Tuberculosis

This study tested a 9-month treatment plan for people with multidrug-resistant tuberculosis (MDR-TB) in Gabon. The goal was to see if this shorter regimen could cure the disease with fewer side effects. 23 patients aged 15 and older took part, and the study tracked how many were …

This study tested an experimental vaccine called H56:IC31 in 831 adults who had just finished treatment for tuberculosis (TB). The goal was to see if the vaccine could lower the chance of TB coming back. Participants were randomly assigned to get either the vaccine or a placebo, …

This early-stage trial tested two experimental vaccines (BNT164a1 and BNT164b1) against tuberculosis in 120 healthy adults who had never been exposed to TB or received the BCG vaccine. The main goal was to check safety and find the best dose. Participants received three doses of …

This study compares two ways of making sure people with tuberculosis (TB) take their medicine correctly: traditional in-person observation by a healthcare worker versus electronic observation using live video or recorded videos on a computer or phone. The trial involves 216 TB pa…

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This study tested the drug delamanid in 37 children with multidrug-resistant tuberculosis (MDR-TB), some of whom also had HIV. The goal was to see how the drug works in the body, check for side effects, and find the right dose. Children took delamanid along with their regular TB …

This study tested an experimental drug called GSK3036656 in combination with other tuberculosis medications in 127 adults with newly diagnosed, drug-sensitive pulmonary TB. Participants received one of several two-drug combinations or standard care for 14 days, then switched to s…

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This trial tested a new 4-month combination of three drugs (OPC-167832, delamanid, and bedaquiline) against the standard 6-month treatment for drug-susceptible pulmonary tuberculosis. 122 adults with newly diagnosed TB took part. The goal was to see if the shorter regimen is safe…

This study tested a single dose of the drug pretomanid in 32 children with rifampicin-resistant tuberculosis (TB). The goal was to see how the drug moves through the body and whether it is safe when added to their regular TB treatment. The children were monitored for 48 hours aft…

This study looked at how to best dose two medicines, rifapentine and isoniazid, for children aged 0-12 with latent (hidden) tuberculosis infection. The goal was to find a dose that works as well as in adults to prevent the infection from turning into active TB. The study included…

This study tested two different doses of the antibiotic linezolid, combined with three other drugs (bedaquiline, delamanid, and clofazimine), in 138 people with drug-resistant pulmonary tuberculosis. The goal was to see which dose worked better at clearing the infection and was e…

This study tested whether taking a higher dose of the drug rifampin for 2 months is as safe and effective as the standard 4-month dose for treating latent tuberculosis (TB) infection. Over 1,300 adults and children aged 10 and older with latent TB were randomly assigned to receiv…

This study tested a once-daily combination of three HIV drugs (tenofovir, emtricitabine, and efavirenz) in 70 adults with both HIV and tuberculosis. Participants had not taken HIV medication before and had been on TB treatment for less than three months. The goal was to see if th…

This study looked at whether adding metformin, a diabetes drug, to standard tuberculosis (TB) treatment is safe and tolerable for people also living with HIV. 112 adults with TB and HIV took either standard TB medicines alone or with metformin for 11 weeks. Researchers monitored …

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This study tested whether a stronger tuberculosis (TB) treatment could save more lives in people with HIV and very weak immune systems. Over 1,300 hospitalized patients received either the standard TB drugs or an intensified version with higher doses of two key medicines, plus a …

This study tested a therapeutic vaccine called RUTI in 41 adults with active pulmonary tuberculosis. Participants received either the vaccine or a placebo alongside their regular antibiotic treatment. The goal was to see if the vaccine could boost the immune system to kill bacter…

This study tested a therapeutic vaccine called RUTI in 140 people with tuberculosis (TB), including drug-resistant forms. Participants received either one dose of RUTI or a placebo alongside their standard TB medications. The goal was to see if the vaccine could help clear the TB…

This study tested two different antibiotics—clarithromycin or moxifloxacin—alongside standard drugs to treat a rare lung infection caused by M. xenopi bacteria. Researchers tracked whether patients' sputum samples became bacteria-free after 6 months. The goal was to find the more…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested a new HIV medication (Biktarvy) taken twice daily in 122 adults who also have drug-sensitive tuberculosis (TB) and are on standard TB treatment. The goal was to see if the new pill can control HIV just as well as the current standard treatment. The study measure…

