Indiana University

This study looks at how much caregiver involvement helps teens aged 12-17 with mild alcohol problems reduce their drinking. Researchers will compare three approaches: no caregiver involvement, a single live session with a caregiver, or an online self-paced program for caregivers.…

This study tests whether a supplement called SAMe can improve liver function and lower the risk of death in people with alcoholic cirrhosis. About 196 adults with mild to moderate cirrhosis will receive either SAMe or a placebo for a period of time. The goal is to see if SAMe hel…

This study looks at whether treating depression with an online therapy program can help the body use insulin better in people with HIV who are on HIV medication. Researchers will compare a 9-session online cognitive behavioral therapy program with depression education materials. …

This study tests a new way to help people with epilepsy in Kenya stick to their medication and stay in care. It uses a shared-care model where trained non-specialists work alongside an epilepsy medical records system to track patients and send reminders. About 650 people aged 12 …

This study tests a daily cream called tapinarof, originally used for psoriasis, in 6 adults with palmoplantar keratoderma—a condition causing thick, rough skin on the palms and soles. Researchers want to see if the cream safely improves skin appearance and symptoms. Participants …

This study tests whether ondansetron, a drug typically used to prevent nausea in cancer patients, can help people with atrial fibrillation (Afib). Afib is a common heart rhythm problem that raises the risk of stroke and other serious issues. The researchers will give 80 people sc…

This study tests whether a virtual reality (VR) experience can help people in early recovery from alcohol use disorder drink less and stay sober longer. Researchers will compare a VR group to a control group, measuring abstinence, future thinking, and decision-making. The trial a…

This study tests whether guanfacine, a drug used for high blood pressure, can help 200 adults with moderate to severe alcohol use disorder drink less. Participants take the drug or a placebo for 12 weeks and report their drinking, stress, and cravings through a smartphone app and…

This study tests whether delivering healthy food and teaching kitchen skills at home can improve blood pressure and nutrition in adults who have high blood pressure and struggle to afford food. About 200 participants will be split into two groups: one gets the food and skills pro…

This study looks at whether taking ketone supplements can help older adults (ages 60-85) avoid the negative effects of a high-salt diet, like higher blood pressure and kidney problems. Researchers will give 30 healthy volunteers a high-salt diet with or without ketone supplements…

This study looks at whether taking ketone supplements can help prevent the negative health effects of eating too much salt, like high blood pressure and kidney damage. Researchers will give 35 young adults a high-salt diet with or without ketone supplements and measure changes in…

This study looks at whether a special heart CT scan can find hidden artery plaque in prostate cancer patients who are on or about to start hormone therapy. About 100 participants will either get the scan or usual care. The goal is to see if the scan helps doctors prescribe better…

This study tests whether giving surfactant (a lung medicine) through a thin tube instead of a breathing tube helps premature babies with respiratory distress survive. About 1,500 babies weighing 1.5 to 4.4 pounds will receive this less invasive treatment in African hospitals that…

This study tests a special clinic that helps people with advanced liver disease after they leave the hospital. The goal is to see if this clinic can reduce the number of patients who need to be readmitted within 30 days and improve their quality of life. About 1,000 adults with c…

This study tests whether taking two drugs (zanzalintinib and oral etoposide) after high-dose chemotherapy can help prevent cancer from growing back in people with relapsed germ cell tumors. About 38 adults whose cancer has not been cured by standard treatments will participate. T…

This study tests whether a virtual reality (VR) experience can help people who are in early recovery from stimulant use disorder stay sober longer and reduce their drug use. Researchers will compare a VR group to a control group to see if the VR tool improves abstinence, future t…

This study tests whether simple digital questionnaires can help primary care doctors identify new cases of Alzheimer's disease and related dementias during annual wellness visits. About 3,150 adults aged 65 and older without prior memory loss diagnosis will participate. The goal …

This study tests whether a wearable breath sensor can detect high or low blood sugar in teens with type 1 diabetes. Participants wear the device for 72 hours and provide breath samples while checking blood sugar with a finger prick. The goal is to see if breath chemicals can repl…

