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Which ventilator setting saves more lungs? a Head-to-Head test

NCT ID NCT07741916

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study compares different bedside methods for choosing the optimal ventilator pressure (PEEP) in patients with moderate-to-severe acute respiratory distress syndrome (ARDS). The goal is to see if these methods give similar results and which one best balances keeping lungs open while avoiding overstretching. Researchers will analyze data from 45 ICU patients on mechanical ventilation, measuring lung mechanics and oxygenation at various PEEP levels. The findings could help standardize how doctors set ventilator pressure for ARDS patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Different PEEP (positive end-expiratory pressure) levels set via various bedside assessment tools
What this could lead to
If successful, this could identify the most reliable bedside method to set ventilator pressure, potentially improving outcomes for ARDS patients.
What could go wrong
This is a small observational study, so results may not apply broadly. The methods may not be interchangeable, and no single approach may emerge as clearly superior.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients on invasive mechanical ventilation * With moderate-to-severe ARDS : 1. Bilateral findings on chest X-ray 2. PaO₂/FiO₂ ratio \<200 with PEEP ≥+5 cmH₂O 3. No evidence of cardiogenic pulmonary overload * Patients without inspiratory effort (curare administration not required) * Patient already fitted with an esophageal pressure probe * Patient already fitted with a thoracic impedance belt * No objection from the patient or a family member to the processing of their clinical data Exclusion Criteria: * Protected individuals, namely: 1. Individuals receiving enhanced protection, namely minors 2. Individuals deprived of their liberty by a judicial or administrative decision 3. Pregnant and breastfeeding women 4. Individuals residing in a health or social care facility 5. Adults under legal guardianship * Patients with a do-not-resuscitate order or a decision to limit care * Patients with a pacemaker or an implantable cardioverter-defibrillator * Acute cor pulmonale * Pneumothorax or ongoing pleural/thoracic drainage * Patients in the prone position * Hemodynamic instability 1. An increase of \>30% in the norepinephrine dosage over the past 6 hours 2. Norepinephrine dosage \> 0.5 µg/kg/min * Patients on veno-venous ECMO

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU de Nice

    Nice, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.