This study tested whether giving HIV-infected infants with severe pneumonia early treatment for cytomegalovirus (CMV) and tuberculosis (TB) could help them survive. Over 500 babies aged 1 month to 1 year were randomly assigned to receive either standard care or additional drugs f…

This phase IIb trial tested an experimental antibiotic called delpazolid, added to a standard three-drug regimen (bedaquiline, delamanid, moxifloxacin), in 76 adults with newly diagnosed, drug-sensitive pulmonary tuberculosis. The main goals were to check safety and how the drug …

This completed trial tested whether zinc and selenium supplements could boost the immune system of tuberculosis patients. Researchers gave 90 adults with pulmonary TB either fortified cookies or a supplement called Myrin P Fort, and measured changes in body measurements, blood co…

This study tested a combination of three drugs—bedaquiline, pretomanid, and linezolid—in 109 people with extensively drug-resistant TB (XDR-TB) or multi-drug resistant TB (MDR-TB) that didn't respond to other treatments. Participants took the drugs for 6 to 9 months. The goal was…

This study looked at how safe and tolerable the drug bedaquiline is for children and teens with rifampin-resistant tuberculosis, including those also living with HIV. Fifty-four participants received bedaquiline along with their regular TB treatment for 24 weeks. Researchers meas…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a new skin test called C-TST to find latent (hidden) tuberculosis infections in 300 adults in Indonesia who were close contacts of TB patients. Participants received both the skin test and a standard blood test (IGRA) to see how well the new test worked. The goa…

This study tested a new skin test called EC to see if it can accurately diagnose tuberculosis (TB) infection in adults aged 65 and older. Researchers compared EC with a standard TB skin test (TB-PPD) and a blood test (T-SPOT) in 780 participants, including TB patients and healthy…

This study looked at whether measuring TB DNA in fluid from around the lungs (pleural fluid) can quickly and accurately diagnose tuberculosis. Researchers tested fluid from 329 adults with lung fluid buildup. The goal was to see if this DNA test works better than standard tests, …

This study tested a new rapid blood test called SeroSelectTB to see if it can diagnose active tuberculosis (TB) faster than current methods. Over 9,000 adults in South Africa, Tanzania, and Ethiopia who were unwell and suspected of having TB or pneumonia took part. The goal is to…

This study evaluated a new stool-based test (qPCR) to diagnose tuberculosis (TB) in children under 8 and people living with HIV. Researchers in Mozambique, Eswatini, and Uganda tested nearly 2,000 participants to see if the stool test could improve TB detection rates compared to …

This study looked at whether a bronchoscopy (a thin, flexible tube with a camera) can help diagnose tuberculosis in the airways of people whose usual sputum tests came back negative. 63 adults with suspected lung TB took part. The goal was to catch the disease earlier and more ac…

This study aimed to create a quick, simple test to diagnose tuberculous meningitis (TBM) in children. TBM is a severe form of TB that affects the brain and is hard to detect with current methods, especially in places with limited resources. Researchers tested 51 inflammatory mark…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study involved 603 hospitalized children aged 2 to 59 months with severe acute malnutrition in Uganda and Zambia. Researchers tested various diagnostic methods—including chest X-rays, lab cultures, and symptom checks—to develop a score that helps doctors decide whether a chi…

This study tested whether adding a rapid tuberculosis (TB) test to standard care for children hospitalized with severe pneumonia could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB countries were enrolled. The test, called Xpert MTB/RIF Ultra, was done on …

This completed study tested several tuberculosis (TB) diagnostic tools in over 14,000 people across seven countries. The goal was to find tests that are accurate enough to use in local clinics, without needing special lab equipment. Researchers looked at a simple blood test for C…

This study tested two new tools for diagnosing tuberculosis (TB): a software that analyzes chest X-rays (CAD4TB) and a blood test that measures C-reactive protein (CRP). Researchers enrolled 1,400 adults with TB symptoms in Lesotho and South Africa. They compared these tests to s…

