CRITICAL ILLNESS

This study is testing whether a daily food supplement containing a specific pasteurized gut bacteria can help adults recover after being treated in an intensive care unit (ICU) for sepsis. Researchers want to see if the supplement is safe to take for 56 days and if it helps resto…

This study aims to see if adding a natural blood protein called albumin to standard intensive care improves survival for patients with surgical septic shock. About 304 adult patients in a surgical ICU will be randomly assigned to receive either standard care alone or standard car…

This study is testing if a computer system that gives doctors real-time feedback can help them better protect the lungs of critically ill patients on breathing machines. It will compare the new alert system to standard ICU care in over 200 patients with severe breathing problems.…

This study tests a new rehabilitation approach for patients with severe burns who are on a ventilator and sedated. It aims to see if stimulating the brain with techniques like magnetic pulses and virtual reality can help prevent the severe muscle wasting that often occurs. The go…

This study aims to find the best daily schedule for tube feeding in critically ill ICU patients. Researchers will compare continuous 24-hour feeding against shorter 20-hour and 18-hour feeding cycles that include fasting periods. They want to see if these shorter feeding windows …

This study aims to find out if giving sodium bicarbonate (a common medication) to critically ill ICU patients who have both acute kidney injury and metabolic acidosis (too much acid in the blood) can improve their chances of survival and recovery 90 days later. It will enroll 660…

This study tests a recovery navigation program for people aged 65+ who have survived a serious illness requiring intensive care. It provides personalized information and support to help patients and their doctors coordinate care after leaving the hospital. The goal is to improve …

This study tests whether using a special bedside imaging tool to guide breathing therapy helps critically ill adults get off mechanical ventilators faster. It will compare the new guided approach to standard therapy in 200 patients who have been on a ventilator for at least 21 da…

This study aims to find the best way to feed critically ill adults who are starting to recover from shock in the intensive care unit. It will compare feeding through a tube into the stomach (enteral) versus feeding directly into the bloodstream (parenteral). The main goal is to s…

This project tests whether using a standardized 1-hour checklist for treating sepsis can save more lives. It will compare outcomes for about 120 patients treated before and after the new protocol is introduced at a hospital's emergency and intensive care units. The goal is to get…

This large study aims to determine whether the specific setting used on breathing machines (ventilators) affects how quickly critically ill patients recover and survive. Researchers will test three different ventilator modes across multiple hospital intensive care units, involvin…

This study aims to find out if using a special device to measure a patient's exact calorie needs leads to better recovery for critically ill adults on breathing machines in the ICU. It compares this personalized nutrition plan to the standard formula-based feeding. The main goal …

This study tests whether using a brain monitor to guide sedation can reduce sedative medication in adults recovering from heart surgery in intensive care. About 144 participants will be randomly assigned to receive either standard sedation or sedation guided by the brain monitor.…

This study is testing whether a special ketone supplement drink is safe and practical to give to patients in the intensive care unit (ICU). Researchers want to see if this drink might help reduce or shorten episodes of delirium, a state of severe confusion and disorientation that…

This study aims to find the right dose and check the safety of montelukast, a drug used for asthma, in very premature, critically ill infants who are at high risk for developing a serious chronic lung condition called Bronchopulmonary Dysplasia (BPD). It will involve 28 infants w…

This study aims to see if ultrasound scans of the heart and blood vessels can predict which critically ill patients will experience a dangerous drop in blood pressure when they start a specific type of dialysis. Researchers will observe 80 adult patients in the intensive care uni…

This study aims to find better ways to detect kidney injury early in adults with sepsis, a life-threatening infection. Researchers will test if a special kidney ultrasound and a urine test can spot signs of kidney stress before standard blood tests show a problem. The goal is to …

This study aims to find a better way to guide fluid treatment for critically ill patients in the ICU. Researchers will test if a simple, non-invasive breath monitor can accurately predict which patients will benefit from receiving IV fluids. They will compare this breath test to …

This study is testing a new, personalized method to prevent pneumonia in critically ill patients on breathing machines in the ICU. Researchers will use a rapid test to analyze the bacteria in a patient's airway. If harmful bacteria are found, the patient receives a targeted inhal…

This study is testing whether giving extra protein shakes helps older adults recover better after a serious injury. Researchers will compare patients who get the shakes to those who receive standard nutrition advice. The goal is to see if the extra nutrition helps patients regain…

This study aims to see if a newer anesthesia drug (remimazolam) causes less post-surgery confusion (delirium) than the commonly used drug (midazolam) in older adults having heart valve surgery. Researchers will randomly assign 300 patients aged 65+ to receive one of the two drugs…

This study is testing a new device that sends mild electrical signals to the thigh muscles of people in the Intensive Care Unit (ICU). The goal is to see if using the device is safe and practical, and if it can help slow down the severe muscle weakness that often develops in crit…

