CRITICAL ILLNESS

This study is testing whether giving tube feedings only during the daytime hours is better than giving them around the clock for patients in the intensive care unit (ICU). Researchers want to see which feeding schedule leads to more stable blood sugar, better digestion, and impro…

This study aims to find the best way for paramedics to help critically ill children breathe during emergencies like cardiac arrest or severe injury. It will compare three different airway management strategies used by Emergency Medical Services (EMS) on 3,000 children. The main g…

This study is testing whether connecting ambulances to remote pediatric doctors via simple video calls can improve emergency care for critically ill children in Pakistan. During transport, one group of children will get a video consultation with a doctor, while another group rece…

This study is testing whether giving critically ill ICU patients a higher amount of protein through their feeding tube can help their bodies build and maintain muscle better than a standard amount. Researchers will compare two protein levels in 26 patients who are on a ventilator…

This large study is testing whether high-dose vitamin D can reduce deaths in critically ill patients who have severe vitamin D deficiency. The trial will enroll 2,400 adult ICU patients across multiple hospitals, randomly giving them either vitamin D or a placebo. Researchers wan…

This study is testing if using intravenous (IV) fluids with less salt helps adults who are very sick in the intensive care unit (ICU). It compares two strategies: one using lower-salt fluids for daily hydration and for diluting medicines, and another using the standard, saltier f…

This study aims to find out which of two common sedative drugs is better for protecting brain function in infants and children who need a breathing machine in the intensive care unit. It will compare dexmedetomidine and midazolam in 372 young patients to see which one reduces del…

This study compares two sedation drugs (remazolam besylate vs dexmedetomidine) for patients who need breathing machine support in the ICU after non-cardiac surgery. It aims to see if the new drug is at least as safe and effective at helping patients wake up and breathe on their o…

This study is looking back at past medical records to see if a treatment called gamma globulin helps children with severe infections. These children have a dangerous overreaction of their immune system, called an inflammatory storm, which can lead to organ failure. Researchers wi…

This study is testing whether personalized nutrition care from a dietitian helps patients recover better after a serious illness requiring intensive care. It will compare 300 patients who receive standard hospital nutrition with those who get a tailored plan and follow-up for six…

This early-stage study is testing the safety of a new intravenous treatment called DNase I for patients with sepsis in intensive care. The treatment aims to break down harmful webs released by the immune system that can clog blood vessels and damage organs. Researchers will enrol…

This study aims to find the best target level for magnesium, a common mineral given in the ICU, to help critically ill patients. It will compare whether aiming for a higher or lower magnesium level leads to better 30-day survival and fewer episodes of a dangerous irregular heartb…

This study is testing whether adding the antibiotic azithromycin to standard treatments helps children hospitalized with severe asthma attacks. Researchers want to see if the drug reduces harmful inflammation in the lungs and helps kids recover faster. The study will enroll 100 c…

This large study is testing a new care program called 'PICU Up!' for children who are very sick and on breathing machines in intensive care. The program combines early movement, managing medications, preventing confusion, and involving families to see if it helps kids get off the…

This study aims to determine whether critically ill patients on breathing machines and feeding tubes should stop eating before medical procedures. Researchers will compare two approaches: stopping tube feeding 8 hours before procedures versus continuing feeding until right before…

This study is testing whether starting supplemental IV nutrition earlier (on day 4 in the ICU) is better than starting later (on day 8) for patients who are critically ill and cannot get enough nutrition through a feeding tube. It will involve about 946 adults with organ failure …

This large international study is testing whether giving extra protein through feeding tubes helps critically ill patients survive and recover better. The trial will compare high-protein feeding against standard feeding in over 2,500 ICU patients on breathing machines. The main g…

This small, early-stage study is testing whether high doses of inhaled nitric oxide gas can help critically ill adults with pneumonia who are on breathing machines. Researchers will compare the gas treatment to a placebo to see if it helps patients recover and will closely monito…

