Epilepsy

This study tests whether cenobamate, an experimental anti-epileptic drug, can safely reduce primary generalized tonic-clonic (PGTC) seizures when added to a person's usual seizure medications. Adults and adolescents aged 12 and older with PGTC seizures are randomly assigned to re…

This study looked at the long-term safety of the drug cenobamate when added to existing treatment for people with primary generalized tonic-clonic seizures. A total of 147 participants who completed an earlier study took cenobamate for up to 52 weeks. Researchers tracked side eff…

This study tested a brain implant (RNS System) that delivers targeted electrical stimulation to the thalamus to reduce seizures in people aged 12 and older with drug-resistant idiopathic generalized epilepsy. The goal was to see if the device is safe and effective at cutting down…

This study tested how a pill called 2-deoxy-D-glucose (2DG) is absorbed and processed in 9 adults with epilepsy. 2DG is similar to sugar but can't be used for energy, so it may 'clog' the brain's fuel supply during a seizure and stop it. Researchers measured drug levels in the bl…

This study tested a drug called cenobamate in 519 adults with partial onset seizures (focal seizures). Participants took cenobamate or a placebo alongside their usual seizure medications. The goal was to see if cenobamate could safely reduce seizure frequency. Results showed a si…

This Phase 3 trial tested a drug called XEN1101 (azetukalner) in 380 adults with focal-onset seizures that were not well-controlled by other medications. Participants took either XEN1101 or a placebo alongside their usual seizure drugs. The study measured whether XEN1101 reduced …

This pilot study tested a non-invasive brain stimulation technique called tDCS in 17 people with drug-resistant epilepsy. The stimulation was personalized using prior brain recordings to target the exact area causing seizures. The goal was to see if this approach could safely red…

This study looked at the long-term safety of brivaracetam, a drug added to existing epilepsy treatments for people with uncontrolled focal seizures. 141 Chinese adults who completed a prior trial took brivaracetam for up to a year or more. Researchers tracked side effects and sei…

This study tested whether taking coenzyme Q10, a natural supplement, can help reduce seizures in adults with drug-resistant epilepsy. Thirty-nine participants took either coenzyme Q10 or a placebo daily for 12 weeks alongside their usual seizure medications. Researchers tracked s…

This study tested whether adding lacosamide (Vimpat) to a low dose of levetiracetam works better than a high dose of levetiracetam alone for controlling seizures. Fifty-six adults with epilepsy who had seizures on low-dose levetiracetam took part. The main goal was to see how man…

This study followed 345 people with epilepsy who already had a brain implant called the RNS System. The goal was to see how safe and effective the device is over 5 years in everyday medical practice. Researchers measured side effects, seizure reduction, and how well doctors could…

This study tested the drug allopurinol in 8 children and adults with adenylosuccinate lyase deficiency (ADSL), a rare genetic disorder that can cause autism, seizures, and developmental delays. Researchers measured changes in thinking, daily skills, and seizure control over 12 mo…

This study tested whether training community health workers to manage childhood epilepsy can help the many children in Africa who go untreated. Over 1,600 children in Nigeria received either care from trained health workers or standard doctor care. The goal was to see if the comm…

This study tested the drug levetiracetam in 137 elderly patients (age 60+) with epilepsy. Researchers measured how many stayed seizure-free, how long until the next seizure, and how well patients tolerated the medication. The goal was to see if this drug is effective and safe for…

This completed phase II study tested a combination of two drugs—tadalafil (Cialis) and pembrolizumab (Keytruda)—in 7 adults with advanced head and neck cancer that had spread or come back. The goal was to see if the combination was safe and could help control the disease. Because…

This study tested an investigational drug called RAP-219 in 30 adults with refractory focal epilepsy—seizures that don't respond well to current treatments. Participants took RAP-219 tablets to see if it safely reduces seizure frequency. The trial is now complete, and results wil…

This pilot trial tested whether taking oral zinc every day for 6 months is safe and doable for people with GNAO1 disorders, a rare genetic condition that causes movement problems, seizures, and developmental delays. 13 participants aged 6 months to 30 years took zinc acetate. The…

This study tested a new drug called OMT-28 in 28 people with primary mitochondrial disease, a condition that affects how cells produce energy. Participants took the drug once daily for 6 months, and researchers measured safety, blood markers of inflammation, and symptoms like fat…

