Virus and pill combo takes on recurrent brain tumors
NCT ID NCT06264388
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests a two-part treatment for people with recurrent high-grade gliomas, a serious brain cancer. The treatment uses a virus (DB107-RRV) injected into the tumor and a chemotherapy pill (DB107-FC) taken by mouth. The goal is to shrink tumors and slow disease progression. The study enrolls 33 adults aged 18-75 whose cancer has returned after prior treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
DB107-RRV (a virus that targets cancer cells) and DB107-FC (a chemotherapy pill)
What this could lead to
If it works, this could offer a new way to control recurrent high-grade gliomas, potentially shrinking tumors and extending survival.
What could go wrong
This is an early Phase 2 trial with only 33 participants, so results may not apply to all patients. The treatment involves brain surgery and virus injections, which carry risks like infection or inflammation.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Miami Hospital
RECRUITINGMiami, Florida, 33136, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••