Malignant glioma

This study tests a personalized DNA vaccine for children and young adults (ages 12-25) with central nervous system tumors that have come back or not responded to treatment. The vaccine is made from each patient's unique tumor DNA to train the immune system to fight the cancer. Th…

This trial tests a drug called selinexor combined with standard radiation in children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) that has a specific genetic change (H3 K27M mutation). The study has two parts: first, fi…

This study provides continued access to dabrafenib and/or trametinib for up to 100 patients with melanoma, lung cancer, or other solid tumors who were benefiting from these drugs in a prior Novartis or GSK trial. The main goal is to track long-term side effects and safety over ti…

This early-phase trial tests a nasal spray called NEO100 (a purified natural compound) in 12 children with certain aggressive brain tumors. The goal is to see if it's safe, find the best dose, and check if the drug reaches the tumor. Participants will receive increasing doses, an…

This early-phase study tests a new two-drug combination for adults whose high-grade glioma (a fast-growing brain tumor) has returned after standard treatment. The drugs are temozolomide (a chemotherapy pill given daily at low doses) and abexinostat (an experimental drug that may …

This study tests two drugs—tarlatamab and temozolomide—in adolescents and adults with high-grade brain tumors that have a specific marker called DLL3. The goal is to see if the combination is safe and can shrink tumors. About 70 participants will be enrolled across multiple cente…

Researchers are testing a radioactive gel called rhenium-186 obisbemeda in children and young adults, ages 6 to 21, whose ependymoma or high-grade glioma has come back or keeps growing after treatment. The gel is infused directly into the tumor through a thin tube, a method calle…

This early-stage trial tests a new treatment for people with glioblastoma, an aggressive brain cancer that has come back. The therapy uses special neural stem cells that can find cancer cells in the brain and release a virus that kills them. The main goal is to check the safety o…

This early-stage trial tests whether using focused ultrasound with microbubbles can temporarily open the blood-brain barrier, allowing the immunotherapy drug nivolumab to reach brain tumors more effectively. It includes 30 children and young adults with relapsed diffuse midline g…

This study tests whether adding the drug olutasidenib to standard chemotherapy (temozolomide) can help children and young adults with a specific type of brain cancer (IDH1-mutant high-grade glioma) live longer. About 60 participants will receive the combination as maintenance the…

This early-phase study tests a new drug called GNC-039 in people with advanced solid tumors, including a type of brain cancer called glioma, that have come back or spread. The main goals are to check the drug's safety, find the best dose, and see if it can help control the diseas…

This study is testing proton radiation as a treatment for adults with benign or slow-growing brain tumors. Researchers want to see how well it controls tumor growth and how it affects quality of life and side effects. About 100 participants will receive proton radiation and be fo…

This early-phase study tests the drug TURALIO (pexidartinib) in people aged 3 to 35 whose cancer has not responded to standard treatments. The goal is to find a safe dose and see if it can shrink tumors or control leukemia. Participants take a daily capsule for up to 2 years, wit…

This Phase 2 trial is testing a vaccine called PEP-CMV in 120 children and young adults with high-grade glioma, diffuse intrinsic pontine glioma (DIPG), or recurrent medulloblastoma. The vaccine targets a common virus (CMV) found in many brain tumors, aiming to boost the immune s…

This early-stage trial is testing the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose gliomas (a type of brain tumor) have come back after previous treatment. The study aims to find the highest dose that is safe and …

This early-phase trial tests whether letrozole, a drug normally used for breast cancer, can reach and concentrate in recurrent high-grade gliomas (aggressive brain tumors). About 39 adults will take letrozole pills daily along with standard temozolomide chemotherapy. Researchers …

This early-stage trial tests a modified herpes virus (C5252) injected directly into the brain tumor cavity of 36 adults with recurrent high-grade glioma who have run out of standard options. The goal is to see if the virus is safe and can help control the disease. Participants wi…