This phase 3 trial tested whether giving two anti-seizure drugs together (levetiracetam plus clonazepam) works better than clonazepam alone for stopping prolonged seizures in the ambulance or at home. 203 adults with generalized tonic-clonic status epilepticus took part. The main…

This study tested the drug levetiracetam as the first treatment for seizures in 18 full-term newborns who had brain injury from lack of oxygen at birth. The goal was to find the right dose and check if it is safe and effective at reducing seizure activity on brain recordings. The…

This study looked at the safety of vatiquinone in 101 people with inherited mitochondrial disease who had already taken the drug in a previous study or treatment plan. The goal was to track any side effects until the drug became commercially available or the program ended. Partic…

This study looked at 200 women with eclampsia (a serious condition causing seizures during pregnancy) to see if giving magnesium sulphate into a vein (IV) or into a muscle (IM) works better to stop seizures from coming back. Women were randomly assigned to one of two treatment gr…

This study tested the long-term safety of a drug called LP352 (bexicaserin) in 41 people aged 12 to 65 with severe epilepsy syndromes like Dravet or Lennox-Gastaut. Participants took the drug three times daily for up to 52 weeks. The main goal was to check for side effects, while…

This study looked at the long-term safety of a drug called fenfluramine (ZX008) for people with rare seizure disorders like Dravet syndrome and Lennox-Gastaut syndrome. A total of 412 participants who had completed earlier studies took the drug and were monitored for side effects…

This study tested a smartphone-based system to help children with epilepsy take their anti-seizure medication as prescribed. The system included educational information, automated reminders, and personalized feedback. The goal was to improve medication adherence, reduce seizures,…

This study looked at the long-term safety and tolerability of the drug brivaracetam in 84 children and young adults (ages 2 to 26) with childhood or juvenile absence epilepsy. Participants who had already been in a previous study were given brivaracetam and monitored for side eff…

This study looked at the long-term safety of brivaracetam, a seizure medication, when added to existing treatment in 257 children with epilepsy. The main goal was to track side effects over time. Researchers also measured how well the drug controlled seizures. The results help do…

This Phase 3 trial tested whether adding brivaracetam (Briviact) to existing epilepsy medications could safely reduce partial seizures in adults aged 16 to 80. About 449 participants who still had frequent seizures despite taking 1 or 2 other drugs were randomly assigned to recei…

This phase 2 trial tested triheptanoin oil in 20 people with GLUT1 deficiency syndrome, a rare genetic condition that prevents glucose from properly fueling the brain. The goal was to see if this special oil could reduce the number of seizures and abnormal movement episodes. Part…

This study tested whether a single dose of naloxone, given right after a generalized tonic-clonic seizure, can help people with epilepsy breathe better and avoid sudden death. Researchers enrolled 485 adults with drug-resistant epilepsy who were already in the hospital for monito…

This study reviewed medical records of 66 adults in intensive care who received the anesthetic gas isoflurane for severe seizures that didn't respond to standard treatments. Researchers wanted to see how often isoflurane stopped the seizures or led to full awakening. The goal is …

This completed study compared two oral seizure medications, brivaracetam and levetiracetam, as first treatments in 102 children aged 1 month to 14 years with newly diagnosed epilepsy. Researchers looked at how well each drug stopped seizures and what side effects occurred. The go…

This study tested a drug called NBI-827104 in 24 children with a rare epilepsy that causes constant brain spikes during sleep. The drug is a calcium channel blocker given daily for 13 weeks. The main goal was to see if it reduces abnormal brain activity measured by EEG.

This study tested whether a special type of MRI that measures sodium levels in the brain can help locate the exact area causing seizures in people with drug-resistant epilepsy. 78 patients who were already scheduled for epilepsy surgery received a sodium MRI scan. Researchers com…

This study tested whether a powerful genetic test called exome sequencing can find the cause of severe epilepsy in children when standard tests fail. Researchers studied 15 children with epileptic encephalopathy of unknown genetic origin. The goal was to see if this test could im…

This study tested a system called Nelli that uses cameras and artificial intelligence to detect seizures in children without needing the usual brain-wave sensors. The system was compared to standard video-EEG monitoring in 150 children aged 6 to 21 who were already being monitore…

This completed study tested a high-density EEG (using up to 256 electrodes) to map brain areas involved in movement, sensation, language, and emotion. It included 122 people with epilepsy, brain tumors, or healthy controls. The goal was to see if this technique can more precisely…