This study tested two ways to find tuberculosis (TB) in communities in Lesotho and South Africa. One method used a chest X-ray analyzed by computer software (CAD4TB). The other added a finger-prick blood test (CRP) for people whose X-ray results were unclear. Both methods were fo…

This study tested whether a smartwatch app called Hyfe can accurately count how often people cough. Researchers compared the app's cough counts to manual counts from audio recordings in 31 adults with various cough-related conditions. The goal is to see if the smartwatch can be a…

This study tested whether adjusting the dose of a tuberculosis (TB) prevention drug based on a person's genetic makeup could improve treatment. Researchers enrolled 78 people and used a quick genetic test to guide the dose of isoniazid. The goal was to see if this personalized ap…

This study tested whether taking the tuberculosis prevention drug isoniazid for 36 months instead of the usual 6 months could better prevent TB in adults with HIV. Nearly 2,000 participants in Botswana were randomly assigned to either short or long treatment. The goal was to see …

This completed study tested a new public health pack to find and prevent tuberculosis (TB) early in people living with someone who has TB. Over 7,400 participants in Thailand were involved. The pack included active screening, treatment for active TB, and preventive therapy for th…

This study tested whether giving a full 3-month supply of TB preventive medicine directly in the community helps more people finish their treatment compared to standard clinic visits. Researchers enrolled 301 adults in South Africa who were at risk for TB, including those with HI…

This study tested whether a supervised exercise program can improve heart and lung function and quality of life in people with lasting lung damage from tuberculosis. 60 participants were split into an exercise group and a control group. The goal was to see if physical training he…

This study tested whether a probiotic called Bifidobacterium breve PRL2020 could reduce stomach issues like diarrhea in 121 children aged 3-12 who were taking amoxicillin antibiotics. The children took the probiotic alongside their antibiotic treatment. The goal was to see if it …

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This study examined whether the standard dose of isoniazid, a key tuberculosis drug, is right for all adults. Researchers measured drug levels in 112 patients to see if some were getting too much or too little. The goal was to understand how individual differences in drug process…

This study tested a new drug called MK-7762 in 119 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo in single or multiple doses. The goal was to check for side effects and measure drug levels in the blood, not t…

This study looked at how a new drug called OPC-167832 is processed by the liver when taken with other common medicines. Twenty-four healthy adults took part to see if certain drugs slow down or speed up the breakdown of OPC-167832. The goal was to gather safety information, not t…

This study looked at how immune cells in the lungs respond to tuberculosis (TB) proteins in 17 adults—some with latent TB (no symptoms) and some never exposed. Researchers used a thin tube to deliver the protein directly into the lung and collected cells to measure immune reactio…

This study tested whether a virtual reality (VR) room called VR CAVE can teach community health nursing skills as effectively as a physical mock home. 150 final-year nursing students practiced home visits for patients with COPD and tuberculosis in both settings. Results showed bo…

This study tested whether bringing a portable TB test (Gene Xpert) directly to people in crowded communities helps find and treat more TB cases than the usual method of waiting for people to visit a clinic. Over 3,500 adults in South Africa took part. The goal was to see if this …

This completed study monitored over 14,000 hospital patients for multidrug-resistant organisms (MDROs) by taking rectal swabs and tracking bloodstream infections. Researchers analyzed the bacteria's genetics and how they resist antibiotics, aiming to understand how resistance eme…

This study surveyed 418 respiratory doctors in the Asia-Pacific region to understand how they diagnose tuberculous pleuritis, a type of TB that affects the lining around the lungs. The goal was to see which tests are used, how available they are, and how doctors decide to start t…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This study tested a simple way to get more HIV patients in South Africa the medicine that prevents tuberculosis (TB). Instead of doctors having to choose to prescribe it, the new approach made TB prevention the standard option, requiring doctors to actively opt out if they didn't…

This study explored why some people with latent (inactive) tuberculosis (TB) are more likely to develop active TB. Researchers looked at 626 people in South India to see how malnutrition, diabetes, and worm infections might change the body's response to TB. Participants gave bloo…

