Indiana University

This study tests whether a portable, low-resistance bike that attaches to hospital beds can help patients stay active during their stay. Hospitalized people often lose muscle and face risks like blood clots and confusion from too much bed rest. The study will include 80 adults ex…

This pilot study aims to see if a computer-controlled gas challenge is safe and effective for identifying coronary artery disease in healthy adults aged 45 and older. Participants will breathe controlled gas mixtures while their vital signs and symptoms are monitored. The goal is…

This study will test a new, non-invasive device that measures blood flow and oxygen levels in the brains of newborn babies. Researchers will compare babies who were exposed to opioids before birth with those who were not. The goal is to see if the device can detect signs of opioi…

This study tests a new, gentle device called Boppli that continuously measures blood pressure in newborn babies in the NICU. Researchers will compare it to the standard blood pressure cuff to see if it works better at finding high blood pressure. The study includes 30 infants at …

This study tests whether extra diet and exercise counseling helps high-risk pregnant women keep blood sugar levels normal and avoid gestational diabetes. About 100 women early in pregnancy will receive either standard advice or a more intensive program. The goal is to see if the …

This study looks at whether high-intensity walking training can help people with cerebellar damage walk better. Researchers will compare this training to standard therapy in 20 adults aged 18-85. The goal is to see if the training is practical and effective for improving mobility…

This study compares a new suction-based cervical stabilizer (Carevix) to the standard clamp (tenaculum) for IUD insertion. About 100 women will be randomly assigned to one device, then report their pain and bleeding. The goal is to see if the new device makes the procedure more c…

This study tests two ways to deliver a group training program for caregivers of children with autism in low-resource areas. The program aims to reduce caregiver stress and improve the child's communication and behavior. About 320 caregivers of children aged 2 to 8 will take part.…

This study aims to see if using a standard method for cervical ripening (preparing the cervix for labor) increases the chance of a vaginal delivery. Researchers will compare two approaches: one using a balloon catheter alone, and another combining the catheter with a medication c…

This study tests a new virtual reality walking program for people with traumatic brain injury. Participants will use VR goggles while walking overground, and their progress will be compared to standard treadmill-based VR therapy. The goal is to see if this approach improves walki…

This study tests whether using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatmen…

This early-stage study tests whether a single dose of psilocybin (5, 10, or 25 mg) combined with psychotherapy is safe and can reduce depression and substance use in 50 veterans and first responders with treatment-resistant depression and substance use disorder. Participants unde…

This study tests if a mild electrical pulse to the ear can help control nausea, vomiting, and stomach discomfort in people with diabetes and gastroparesis (slow stomach emptying). Researchers will use a small device on the outer ear to stimulate the vagus nerve, hoping it improve…

This study tests whether a slow-release form of the hormone DHEA can improve asthma control and is safe for adults with asthma. Asthma treatments like glucocorticoids lower DHEA levels, so adding DHEA might help. The trial will enroll 30 adults aged 18 to 50 and measure asthma co…

This study tests a program that offers mental health screening, therapy, and follow-up to pregnant women who are in the hospital for medical complications. About 50 participants will receive brief counseling and symptom tracking during their stay and for three months after. The g…

This study looks at using simple, low-cost communication tools like picture boards and gestures for children with autism who have trouble speaking. It involves 500 children and their caregivers in rural Virginia and western Kenya. The goal is to find better ways to match each chi…

This study will collect blood samples from 100 adults with cancer who are starting immunotherapy. Researchers will analyze the samples to find patterns in immune cells and molecules that might predict how well the treatment works or if it causes side effects. The goal is to bette…

This study looks at whether immunotherapy drugs for cancer change how the liver processes other medications. About 80 adults with various cancers will take a mix of seven common drugs before and during immunotherapy. The goal is to understand if these interactions cause more side…

This study looks at whether chemicals and other substances in a mother's body during pregnancy can help predict if her child will develop autism. Researchers will use stored urine and cord blood samples from 600 first-time mothers. The goal is to build a model that could estimate…

This study looks at whether using growth charts made specifically for twins, instead of the standard ones used for all pregnancies, leads to better care. About 150 pregnant people with twins will be randomly assigned to one of two groups. The goal is to see if the twin-specific c…

This study tests a special monitor that tracks sleep without touching the person. It will be used for 100 people with Alzheimer's or related dementias living in long-term care facilities. The goal is to see if sharing sleep data with staff helps them find and treat sleep problems…

This study explores whether pregnancy complications like gestational diabetes or high blood pressure can speed up ovarian aging, which is linked to higher risks for heart disease and bone loss. Researchers will follow 655 women over time, measuring hormones and health markers. Th…

This study aims to find out how often primary ciliary dyskinesia (PCD) goes undiagnosed in adults with bronchiectasis. Researchers will use two non-invasive tests—a nasal nitric oxide measurement and high-speed video microscopy—to screen 60 participants. The goal is to improve de…

This study looks at two different methods to help people who have had a traumatic brain injury (TBI) feel more in control of their health. About 142 adults who are at least one year past their injury and see a brain injury doctor will take part. They will have one virtual session…

This study aims to improve cervical cancer prevention in rural Kenya by testing a self-swab method for HPV and giving the HPV vaccine to girls. Researchers will also talk to families who did not take part before to understand why. About 2,500 women and girls will join to help mak…

This study tests a special PET scan called [18F]-AraG to see how well standard chemoradiotherapy is working in people with advanced head and neck cancer. The scan looks at immune cells in the tumor to help doctors understand treatment response. Only 5 adults with stage III or IV …

This study looks at whether a 6-month or 12-month follow-up colonoscopy is better for people who had a large colon polyp (20-50 mm) removed that was not cancerous. About 546 adults will be assigned to one of the two follow-up schedules. The goal is to see which timing finds any r…