This study tested a smartphone app that guides children through deep breathing (hyperventilation) and records their face and sounds to detect absence seizures. 65 children with and without seizure history participated. The app's accuracy was compared to standard EEG monitoring. T…

This study tested whether a simple eye-tracking system can identify children with childhood absence epilepsy and related thinking problems. Researchers compared eye movement recordings from 60 participants (kids with epilepsy and healthy controls) to standard tests. The goal is t…

This study tested a simplified brain wave test (point-of-care EEG) on 200 children with confusion or ongoing seizures in the pediatric emergency department. The quick EEG uses just five stickers on the scalp. Researchers compared it to the standard full EEG to see if it can relia…

This study tested whether giving the seizure drug levetiracetam right away can prevent seizures in people who had a brain bleed (hemorrhagic stroke). About 50 adults with a recent brain bleed received either the drug or a placebo. The goal was to see if the drug could reduce seiz…

This study tested whether giving midazolam in the mouth (buccal) works as well as a shot in the thigh (intramuscular) to stop seizures in children aged 6 months to 12 years. 90 children were randomly assigned to one of the two methods. The main goal was to see if seizures stopped…

This study tested whether remote occupational therapy could help children and teens (ages 7-18) with Dravet syndrome improve their daily living skills and satisfaction. 14 families participated in online sessions where a therapist coached the child or parent. The goal was to see …

This study tested a wearable device that uses magnetic pulses to stimulate the brain in 10 children with a rare epilepsy called CSWS, where abnormal brain activity occurs during sleep. The device was applied for just 10 minutes to the area causing the seizures. Researchers measur…

This study looked at whether adding Epidiolex (a CBD-based medicine) to usual treatment can improve seizures, behavior, sleep, and quality of life in people aged 1 to 65 with tuberous sclerosis complex (TSC). 79 participants took the drug and were monitored for changes in symptom…

This study tested a special light helmet (called tPBM) on 6 autistic children aged 4–12 who also had abnormal brain activity or epilepsy. The helmet delivered near-infrared light to specific brain areas twice a week for 10 weeks. The goal was to see if it could safely improve foc…

This small study tested whether a single dose of Staccato Alprazolam (a fast-acting form of a common anxiety drug) could reduce seizure-related brain activity in people with photosensitive epilepsy. Five adults with a history of light-triggered brain responses took the drug or a …

This study tested whether coloring mandalas (circular patterns) at home can improve quality of life for adults with epilepsy. 70 participants were split into two groups: one colored mandalas three times a week for two months, the other did not. Researchers measured changes in qua…

This study tested whether daily 20-minute warm baths could safely reduce seizures in 8 children (ages 6 months to 6 years) with CDKL5 deficiency, a rare genetic disorder causing hard-to-control seizures. The treatment was added to their usual medications for 12 weeks. The goal wa…

This study looked at using a heat-based technique called thermocoagulation in 100 children aged 1.5 to 17 years with focal epilepsy that doesn't respond to medication. During a brain monitoring procedure, doctors applied small heat lesions to the area where seizures start, aiming…

This pilot study tested a device called NaviFUS that uses focused ultrasound to stimulate the brain in 12 adults with drug-resistant epilepsy. The goal was to see if it is safe and can reduce seizure frequency. Participants kept seizure diaries and reported any side effects over …

This study tested a device that sends a very mild electrical current to the brain (tDCS) to see if it can safely reduce seizures in people with epilepsy that doesn't respond to medication. 127 participants aged 9 and older received either real or fake (sham) stimulation for 10 se…

This study tested whether foot reflexology massage could help people with epilepsy. 70 patients received reflexology sessions, and researchers measured changes in seizure frequency, fatigue, stress, and sleep quality. The goal was to see if this gentle foot massage could improve …

This study tested whether a 6-week exercise program could improve memory in 71 adults with idiopathic generalized epilepsy. Participants either exercised or did nothing extra, and researchers measured memory and brain changes. The goal was to see if exercise helps memory and if t…

This study tested whether a structured education program could improve the quality of life for adults with epilepsy. 80 participants either received individual and group educational sessions or standard care. The goal was to see if learning more about the disease and its manageme…

This study tested whether mindfulness meditation training can improve quality of life and brain activity in people with refractory epilepsy (seizures that don't respond to drugs). 37 participants (patients and healthy volunteers) took part in meditation sessions. The main goal wa…

This pilot study tested whether prolonged exposure teletherapy can help adults with psychogenic nonepileptic seizures (PNES) and PTSD. Forty-four participants received either the teletherapy or standard education about PNES. The goal was to see if the therapy reduces seizure freq…