This early-phase study tested a single dose of the antibiotic omadacycline (Nuzyra) in 23 children aged 8 to 17 who were hospitalized with bacterial infections. Researchers measured how the drug moved through the body and checked for side effects. The goal was to gather safety an…

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This completed study looked for tuberculosis (TB) cases in 5,694 people who had already finished a COVID-19 vaccine trial. Participants had physical exams, blood tests, and tongue swabs to find TB and study related biomarkers. The goal was to understand how common TB is in this g…

This study tested a new imaging technique using a radioactive tracer called 11C-trimethoprim to see how it spreads in the bodies of 16 adults with suspected bacterial infections. Participants had PET/CT scans to track the tracer over time. The goal was to learn how the tracer beh…

This study looked at why some people infected with TB bacteria get sick while others don't. Researchers in India studied 120 household contacts of TB patients, comparing those who were malnourished or had parasitic worms. They provided food and deworming medication to see how the…

This study tested a new method to evaluate tuberculosis (TB) drugs and vaccines in 20 healthy adults. Researchers used a harmless version of the TB bacteria (BCG) to see how the body fights it and how treatments work. The goal was to create a faster, safer way to test new TB trea…

This study used a special PET scan to track how the tuberculosis drug pretomanid moves through the body. Ten people with or without TB received a tiny radioactive version of the drug, and the scanner measured where it went. The goal was to see how much drug reaches infected areas…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study looked at how HIV and tuberculosis (TB) medications are processed in the bodies of pregnant women and their newborns. Researchers measured drug levels in blood and vaginal fluids to see if dosing needs to change during pregnancy and after birth. Over 1,500 women took p…

This study looked at how the tuberculosis drug pretomanid is processed in people with different levels of kidney function. Twelve participants received a single 200 mg dose, and researchers compared drug levels in those with kidney impairment to healthy matched controls. The goal…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can accurately count coughs in people with lung conditions like COPD, asthma, or COVID-19. Researchers compared the app's cough counts to patients' own reports and expert listening. The goal was to improve …

This study looked at whether providing nutritional support to people being treated for tuberculosis (TB) improves their outcomes. Researchers compared TB patients in Benin, who receive food baskets and meals, to similar patients in Togo, who do not get systematic nutritional supp…

This study looked at how HIV and tuberculosis (TB) medications are processed in the bodies of pregnant women and new mothers. Researchers measured drug levels in the blood of 205 women during pregnancy and after delivery to see if standard doses are effective. The goal was to gat…

This completed study looked at 141 people being treated for tuberculosis (TB) to see if intestinal parasites or poor nutrition made their recovery harder. Researchers checked stool samples for parasites and measured weight gain and treatment success. Some participants received nu…

This study tested a new way to find people exposed to tuberculosis (TB) in Cali, Colombia. Instead of relying only on in-person visits, researchers used a mobile phone chatbot and a simple oral (mouth) test that people could do at home. The goal was to see if this approach was pr…

This study tested special wearable pumps (elastomeric pumps) to give antibiotics through a drip to hospital patients. Nine adults with bacterial infections took part to see if the pumps are safe, easy to use, and could save time and money compared to traditional methods. The goal…

This completed Phase 3 study measured how high doses of the tuberculosis drugs rifapentine and moxifloxacin move through the body in 53 adults with TB. Participants gave multiple blood samples to track drug levels. The goal was to understand the best doses to kill TB bacteria whi…

This study looked at 350 patients who had surgery (decortication) to treat severe lung infections called empyema, including cases caused by tuberculosis and drug-resistant bacteria. The goal was to understand the types of germs causing these infections and how they affect recover…

This study tested a new AI system (Janus Pro 1B-CXR) designed to help radiologists interpret chest X-rays. The AI was developed using public data and evaluated in 296 patients with suspected chest diseases. Researchers compared report quality, reading time, and agreement between …

This study tested whether people with active tuberculosis can use a smartphone app to send videos of themselves taking their medication, instead of going to a clinic for direct observation. Researchers enrolled 51 patients in Switzerland and measured how many agreed to use the ap…