This phase I trial is testing whether giving a single, high dose of radiation (radiosurgery) before surgery can help control high grade glioma, a fast-growing brain tumor. About 28 adults with newly diagnosed or previously biopsied high grade glioma will receive radiosurgery foll…

This early-phase trial tests the safety of a new treatment for people with recurrent or progressive high-grade glioma, a serious brain cancer. The therapy uses the patient's own immune cells, modified in a lab to recognize and attack tumor cells, and delivers them directly into t…

This early-phase trial is testing whether adding the drug atovaquone to standard radiation therapy is safe and tolerable for children with certain malignant brain tumors, including high-grade glioma, diffuse midline glioma, and medulloblastoma. The study includes two groups: chil…

This early-phase trial tests a new type of immune therapy for people with certain aggressive brain tumors, including DIPG and high-grade glioma. The treatment uses the patient's own T cells, which are modified in the lab to recognize a protein called GD2 on cancer cells and to pr…

This early-stage trial tests an oral drug called GLIX1 in 30 adults with recurrent or progressive high-grade glioma, a fast-growing brain cancer. The study aims to find the safest dose and check for any signs of tumor control. Participants take the drug daily until their disease …

This study tests a new drug called LMP744 in people whose glioblastoma has come back after standard treatment. The drug is designed to kill cancer cells by blocking a key growth signal and interfering with DNA repair. Participants will receive the drug through a vein for 5 days e…

This study is testing a new way to treat glioblastoma, an aggressive brain cancer that has come back after initial treatment. Doctors will place tiny devices that release a special type of radiation directly into the tumor. The goal is to see if this approach is safe and possible…

This study is testing a drug called Lutathera in children and young adults (ages 4 to 39) whose brain tumors have come back or are growing despite treatment. The drug delivers radiation directly to tumor cells that show up on a special PET scan. The goal is to find the safest dos…

This early-stage trial tests an experimental drug called NRG-103 in about 24 adults with recurrent or progressive high-grade glioma, an aggressive brain cancer. The main goals are to find a safe dose and check for side effects, while also looking for early signs that the drug mig…

This trial investigates whether giving a short course of targeted proton radiation before surgery is safe for people with high-grade gliomas, an aggressive type of brain tumor. Nine participants will receive one of three escalating doses of proton therapy, followed by standard su…

This early-phase trial tests a modified cold virus (DNX-2401) that is loaded into donor stem cells and injected into the brain's blood supply to target recurrent high-grade gliomas. The virus is designed to infect and kill cancer cells while leaving healthy cells alone. The study…

This early-stage trial is testing a new treatment called CARv3-TEAM-E T cells for people with glioblastoma, a serious brain cancer that has come back. The treatment uses a patient's own immune cells that are modified in a lab to better recognize and attack the cancer. The main go…

This study compares bevacizumab (Avastin) to standard steroid treatment (dexamethasone) as the first therapy for people with brain radiation necrosis—a side effect of radiation therapy for brain tumors. About 408 participants with high-grade glioma or brain metastases will be ran…

This pilot study tests whether combining targeted therapy (MAPK inhibitors like trametinib and dabrafenib) with an immunotherapy drug (nivolumab) can safely and effectively treat children with BRAF-altered gliomas, a type of brain tumor. The study includes children with low-grade…

This early-phase study tests the drug lorlatinib in children and young adults (ages 1 to 21) with newly diagnosed high-grade glioma, a fast-growing brain tumor, that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor…

This study tests two drugs—retifanlimab (an immunotherapy) and DFMO (a growth blocker)—alone or together in 33 adults with progressive high-grade glioma, an aggressive brain cancer. The goal is to find the safest, most effective dose and see if the combination boosts the immune s…

This early-stage study tests a combination of antiretroviral drugs (normally used for HIV) and a laser procedure to treat high-grade gliomas—aggressive brain tumors that cannot be surgically removed. About 24 adults with newly diagnosed tumors will receive the laser treatment fol…

