CRITICAL ILLNESS

This study looks at 1,150 critically ill adults in the ICU who are recovering from shock and needing less medication to support their blood pressure. Patients are randomly assigned to receive nutrition either through a feeding tube (enteral) or through a vein (parenteral). The go…

This study looks at whether giving extra human albumin (a natural blood protein) to people with surgical septic shock can help them survive. Septic shock is a life-threatening condition from severe infection. The trial will involve 304 adults in intensive care, comparing standard…

This study tests whether a real-time computer algorithm can help doctors set ventilators more safely for critically ill patients with lung injuries like ARDS. About 208 adults on breathing machines will be randomly assigned to receive either standard care or automated feedback ba…

This study tests whether giving sodium bicarbonate (a common substance that neutralizes acid) can reduce serious kidney problems in critically ill patients with both metabolic acidosis (too much acid in the blood) and acute kidney injury. About 660 adults in intensive care will r…

This study tests whether combining high-protein supplements, mobility-based physical therapy, and neuromuscular electric stimulation can help older adults (60+) recover muscle mass, strength, and function after a long ICU stay. About 78 participants will receive the combination t…

This study tests whether a new set of steps for treating sepsis can help patients get the right care faster. Researchers will compare outcomes for 120 adults treated before and after the new protocol is introduced. The goal is to give key treatments like antibiotics and fluids wi…

This study looks at 80 adults in the ICU after major abdominal surgery who need tube feeding. Half will get diluted formula (with extra fluids) and half undiluted. The goal is to see which approach causes fewer problems like vomiting, nausea, or diarrhea, helping doctors choose t…

This study tests a new way to prevent ventilator-associated pneumonia (VAP), a common and serious infection in ICU patients on breathing machines. Researchers will use a rapid test (about 4 hours) to find harmful bacteria in the airway, then give targeted inhaled antibiotics only…

This study looks at whether giving older adults extra protein drinks after a serious injury helps them regain muscle and get back to normal activities faster. Sixty participants will be split into two groups: one gets the extra protein, the other gets standard hospital nutrition.…

This early study tests whether a special ketone drink is safe and practical for ICU patients experiencing delirium—a state of sudden confusion and trouble thinking clearly. About 40 adults in the ICU will receive either the ketone drink or a placebo. The goal is to see if the dri…

This study tests whether using a special brain monitor (BIS) to guide sedation can reduce the amount of sedative medicine given to adults in the ICU after heart surgery. About 144 participants will be randomly assigned to either BIS-guided sedation or standard care. The goal is t…

This study compares two sedatives, remimazolam and midazolam, to see which one causes less confusion (delirium) after heart valve surgery in people aged 65 and older. Delirium is a common and serious problem after heart surgery, leading to longer hospital stays and worse outcomes…

This study tests whether a virtual reality (VR) program can help adults who have been in the intensive care unit (ICU) feel less stressed and in less pain after moving to a regular hospital room. 150 participants will either get standard care or extra VR sessions designed to rela…

This study tests whether a sleep medication called lemborexant can help older adults (65+) in the intensive care unit sleep better and reduce their risk of delirium, a common and serious confusion. One hundred patients will receive either the drug or a placebo for three nights. T…

This study tests a device that sends mild electrical pulses to the thigh muscles of people in the intensive care unit (ICU). The goal is to see if it is safe and practical to use, and whether it can help prevent muscle weakness that often happens during long ICU stays. About 50 a…

This study tests a new rehabilitation program for adults with severe burns who are on breathing machines. The program uses special sedation, brain stimulation, and virtual reality to try to prevent muscle loss. Thirty patients will be split into two groups: one gets standard care…

This study is for people aged 65 and older who have survived a serious illness in the ICU. It tests whether giving patients and their doctors personalized information helps them make better care decisions after leaving the hospital. The goal is to improve recovery and reduce avoi…

This study looks at whether giving tube-fed ICU patients a break from feeding (4 or 6 hours daily) helps them leave the ICU sooner and have fewer infections compared to continuous 24-hour feeding. About 150 critically ill adults on ventilators will be randomly assigned to one of …

This study looks at how acute kidney injury (AKI) impacts the success and safety of removing breathing tubes in critically ill adults in the ICU. Researchers will track 85 patients to see if AKI makes it harder to wean off mechanical ventilation. The goal is to understand if kidn…

This study tests whether giving ICU patients on breathing machines personalized nutrition based on their exact energy needs improves their quality of life three months later. About 356 adults will be randomly assigned to either standard formula-based nutrition or a tailored plan …

This study looks at whether adding a measure of gut function to a standard organ failure score can better predict the risk of death in critically ill adults in the intensive care unit (ICU). Researchers will compare the usual SOFA2 score with a new version that includes a gut hea…

This study follows 40 adults with serious burns to collect blood, tissue, and medical data. Researchers will look for patterns that could help predict who is at higher risk for infections like sepsis. The goal is to build computer models that improve burn care and outcomes.

