Brain zapping trial targets 'Rumination' in Tough-to-Treat depression

This pilot study tests whether a non-invasive brain stimulation technique called TMS can reduce rumination—repetitive negative thinking—in adults with treatment-resistant depression. Twenty participants will receive 20 TMS sessions targeting a specific brain region and undergo brain scans to see if brain activity changes. The goal is to understand if this approach can ease a common and distressing symptom.