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Could simply sitting up ease breathing in severe lung failure?

NCT ID NCT04371016

Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This study tests whether gradually tilting patients with acute respiratory distress syndrome (ARDS) upright—from lying flat to a 90° seated position—improves how their lungs handle mechanical ventilation. Researchers will measure lung pressure, aeration, and oxygen levels at each tilt angle in 30 sedated, ventilated patients. The goal is to see if this simple repositioning reduces strain on the lungs and improves breathing mechanics.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bed verticalization (tilting the patient upright using a specialized ICU bed)
What this could lead to
If tilting patients upright improves lung function, it could offer a simple, drug-free way to ease breathing and reduce lung injury in intensive care.
What could go wrong
This is a small, early exploratory study, so results may not apply broadly. Tilting critically ill patients carries risks like blood pressure changes or tube displacement, and the benefit is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Mar 2020

Finished

Jan 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient with moderate or severe Acute Respiratory Distress Syndrome (ARDS) (PaO2/FiO2 \< 200 mmHg), at their early phase (\< 12h), under invasive mechanical ventilation with controlled ventilation (intubation or tracheotomy). * Patient equipped with an arterial catheter. * Patient sedated (BIS between 30 and 50) and, if necessary, under neuromuscular blocking agent (TOF \< 2/4 at the orbicular) to avoid inspiratory effort. * Patient hemodynamically optimized following the Swan-Ganz catheter data. Exclusion Criteria: * Refusal to participate in the proposed study. * Unavailability of the bed dedicated to verticalization (Total Lift Bed™, VitalGo Systems Inc., Arjo AB) * Obesity with BMI ≥ 35 kg.m-2 * Significant hemodynamic instability defined as an increase of more than 20% in catecholamine doses in the last hour, despite optimization of blood volume, for a target mean blood pressure between 65 and 75 mmHg. * Contraindication to the insertion of a nasogastric tube * Contraindication to the use of the chest electrical impedance tomography * Contraindication to the insertion of a Swan-Ganz catheter * Contraindication to the application of compression stockings * Patient under guardianship * Pregnancy

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome

Contacts and locations

Locations

  • CHU

    Clermont-Ferrand, 63000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.