Personalized antibiotic spray aims to stop deadly pneumonia in ICU patients
NCT ID NCT07463339
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tests whether rapid analysis of the airway microbiome can guide inhaled antibiotics to prevent ventilator-associated pneumonia (VAP) in ICU patients. 70 adults on ventilators will receive either microbiome-guided inhaled antibiotics or a placebo for up to 5 days. The goal is to see if this personalized prevention strategy is feasible and safe.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
inhaled antibiotics (tobramycin, aztreonam, vancomycin)
What this could lead to
If successful, this approach could reduce pneumonia rates in ventilated ICU patients by targeting antibiotics to those most likely to benefit.
What could go wrong
This is a small pilot study (70 people) testing feasibility, not yet proven to prevent pneumonia. Inhaled antibiotics may cause side effects or not work as hoped.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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