This study is testing whether a virtual reality (VR) program can help adults who are leaving the intensive care unit (ICU). The goal is to see if VR sessions can reduce stress, ease pain, and help patients' bodies stay stable after moving to a regular hospital room, which might l…

This study aims to find the best way to feed patients through a tube after major abdominal surgery to reduce stomach problems like nausea and vomiting. Researchers will compare giving nutrition with extra fluids mixed in versus giving it straight, in 80 adults recovering in inten…

This study is testing if a sleep medication called lemborexant can help older patients in the intensive care unit (ICU) sleep better and reduce their risk of developing delirium, a serious state of confusion. It will involve 100 patients aged 65+ who are in the ICU after surgery.…

This study tests whether a digital mental health program helps people recovering from intensive care. 150 patients will either use a special app with coaching and support or receive standard follow-up care. Researchers will compare anxiety, depression, and PTSD symptoms after six…

This study aims to test whether a new scoring system (SOFA-2) can better predict which ICU patients with sepsis will survive. Researchers will collect routine medical data from 2,500 adult ICU patients across Turkey to compare the new score against the old one. The study will als…

This study aims to understand how emergency resuscitation rooms work in France and whether patients admitted directly to these rooms have different outcomes than those who wait in the regular emergency department first. Researchers will observe 1,200 critically ill adult patients…

This study aims to learn how the body's natural inflammation-resolving molecules change in adults with severe infections in the ICU. Researchers will measure these molecules in blood already taken for routine care from about 300 patients to see if their levels can help identify p…

This study aims to check how reliable a special camera is for measuring the smallest blood vessels under the tongue. Researchers will test the camera on both healthy volunteers and critically ill patients in the ICU to see if it gives consistent results. The goal is to validate t…

This study aims to understand how a common blood thinner (enoxaparin) works in critically ill patients with kidney failure, including those on dialysis. Researchers will measure blood levels of the drug in 60 ICU patients to see if current dosing guidelines are effective. The goa…

This study aims to understand if sudden kidney injury makes it harder for critically ill adults to be successfully taken off mechanical ventilators. Researchers will observe 85 patients in intensive care to see if kidney problems independently predict a more difficult or failed w…

This study aims to learn if tracking changes in a blood protein called prealbumin over time can help doctors better understand the health and recovery of critically ill patients in the Intensive Care Unit (ICU). Researchers will observe 500 adult ICU patients to see if specific p…

This study aims to find a better way to predict which critically ill patients on breathing machines will benefit from receiving extra IV fluids. Researchers will compare two measurement techniques taken during a simple leg-raising maneuver in 48 adult ICU patients. The goal is to…

This study aims to understand why some surgery patients in intensive care units don't survive. Researchers will examine hospital records from 2022-2024 for 1,000 patients who had surgery and were admitted to the ICU. By identifying patterns and risk factors, they hope to improve …

This study aims to understand how sepsis (a severe body-wide infection) changes the immune system's activity over time. Researchers will track 290 ICU patients—including 200 with sepsis, 50 critically ill without infection, and 40 healthy controls—for up to one year. By analyzing…

This study aims to understand how doctors in Sweden make difficult decisions about when to stop life-sustaining treatments for critically ill children in intensive care. Researchers will interview 30 specialist physicians about their experiences, attitudes, and challenges when fa…

This study aims to create the first international expert guidelines for using cough-assist machines on critically ill patients in intensive care. A panel of 20-30 global specialists will use a structured survey method to agree on the safest and most effective ways to use this the…

This study aims to better understand how the body recovers from serious burns and to identify early warning signs for dangerous infections like sepsis. Researchers will follow 80 adult patients with major burns, collecting small blood samples and reviewing their medical records d…

This international study aims to understand how continuous kidney dialysis (CRRT) is used in intensive care units worldwide. Researchers will observe 100,000 critically ill patients receiving this life-support treatment as part of their normal care. The goal is to document curren…

This study aims to learn what happens when patients become critically ill after a stem cell transplant. It will follow 4000 patients in China who are admitted to intensive care after their transplant. Researchers will collect detailed information on their health, treatments, and …

This study aims to validate a Turkish version of a tool that helps nurses and doctors assess breathing distress in critically ill patients who cannot communicate, such as those on ventilators or heavily sedated. Researchers will test the tool by comparing its scores against readi…

This study is testing whether an AI assistant can help doctors make better decisions for critically ill patients in intensive care. About 1000 adult ICU patients will be randomly assigned to receive either standard care or care where doctors can see AI suggestions. Researchers wi…

This study follows adults with serious burns to understand how their bodies recover and identify who might develop dangerous infections like sepsis. Researchers will collect small blood and tissue samples along with medical record information to look for patterns. The goal is to …