This study is testing whether the type of IV fluid given to patients after a serious brain bleed affects their recovery. Researchers are comparing a salt-rich fluid (normal saline) to a more balanced fluid (lactated Ringer's) to see which one better prevents dangerous blood vesse…

This study is testing how well a new non-invasive blood pressure monitor from Philips works compared to the current gold standard method that requires inserting a small tube into an artery. Researchers will enroll 189 critically ill patients of all ages, from newborns to adults, …

This study is testing if a quick, non-invasive ultrasound scan can detect early signs of kidney injury in high-risk patients in the surgical intensive care unit. Researchers will compare this scan to standard blood and urine tests to see if it provides an earlier warning. The goa…

This study is testing a new, non-invasive device that uses light on a patient's forearm to measure blood flow. The goal is to see if this simple test can accurately predict whether a critically ill patient in the ICU needs more intravenous fluids. Researchers will compare the lig…

This trial is testing whether two existing bone-strengthening drugs, denosumab or zoledronic acid, can prevent bone loss in older adults who have survived a serious illness requiring intensive care. It will involve 450 women aged 50+ and men aged 70+ who spent more than a day in …

This study is testing whether giving magnesium through an IV can prevent critically ill patients from developing dangerous irregular heartbeats while in intensive care. Researchers will compare magnesium injections to a placebo in 200 ICU patients to see if this approach is pract…

This study is testing whether listening to music can prevent delirium, a serious state of confusion, in older adults who are critically ill in the Intensive Care Unit (ICU). Researchers will compare two types of music—personalized playlists and generic relaxing music—against stan…

This study is testing whether a simple photo-sharing activity helps parents of children with severe neurological conditions communicate better with their child's intensive care doctors and nurses. About 160 parents and their medical teams will try this tool during hospital stays …

This study is testing a bundle of non-drug treatments to help fix the sleep and internal body clock of patients in the intensive care unit (ICU). It will involve about 160 critically ill adults and combines bright daytime light, scheduled meals and activity, and overnight sleep p…

This study is testing a mobile app called ICUconnect, designed to help families of older adults in intensive care. The app helps families report their needs and stress levels, aiming to improve communication with doctors and reduce emotional distress. The trial will involve 350 p…

This study is testing a self-balancing robotic exoskeleton to help patients walk safely in the intensive care unit after major chest surgery. The goal is to see if the device can safely support early movement, which may help prevent muscle weakness and other complications from be…

This study is testing whether eating more fermented foods like yogurt, kimchi, and sauerkraut can help people recover mentally and emotionally after a life-threatening illness like severe COVID-19. Researchers want to see if this diet improves gut health, reduces inflammation, an…

This study is testing whether listening to music can help reduce stress and pain in children who are critically ill and on a breathing machine in the intensive care unit. Researchers will compare the effects of live music versus recorded music by measuring stress hormones and oth…

This study is testing if adding electrical muscle stimulation to standard physical therapy helps patients in the intensive care unit (ICU) who are on breathing machines. 150 participants will be randomly assigned to receive either standard therapy alone or standard therapy plus g…

This pilot study aims to find out if giving protein in large, spaced-out doses (bolus) is better than a slow, steady drip (continuous) at helping critically ill children ages 1-11 maintain their weight and muscle mass. Researchers will compare the two methods by measuring the chi…

This study aims to better understand how much energy critically ill patients use while in the hospital. Researchers will use a special, non-invasive water test on 50 adult ICU patients to measure their energy burn over time. The goal is to gather more accurate information to help…

This study aims to collect blood, urine, wound tissue, and other samples from up to 5,000 seriously ill or injured patients and healthy volunteers. The purpose is to use these samples to develop and test new tools that help doctors choose the best treatments for critical care pat…

This study aims to understand if high pressure inside the belly is linked to more fluid from the stomach getting into the lungs of critically ill patients with liver cirrhosis who are on breathing machines. Researchers will monitor belly pressure and test fluid from patients' bre…