This early-phase trial tests a personalized RNA vaccine made from each patient's own tumor. It aims to teach the immune system to attack the cancer. The study includes adults with glioblastoma and children with high-grade gliomas or medulloblastoma. The main goals are to see if t…

This early-phase trial is testing a new radioactive drug, [177Lu]Lu-DOTA-EB-RGD2, in 24 patients with recurrent high-grade glioma, a fast-growing brain cancer. The drug is designed to seek out and deliver radiation directly to tumor blood vessels. It can be given through a vein o…

This early-phase study tests the safety of delivering the chemotherapy drug topotecan directly to the brain using a pump and catheter system (convection-enhanced delivery) in 6 people with a recurrent, aggressive type of brain tumor called IDH-mutant malignant glioma. The treatme…

This trial tests a new gene therapy called TGX-007 for people with a fast-growing brain cancer called glioblastoma. The therapy uses a harmless virus to deliver two special instructions: one helps a common drug kill cancer cells, and the other wakes up the immune system to attack…

This pilot study tests whether adding APG-157 (a pastille dissolved in the mouth) to standard bevacizumab can help people with recurrent high-grade glioma. About 30 participants will take APG-157 three times daily while continuing bevacizumab. The study tracks survival, tumor res…

This early-phase trial tests a combination of two drugs—D2C7-IT and 2141-V11—for adults with recurrent malignant glioma, a serious brain cancer. The drugs are delivered directly into the tumor and nearby lymph areas. The main goal is to check safety and find the right dose in 90 …

This study is testing a combination of two drugs—a targeted radioactive drug (177Lu-DOTATATE) and a PARP inhibitor (olaparib)—in children and teens aged 3 to 18 with certain solid tumors that have come back or not responded to treatment. The goal is to see if the combination is s…

This early study tests if a piece of belly tissue placed in the brain during surgery can safely bypass the blood-brain barrier in people with recurrent glioblastoma, an aggressive brain cancer. Ten adults will be followed for 6 months to check for side effects like rapid tumor gr…

This phase III trial is testing whether delivering the drug bevacizumab (Avastin) directly to the brain through a catheter, along with standard chemo and radiation, can help people with newly diagnosed glioblastoma live longer. The study will enroll 432 adults with this aggressiv…

This study tests a new surgical technique for people with glioblastoma, an aggressive brain cancer. Surgeons place a piece of the patient's own tissue (from the scalp or skull lining) into the area where the tumor was removed. This tissue flap may help bypass the blood-brain barr…

This study is testing a special type of proton radiation called PRDR for people whose fast-growing brain tumor (high-grade glioma) has come back after prior treatment. The goal is to see if this radiation can help control the tumor and improve survival while keeping side effects …

This study tests whether adding two different drug combinations after radiation can help children and young adults (up to age 21) with high-grade gliomas, including DIPG, live longer. One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The go…

This Phase 2 trial tests a two-part treatment for people with recurrent high-grade gliomas, a serious brain cancer. The treatment uses a virus (DB107-RRV) injected into the tumor and a chemotherapy pill (DB107-FC) taken by mouth. The goal is to shrink tumors and slow disease prog…

This phase 2 trial tests whether a single injection of DNX-2401, a virus designed to kill cancer cells, can shrink or stabilize recurrent high-grade brain tumors in 39 children and young adults. Participants receive the virus directly into the tumor during a biopsy procedure. The…

This study tests the drug entrectinib in children under 3 with certain brain tumors (NTRK or ROS1 gene fusions). The goal is to see if the drug can shrink tumors and delay the need for chemotherapy. About 52 children will take entrectinib by mouth, and doctors will monitor tumor …

This early-phase trial is testing a new type of immunotherapy called anti-GARP CAR T-cell therapy for people with recurrent high-grade gliomas (aggressive brain tumors). Researchers will take a patient's own immune cells, modify them in the lab to target a protein called GARP fou…