This study looks at whether a urine test can quickly detect pancreatitis after pancreas removal surgery. About 50 adults having elective pancreatectomy will provide urine samples before, during, and after surgery. The results will be compared with standard blood tests to see if t…

This study checks if a smartphone app called VisionApp can accurately measure ghosting (double vision) in people with mild nearsightedness or astigmatism. About 12 participants will compare their own ratings of ghosting with the app's measurements. The goal is to see if the app i…

This study is testing whether a non-invasive eye-tracking device can help predict autism in young children (ages 2-6) born to mothers with HIV in Kenya. Researchers will compare eye-tracking results with standard clinical autism evaluations in 850 children. The goal is to find a …

This study tests whether a simple, non-invasive eye-tracking device can help identify autism risk in children aged 12 to 48 months. Researchers will compare eye-tracking scores with standard clinical diagnoses. The goal is to see if this quick, remote tool can aid in early detect…

This study is testing a small, handheld device that doctors can use at the bedside to quickly check brain and nerve function. The goal is to see if this portable tool can give the same useful information as standard tests like MRI or EEG, but much faster. About 30 adults with neu…

This study tests a new imaging system that uses light to monitor how breast cancer responds to chemotherapy before surgery. Researchers want to see if it can accurately predict when the cancer is completely gone. The study involves 15 women with specific types of breast cancer. I…

This study looks at whether a bedside ultrasound (POCUS) can reliably diagnose acute chest syndrome in children and young adults with sickle cell disease. Researchers will compare ultrasound results to standard chest X-rays. The goal is to see if this faster, radiation-free tool …

This study tests whether a smartphone app (AWARE) can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing breathing sounds. Researchers will enroll 800 people aged 8-70, including healthy volunteers and those with airway conditions. The…

This study looks at whether combining the MIND diet (a mix of Mediterranean and DASH diets) with aerobic exercise can help prevent memory and thinking problems in Black adults aged 35-75 who have high blood pressure. Participants will be randomly assigned to either receive food d…

This study tests a new way to give radiation for prostate cancer that combines external beams with a short internal implant. The goal is to see if this approach causes fewer urinary and bowel side effects. About 31 men with higher-risk prostate cancer will take part.

This study looks at whether adding pelvic floor physical therapy before standard radiation treatment can help reduce pain and sexual problems in women with cervical, vaginal, vulvar, uterine, or anal cancer. About 20 participants will receive education on using a vaginal dilator …

This study compares a Mediterranean diet to a Western diet to see which one better reduces fatigue in people with autoimmune hepatitis. About 48 adults will try both diets in a random order. Researchers will measure changes in fatigue and quality of life using a standard question…

This study tests whether a virtual, home-based exercise program can reduce depression and anxiety in family caregivers of people with Alzheimer's disease. About 25 caregivers will be randomly assigned to either a 3-month virtual group exercise program or a wait-list group. The pr…

This study tests whether spiritual care sessions can improve spiritual wellbeing, reduce anxiety and depression, and increase satisfaction with care for people with stage IV lung or gastrointestinal cancer. About 36 adults will be randomly assigned to receive either spiritual car…

This study looks at whether doing high-intensity walking training more often helps people who had a stroke more than six months ago improve their walking ability. Forty adults will be assigned to either frequent or less frequent training sessions, plus a home walking program. The…

This study looks at whether a 16-week virtual exercise program (a mix of aerobic and strength training) can improve fitness, muscle strength, and quality of life in people with indolent (slow-growing) metastatic breast cancer. The study enrolls 100 adults whose cancer has not wor…

This study tests a new kind of talk therapy called Smart Virtual Reminiscence (SVR) for older adults with mild cognitive impairment or early dementia. The therapy uses artificial intelligence to guide conversations about past memories, aiming to reduce troubling symptoms like agi…

This study tests a coaching program for Black patients with long-term muscle or joint pain and depression. The program helps patients learn about non-drug pain treatments and talk to their doctors about them. Researchers want to see if this approach reduces pain interference and …

This study looks at whether acupuncture can reduce pain in people with sickle cell disease. Researchers will also use brain scans and other tests to understand how acupuncture works. The study involves 120 participants aged 14 to 80 who have chronic pain or recent pain crises.