This study will look back at the records of 1,000 surgery patients who were admitted to the intensive care unit (ICU) in Villavicencio, Colombia, between 2022 and 2024. The goal is to understand what factors are linked to death in the ICU for this specific group. By learning more…

This study observes 300 adults in the intensive care unit with severe infection or sepsis. Researchers will measure natural fat molecules called SPMs that help stop inflammation and promote healing. No extra treatments or blood draws are given—only routine samples are used. The g…

This study will test whether an artificial intelligence (AI) tool, similar to ChatGPT-5, can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults will be randomly assigned to either standard care or care where doctors …

This study tracks prealbumin, a protein in the blood, in 500 critically ill adults in the ICU. Researchers want to see if changes in prealbumin levels over time are linked to patient outcomes like death or infections. The goal is to find a simple way to monitor if nutritional sup…

This study looks at how a blood thinner called enoxaparin works in critically ill patients with kidney failure, some of whom are on a blood-filtering machine. Researchers will measure drug levels in 60 ICU adults to see if standard doses are enough. The goal is to find the right …

This study follows 80 adults with serious burns to collect blood, tissue, and medical record information. Researchers will look for patterns that could help predict who is at higher risk for infections like sepsis or other complications. The goal is to use this data to build comp…

This study interviews 30 specialist doctors in Swedish intensive care units to understand how they decide whether to withhold or stop life-sustaining treatment for critically ill children. The goal is to learn about the challenges and ethical dilemmas they face, without testing a…

This study will look at metabolic changes in 540 high-risk patients after heart surgery to find early warning signs of kidney injury. Researchers will use advanced techniques to identify markers that predict kidney problems, helping doctors intervene sooner. The goal is to improv…

This study looks at whether taking a daily capsule of a friendly gut bacteria (Akkermansia muciniphila) for 56 days can help adults recover after being treated in the ICU for sepsis. The main goals are to check if the supplement is safe and if it increases helpful gut bacteria. R…

This study looks at whether giving critically ill patients on breathing machines a lower amount of protein (similar to what healthy people need) helps them feel better and have a higher quality of life after leaving the hospital, compared to the standard higher protein dose. Abou…

This study will use ultrasound to measure how well the diaphragm moves in 35 critically ill patients. The goal is to compare different ultrasound methods to see which one gives the most consistent results, especially for the left side of the diaphragm. The findings may help docto…

This study will follow 4,000 patients who become critically ill after a stem cell transplant and need intensive care. Researchers will collect information on their health, treatments, and survival. The goal is to learn more about what happens to these patients to help improve car…

This study gathers data from up to 100,000 critically ill patients worldwide who receive continuous kidney dialysis (CRRT) in intensive care units. Researchers will analyze treatment patterns, patient outcomes, and differences between hospitals. The goal is to learn what works be…

This study will observe 1,200 adults admitted to resuscitation rooms in French hospitals. Researchers want to see if patients who go straight to the resuscitation room do better than those who are treated in the emergency department first. The goal is to understand how care is de…

This study looks at whether ultrasound tests done before dialysis can predict a sudden drop in blood pressure in critically ill patients. Researchers will monitor 80 adults in the intensive care unit who need a type of dialysis called continuous venovenous hemodiafiltration. The …

This study looks at whether measuring changes in exhaled carbon dioxide during a leg-raising maneuver can help predict if a critically ill patient on a breathing machine needs more fluids. Researchers will observe 68 adults in the intensive care unit and compare this simple, non-…

This study looks at 48 critically ill adults on ventilators to see which method better predicts if they need more fluids. Doctors will compare a standard blood pressure measure (pulse pressure variation) with an ultrasound-based heart measurement (LVOT VTI) during a leg-raising t…

This study brings together 30 healthcare experts from around the world to agree on the best ways to use a machine called Mechanical Insufflation-Exsufflation (MI-E) in intensive care units (ICUs). The machine helps clear mucus from the lungs of patients who cannot cough effective…

This study checks if a special camera can consistently measure tiny blood vessels under the tongue in healthy people and critically ill patients. Researchers will take multiple videos from each person to see if the results are repeatable. The goal is to validate this tool for fut…

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) works well for ICU patients who cannot describe their breathing trouble. Researchers will compare the scale's scores with carbon dioxide levels measured by a breathing monitor. 64 adults w…

This study looks at a new way to assess pain in intensive care unit (ICU) patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to better measure pain and adjust painkillers. The goal is to see if this approach reduc…

This study looks at how sepsis alters the RNA in white blood cells, which may explain why some patients have long-lasting immune problems. Researchers will follow 290 adults, including 200 with sepsis, 50 critically ill without infection, and 40 healthy controls. They will take b…

This study aims to see if a new scoring system called SOFA-2 can better predict which intensive care patients are at risk of dying within 30 days. Researchers will also measure how common sepsis and septic shock are in Turkish ICUs. About 2,500 adult patients will have their rout…

This study looks at whether a simple ultrasound of the kidneys and a urine test can help doctors detect kidney injury early in people with sepsis. Researchers will follow 130 adults with sepsis to see if these tests can predict kidney problems before they become serious. The goal…