This study looked at whether a 12-week, at-home walking program using a step counter is practical for adults with epilepsy. Twenty-six participants used a Garmin watch to track steps and attended virtual sessions. The goal was to see if people could stick with their step targets …

This study tested whether stimulating a deep brain area (the central thalamus) could help people with temporal lobe epilepsy stay conscious during seizures. Five participants received implanted electrodes that delivered stimulation when a seizure was detected. The goal was not to…

This study tested whether baby SPA (hydrotherapy) and massage can reduce colic symptoms in infants. 72 babies aged 40 days to 4 months with diagnosed colic were enrolled. The intervention involved weekly SPA and massage sessions for four weeks, with symptoms tracked using a colic…

This small pilot study tested whether intermittent fasting (eating only during an 8-hour window each day) could reduce seizures in 22 adults with epilepsy that doesn't respond to medication. Some participants also took medium-chain triglycerides (MCTs), a type of fat. The goal wa…

This study tested whether virtual reality (VR) exposure therapy could reduce anxiety in people with epilepsy who worry about their seizures. Fourteen participants were split into two groups: one received VR therapy using 360-degree videos of social or public settings, and the oth…

This study tested whether a neck massage program, based on a caring model, could help people with epilepsy feel more confident managing their condition, reduce their symptoms, and lighten the burden on their caregivers. 96 adults with epilepsy and their caregivers took part. The …

This study looks at how the epilepsy drug levetiracetam is processed in pregnant women and how much reaches the baby. Researchers will collect blood and saliva samples throughout pregnancy and at delivery, plus cord blood and amniotic fluid. The goal is to create a model that cou…

This study tested whether using role-playing exercises to teach epilepsy care improves nursing students' communication skills, confidence, and knowledge compared to standard lectures. 135 third-year nursing students in China took part. The goal is to find more effective ways to p…

This completed study followed 316 people with idiopathic generalized epilepsy, including those newly diagnosed and those already known to respond or not respond to treatment. Researchers collected data from seizure diaries, fitness trackers, quality-of-life surveys, and cognitive…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This study looked at brain activity in 37 children with epilepsy using two devices: EEG (which records electrical brain signals) and NIRS (which measures blood oxygen levels in the brain). The goal was to better understand what happens in the brain during seizures and between sei…

This study looked at how Doose syndrome, a rare form of epilepsy, affects children's ability to learn and develop. Researchers followed 9 children and asked their parents about the disease's impact on school and daily life. The goal was to better understand the link between seizu…

This study looked at 10 children aged 3 to 14 with absence epilepsy, a type of seizure that causes brief lapses in awareness. Researchers used two noninvasive tools—near-infrared spectroscopy (NIRS) and electroencephalography (EEG)—to record brain activity and blood flow changes …

This study uses a non-invasive light-based technique called near-infrared spectroscopy (NIRS) combined with EEG to measure blood flow changes in the brains of children aged 3 to 6 years during infantile epilepsy spasms. The goal is to better understand what happens in the brain b…

This study looked at how people with temporal lobe epilepsy (TLE) remember spatial information, like directions, compared to healthy volunteers. Researchers tested memory right after a navigation task and again six weeks later. They wanted to see if people with TLE forget spatial…

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This completed Stanford study looked at whether video-recorded facial expressions and speech patterns can reflect a person's mood. Eleven adults with depression or epilepsy had electrodes temporarily placed in their brains to record brain activity. Researchers stimulated certain …

This study surveyed 151 adults who had epilepsy surgery at least two years ago to see how their quality of life and daily experiences changed. Researchers used several questionnaires to measure satisfaction, anxiety, depression, and personal changes. The goal is to understand the…

This study looked at whether a special walking test (3D gait analysis) can help identify movement problems in people with rare genetic diseases like Tuberous Sclerosis and STXBP1. About 40 participants aged 6 and older who could walk without help took part. The goal was to see if…

This study looked at how weak electric currents applied to the scalp can change brain activity in people with drug-resistant focal epilepsy. Researchers used special brain recordings to measure spikes and connections between brain regions during and right after stimulation. The g…

This study uses computer models to simulate brain activity in 20 epilepsy patients. The goal is to better interpret EEG and MEG signals to locate where seizures start. Researchers hope this will lead to a tool that helps surgeons remove the right brain tissue to stop seizures.