This study looks at whether a silk-based wound dressing helps people heal better after double-incision mastectomy for female-to-male gender affirmation surgery. About 50 adults will be enrolled, and researchers will compare silk dressings to standard ones. The goal is to see if s…

This study tests a gel called PuraGel (RADA16) to see if it helps the nose heal faster and with less pain after skull base surgery. About 30 adults having this surgery will get the gel on one side of their nose, and the other side will be the comparison. Doctors will check healin…

This study tests whether an internet-based therapy program (Good Days Ahead) can reduce depression and slow memory decline in older adults who survived an ICU stay. About 300 people aged 50 and older with depressive symptoms will participate. The goal is to see if treating depres…

This study tests a specially adapted version of cognitive behavioral therapy for insomnia (Teen CBT-I) in 28 adolescents aged 13-18 with chronic insomnia. Teens are randomly assigned to receive 4-6 virtual therapy sessions or join a waitlist. The goal is to see if Teen CBT-I impr…

This study looks at whether different foot-strengthening methods—like wearing minimalist shoes, doing foot exercises, or using a device called ToePro—can make feet stronger and improve balance and walking in adults aged 45 to 85. Over 8 weeks, participants will try one of these a…

This study compares two pain medications, sufentanil and methadone, to see which provides better pain control after head and neck reconstruction surgery. About 128 adults having this surgery will be randomly assigned to receive one of the two drugs. Researchers will track pain le…

This study tests whether a telephone counseling program helps people with advanced gastrointestinal cancer manage fatigue and helps their family caregivers feel less burdened. About 488 patient-caregiver pairs will take part, receiving either the counseling program or a standard …

This study tests a program called the Green Activity Program, designed for people aged 45+ with mild memory problems. The program encourages enjoyable nature activities like walking, gardening, or outdoor yoga, with a partner. Researchers want to see if the program is easy to do …

This small pilot study tests whether using a hand-held vibration device for just 3 minutes each day can safely reduce nerve pain and numbness in the hands caused by chemotherapy. Sixteen adults who finished chemotherapy at least 60 days ago will try the therapy at home. The main …

This study tests whether SYSTANE PRO eye drops work as well as MIEBO for people with dry eye disease. About 260 adults will use one of the two drops for one month. The goal is to see which one better eases dry eye symptoms.

This study is testing whether a natural supplement called 5HTP can improve breathing and reduce anxiety in children aged 8-18 with mild to moderate asthma and allergies. About 20 participants will be randomly assigned to take either 5HTP or a placebo, then switch groups later. Th…

This pilot study tests whether a non-invasive brain stimulation technique called TMS can reduce rumination—repetitive negative thinking—in adults with treatment-resistant depression. Twenty participants will receive 20 TMS sessions targeting a specific brain region and undergo br…

This study tests whether virtual reality brain games can help older adults who survived a stay in the intensive care unit (ICU) and had delirium. About 100 people aged 50 and older will use a VR headset at home to play memory and attention games for 4 weeks. The goal is to see if…

This study tests a short, virtual therapy for pregnant women and new mothers with PTSD. About 90 participants will either receive the therapy or standard care. The goal is to see if the therapy is practical and well-liked, and to measure its effect on PTSD and depression symptoms…

This study tests whether daily leg heat therapy can improve walking ability and quality of life in people with peripheral artery disease (PAD). About 106 adults over 50 with PAD will use special heated trousers for 90 minutes a day at home for 12 weeks. Researchers will measure c…

This study compares two standard pain relief methods—morphine given via a spinal injection and methadone given through an IV—for men undergoing testicular cancer surgery. The goal is to see which approach provides better pain control and reduces the need for additional opioids. A…

This study is tracking how well a procedure called G-POEM helps people with gastroparesis, a condition where the stomach doesn't empty properly. Researchers will follow 75 adults who are already scheduled for the procedure to see if their symptoms like nausea, bloating, and feeli…