This study aims to see if ultrasound scans can help doctors better understand how the bodies of critically ill pregnant women change during their illness. Researchers will use portable ultrasound machines to measure muscle loss, fat changes, and fluid buildup in 121 patients. The…

This study aims to understand why people who survive a serious illness in the Intensive Care Unit (ICU) often have long-lasting muscle weakness and trouble exercising. Researchers will measure heart and lung fitness, as well as blood flow in the muscles, in 50 ICU survivors at 6 …

This study aims to understand why many patients who survive a serious illness in the intensive care unit (ICU) develop long-lasting muscle weakness. Researchers will compare 100 ICU survivors with patients who had major abdominal surgery to see if patterns of inflammation and met…

This study aims to understand how different types and amounts of early physical therapy (like sitting up or walking) affect recovery for intensive care patients worldwide. Researchers will observe over 6,000 patients across 200+ hospitals to see which therapy approaches lead to b…

This study aims to find out how many patients in intensive care have undiagnosed diabetes or prediabetes, which current hospital records often miss. Researchers will measure a long-term blood sugar marker (HbA1c) in 4395 adult ICU patients to get a more accurate picture. The goal…

This study is creating a new, flexible research system to test many different treatments for critically ill patients at the same time. It will enroll up to 10,000 adults admitted to intensive care units. The goal is to continuously learn which treatments help patients survive lon…

This study aims to understand which type of bed-cycling exercise is better for stimulating the leg muscles of critically ill patients in the ICU. Researchers will compare steady, moderate cycling with interval training that mixes high and low intensity. They will measure muscle o…

This study aims to develop and test a new method for setting goals with children in the pediatric intensive care unit (PICU) and their families. Researchers will first ask healthcare experts to agree on how to use the method, then test it with a small group of 5 caregivers and th…

This study aims to find out if continuing tube feeding right up to tracheostomy surgery helps critically ill patients get more nutrition without increasing the risk of food entering their lungs. Researchers will compare two groups: one that stops feeding 6 hours before surgery an…

This study aims to understand if a low blood level of creatinine, a marker of muscle mass, can predict which patients will struggle to stop using a breathing machine (ventilator). It will also test if giving a dietary supplement called creatine to patients with low creatinine hel…

This study aims to see if certain markers of inflammation in the blood can help predict which patients are at higher risk of complications or death after major surgery. Researchers will observe 42 adults admitted to the intensive care unit (ICU) after an operation, using only dat…

This study aims to collect detailed information from 5,000 children in China who have severe infections like sepsis or pneumonia. The goal is to understand how common these illnesses are, what treatments work best, and to create better tools for predicting and diagnosing them. It…

This study aims to collect data on pupil size and reactions in 1,000 patients in intensive care units. Researchers are using a special device called a pupillometer to take these measurements. The goal is to establish what 'normal' pupil readings look like in very sick patients, w…

This study aims to understand why some critically ill patients in the ICU have trouble tolerating liquid food given through a tube. Researchers will use a bedside ultrasound machine to measure blood flow in the gut before and after feeding. They hope to find patterns that can pre…

This study aims to create a tool that helps doctors predict which elderly patients (age 75+) are most likely to survive after being admitted to intensive care. Researchers will follow 450 older adults admitted to the ICU from the emergency room, tracking who survives for 90 days.…

This study aims to understand how a patient's immune system responds during a critical illness requiring intensive care. Researchers will collect small blood samples from 540 ICU patients to measure immune cells and inflammation markers. The goal is to find patterns that might he…

This study aims to find early warning signs of organ problems in critically ill patients on breathing machines. Researchers will collect and analyze tiny samples of breath and blood from 200 patients in intensive care. By looking for specific patterns in these samples, they hope …

This study aims to understand how quickly patients in intensive care lose muscle in their mouth and throat, and if this causes dangerous swallowing problems. Researchers will measure muscle size and swallowing ability in 160 critically ill patients and compare them to less ill pa…