Infantile spasms are a type of seizure that can harm development if not treated quickly, but they are often mistaken for normal movements. This study tested a computer program that learns from parent-recorded videos to tell the difference between these seizures and harmless movem…

This study looked at 60 epilepsy patients who already had electrodes implanted in their brains. Researchers recorded brain activity at the same time using scalp sensors and the implants. The goal was to see how well non-invasive methods can detect the same brain signals as the im…

This study tested whether special microelectrodes can record 'fast ripples'—tiny brain signals that may help locate where seizures start. 54 adults with drug-resistant epilepsy who needed brain monitoring for surgery planning took part. The goal was to see if these electrodes cou…

This completed study surveyed 90 adults with epilepsy to explore the stigma, misconceptions, and barriers they face in education, employment, and social settings. Participants filled out questionnaires designed by the research team. The goal is to identify unmet needs and inform …

This study looked at how epilepsy affects the quality of life of 90 adults. Researchers used a standard questionnaire called QOLIE-31 during routine clinic visits. The goal was to understand which parts of daily life are most impacted by epilepsy. This was an observational study,…

This completed study looked at whether healthcare professionals in Saudi Arabia received and understood safety materials about the epilepsy drug Depakine (sodium valproate). Researchers surveyed 455 doctors, pharmacists, and gynecologists to measure their knowledge and behavior. …

This study looked at how electrical brain stimulation influences approach and avoidance behavior in 13 patients with deep brain stimulators for OCD, depression, or epilepsy. Participants played a computer task with their stimulator turned on and off. The goal was to understand br…

This study looked at how fever changes seizure patterns in people with CDKL5 deficiency disorder, a rare genetic condition that causes hard-to-control seizures. Researchers surveyed parents of 131 affected individuals to collect information on fever history and seizure frequency.…

This study tested a new type of brain sensor that is cheaper and easier to use than current ones. Researchers compared it to standard sensors in 4 people with epilepsy to see if it could detect abnormal brain activity. The goal is to make advanced brain imaging more widely availa…

This study looked at how blood pressure and heart rate change in the hour after an epileptic seizure. Researchers measured these vital signs at several time points in 1,100 people with epilepsy. The goal was to better understand the body's response right after a seizure, which ma…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This study tested a new portable, wireless EEG monitor called NeuroBell on 17 full-term newborns who already needed brain monitoring. The goal was to see if the new device records brain signals as well as standard EEG machines. The study did not treat any condition, but aimed to …

This study tested a new version of NPT 2042 soft-gelatin capsules to see if it is absorbed better than the original version. Eight healthy adults took single doses of both formulations. The goal was to measure how the drug moves through the body, not to treat any disease.

This study tested a medicine called cenobamate in 26 children with partial-onset seizures. The goal was to see how the drug moves through the body and if it is safe. The study did not aim to cure or control seizures long-term, but to gather important information for future use.

This study tested a new way to analyze brain wave recordings (EEG) to see if it can tell people with epilepsy from healthy people. Researchers looked at very fast brain waves called high-frequency oscillations. 80 adults took part. The goal was to see if this method could become …

This study tested different settings of vagus nerve stimulation (VNS) in 16 adults with epilepsy who were already scheduled for VNS device surgery. Researchers measured how stimulation affected heart rate and throat muscle contractions to find ways to reduce side effects. The goa…

This study used 30 epilepsy patients who already had electrodes implanted in their brains for surgery planning. Researchers applied a mild electrical stimulation called tDCS and measured exactly how the current spread. The goal was to improve computer models that predict where th…

This study tested a mobile app called OASES that guides nurses and clinical officers in rural Uganda through emergency care steps for severe diarrhea, breathing problems, and seizures. About 15 clinicians used the app during simulated patient scenarios to see if it helped them fo…

This study tested whether adding Nutri-score labels (A to E ratings) to restaurant menus, alongside calorie information, helps people pick healthier meals. Over 600 adults in Liverpool ordered from a menu with either calorie info alone or calorie info plus Nutri-score labels. Res…

This study looked at how the brain chemical dopamine behaves in people with idiopathic generalized epilepsy compared to healthy volunteers. Researchers measured yawning and blinking after giving a low dose of apomorphine, a drug that mimics dopamine. The goal was to understand br…

This study tested a computer system called Nelli that uses video cameras and machine learning to automatically detect seizures. Researchers compared Nelli's detection to the standard method (video-EEG) in 33 epilepsy patients. The goal was to see how accurately the AI could spot …

