Indiana University

This study compares two cold snare techniques for removing medium-to-large colon polyps during a colonoscopy. About 570 adults will be randomly assigned to either piecemeal resection or endoscopic mucosal resection. The goal is to see which method removes polyps more completely a…

This study looks at whether a supervised ketogenic diet is safe and effective for weight loss in 40 obese adults with NASH cirrhosis. Participants are randomly assigned to either a ketogenic diet or standard dietary advice for 16 weeks. The main goals are to check for liver compl…

This study tests a program called PATH4YOU that helps women get birth control easily and affordably. It provides pregnancy intention screening, counseling, and same-day access to contraception at health centers. About 1,200 women aged 18-49 in Indiana will take part to see if the…

This study looks at whether cutting back or stopping additional treatments (like chemo or radiation) after surgery for HPV-positive throat cancer can work just as well as the standard full treatment. The goal is to reduce long-term side effects while still controlling the cancer.…

This study aimed to see if a supplement called chondroitin sulfate is safe for newborns with necrotizing enterocolitis (NEC), a severe gut injury. It planned to compare babies who got the supplement with those who got a placebo. However, the study was withdrawn before any partici…

This study tests whether special soft contact lenses with built-in sensors can safely and accurately measure eye pressure continuously for 24 hours in people with glaucoma and in healthy adults. Researchers will compare the smart lens readings to standard eye pressure tests and c…

This study tests a special soft contact lens that measures pressure inside the skull in newborns and infants at risk for hydrocephalus (fluid buildup in the brain). Researchers want to see if the lens can tell the difference between babies with and without the condition, and trac…

This study looks at whether carefully reducing or stopping certain medications (called anticholinergics) can help prevent dementia in older adults. Researchers are following 344 people aged 65 and older who take these medications, comparing those who get a deprescribing plan with…

This study aimed to see if a special oxygen mask (nasal positive airway pressure) could prevent drops in oxygen levels better than a standard nasal tube during colonoscopy sedation. It was designed for patients at higher risk, such as those with obesity or sleep apnea. The study …

This study tests an experimental inhaled nasal spray called Optate in 24 adults with mild COVID-19. Researchers measure how well it lowers virus levels in the nose and eases symptoms like congestion and discomfort over 24 hours. The goal is to see if this treatment can provide qu…

This early-phase study tests whether adding lacosamide, a seizure medication, to opioid therapy is safe and tolerable for people with chronic pancreatitis and ongoing abdominal pain. The goal is to reduce a condition called opioid-induced hyperalgesia, where opioids actually make…

This study tests whether a simple, self-administered acupressure routine can help adults with sickle cell disease manage their chronic pain. Researchers will enroll 300 participants who will learn acupressure techniques remotely and apply them every other day. The goal is to see …

This study tests whether a combination of virtual reality exercises and computer-based cognitive training can improve memory and thinking in 172 older adults (55+) who have both heart failure and mild cognitive impairment. Participants will use VR and computer programs designed t…

This study tests whether acupuncture can reduce chronic pain in people with sickle cell disease. Researchers will use brain scans and pain tests to see how acupuncture affects the brain's pain pathways. The study involves 60 participants aged 14 to 80 who have had sickle cell pai…

This study aimed to see if a combination of two sedation drugs, remimazolam and fentanyl, could safely put people to sleep during a short dental extraction (30 minutes or less). It also measured how quickly patients woke up afterward. The study was withdrawn before any participan…

This study tracks how well a non-surgical procedure called POEM works for people with achalasia, a condition that makes swallowing difficult. POEM uses an endoscope (a thin tube) to cut the tight muscle at the bottom of the esophagus without any cuts on the body. The goal is to i…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…

This study compares how full and satisfied people feel after eating a high protein snack bar versus a high carbohydrate snack bar. About 150 healthy adults aged 18-65 with a normal or slightly overweight BMI will eat each type of bar on separate days and rate their hunger, fullne…

This study aimed to test a virtual reality system that helps people with brain injuries practice everyday tasks like reaching and grabbing. It was designed for adults at least two months after a stroke or similar injury. However, the study was withdrawn before enrolling any parti…

This study looks at health insurance records of 125,000 adults in Indiana to see if obesity medications like GLP-1 drugs help people lose weight, use less emergency care, and lower medical costs. Researchers compare those who take the drugs to those who don't. No new treatments a…

This study looks at thousands of newborns in intensive care units around the world to learn more about kidney injury. Researchers will track which babies develop kidney problems and what factors increase their risk. The goal is to improve detection and long-term care, but no new …

This study tests whether stimulating a nerve in the ear can activate the vagus nerve, which controls stomach function. Researchers will measure nerve activity in 30 healthy volunteers using skin electrodes. The goal is to learn how to study this nerve better, which could lead to …

