Hormone shield: could progesterone or testosterone guard against Drug-Induced heart risks?

NCT ID NCT04675788

Completed Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether taking progesterone (in women) or testosterone (in men) could reduce dangerous changes in heart rhythm caused by certain medications. 73 healthy older adults (postmenopausal women and men 65+) took either the hormone or a placebo, then received a small dose of a heart-rhythm-altering drug. Researchers measured heart electrical activity to see if the hormones offered protection. The goal was to find new ways to prevent drug-induced heart problems.

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Conditions

The condition(s) this trial relates to.

long QT syndrome toxic or drug-related embryofetopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ABNORMALITIES, DRUG-INDUCED LONG QT SYNDROME

Contacts and locations

Locations

Indiana Clinical Research Center

Indianapolis, Indiana, 46202, United States
Indiana University

Indianapolis, Indiana, 46202, United States
Purdue University

Indianapolis, Indiana, 46202, United States

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