ICU fluid overload: could cutting salt save lives?
NCT ID NCT07189091
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 41 times
Summary
This study tests whether using lower-salt intravenous fluids in ICU patients reduces the number of days they need life support like ventilators or dialysis. Researchers will compare a salt-free glucose solution for medication dilution and a low-salt maintenance fluid against the usual higher-salt fluids. The trial enrolls 640 critically ill adults expected to stay in the ICU for several days.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Antwerp University Hopsital (UZA)
NOT_YET_RECRUITINGEdegem, 2650, Belgium
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ZAS Cadix
RECRUITINGAntwerp, 2030, Belgium
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ZAS Middelheim
NOT_YET_RECRUITINGAntwerp, 2020, Belgium
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ZAS Paflijn
NOT_YET_RECRUITINGMerksem, 2170, Belgium
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lower-salt intravenous fluids (glucose 5% and NaCl 0.3% in glucose 3.3%)
What this could lead to
If it works, this could lead to a simple change in ICU fluid practices that helps patients recover faster and spend fewer days on life support.
What could go wrong
This is a single-center trial, so results may not apply everywhere. The benefit may be small or none, and lower-salt fluids could cause electrolyte imbalances in some patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.