Indiana University

This study tested whether mobile phone reminders, real-time appointment alerts, and counseling could help more children complete their routine vaccines on time. Over 2,800 parents and caregivers in a low-resource setting took part. The goal was to see if these simple digital tool…

This study looked at whether children with cystic fibrosis whose pancreas function improved after taking CFTR modulators could safely stop taking pancreatic enzyme replacement therapy (PERT). Seventeen children were followed for six months to check their growth, digestion, and nu…

This study tested a one-year virtual program for people with Alzheimer's or related dementias and their care partners. Nurses or social workers provided monthly check-ins, then quarterly visits, using tools to address behavior issues, caregiver stress, medications, and care plann…

This study tested whether delivering coordinated specialty care (CSC) via telehealth helps young people (ages 16-35) with early psychosis stay engaged in treatment and avoid hospital stays. 74 participants were randomly assigned to receive care either through video visits or in-p…

This study tested whether injecting stem cells into the leg could prevent wound complications and reduce the need for more surgery after a major leg amputation. It involved 81 adults aged 40 to 90 who needed a leg amputation due to poor blood flow from artery disease. The stem ce…

This study tested a virtual reality (VR) program designed to help people in early recovery from opioid use disorder focus on their future and reduce drug use. 104 participants who had been abstinent for at least 14 days but less than a year were split into a VR group and a contro…

This study tested whether a 3D intraoral scanner can detect cavities, tooth wear, and fluorosis in children's baby teeth as well as a traditional visual exam. 36 children aged 3-12 had their teeth cleaned, examined visually, and then scanned. The goal was to see if the 3D scan co…

This study tested whether a dye called Cytalux, which makes cancer cells glow under near-infrared light, can help surgeons find and remove prostate cancer that might otherwise be missed. Nine men with aggressive prostate cancer received the dye before surgery. The goal was to see…

This study tested whether a portable eye-tracking device can help diagnose autism in young children in Kenya. Researchers measured how 27 children looked at images and compared the results to standard clinical diagnoses. The goal was to see if this quick, non-invasive method coul…

This study tested whether daily zinc supplements can lower the number of severe infections in young children (ages 1 to 5) with sickle cell anemia. Researchers in Uganda gave 100 children either zinc or a placebo (fake pill) and tracked how many got sick. The goal was to see if z…

This study tested a new digital system (Symphonie Aqua Digital) that creates prosthetic sockets while the person puts weight on their limb, aiming for a better fit than traditional non-weight-bearing methods. Ten adults with below-knee amputations who walk well participated. Rese…

This study looked at ways to help people with traumatic brain injury (TBI) who struggle with irritability and aggression. Researchers tested different treatments to see if they could improve behavior control. A total of 81 adults with a closed head injury took part, and their pro…

This study tested a program called UPLIFT-AD that brings palliative care—a type of care focused on comfort and quality of life—into nursing homes for people with moderate to severe Alzheimer's disease. The program trained nursing home staff and provided access to specialist palli…

This study looked at whether special breathing muscle training could reduce asthma symptoms triggered by exercise and improve cycling performance. Fifteen athletes with mild to moderate asthma or exercise-induced bronchoconstriction completed the training. Researchers measured lu…

This study tested a program to help veterans with Alzheimer's disease or traumatic brain injury and the family or friends who care for them. The goal was to see if the program could improve the caregivers' quality of life and reduce their stress. About 236 veterans and their care…

This study tested whether eating beef daily for 8 weeks reduces muscle fatigue in adults aged 60-85 compared to a vegetarian diet. Twenty-four participants ate both diets in a crossover design, with tests like sit-to-stand and walking. The goal was to see if beef's natural beta-a…

This study looked at whether playing virtual reality games (like Nintendo Switch Sports) could help improve balance in 13 young people with autism, compared to doing standard physical therapy exercises. Participants did 6 sessions over 2 weeks from home, supervised via Zoom. Rese…

This study looked at whether high-intensity walking training is better than lower-intensity walking exercise for people with chronic, motor incomplete spinal cord injury. Researchers measured walking speed and distance in 53 participants. The goal was to find a more effective way…

This study tested whether standing on a low-intensity vibrating platform for 10 minutes twice a day for 12 months could improve muscle function and reduce pain in early-stage breast cancer survivors starting aromatase inhibitor therapy. 72 women who did not exercise regularly wer…

This study tested whether listening to slow-tempo music for seven days could help older adults in the intensive care unit (ICU) avoid delirium—a state of confusion that can lead to longer hospital stays and memory problems. Researchers enrolled 160 patients aged 50 and older who …

This study tested a special type of radiation therapy (SBRT) that targets pancreatic tumors while limiting damage to nearby organs. It included 36 adults with pancreatic cancer that could not be removed by surgery or had come back after other treatments. The main goal was to chec…

This small pilot study tested the Safe and Sound Protocol (SSP), a passive listening program, in 45 adults with PTSD or anxiety. Participants listened to specially filtered music as a 'neural exercise' to help regulate their body's stress response. The study measured changes in P…

This study compared two methods for breaking up large stones in the pancreatic duct: external shock waves (ESWL) and a newer technique using a tiny scope inside the duct (SOPIL). Thirty adults with chronic pancreatitis and painful, large stones took part. The goal was to see whic…

