Could a drug combo stop seizures faster? new trial tests the idea
NCT ID NCT01150331
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial tested whether giving two anti-seizure drugs together (levetiracetam plus clonazepam) works better than clonazepam alone for stopping prolonged seizures in the ambulance or at home. 203 adults with generalized tonic-clonic status epilepticus took part. The main goal was to see if seizures stopped within 15 minutes after the injection.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- levetiracetam and clonazepam (anti-seizure drugs)
- What this could lead to
- If it works, this could point toward a more effective first-line treatment for stopping prolonged seizures before reaching the hospital.
- What could go wrong
- This trial is completed but results are not yet widely confirmed. Adding levetiracetam may not improve outcomes over clonazepam alone, and both drugs carry risks like drowsiness or breathing problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Necker Hospital
Paris, 75015, France