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills, behavior, and daily function. The goal is to understand which children are at higher risk for conditions like cerebral palsy or intellect…

This study looked for early signs of epilepsy in children with autism and tested whether a structured exercise program could influence those signs. Fifty children aged 10-15 with autism, epilepsy, or both took part. Researchers analyzed blood, sleep, brain activity, and thinking …

This completed study looked at 72 newborns who had seizures shortly after birth. Researchers measured inflammation markers in their blood and tracked whether they later developed epilepsy. The goal was to understand if inflammation plays a role in epilepsy risk after neonatal sei…

This study aims to create an algorithm that detects epileptic seizures by continuously analyzing the heart's electrical activity (ECG). Researchers will use data from 40 epilepsy patients who had seizures recorded during long-term video-EEG monitoring. The goal is to see how accu…

This completed study enrolled over 1,000 people with drug-resistant partial epilepsy to see if severe drops in oxygen levels during seizures can predict later sudden unexpected death (SUDEP). Participants had their seizures recorded with video-EEG monitoring. The goal is to bette…

This completed study looked at whether the sedative ketamine can cause seizure-like brain activity in people without epilepsy. Researchers monitored 300 adults undergoing a routine stomach scope procedure using EEG brain scans. They compared ketamine to two other common sedatives…

This study tested whether a gentle electrical current applied to the scalp can improve working memory in 9 adults with epilepsy who already had brain electrodes implanted. The stimulation targeted frontal and parietal brain areas at different frequencies. Researchers measured cha…

This study aimed to create a database of heart rate and movement data from 13 adults with drug-resistant epilepsy. Participants wore a connected patch that recorded heart rate and motion, while also undergoing video-EEG monitoring to confirm when seizures occurred. The goal was t…

This study looked at whether combining EEG and fMRI scans can better pinpoint the exact brain area causing seizures in people with drug-resistant focal epilepsy. 102 participants who were already being evaluated for surgery had this extra scan. The goal was to see if the combined…

This completed study looked at 753 children with epilepsy to better understand how their bodies process antiepileptic drugs. Researchers measured drug levels in the blood and considered factors like age, weight, and other medications. The goal is to create models that help doctor…

This study tested four different ways to deliver anxiety and depression screening questionnaires to adults with epilepsy before their clinic visits. Researchers wanted to see which method led to the highest completion rates. The goal is to make mental health screening easier and …

This study tested a mobile app designed to educate parents and caregivers of children with epilepsy. The app provides information about the condition, tracks symptoms, and helps manage appointments. Researchers wanted to see if using the app for one month would increase parents' …

This study looked at whether tiny molecules in the blood, called microRNAs, can identify epilepsy patients who have dangerous drops in oxygen during seizures. Researchers compared 50 drug-resistant epilepsy patients undergoing video-EEG monitoring, splitting them into those who h…

This first-in-human study tested a new soft neural probe in 5 adults already scheduled for brain surgery to remove a tumor or epileptic tissue. The probe was inserted into the part of the brain being removed to see if it could be placed safely and record electrical signals. Parti…

This study tested two versions of the seizure medication stiripentol (Diacomit®) in 24 healthy adults: a capsule and a liquid suspension. The goal was to see if the liquid form is absorbed by the body in a similar way to the capsule. If so, it could provide a more convenient opti…

This study looked at how the brain's temporal lobe processes speech in 48 people with epilepsy who were already undergoing brain monitoring for their condition. Participants listened to sounds with varying pitch and timing while their brain activity was recorded. The goal was to …

This study looked at whether the ADHD Rating Scale-IV can detect changes in attention problems in children with epilepsy. Researchers followed 173 children aged 6 to 15 who had both epilepsy and ADHD. They compared scores over 12 to 16 weeks in treated versus untreated children t…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce abnormal brain activity and improve language in children with benign epilepsy with centrotemporal spikes (BECTS). Twenty-two children receive…

This study looks at how frontal lobe epilepsy changes cooperative behavior and decision-making. Researchers will have 30 patients and 30 healthy volunteers play a classic economic game called the Prisoner's Dilemma while their brain activity is measured with fMRI. The goal is to …

This study involved 47 people with drug-resistant epilepsy and healthy volunteers. Researchers recorded brain activity simultaneously using implanted electrodes (intracranial EEG) and non-invasive scans (MEG or fMRI). The goal was to better identify seizure-causing brain areas an…