This study was designed to test whether scheduled video or audio calls could help family members who make medical decisions for hospitalized older adults with Alzheimer's or other cognitive impairments. The goal was to improve communication and reduce anxiety and depression for t…

This study looks at whether two types of telemedicine (remote doctor visits) can help children with sickle cell disease in areas with limited medical access. About 24 families will try these models to see if they make it easier to keep appointments and get lab tests. The goal is …

This study looks at how CFTR modulators—medicines that treat cystic fibrosis—affect bone strength and muscle mass in adults. Researchers will measure changes in bone density and lean body mass over 12 to 24 months. The goal is to understand whether these treatments help or harm b…

This research studies a program that puts mental health social workers directly in children's primary care clinics across Indiana. The goal is to catch mental health issues early and provide quick treatment during regular checkups. About 575 patients and staff will take part to s…

This study aims to improve how overdose fatality review teams work by giving them a data dashboard and training. Instead of reviewing just one or two cases at a time, teams will use near real-time data to spot patterns and make better recommendations. About 400 team members and l…

This study looks at how a device that electrically stimulates the stomach (gastric electrical stimulation) affects the vagus nerve and heart rate in people with gastroparesis, a condition where the stomach empties slowly. Researchers will measure heart signals and hormone levels …

This study gathers information from 500 people who had a TIF procedure—a no-incision surgery for acid reflux—at Indiana University. Researchers will track changes in quality of life and reflux symptoms over time using standard questionnaires. The goal is to better understand how …

This study tests whether mild electrical stimulation of a nerve in the ear can reach the vagus nerve, which controls stomach function. Researchers hope this approach could eventually help treat nausea, vomiting, and stomach problems in people with gastroparesis. The study involve…

This study looks at how the vagus nerve works in people with gastroparesis (stomach paralysis) who already have a gastric electrical stimulator device. Researchers will use a flexible, non-invasive electrode patch on the neck to measure nerve signals and link them to symptom reli…

This study checks if a special UV flashlight, often used to spot pet urine or saliva, can change nitric oxide levels on human skin. Researchers will measure gas released from the ear, hand, or forehead during light exposure. The goal is to develop a simpler way to measure nitric …

This study is testing a decision aid to help patients and their doctors talk about and choose the best colorectal cancer screening option. About 400 patients and healthcare staff from two Indiana health systems will take part. The goal is to see if the tool improves shared decisi…

This study is creating a new tool for children with spina bifida and their doctors to work together on setting personal goals for managing bladder and bowel leakage. The goal is to improve the child's quality of life by focusing on what matters most to them, rather than just medi…

This study follows 180 infants from birth to age 2 to see how bacteria in their upper airways change over time. Researchers want to learn if certain bacteria lead to more airway inflammation and lower lung function, which could increase asthma risk. The study does not test any tr…

This study tests a new tool called PATH that helps doctors check and manage age-related health problems in people with HIV who are 50 or older. About 60 participants from two HIV clinics will try the tool, and researchers will see if it is practical and acceptable for patients an…

This study looks at whether new guidelines can help doctors make fairer decisions about who gets advanced heart failure treatments like heart transplants and heart pumps. Researchers will work with over 1,400 patients and doctors at transplant centers across the U.S. to reduce un…

This study looks at how to help rural clinics in Indiana get more people screened for colorectal cancer. Clinics will mail test kits, send text reminders, and use patient navigators to guide adults aged 45-75 through the screening process. The goal is to see which methods work be…

This study tests whether an AI tool that uses electronic medical records can help predict and reduce delirium (sudden confusion) in older adults after major surgery. About 60 people aged 65 and older will take part. The goal is to see if giving doctors a delirium risk alert can l…

This study tests a remote program called ICARE for people with traumatic brain injury (TBI) and their care partners. The goal is to see if it's practical and helpful for improving how they recognize and respond to others' emotions. About 85 pairs of participants will use the prog…

This study looks at how premature birth affects lung development in babies during their first year. Researchers will measure lung function in about 250 infants to identify patterns that may predict future breathing issues. The goal is to better understand which babies are at high…

This study tests whether showing parents an infographic about obstructive sleep apnea (OSA) helps them talk to their child's doctor and leads to more children being diagnosed. About 200 parents and their children (ages 2-13) with OSA symptoms will take part. Half will see the inf…

This study collects blood samples from 19 adults with metastatic melanoma or kidney cancer that shrank without treatment (spontaneous regression). Researchers want to study immune cells and other factors that might explain why the cancer went away. The goal is to learn how the bo…

This study aims to find better ways to collect and analyze breath samples from 1,000 people, including those with and without lung disease. The goal is to improve methods for future research, not to test a treatment. Participants will simply provide breath samples for analysis.