This early-stage trial tests whether a device called SonoCloud-9 can safely open the blood-brain barrier in children aged 5 to 17 with recurrent malignant brain tumors. The barrier normally blocks chemotherapy from reaching the brain. By using low-intensity ultrasound just before…

This study looks at whether using a special PET scan before surgery helps surgeons remove more of a high-grade glioma (a fast-growing brain tumor) safely. About 100 adults with newly diagnosed tumors will get both a PET and MRI scan before surgery. After surgery, doctors will che…

This study tests a two-step treatment for people with newly diagnosed high-grade gliomas, a type of aggressive brain cancer. First, doctors use a laser to heat and destroy tumor tissue, then follow up with a shorter course of radiation. The goal is to see if this approach is safe…

This early-phase trial is testing a combination of three treatments for children whose brain tumors have come back or not responded to standard care. The experimental drug SGT-53 delivers a normal TP53 gene to tumor cells, and is given alongside the immunotherapy Nivolumab and ra…

This early-phase trial tests a new treatment for people with recurrent glioblastoma, a fast-growing brain cancer. The treatment uses a patient's own immune cells (NK cells) that have been engineered in a lab to better recognize and attack tumor cells. The cells are delivered dire…

This early-stage trial is testing a specially designed herpes virus, MVR-C5252, that is injected directly into brain tumors in people whose high-grade glioma has returned. The virus is modified to attack cancer cells and boost the immune system. The main goal is to see if it is s…

This study tests a new drug called TNG456, alone or with another drug (abemaciclib), in people with advanced cancers that have lost a gene called MTAP. The trial has two parts: first finding a safe dose, then testing how well it shrinks tumors. Up to 191 adults with lung cancer, …

This study tests a new treatment for aggressive brain tumors (glioblastoma) that uses a radioactive substance attached to a targeting molecule. The therapy is given directly into the tumor area after standard treatments like surgery and chemotherapy. The goal is to see if it can …

This early-stage trial tests a new treatment called TX103 CAR-T cells for people with recurrent or progressive grade 4 glioma, a very aggressive brain cancer. The treatment involves taking a patient's own immune cells, engineering them to recognize and attack cancer cells, and in…

This early-phase trial is testing the drug larotrectinib in 15 children (up to age 21) with newly diagnosed high-grade glioma or DIPG that have a specific genetic change called NTRK fusion. The study aims to see if the drug can control the disease after two cycles, and how safe i…

This early-stage trial tests a new approach for people with recurrent glioblastoma, a fast-growing brain tumor. Doctors take immune cells called NK cells, engineer them to recognize and attack tumor cells, and deliver them directly into the brain. The study will check safety and …

This study tests whether adding two experimental drugs, DB107-RRV and DB107-FC, to standard treatment (radiation and chemotherapy) can help people with newly diagnosed high grade glioma, a fast-growing brain cancer. About 70 adults aged 18-75 will receive the drugs during and aft…

This early-phase trial tests an experimental drug called CUE-102 in 18 adults with recurrent glioblastoma, a type of brain cancer that has come back. The drug is a fusion protein designed to help the immune system attack cancer cells. The main goal is to find a safe dose and chec…

This study tests a new drug called paxalisib combined with standard chemotherapy (temozolomide) in people with high-grade brain tumours like glioblastoma. The goal is to find a safe dose and see if the combination can slow tumour growth. About 64 participants will be enrolled, an…

This trial is testing two experimental drugs, avutometinib and defactinib, alone or with a standard chemotherapy (temozolomide), in people with high-grade malignant brain tumours like glioblastoma. The study aims to find a safe dose and see if the drugs can shrink tumours or stop…

This early-phase trial tests an experimental drug called XRD-0394 combined with radiation therapy in 39 people with high-grade glioma, an aggressive brain cancer. The drug is designed to make radiation more effective at killing tumor cells. The main goal is to find a safe dose an…

