Could a psoriasis drug help thickened hands and feet?
NCT ID NCT06561321
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a daily cream called tapinarof, already used for psoriasis, in 6 adults with palmoplantar keratoderma — a condition that causes painful thickening of skin on the palms and soles. Researchers want to see if the cream can clear or improve the skin and check for side effects. It's a small, early-phase trial at Indiana University.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tapinarof cream
- What this could lead to
- If it works, this could point toward a new topical treatment for palmoplantar keratoderma, a rare skin condition with limited options.
- What could go wrong
- This is a very small early-phase trial with only 6 participants, so results may not apply to everyone. The drug may not work or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Indiana University Department of Dermatology
Indianapolis, Indiana, 46202, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.