Brain tumor virus therapy tested in kids and young adults

NCT ID NCT07424092

Recruiting now Disease control Sponsor: Clinica Universidad de Navarra, Universidad de Navarra Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether a single injection of DNX-2401, a virus designed to kill cancer cells, can shrink or stabilize recurrent high-grade brain tumors in 39 children and young adults. Participants receive the virus directly into the tumor during a biopsy procedure. The study aims to see if the treatment improves survival and is safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DNX-2401 (a virus that infects and kills cancer cells)
What this could lead to: If it works, this could offer a new treatment option for children and young adults with hard-to-treat brain tumors that have come back.
What could go wrong: This is a small, early-phase trial (39 people) with no control group, so results may not apply widely. The virus is injected directly into the brain, which carries risks like swelling or infection.

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Conditions

The condition(s) this trial relates to.

central nervous system primitive neuroectodermal neoplasm embryonal neoplasm ependymoma glioma malignant glioma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMBRYONAL TUMOR OF BRAIN EPENDYMOMA HIGH GRADE GLIOMA PEDIATRIC RECURRENCE REFRACTORY YOUNG ADULT

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Cancer Center Clínica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
Princess Máxima Centrum
NOT_YET_RECRUITING

Utrecht, 3584, Netherlands

Contact Phone: •••-•••-•••• Email: •••••@•••••

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