This early-stage trial tests a universal mRNA vaccine designed to target common mutations in high-grade glioma, a type of aggressive brain cancer. Ten patients with recurrent or progressive disease will receive the vaccine to see if it is safe and can stimulate an immune response…

This study tests an oral drug called LAM561 in children under 18 with advanced brain tumors (like high-grade glioma) or other solid tumors that have not responded to standard treatments. The trial has two phases: first, finding a safe dose in up to 18 children, then testing that …

This study tests an experimental drug called BDTX-1535 in people with aggressive brain tumors (high-grade glioma or glioblastoma) that have certain changes in the EGFR gene. The drug aims to block a growth signal that these tumors rely on. The trial first measures how much drug r…

This study tests whether drawing blood directly from veins inside the brain can safely diagnose high-grade glioma, a type of brain cancer. Researchers will compare this liquid biopsy to traditional surgical biopsy. Only 20 adults with suspected or confirmed brain cancer will part…

This study tests a radioactive tracer called FET that lights up brain tumor cells on a PET scan. Researchers want to see if FET can better detect whether a brain tumor has come back after treatment, and help tell high-grade from low-grade tumors. About 199 people with known or su…

This early-phase study tests a new type of PET/MRI scan that uses special radioactive tracers to detect leftover high grade glioma (a fast-growing brain cancer) after standard radiation therapy. About 20 patients aged 10 and older will receive up to three imaging sessions. The go…

This phase 1 trial is testing whether a new imaging tracer called 18F-TRX can safely and effectively detect solid tumors using PET scans. The tracer targets unstable iron levels, which are often elevated in cancerous tissue. Adults with advanced solid tumors, including certain pr…

This study tests a special dye that makes brain tumor cells glow under a camera during surgery. The goal is to help surgeons see and remove more of the tumor while sparing healthy brain tissue. About 46 adults with malignant glioma or vestibular schwannoma will receive the dye be…

This early-phase trial at Children's Hospital of Philadelphia is testing whether a radioactive tracer called 18F-Fluciclovine (Axumin) can improve PET-MRI scans for children and young adults with low-grade glioma. About 30 participants will receive the tracer before starting trea…

This early-phase trial tests a fluorescent dye called ABY-029 to help surgeons better see high-grade gliomas (a type of brain tumor) during surgery. About 33 adults with suspected high-grade glioma will receive a small amount of the dye before surgery. The goal is to find the rig…

This study tests whether a special PET scan called 18F-Fluciclovine can help doctors tell the difference between actual tumor growth and harmless changes caused by treatment in children with high-grade glioma. About 30 children aged 1 to 21 will receive the scan after radiation t…

This study tests whether slowly reducing the dose of the steroid dexamethasone after brain tumor surgery can lower side effects like high blood sugar and poor wound healing, while still preventing brain swelling. About 200 adults with certain brain tumors will be randomly assigne…

This study tests a remote cognitive rehabilitation program for adults with slow-growing brain tumors (grade 2 or 3 glioma) who often struggle with memory, attention, and thinking. About 187 participants will either receive the program or standard care. The goal is to see if the p…

This study is testing a new technology called SmartMatch that analyzes tumor tissue from people with recurrent brain or spinal cord tumors. The goal is to see if SmartMatch can quickly identify which drugs might work best for each person's specific tumor. About 80 participants ag…

This study is testing whether having additional MRI scans during radiation and chemotherapy can help doctors see how a high-grade glioma (a type of brain tumor) is changing. The goal is to use that information to adjust the treatment plan for each patient. About 80 adults with th…

This study uses genetic testing of brain tumors from children, adolescents, and young adults (ages 1 to 39) with newly diagnosed high-grade glioma, including DIPG. The goal is to identify specific genetic changes in each tumor and then see if patients can join a treatment trial t…

