CRITICAL ILLNESS

This study compares a proactive fluid management plan to standard care in 150 critically ill adults with acute kidney injury who need dialysis. The goal is to see if the plan helps achieve a neutral or negative daily fluid balance. The study focuses on feasibility and fluid balan…

This study compares three emergency breathing techniques used by paramedics for children in cardiac arrest, severe injury, or respiratory failure. About 3000 children will be enrolled to see which method leads to more days alive and out of the ICU within 30 days. The goal is to f…

This study tests a program called PIC-TRFS to help older adults (50+) and their families recover after a stay in the intensive care unit (ICU). The program includes health management, rehabilitation, social support, and care coordination through telehealth. Researchers want to se…

This study tests a program called PICU Up! that helps critically ill children start moving early during their stay in the pediatric intensive care unit (PICU). The program combines sleep support, delirium prevention, and less sedation to encourage safe mobility. Researchers want …

This study tests a special comfort care package for 88 intensive care unit (ICU) patients. The package includes extra nursing actions to reduce discomfort and stress. The goal is to see if it improves patients' comfort and vital signs, and may help prevent long-term issues like a…

This study tests a virtual reality program designed to stimulate thinking and provide emotional support for people in the ICU. About 93 adults with critical illness will use the program alongside standard care. Researchers will check if it improves comfort during the ICU stay and…

This study looks at whether giving nutrition through a feeding tube for only 12 hours a day is safe and works well for critically ill adults in the ICU. Researchers will compare this approach to the standard 24-hour feeding method. The goal is to see if the shorter schedule affec…

This study looks at how common muscle loss (sarcopenia) is in adults who need a breathing machine for more than 48 hours in the intensive care unit. Researchers will use simple tests like questionnaires, body composition scans, and ultrasound to measure muscle changes. The goal i…

This study follows 312 older adults who were in the ICU for critical illness to see how their physical activity during the hospital stay relates to their recovery. Researchers measure disability, physical function, and cognitive function at 3 and 12 months after leaving the ICU. …

This study looks at how much energy critically ill patients on breathing machines use during routine bed exercises. By measuring oxygen consumption with a special device in the ventilator, researchers hope to understand the physical demands of these exercises. The goal is to make…

This study looks at whether measuring the thickness of a thigh muscle with ultrasound can help assess frailty and nutrition risk in critically ill patients aged 65 and older. Researchers will take ultrasound measurements within 24 hours of ICU admission and again on days 3 and 7,…

This study follows 755 children who spent at least 3 days in a pediatric intensive care unit (PICU) for the first time. Researchers want to learn about the physical, mental, and thinking problems that can appear after a serious illness. By tracking their health and quality of lif…

This study looks at whether having a limited resuscitation order (like 'do not resuscitate') is linked to a higher chance of dying in the ICU. Researchers will analyze data from 1,500 critically ill patients, considering age, sex, illness severity, and frailty. The goal is to see…

This study collected information on 7,500 adults with COVID-19 who were treated in Swedish intensive care units (ICUs) during the first two months of the 2020 pandemic. Researchers looked at patient backgrounds, treatments, and survival rates to understand what factors increased …

This study follows 500 adults who were in the ICU with breathing failure—some had COVID-19, some did not. Researchers want to see if COVID-19 leads to different long-term mental and physical problems. The goal is to better understand and treat these lasting effects.

This study follows 567 ICU patients to see how their brain function changes over up to 12 years. Researchers use brain scans, spinal fluid, and brain donation to find out who develops dementia and why. The goal is to learn what causes long-term thinking and memory problems after …

This study looks at how a serious injury or burn that requires intensive care might affect thinking skills like memory and decision-making over time. Researchers are following 432 adults to see if long-term cognitive problems develop and how inflammation in the body might play a …

This study looks at 100 intensive care patients over 65 to see if there is a link between their nutritional status and frailty before they came to the hospital. Researchers will use simple scoring tools to measure nutrition and frailty, then track how these factors affect recover…

This study looks at whether doing computerized brain exercises in the morning or late afternoon works better for older adults who have been in the intensive care unit (ICU). Many ICU survivors have trouble thinking clearly and sleeping well. The goal is to see which time of day h…

This study looks at two different exercise programs for adults in the intensive care unit (ICU). One group uses a stationary bike, while the other group adds electrical muscle stimulation to the bike. Researchers want to see which approach helps patients move better and get stron…

This study looks at 100 people who spent at least 7 days in the ICU and had kidney injury there. Researchers measure kidney function, muscle loss, and bone health to understand long-term effects. No new treatments are given—only tests and observations.

This study tracks 500 adults admitted to the intensive care unit to see how their microbiome (the collection of bacteria in the body) changes during critical illness. Researchers will look at whether these changes are linked to survival, length of hospital stay, and long-term rec…

This study tests a new digital tool that helps hospitals share patient information more reliably when a person is transferred from one hospital to another. The goal is to reduce medical mistakes and improve safety. About 1,000 adults being transferred to a major hospital will tak…

This study aims to create and validate an Italian version of the ICU Mobility Scale, a tool that measures how well patients in intensive care can move. Researchers will enroll 100 adults to test the scale's accuracy and reliability. The goal is to help doctors and nurses better a…

This study looks at whether the type of breathing machine setting used in the ICU affects how well patients recover. Over 4,700 critically ill adults on ventilators will take part across multiple hospitals. Researchers will switch the entire ICU's ventilator mode every two months…

This study looks at whether giving extra amino acids to critically ill patients on breathing machines can improve how their bodies build protein. Researchers will measure protein balance using special tracers in 30 adults. The goal is to understand how nutrition can better suppor…

This study surveys 100 pediatric intensive care doctors in Sweden to understand their attitudes and experiences when deciding whether to start, continue, or stop life-sustaining treatments for critically ill children. The goal is to gather insights, not to test a new treatment. N…