This study tests a mobile app called Brain CareNotes to see if it can reduce stress for unpaid caregivers of people with Alzheimer's disease. 184 caregivers will use the app for 12 months to track symptoms and get support. The goal is to ease caregiver burden and improve behavior…

This study tests a low-temperature radiofrequency device to reshape cartilage during nose surgery. About 20 adults having functional or cosmetic septorhinoplasty will take part. Researchers will measure how well the device works, patient breathing scores, and cosmetic results. Th…

This study looks at whether Kinesio tape can ease muscle soreness in the upper arm after a tough workout. Researchers will measure pain, movement, and strength in 36 healthy adults aged 18 to 30. The goal is to see if the tape helps reduce discomfort and improve recovery.

This study tests whether daily leg heat therapy can improve exercise ability in people with heart failure with preserved ejection fraction (HFpEF). Participants will wear heated trousers for 90 minutes a day at home. Researchers will measure changes in treadmill exercise time and…

This study looks at tooth wear and tooth sensitivity in 2,500 adults across five U.S. locations. Researchers will use dental scans and questionnaires to find out how common these problems are and what factors—like diet or brushing habits—might cause them. Participants must be 18 …

This study looks at how older adults with and without vision problems step over obstacles of different heights and colors. Researchers want to understand how vision and eye movements affect walking to help prevent falls. About 200 adults who can walk on their own will take part.

This study uses a new technique called temporal interference (TI) to stimulate deep brain areas without surgery or affecting the surface of the brain. Researchers will measure brain activity with MRI scans in 30 healthy adults aged 18 to 50. The goal is to understand how deep bra…

This study looks at whether training your breathing muscles can help you think better when you have to breathe against resistance. Researchers will measure diaphragm thickness and cognitive performance in 32 healthy adults aged 18-40. The goal is to understand the connection betw…

This study looks at how Rhopressa eye drops affect the eye's drainage tissue in people with high eye pressure or glaucoma. About 50 adults will receive either Rhopressa or artificial tears for two weeks. Researchers will use special cameras to see if the drainage tissue changes s…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 will get a brain scan and then take part in 10 weekly virtual sessions where they report their cannabis use and take dru…

This study looks at whether a program called ADAPT, where nurses and social workers call people with heart failure weekly to help manage symptoms and improve well-being, can work outside of a research setting. The program aims to reduce hospital visits and improve quality of life…

This study tests whether taking fish oil (DHA and EPA) before soccer heading can reduce brain injury markers. 208 soccer players aged 18-30 will take supplements or a placebo, then undergo blood tests, brain scans, and heading drills. The goal is to understand if omega-3s help pr…

This study explores whether a gentle electrical current applied to the scalp (tDCS) can help healthy adults learn a virtual reality game called Beat Saber more quickly. Researchers will compare game performance before and after stimulation in 52 participants aged 18-45. This is a…

This study follows 150 people who recently had a stroke to see how their walking ability recovers over time. Researchers will measure walking speed and distance, and test if specific therapies can improve recovery. The goal is to create better rules for predicting and enhancing r…

This study looks at how often doctors use a portable ultrasound device (POCUS) during checkups at free clinics and street medicine sites in Indianapolis. Researchers will track what they find and whether the ultrasound changes the patient's treatment plan. About 50 adults will ta…

This study looks at how well a portable device called TEG 6s measures blood clotting in children. About 125 healthy kids having planned surgery will give a small blood sample at the start of their operation. The results will be compared to known normal ranges to see if the device…

This study is collecting information from people with chronic pancreatitis who receive a nerve block procedure (EUS-CPN) to manage their pain. Researchers will track pain levels and pain medication use for 24 weeks after the procedure. The goal is to better understand how well th…

This study looks at how brain tumors (gliomas) may change over time and whether advanced MRI and PET scans can predict those changes. About 20 adults with suspected or confirmed glioma will have imaging before surgery, and researchers will compare the scans with tumor tissue. The…

