fudan University

    RECRUITING

    Shanghai, China Mainland, 200000, China

  • First Affiliated Hospital of Xi'an Jiaotong University

    NOT_YET_RECRUITING

    Xian, Shanxi, China

  • People's Hospital of Quzhou

    NOT_YET_RECRUITING

    Quzhou, Zhejiang, China

  • Qinghai University Affiliated Hospital

    NOT_YET_RECRUITING

    Xining, Qinghai, China

  • Ruijin Hospital Shanghai Jiaotong University School Of Medicine

    NOT_YET_RECRUITING

    Shanghai, China

  • Run Run Shaw Hospital affiliated to Zhejiang University School of Medicine

    NOT_YET_RECRUITING

    Hangzhou, China

  • Second Hospital of Anhui Medical University

    NOT_YET_RECRUITING

    Hefei, Anhui, China

  • Taichung Veterans General Hospital

    NOT_YET_RECRUITING

    Taichung, Taiwan

  • The Affiliated Hospital of Hangzhou Normal University

    NOT_YET_RECRUITING

    Hangzhou, Jiangsu, 210009, China

  • The Affiliated Hospital of Xuzhou Medical University

    NOT_YET_RECRUITING

    Xuzhou, Jiangsu, 210009, China

  • The First Affiliated Hospital of Guangzhou Medical University

    NOT_YET_RECRUITING

    Guangzhou, Guangdong, China

  • The First Affiliated Hospital of Nanchang University

    NOT_YET_RECRUITING

    Nanchang, Jiangxi, China

  • Zhengzhou Central Hospital Affiliated to Zhengzhou University

    NOT_YET_RECRUITING

    Zhengzhou, Henan, China

  • Zhongda Hospital, School of Medicine, Southeast University

    RECRUITING

    Nanjing, Jiangsu, 210009, China

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