This study checked how accurate and repeatable a smartphone app called VisionApp is at measuring nearsightedness and presbyopia (age-related reading problems). Sixteen adults aged 40 and older with mild to moderate refractive errors and good vision took part. The app uses the pho…

This study tested a program that trains nursing home staff to have conversations about care preferences with Alzheimer's patients and their families. The goal was to reduce unwanted hospital trips by making sure patients' wishes are known and followed. Over 47,000 people in nursi…

This study tested a computer system that gives ER doctors a risk score showing which adult patients might have social needs like trouble with housing, food, or transportation. The goal was to see if this tool helps doctors screen and refer more patients to support services. Over …

This study looked at brain activity in pregnant women with opioid use disorder who were taking medication therapy. Researchers compared their brain scans to those of healthy pregnant women to see if there were differences. The goal was to learn more about how the body processes t…

This study looked at whether taking progesterone (in women) or testosterone (in men) could reduce dangerous changes in heart rhythm caused by certain medications. 73 healthy older adults (postmenopausal women and men 65+) took either the hormone or a placebo, then received a smal…

This study looked at whether a special planning form (called POST) helps older adults, including those with dementia, receive medical care at the end of life that matches their personal wishes. Researchers worked with 389 people aged 65 and older who were at higher risk of dying …

This study looked at how different parts of the brain work together to keep hand movements precise. 76 healthy adults had their brain activity measured with MRI while resting. The goal was to understand how the brain uses vision and touch to guide movement, which could one day he…

This study reviewed medical records of 150 people who had a hole or tear in their esophagus, either from an injury or a medical procedure. Researchers compared different ways to close these defects using a scope, such as placing a stent or stitching. The goal was to see which met…

This study looked at how different parts of the brain help us sense where our limbs are and learn new hand movements. Researchers tested 118 healthy adults using a robot to measure arm position awareness and a maze-tracing task to track motor skill learning. The goal is to use th…

This study tested a method called public deliberation, where community members learn about a topic, hear different views, and discuss it together to find fair solutions. Researchers wanted to see if this approach could improve how teens from marginalized communities give consent …

This study looked at how cannabidiol (CBD) interacts with tacrolimus, a drug used to prevent organ rejection in transplant patients. Researchers wanted to understand how to adjust doses for better health outcomes. The study involved 57 healthy adults and those with chronic kidney…

This study looked at how a single high-salt meal affects blood pressure and blood vessel function in healthy adults aged 19-40. Researchers compared Black and white participants to see if there are racial differences in how the body handles salt. The goal is to understand why Bla…

This study looked at whether training the muscles used for breathing can improve heart health and mood in women who have gone through menopause. Researchers measured how quickly the body uses oxygen during exercise and how far women could walk in six minutes. The goal is to learn…

This study tested whether vitamin C (ascorbic acid) tablets can temporarily lower stomach pH in healthy young men whose stomach acid was reduced by a common heartburn drug. Eleven participants took vitamin C and had their stomach pH monitored for five hours. The goal was to see i…

This study looked at how to make surgical residency programs better and less stressful for doctors in training. Researchers collected information from over 200 US surgery programs about burnout, mistreatment, and other problems. The goal was to find ways to improve the workplace …

This study looked at 98 adults with cancers like melanoma and lung cancer who were starting immunotherapy. Researchers measured inflammatory markers in their blood to understand how the body reacts to these drugs. The goal was to find ways to better manage side effects from treat…

This study tested whether personalized, vivid future-thinking cues can help people with alcohol use disorder choose long-term rewards over immediate ones. 58 adults in early recovery (abstinent 30 days to 1 year) viewed either high-intensity or low-intensity future scenarios. Res…

This study tested a special communication program for doctors and parents of children with advanced cancer. The goal was to help families and doctors agree on treatment goals, especially for children nearing end of life. Researchers measured whether this improved the child's qual…

This study gathered information from 105 stroke patients to see how well a new wire device (Aristotle Colossus) helps doctors remove blood clots from the brain. The main goal was to see if the wire alone could deliver a catheter to the clot. The study did not test a cure or treat…

This study tested a streamlined HIV care approach for pregnant and postpartum women and their infants at a hospital in Kenya. The goal was to see if offering simpler, more flexible services could reduce clinic wait times and keep mothers and babies healthy. Researchers tracked vi…

This study tested a new electronic camera to see the cells of the retina in much finer detail than current clinical cameras allow. Researchers compared images from 5 participants with retinal disease to learn how cells change in health and disease. The goal was to better understa…

This study looked at whether playing music during gym class helps kids be more active and enjoy exercise more. 26 fifth and sixth graders took part in an 8-week sports program, with some classes having music and others not. Researchers measured steps, mood, and motivation to see …

This study tested a computer program that helps doctors diagnose common stomach and bowel problems in children. 33 children and their doctors took part. The goal was to see if the tool leads to more accurate diagnoses and better care.

This study looked at whether a program called Patient Priorities Care can work in regular doctor's offices for people with dementia or mild cognitive impairment. 178 participants received a packet before their appointment and could talk with a trained helper about their personal …