This study looks at how the brain's sensory and motor areas work together to keep hand movements precise. Researchers will test 300 healthy right-handed adults aged 18-45 using touchscreen tasks. The goal is to understand sensorimotor learning, which may one day help improve reha…

This study is testing a simple scoring system to predict whether people with metastatic cancer will survive at least 30 days after starting palliative radiation therapy. The score uses lab results, emergency room visits, and cancer type. About 214 adults will join to see if the t…

This study is testing whether a non-invasive test called Body Surface Gastric Mapping can help predict which patients with gastroparesis will benefit from a procedure called G-POEM. About 20 adults who are already eligible for G-POEM will have the mapping test before and after th…

This study tests a digital tool called CGM ASSIST for people with both Alzheimer's disease (or other dementias) and diabetes. The tool uses a continuous glucose monitor and easy-to-read displays to help patients, caregivers, and doctors spot and prevent dangerously low blood suga…

This study looks at how replacing red meat with other protein sources affects harmful gut toxins in people with stage 3 chronic kidney disease. Researchers will measure changes in blood and urine toxins and gut bacteria. The study involves 15 adults aged 40-70 who will follow a c…

This study tests whether stimulating the vagus nerve (a key nerve that controls stomach and other functions) through a small device placed behind the ear can change insulin, C-peptide, and blood sugar levels. Researchers will measure these levels in 30 healthy adults before, duri…

This study tests a program called HCC Liver-Link for Black patients with early-stage liver cancer. The program provides education, social support, and faster access to cancer specialists. Researchers want to see if it helps patients get curative treatments like transplant or surg…

This study looks at whether a common vitamin, niacin (nicotinic acid), can get into the brain fluid of people with Alzheimer's disease. Researchers will give 30 adults aged 60-85 with mild-to-moderate Alzheimer's a single 500 mg dose of extended-release niacin or a placebo. The m…

This study looks at whether people who break a hip after a simple fall might have an undiagnosed neck condition called cervical myelopathy, which affects the spinal cord. Researchers will check 75 hip fracture patients with a history and physical exam, and offer an MRI if signs a…

This small study looks at whether treating inflammation in the esophagus with proton pump inhibitors (PPIs) can improve its ability to stretch and move. Ten adults with eosinophilic esophagitis (EoE) will have their esophagus flexibility measured before and after PPI treatment. T…

This study aims to understand if bacterial biofilms (layers of bacteria) on breast implants lead to complications like chronic inflammation or Breast Implant Illness. Researchers will compare blood and tissue samples from 1,000 women with and without implants, as well as those ha…

This study follows 850 people aged 40-64 with early-onset cognitive impairment to understand how Alzheimer's disease progresses. Participants undergo cognitive tests, brain scans, and genetic analysis, but no treatment is given. The goal is to gather data to improve future diagno…

This study looks at the social and economic challenges faced by people with chronic liver disease, such as trouble paying for medicine or finding transportation. Researchers will survey 200 patients and their doctors to learn what help is needed and how clinics can better support…

This study looks at why some people who have had a stem cell transplant continue to have severe dry eye and discomfort. Researchers think nerve damage in the cornea (the clear front part of the eye) may be the cause. They will measure corneal sensation in 30 patients with ocular …

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find leftover cancer cells in people with stage I, II, or III germ cell tumors. About 130 adults will give blood samples after their initial treatment. The goal is to see how well this test works at d…

This study looks at how men and women react differently to two weeks of not drinking alcohol. Researchers will measure alcohol intake, brain responses, and personal feelings after the break. The goal is to use this information to create better ways to prevent and treat alcohol us…

This study watches what happens to insulin and blood sugar when a gastric electrical stimulator (a stomach pacemaker) is turned off for up to 4 hours. It involves 32 adults with gastroparesis who have had the device for at least 3 months and do not take insulin for diabetes. Rese…

This study looks at whether breathing a lighter gas mixture (heliox) can reduce the feeling of breathing difficulty and improve thinking in healthy adults, especially military personnel. Fifteen participants will perform thinking tasks while breathing normal air or heliox. The go…