This study is testing whether PET scans and blood tests can predict memory and thinking problems that often occur after radiation treatment for high-grade glioma. Sixteen participants will have scans and cognitive tests before, during, and after radiation. The goal is to see if t…

This study tracks how brain areas controlling movement, language, and sensation change during glioma treatment. Twenty patients with brain tumors will undergo repeated MRI scans as part of their regular care. Researchers aim to understand the brain's ability to adapt over time, w…

This study looks at whether recording electrical activity in and around high-grade glioma tumors during surgery can help predict how the tumor will progress. Ten adults with suspected or confirmed high-grade glioma will undergo standard surgery plus extra brain recordings and a s…

This study tests whether educational tools can help adolescents and young adults (ages 18-39) with advanced solid tumors or high-grade brain tumors start advance care planning early. Participants watch an educational video and attend a special appointment to discuss their care go…

This early-phase trial tests a special version of the immunotherapy drug nivolumab that has a fluorescent dye attached (nivo800). The dye makes the drug glow under near-infrared light, allowing researchers to see exactly where the drug goes in the tumor during surgery. About 38 a…

This early phase 1 trial is testing an oral drug called DSP-0390 in 20 people with IDH-mutant gliomas who are scheduled for tumor removal surgery. The goal is to see how much of the drug gets into the brain tumor and blood, and whether it affects cholesterol-related pathways. Par…

This pilot study is testing whether a combined PET-MRI scan can better detect if a child's brain tumor has returned after treatment. The study will include 5 children with high-grade gliomas or medulloblastomas who have unclear results from standard MRI. The main goal is to see i…

This pilot study is testing whether a special MRI scan can measure a substance called 2-hydroxyglutarate (2HG) in brain tumors (gliomas) without needing surgery. Researchers will compare the MRI results with measurements from actual tumor tissue removed during surgery. If the MRI…

This study looks at why some people with brain tumors (gliomas) develop low blood cell counts from the drug temozolomide, while others don't. Researchers will analyze genes, gut bacteria, and other factors in 55 patients to find clues. The goal is to help doctors predict and prev…

This study tests whether a special type of MRI, called spectroscopic MRI, can help guide proton therapy for children with high-grade glioma. The MRI maps tumor metabolism without needing a contrast dye. Researchers hope this will allow more precise radiation targeting. About 25 c…

This study is looking at whether special MRI scans and blood tests can help predict how a type of aggressive brain tumor (malignant glioma) changes over time. Researchers will follow 15 adults with newly diagnosed tumors, using imaging and blood samples to track certain iron-rela…

This Mayo Clinic study uses special MRI scans to map electrical activity in the brain. Researchers will compare healthy volunteers and people with a type of brain tumor called glioma. The goal is to improve how doctors diagnose and understand brain conditions.

This study collects tumor samples from 50 adults with low- or high-grade glioma to grow mini-tumors (organoids) in the lab. Researchers will study these organoids to learn why gliomas are so hard to treat and how they spread. The goal is to create personalized 'avatars' for testi…

This study looks at whether early telehealth visits can help people with aggressive brain tumors (high-grade glioma) discuss and document their end-of-life wishes soon after diagnosis. About 50 patients and their families will take part. The goal is to see if these visits are pra…

This study is testing a new fiber optic probe that combines three technologies (fluorescence, Raman spectroscopy, and ultrasound) to help doctors see tumor tissue and blood vessels during brain biopsies. The probe will be tested on brain tumor tissue removed from 20 patients with…

This early phase trial at Mayo Clinic is studying how two drugs, DFMO and AMXT 1501, change the metabolism of brain tumors (gliomas) in 18 adult patients. The goal is to measure molecules in the tumor's fluid to understand how these drugs affect tumor growth and survival. Partici…

This study uses advanced MRI scans to better identify parts of brain tumors that are likely to grow back after standard treatment. Researchers will compare these scans with usual methods to see if they can improve radiation planning. About 135 adults with certain brain tumors wil…