This study aims to find better ways to predict when a critically ill patient in the ICU is ready to breathe on their own after using a ventilator. Researchers will test a new, non-invasive sensor that measures muscle activity and oxygen use during a short breathing test. The goal…

This study aims to understand how two different methods of helping patients breathe affect heart function in people who have received a mechanical heart pump (LVAD). Researchers will compare standard breathing support with a newer external method in 30 stable patients. The main g…

This study aims to understand why many people who survive a serious illness in the Intensive Care Unit (ICU) struggle to regain their muscle strength and physical abilities. Researchers will follow about 200 adult ICU survivors for a year, measuring their muscle function and look…

This study aims to understand how brief increases in oxygen affect blood flow in the brains of critically ill patients on breathing machines. Researchers will temporarily adjust the oxygen levels for 80 ventilated ICU patients and use a non-invasive ultrasound to monitor brain ar…

This study is testing whether feeding critically ill patients for only 12 hours per day is as safe and practical as the standard 24-hour feeding. Researchers will compare both schedules in 20 ICU patients to see how they affect blood sugar control, sleep, and feeding tolerance. T…

This study is testing whether it's possible to measure and improve sleep for children aged 3-6 who are critically ill in intensive care. Researchers will use wrist monitors and saliva tests to track sleep patterns while trying two simple interventions: providing normal daytime li…

This study aims to understand how a common pain and sedation medication (remifentanil) behaves in the bodies of low-weight patients who are critically ill and on breathing machines. Researchers will measure drug levels in the blood and monitor patients' blood pressure and heart r…

This study aims to understand how often and why joint stiffness (contractures) develops in sedated adult patients on breathing machines in the ICU. Researchers will observe 150 patients, measuring their joint movement regularly during their ICU stay, but will not change their sta…

This study aims to find the safest and most effective spot to place a central venous catheter (a major IV line) in critically ill adults who are difficult to treat because their neck veins are small or collapse when they breathe. Researchers will compare success rates and safety …

This study aims to understand how severe physical trauma disrupts communication between the brain, bone marrow, and gut. Researchers will observe 275 adults who have suffered major injuries, along with a smaller group having elective hip surgery for comparison. The goal is to lea…

This study aims to find new markers in blood and urine that can predict which heart surgery patients are most likely to develop kidney problems after their operation. Researchers will enroll about 1,491 high-risk adults and test samples taken before and after surgery. The goal is…

This small pilot study aims to understand why some patients develop severe muscle weakness after a long stay in intensive care. Researchers will collect blood and small muscle samples from up to 20 surgical patients at high risk for this condition. By analyzing these samples, the…

This study aims to find out if safely reducing unnecessary blood tests and x-rays in intensive care units (ICUs) affects patient survival. It will involve 10,000 adult patients across Sweden's ICUs. Researchers will compare standard care to a new approach that questions the need …

This study aims to find the best way to help intensive care unit (ICU) teams consistently use a proven set of care practices known as the ABCDEF bundle. Researchers will test two different support strategies for hospital staff across 12 ICUs, involving about 8,100 critically ill …

This study aims to understand why some critically ill patients with severe abdominal infections develop dangerous fungal infections while others do not. Researchers will measure specific immune system markers in 100 patients after abdominal surgery to see if immune weakness predi…

This study aims to find the best way to calculate how much protein critically ill patients in the ICU need. Researchers are comparing two methods: one based on a patient's total body weight and another based on their lean muscle mass. They will look at 620 past and current patien…

This study aims to find out if starting continuous kidney dialysis (CRRT) earlier is better than starting it later for critically ill patients with sudden kidney failure. Researchers will analyze the medical records of 50,000 ICU patients from three Swedish hospitals to compare s…

This study aims to understand the biology of life-threatening conditions like sepsis and ARDS by observing 1,000 critically ill patients in the ICU. Researchers will collect blood and fluid samples to identify early biological signs that could lead to faster diagnosis and better …