CRITICAL ILLNESS

This study tests a program called PICU Up! that helps critically ill children in the intensive care unit start moving earlier than usual. The program combines sleep support, delirium prevention, and less sedation to encourage safe mobility. Researchers will see if this approach r…

This study tests three ways emergency responders help children breathe: a bag-mask, a throat tube, or a breathing tube. It includes 3,000 children under 18 with cardiac arrest, severe injury, or breathing failure. The goal is to see which method leads to more days alive and out o…

This study tests whether a diet rich in fermented foods (like yogurt and kimchi) is tolerable and can improve quality of life for survivors of critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation. The study involves 40 partic…

This study tests a non-immersive virtual reality program (RGS-ICU) for ICU patients. The program includes daily 20-minute sessions of cognitive exercises and psychological support alongside standard care. Researchers will enroll 93 adults in ICUs for respiratory failure, cardioge…

This study tests a comfort care bundle for ICU patients. The bundle includes physical, emotional, and environmental support from nurses. 88 patients in Turkey will either get standard care or the comfort bundle. The goal is to see if it improves comfort and vital signs.

This study looks at whether measuring lactate in stool can help doctors predict how well critically ill patients with low blood flow will respond to treatment. About 40 adults in the ICU will provide a stool sample within 24 hours of admission. Researchers will check if high stoo…

This study examines whether a routine blood test called Mean Platelet Volume (MPV), taken when a cancer patient is admitted to the intensive care unit (ICU), can help predict their risk of dying. Researchers will review the medical records of 425 adult cancer patients who stayed …

This study looks at whether giving parents a special journal to write in while their child is in the pediatric intensive care unit (PICU) can lower their stress and help them feel more involved. About 75 parents of children in the PICU will use the journal and answer surveys abou…

This study looks at whether the type of breathing machine setting used in the intensive care unit (ICU) affects how well patients recover. Researchers will switch the ventilator mode used across entire ICUs every two months and track outcomes like days alive without a breathing m…

This study follows 755 children who were in the pediatric intensive care unit (PICU) to learn how they recover physically, mentally, and emotionally. Researchers will track quality of life, fatigue, and sleep over time. The goal is to understand what helps children and families h…

This study compares a 12-hour feeding schedule to the usual 24-hour schedule in 20 critically ill adults in the ICU. Researchers want to see if the shorter schedule is safe and works well, looking at feeding tolerance, blood sugar control, and sleep. The goal is to gather knowled…

This study collected data from 7,500 adults admitted to Swedish ICUs with COVID-19 during the first two years of the pandemic. Researchers looked at patient characteristics, treatments, and survival rates at 30 days and one year. The goal is to understand the disease's impact and…

This study looks at how much energy critically ill patients on ventilators use during routine passive physiotherapy. By measuring oxygen consumption with a special device in the breathing tube, researchers hope to understand the physical demands of these exercises. The goal is to…

This study looks at the link between nutritional status and frailty in elderly intensive care patients. Researchers will measure nutrition using two scoring systems and compare them to frailty levels. The goal is to understand how these factors affect recovery and to pave the way…

This study follows 567 ICU survivors to see how their brain function changes over up to 12 years. Researchers will use brain scans, spinal fluid tests, and brain donations to find out why some people develop dementia after critical illness. The goal is to learn the causes of post…

This study looks at whether measuring the thickness of the front thigh muscle with ultrasound can help identify frailty and malnutrition in critically ill patients over 65. Researchers will assess 80 patients within 24 hours of ICU admission and again on days 3 and 7. The goal is…

This study compares a proactive, prescription-based fluid management plan to usual care in 150 critically ill patients who need kidney replacement therapy (dialysis). The goal is to see if a standardized daily prescription can help achieve a neutral or negative fluid balance, pre…

This study surveys pediatric intensive care doctors in Sweden to understand their attitudes about decisions to withdraw or withhold life-sustaining treatments in critically ill children. About 100 physicians will complete a questionnaire. The goal is to gather insights, not to te…

This study looks at whether doing brain-training exercises in the morning or the afternoon helps older adults (60+) recover thinking skills after a stay in the intensive care unit. Forty participants will either train in the morning, in the late afternoon/evening, or receive usua…

This study follows 312 older adults who survived a critical illness to see how much they moved during their ICU stay. Researchers want to learn if more activity leads to less disability, better mobility, and clearer thinking 3 to 12 months later. The goal is to find ways to impro…

This study tests a new digital platform that helps doctors and nurses share important patient information when a person is moved from one hospital to another. About 1,000 adults being transferred to a major hospital will take part. The goal is to see if better information sharing…

This study tests a telehealth program called PIC-TRFS for older adults (50+) who spent at least 48 hours in the ICU and are at risk for long-term problems. The program includes rehabilitation, health management, social support, and care coordination delivered over 6 months. Resea…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study looks at 100 people who spent at least a week in the ICU and had kidney injury. Researchers will measure kidney function, muscle loss, and bone health to understand long-term effects. The goal is to improve follow-up care for ICU survivors.

This study looks at how often muscle loss (sarcopenia) happens in adults who need a breathing machine in the ICU for more than 48 hours. Researchers will measure muscle health using simple tests and ultrasound. The goal is to understand how common this problem is and how it chang…

This study follows 500 ICU patients to compare long-term mental and physical health between those with and without COVID-19. Researchers use surveys and tests to measure quality of life, thinking skills, and emotional well-being. The goal is to identify specific problems caused b…

This study follows 500 adults admitted to the intensive care unit to see how their gut bacteria (microbiome) change during critical illness. Researchers will track deaths and recovery up to one year later. The goal is to understand whether these bacterial shifts affect short- and…

This study looks at whether giving extra amino acids to critically ill patients on breathing machines helps their bodies build more protein. Researchers will measure protein balance using special tracers. The goal is to understand how nutrition affects recovery in the ICU. About …

This study is creating and testing an Italian version of the ICU Mobility Scale, a tool that measures how well patients in intensive care can move. Researchers will enroll 100 adults in Italian ICUs to see if the scale is accurate and reliable when used by different healthcare wo…

This study compares two rehabilitation approaches for patients in intensive care: bicycle exercise alone versus bicycle exercise plus electrical muscle stimulation. Twenty-four adults will participate for five days. Researchers will measure changes in mobility, muscle strength, a…

This study analyzes data from 1500 ICU patients to see if having a resuscitation order other than 'full code' is linked to a higher risk of death. Researchers will use statistical models to account for factors like age, sex, and frailty. The goal is to understand if the order its…