This study looks at why Black Americans often report higher levels of paranoia than White Americans, even without a mental health diagnosis. Researchers will ask 480 Black American adults to take part in an online experiment where they imagine stressful situations related to race…

This study tests a new method called temporal interference (TI) that uses electrical currents to stimulate deep brain areas without surgery. Thirty healthy adults aged 18-50 will receive TI stimulation while their brain activity is measured with fMRI. The goal is to understand ho…

This study looks at how a brain area called the primary motor cortex helps us learn and remember new motor skills. Researchers will use a non-invasive technique called rTMS to temporarily lower activity in this area while 32 healthy adults learn to play a song on Guitar Hero. The…

This study looks at whether making changes at hospitals and dialysis centers can help more people with kidney failure start the process to get a transplant. About 14,000 patients at five large transplant centers will be included. The goal is to see if these changes lead to more p…

This study tests whether imagining positive future events can help people with alcohol use disorder choose long-term rewards over immediate drinking. Researchers will compare high-intensity future-thinking cues to low-intensity ones in 21 adults. The goal is to see if this approa…

This study looks at how inflammation from conditions like type 2 diabetes, irritable bowel syndrome, and end-stage kidney disease might change the way the body processes certain drugs. Researchers will collect blood samples from 150 adults and children to measure inflammation mar…

This study aims to better understand exercise-induced vocal cord dysfunction, a condition where the vocal cords close during exercise, making it hard to breathe. Researchers will use a small wearable device on the neck and MRI scans to measure breathing patterns and vocal cord mo…

This study aims to find out if children with primary ciliary dyskinesia (PCD) also have a condition called bronchial hyperresponsiveness, which makes airways overly sensitive. Researchers will compare 40 participants (those with PCD and healthy volunteers) using breathing tests. …

This study looks at how the COVID-19 pandemic may have changed people's physical activity, sleep, blood pressure, and mental stress. Researchers at Indiana University will track 100 adults aged 18-75 using wearable devices, fitness tests, and blood samples. The goal is to underst…

This study tests a tool called Periviable GOALS that helps parents and doctors make decisions together when a baby might be born extremely early (22-25 weeks). About 300 pregnant adults facing this situation will use the tool or receive standard care. The goal is to see if the to…

This study looks at how eating dried plums (prunes) might help reduce bone loss in women after menopause. Researchers want to know if prunes change immune cell activity and gut bacteria. Thirty women aged 60-75 will eat prunes or their normal diet for four weeks at a time, and pr…

This study looks at how a person's genes (CYP2B6 type) and the HIV drug efavirenz change the way the body handles methadone and tizanidine. Sixty healthy adults will take these drugs with and without efavirenz to measure differences. The goal is to understand potential risks or l…

This study looks at how a pregnant woman's body handles caffeine and how much passes to her baby before delivery. About 30 women at risk for preterm birth will receive a small dose of caffeine, and blood samples from the mother, placenta, and newborn will be measured. The goal is…

This study is creating a large collection of blood samples, tissue, and health information from 2,500 people with plasma cell disorders like multiple myeloma. Researchers will use this repository to better understand how the disease develops and changes over time. No new treatmen…

This study looks at whether taking longer breaks between repeated head impacts (like heading a soccer ball) can reduce brain injury. Researchers will measure blood markers and brain scans in 102 soccer players. The goal is to find safer ways to play sports and serve in the milita…

This study is testing a new ankle brace with built-in motion sensors to see if it can accurately measure how people walk, run, jump, and balance. Researchers will compare the brace's readings to standard lab equipment. The goal is to see if the brace is reliable enough for future…

This study tests whether taking dietary nitrate (found in beets) can help prevent muscle loss and weakness when a leg is immobilized in a brace for 14 days. Researchers will measure muscle function and energy use in 24 healthy young men. The goal is to find a simple, drug-free wa…

This study collects blood or brain tissue from families with two or more members diagnosed with Alzheimer's or dementia. The goal is to build a large DNA bank that researchers can use to find genes linked to the disease. No individual results are returned, but the data may lead t…